Review
Physics, Multidisciplinary
Adrian Hernandez, Jose M. Amigo
Summary: Deep learning models and GPUs have revolutionized machine learning, while attention mechanisms offer a promising solution for sequential reasoning, aiding in modeling complex systems effectively.
Article
Physics, Multidisciplinary
Moritz Reh, Markus Schmitt, Martin Gaerttner
Summary: We developed a variational approach using deep autoregressive neural networks to simulate the dynamics of open quantum many-body systems. The parameters of a compressed representation of a mixed quantum state are dynamically adjusted according to the Lindblad master equation using a time-dependent variational principle. By solving the dissipative quantum Heisenberg model and applying it to the simulation of confinement dynamics in the presence of dissipation, we illustrated the effectiveness of our approach.
PHYSICAL REVIEW LETTERS
(2021)
Article
Biochemical Research Methods
Elena S. Dimitrova, Adam C. Knapp, Brandilyn Stigler, Michael E. Stillman
Summary: This study proposes Cyclone, a software package that can simulate the complete state space of a finite dynamical system over any finite set. Unlike other software packages, Cyclone is capable of computing the complete state space of function-based models.
Article
Neurosciences
Devon Stoliker, Leonardo Novelli, Franz X. Vollenweider, Gary F. Egan, Katrin H. Preller, Adeel Razi
Summary: Classic psychedelic-induced ego dissolution involves a shift in the sense of self and a blurring of the boundary between the self and the world. Our study explores the underlying neural mechanism of LSD-induced ego dissolution through effective connectivity changes in resting-state networks. The findings suggest that the balance of effective connectivity between networks plays a crucial role in altering the sense of self and subject-object boundaries.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Marco Grassia, Manlio De Domenico, Giuseppe Mangioni
Summary: The authors propose a deep-learning framework for network dismantling, which can be utilized to quantify network vulnerability and detect early-warning signals of collapse.
NATURE COMMUNICATIONS
(2021)
Review
Physics, Multidisciplinary
S. Salcedo-Sanz, D. Casillas-Perez, J. Del Ser, C. Casanova-Mateo, L. Cuadra, M. Piles, G. Camps-Valls
Summary: This paper discusses the important definitions, methods, literature, and latest results on persistence in complex systems. It finds that the definitions and methods for short-term and long-term persistence are different, and studying different cases can provide empirical evidence.
PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Mario Siervo, Oliver M. Shannon, David J. Llewellyn, Blossom C. M. Stephan, Luigi Fontana
Summary: The traditional Mediterranean diet is recognized for its protective effects against cardiovascular diseases, diabetes, and maintaining cognitive health. While clinical trial results are inconsistent, observational studies suggest that the diet may be effective for early prevention of dementia.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Computer Science, Information Systems
Masaaki Inoue, Thong Pham, Hidetoshi Shimodaira
Summary: Temporal datasets that describe complex interactions between individuals over time are increasingly common in various domains. Conventional graph representations may result in information loss as higher-order relationships need to be broken into multiple pairwise relationships. Hypergraph representation, on the other hand, preserves higher-order relationships using hyperedges. We propose a new hypergraph growth model with a data-driven preferential attachment mechanism and show that it outperforms conventional models in replicating the observed first-order and second-order structures in real-world datasets.
Review
Physics, Multidisciplinary
Hendrik Weimer, Augustine Kshetrimayum, Roman Orus
Summary: Coupling a quantum many-body system to an external environment can significantly alter its dynamics, leading to new possibilities not available in closed systems. Understanding the properties of the steady state and relaxation dynamics of open quantum many-body systems is of particular interest. New computational tools are needed to simulate these systems, as existing methods for closed systems are not directly applicable. This review discusses various approaches to simulating open many-body systems and highlights recent advances in simulating large system sizes.
REVIEWS OF MODERN PHYSICS
(2021)
Article
Biochemical Research Methods
Gang Xu, Qinghua Wang, Jianpeng Ma
Summary: The study developed an open-source toolkit named OPUS-X for predicting protein 3D structure, consisting of three modules: OPUS-TASS2, OPUS-Contact, and OPUS-Fold2. OPUS-TASS2 integrates global protein structure information, OPUS-Contact combines multiple raw features, and OPUS-Fold2 utilizes different protein folding methods.
Article
Public, Environmental & Occupational Health
Ruoxi Ding, Ping He
Summary: The study found negative linkages between childhood adversities and cognitive function in the middle-aged and older Chinese population, primarily functioning indirectly through factors such as education attainment, self-rated health, and marital status.
SOCIAL SCIENCE & MEDICINE
(2021)
Review
Geriatrics & Gerontology
Xin Wang, Keyi Si, Wei Gu, Xueqiang Wang
Summary: Mild cognitive impairment (MCI) is a global concern among the elderly that affects their health and quality of life. Tai Chi, a form of mind-body exercise, has been recommended as a part of management for MCI patients. This review summarizes epidemiological studies on the effects of Tai Chi on symptom remission in older adults with MCI and explores the potential mechanisms. Evidence suggests that Tai Chi improves cognitive functions and alleviates symptoms of MCI by activating brain signals, altering connectivity, increasing brain volume, and modulating neurotropic and inflammation factors. Studies comparing different types and frequencies of Tai Chi can help identify effective paradigms for MCI in older people.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Engineering, Environmental
Long Jiang, Zongjiang Yu, Yaojie Liu, Mo Xian, Chao Xu
Summary: This study systematically evaluated the adsorption processes of hydroquinone with respect to three adsorbents in different systems. It found that low concentrations of acids could promote the adsorption process, while high concentrations of lactic acid inhibited the adsorption. Coexisting salts exhibited a promotion effect, and competitive binding was observed in homolog coexisting system. The study also revealed the promoting effect of KCl on adsorption and the competitive occupation effect of lactic acid and p-nitrophenol.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Review
Biology
Tyler P. Quigley, Gro Amdam
Summary: Human life expectancy is increasing, but healthspan and quality of life for elderly people may not show the same development. Social relationships have been found to promote healthy ageing, calling for experimental research to uncover causal mechanisms. Insects with developed social behavior, in addition to the widely used fruit fly model, can play a key role in studying these mechanisms.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Hospitality, Leisure, Sport & Tourism
Chun-Hao Wang, Hao-Lun Fu, Shih-Chun Kao, David Moreau, Cheng-Ta Yang
Summary: This study used a non-parametric approach to assess cognitive performance at the level of reaction time distribution and found that interceptive sport athletes had shorter mean reaction time when processing distracting information, while strategic sport athletes showed higher resilience capacity in early responses. These findings indicate that the two types of open-skill sports may have different processing specificities, potentially reflecting domain-specific rules and requirements.
PSYCHOLOGY OF SPORT AND EXERCISE
(2023)
Article
Clinical Neurology
Livia Livint Popa, Mihaela Iancu, Gheorghe Livint, Maria Balea, Constantin Dina, Vitalie Vacaras, Cristian Vladescu, Laura Balanescu, Anca Dana Buzoianu, Stefan Strilciuc, Dafin Muresanu
Summary: N-Pep-12, a dietary supplement, has been shown to have neuroprotective and pro-cognitive effects in patients after ischemic stroke. This study found that a 90-day, 90 mg daily administration of N-Pep-12 significantly impacted some QEEG indicators in patients with supratentorial ischemic stroke, indicating potential enhancement of post-stroke neurorecovery. Further research is needed to confirm these findings.
NEUROLOGICAL SCIENCES
(2022)
Review
Neurosciences
Adina Stan, Hanna Dragos, Stefan Strilciuc, Silvina Ilut, Vitalie Vacaras, Angela Cozma, Paul Stefan Panaitescu, Horatiu Stan, Dafin F. Muresanu
Summary: This review evaluated the circadian distribution of intracranial hemorrhage (ICH) after intravenous thrombolysis (ivT) in acute ischemic stroke (AIS) patients. The results showed that ICH was most common within 6-12 hours after onset and had the lowest risk during the time frame of 18:00-00:00. However, further research is needed to validate this circadian pattern due to the limited number of included studies and inconsistent findings.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Editorial Material
Medicine, General & Internal
Stefan Strilciuc, Adrian Gheorghe
Summary: This Arts and Medicine feature discusses the 2019 film "Collective," which exposes corruption in the Romanian national health system leading to poor patient outcomes. It also provides an update on the individuals and reform efforts depicted in the movie.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Livia Livint Popa, Diana Chira, Victor Dabala, Elian Hapca, Bogdan Ovidiu Popescu, Constantin Dina, Razvan Chereches, Stefan Strilciuc, Dafin F. Muresanu
Summary: Post-stroke depression (PSD) is a complex condition influenced by various biological and psychological factors. This study investigated the use of quantitative electroencephalography (qEEG) to identify markers of PSD in stroke patients. The results showed significant associations between DTABR values and HADS-D scores in post-stroke depressed patients.
Article
Neurosciences
Olivia Verisezan Rosu, Nicoleta Jemna, Elian Hapca, Irina Benedek, Iulia Vadan, Ioana Muresanu, Diana Chira, Constantin Radu, Razvan Chereches, Stefan Strilciuc, Dafin Muresanu
Summary: This randomized controlled trial investigated the safety and efficacy of combining repetitive transcranial magnetic stimulation (rTMS) and Cerebrolysin in improving cognitive and functional outcomes in TBI patients. The study results demonstrated that the combined intervention of rTMS and Cerebrolysin was safe and well-tolerated by patients with TBI. Although no statistically significant differences were observed in the primary outcome measures, the descriptive trends in the study support existing literature on the efficacy and safety of rTMS and Cerebrolysin.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Medicine, General & Internal
Hanna Maria Dragos, Adina Stan, Roxana Pintican, Diana Feier, Andrei Lebovici, Paul-Stefan Panaitescu, Constantin Dina, Stefan Strilciuc, Dafin F. Muresanu
Summary: Stroke is a major cause of disability and death, posing significant socio-economic burden on healthcare systems. Radiomics analysis (RA) utilizing artificial intelligence has been applied to stroke neuroimaging in order to promote personalized precision medicine. In this systematic review, the role of RA as an adjunct tool in predicting disability after stroke was evaluated. Combined predictive models incorporating clinical and radiomics features showed better performance in predicting patient outcomes compared to models based on either clinical or radiomics features alone.
Article
Health Care Sciences & Services
Stefan Strilciuc, Constantin Radu, Diana-Alecsandra Grad, Adina Dora Stan, Cristian Vladescu, Anca Dana Buzoianu, Dafin Muresanu
Summary: This study aims to examine the cost-effectiveness of Cerebrolysin as an add-on therapy for moderate-severe acute ischemic stroke. The findings suggest that Cerebrolysin is cost-effective within a certain threshold.
Review
Medicine, General & Internal
Nicu Catalin Draghici, Vitalie Vacaras, Roxana Bolchis, Atamyrat Bashimov, Diana Maria Domnita, Silvina Ilut, Livia Livint Popa, Tudor Dimitrie Lupescu, Dafin Fior Muresanu
Summary: Entrapment neuropathies of the lower limb are often misdiagnosed as other conditions, but a comprehensive evaluation including medical history, physical examination, and electrodiagnostic studies can help confirm the diagnosis. This article reviews the epidemiology, anatomy, pathophysiology, etiology, clinical presentation, and electrodiagnostic techniques of lower limb entrapment neuropathies, aiming to enhance clinicians' understanding of this disease.
Article
Health Care Sciences & Services
Oliviu Florentiu Sarb, Vitalie Vacaras, Adriana Sarb, Maria Iacobescu, Alina-Ioana Tantau
Summary: Mild cognitive impairment (MCI) and Alzheimer's disease (AD) may be more frequent in patients with inflammatory bowel disease (IBD), and gut-brain axis (GBA) interactions might be a cause of MCI and AD development in patients with IBD. Blood biomarkers could serve as predictive factors for MCI development.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Medicine, General & Internal
Alec Ionescu, Emanuel Stefanescu, Stefan Strilciuc, Alexandru Rafila, Dafin Muresanu
Summary: This study aimed to evaluate the cognitive and visual processing capabilities of stroke patients using eye-tracking metrics and psychological evaluations. The results revealed some notable relationships between eye-tracking metrics and cognitive measures, such as a positive correlation between Symbol Search performance and the number of fixations. Anxiety levels were found to be positively correlated with first fixation duration, while longer first fixation durations were associated with poorer cognitive performance. However, most correlations were not statistically significant. Nonparametric ANOVA showed no significant differences in fixation metrics across the visits. These findings suggest a complex relationship between cognitive status, gaze fixation behavior, and psychological well-being in stroke patients. Further research with larger sample sizes and analysis of saccadic eye movements is needed to better understand these relationships and inform effective interventions for stroke rehabilitation.
MEDICINA-LITHUANIA
(2023)
Article
Rehabilitation
Silvina Ilut, Adina Stan, Imelda Rahovan, Elian Hapca, Ioana Zmaranda, Stefan Strilciuc, Dafin F. Muresanu
Summary: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons, leading to the impairment of voluntary muscle control and eventually death. It accounts for the majority of motor neuron diseases and has significant variability in terms of clinical forms, genetics, survival rate, and diagnostic particularities. Optimizing the accuracy of ALS diagnosis is crucial for effective clinical management and improving patients' quality of life.
BALNEO AND PRM RESEARCH JOURNAL
(2023)
Review
Neurosciences
Livia Livint Popa, Diana Chira, Stefan Strilciuc, Dafin F. Muresanu
Summary: This narrative review examines the application of non-invasive technologies in TBI rehabilitation and emphasizes their potential and future directions.
Meeting Abstract
Medicine, General & Internal
S. Vesa, S. Ilut, L. Perju-Dumbrava, V. Vacaras, R. Pop, D. Sipos-Lascu, C. Barsan, A. D. Buzoianu, S. Crisan
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Meeting Abstract
Immunology
Seema Mahesh, Mahesh Mallappa, Vitalie Vacaras, Viraj Shah, Amritha Belagaje, Pooja Dhamodar, Elena Serzhantova, Nadezhda Kubasheva, Dmitriy Chabanov, Dionysios Tsintzas, Latika Jaggi, Atul Jaggi, George Vithoulkas
JOURNAL OF IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Ioana Anamaria Muresanu, Diana Alecsandra Grad, Dafin Fior Muresanu, Elian Hapca, Irina Benedek, Nicoleta Jemna, Stefan Strilciuc, Bogdan Ovidiu Popescu, Lacramioara Perju-Dumbrava, Razvan Mircea Chereches
Summary: This secondary retrospective trial analysis aimed to analyze the correlations between HADS-Anxiety/HADS-Depression and scales measuring cognitive and motor processes in patients treated with Cerebrolysin compared to the placebo group, as well as compare anxiety and depression scores between the two treatment groups. The results showed that Cerebrolysin had a significant effect in reducing anxiety levels among patients with traumatic brain injuries, and there were correlations between HADS-Anxiety and Depression scores and other neuropsychological scales.
MEDICINA-LITHUANIA
(2022)
