Modeling UBQLN2-mediated neurodegenerative disease in mice: Shared and divergent properties of wild type and mutant UBQLN2 in phase separation, subcellular localization, altered proteostasis pathways, and selective cytotoxicity

Published 2020 View Full Article

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Title
Modeling UBQLN2-mediated neurodegenerative disease in mice: Shared and divergent properties of wild type and mutant UBQLN2 in phase separation, subcellular localization, altered proteostasis pathways, and selective cytotoxicity
Authors
Keywords
Proteostasis, Ubiquilin, Ubiquitin proteasome system, Amyotrophic lateral sclerosis, Frontotemporal dementia, Protein aggregation, Neurodegeneration
Journal
NEUROBIOLOGY OF DISEASE
Volume 143, Issue -, Pages 105016
Publisher
Elsevier BV
Online
2020-07-10
DOI
10.1016/j.nbd.2020.105016

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