Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 106, Issue -, Pages 91-98Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2016.08.002
Keywords
IL-29; Cytokine; Cancer; Immune response
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Funding
- Des Moines University for Yujiang Fang [IOER 05-14-01, IOER112-3749, IOER112-3114]
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Interleukin-29 (IL-29) is a new member of the recently discovered interferon lambda (IFN lambda) family. It is produced predominantly by maturing dendritic cells and macrophages. It has been implicated in numerous immunological responses and has shown antiviral activity similar to the Type I interferons, although its target cell population is more limited than the Type I interferons. In recent years, the role of IL-29 in the pathogenesis of various cancers has also been extensively studied. In this review, we will discuss the recent advances of IL-29 in immunological processes and the pathogenesis of various cancer. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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