A Highly Selective MNK Inhibitor Rescues Deficits Associated with Fragile X Syndrome in Mice

Controlled trial of lovastatin combined with an open-label treatment of a parent-implemented language intervention in youth with fragile X syndrome

(2020) Angela John Thurman et al.   Journal of Neurodevelopmental Disorders

Translation control of the immune checkpoint in cancer and its therapeutic targeting

(2019) Yichen Xu et al.   NATURE MEDICINE

Widespread Alterations in Translation Elongation in the Brain of Juvenile Fmr1 Knockout Mice

(2019) Sohani Das Sharma et al.   Cell Reports

Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome

(2019) Antonis Asiminas et al.   Science Translational Medicine

Reversal of peripheral nerve injury-induced neuropathic pain and cognitive dysfunction via genetic and tomivosertib targeting of MNK

(2019) Stephanie Shiers et al.   NEUROPSYCHOPHARMACOLOGY

Aberrant RNA translation in fragile X syndrome: From FMRP mechanisms to emerging therapeutic strategies

(2018) Anwesha Banerjee et al.   BRAIN RESEARCH

Loss of eIF4E phosphorylation engenders depression-like behaviors via selective mRNA translation

(2018) Inês Silva Amorim et al.   JOURNAL OF NEUROSCIENCE

Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice

(2018) Paulino Barragán-Iglesias et al.   Nature Communications

Of Men and Mice: Modeling the Fragile X Syndrome

(2018) Regina Dahlhaus   Frontiers in Molecular Neuroscience

Serine-threonine protein phosphatases: Lost in translation

(2018) Victoria Kolupaeva   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Recent progress of drug nanoformulations targeting to brain

(2018) Abdur Rauf Khan et al.   JOURNAL OF CONTROLLED RELEASE

Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain

(2018) Salim Megat et al.   JOURNAL OF NEUROSCIENCE

Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with RACK1 on polyribosomes

(2017) Arianna Russo et al.   HUMAN MOLECULAR GENETICS

The MNK–eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain

(2017) Jamie K. Moy et al.   JOURNAL OF NEUROSCIENCE

Metformin ameliorates core deficits in a mouse model of fragile X syndrome

(2017) Ilse Gantois et al.   NATURE MEDICINE

Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome

(2017) Elizabeth M. Berry-Kravis et al.   NATURE REVIEWS DRUG DISCOVERY

Potential Involvement of Impaired BKCa Channel Function in Sensory Defensiveness and Some Behavioral Disturbances Induced by Unfamiliar Environment in a Mouse Model of Fragile X Syndrome

(2017) Maria Isabel Carreno-Munoz et al.   NEUROPSYCHOPHARMACOLOGY

Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice

(2017) Emanuela Santini et al.   Science Signaling

Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat

(2017) Roman Smidak et al.   Frontiers in Aging Neuroscience

Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice

(2017) Emanuela Santini et al.   Science Signaling

Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D)

(2017) Mark E. Gurney et al.   Scientific Reports

Lovastatin corrects ERK pathway hyperactivation in fragile X syndrome: potential of platelet’s signaling cascades as new outcome measures in clinical trials

(2016) David Pellerin et al.   BIOMARKERS

Hippocampal dysfunction and cognitive impairment in Fragile-X Syndrome

(2016) Crystal Bostrom et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Selective Role of the Catalytic PI3K Subunit p110β in Impaired Higher Order Cognition in Fragile X Syndrome

(2015) Christina Gross et al.   Cell Reports

Increased Expression of the PI3K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome

(2015) Christina Gross et al.   Cell Reports

Use of the Open Field Maze to Measure Locomotor and Anxiety-like Behavior in Mice

(2015) Michael L. Seibenhener et al.   Jove-Journal of Visualized Experiments

Targeting Mnks for Cancer Therapy

(2015) Jinqiang Hou et al.   Oncotarget

Protein Phosphatase 2A Negatively Regulates Eukaryotic Initiation Factor 4E Phosphorylation and eIF4F Assembly through Direct Dephosphorylation of Mnk and eIF4E

(2015) Yikun Li et al.   NEOPLASIA

Effect of lovastatin on behavior in children and adults with fragile X syndrome: An open-label study

(2014) Artuela Çaku et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Genetic Removal of Matrix Metalloproteinase 9 Rescues the Symptoms of Fragile X Syndrome in a Mouse Model

(2014) H. Sidhu et al.   JOURNAL OF NEUROSCIENCE

Fragile X Mental Retardation Protein Regulates Translation by Binding Directly to the Ribosome

(2014) Eileen Chen et al.   MOLECULAR CELL

Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes

(2014) Christos G. Gkogkas et al.   Cell Reports

The Fragile X Mental Retardation Protein Regulates Matrix Metalloproteinase 9 mRNA at Synapses

(2013) A. Janusz et al.   JOURNAL OF NEUROSCIENCE

Advances in clinical and molecular understanding of the FMR1 premutation and fragile X-associated tremor/ataxia syndrome

(2013) Randi Hagerman et al.   LANCET NEUROLOGY

Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology

(2013) Tsuyoshi Udagawa et al.   NATURE MEDICINE

Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome

(2013) Emily K. Osterweil et al.   NEURON

Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome

(2012) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

Bidirectional Control of mRNA Translation and Synaptic Plasticity by the Cytoplasmic Polyadenylation Complex

(2012) Tsuyoshi Udagawa et al.   MOLECULAR CELL

Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

(2012) Aditi Bhattacharya et al.   NEURON

The trouble with spines in fragile X syndrome: density, maturity and plasticity

(2012) C.X. He et al.   NEUROSCIENCE

A cellular response linking eIF4AI activity to eIF4AII transcription

(2012) G. Galicia-Vazquez et al.   RNA

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases

(2011) B. W. Konicek et al.   CANCER RESEARCH

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome

(2011) D. D. Krueger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome

(2010) E. K. Osterweil et al.   JOURNAL OF NEUROSCIENCE

Autism spectrum disorder in fragile X syndrome: A longitudinal evaluation

(2009) R. Nick Hernandez et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

(−)-Cercosporamide derivatives as novel antihyperglycemic agents

(2008) Akihiro Furukawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fragile X syndrome

(2008) Kathryn B Garber et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP)

(2007) Doron Gothelf et al.   ANNALS OF NEUROLOGY