Prospects for SARS-CoV-2 diagnostics, therapeutics and vaccines in Africa

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

(2020) Victor M Corman et al.   Eurosurveillance

Positive RT-PCR Test Results in Patients Recovered From COVID-19

(2020) Lan Lan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Looming threat of COVID-19 infection in Africa: act collectively, and fast

(2020) John N Nkengasong et al.   LANCET

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

COVID-19: combining antiviral and anti-inflammatory treatments

(2020) Justin Stebbing et al.   LANCET INFECTIOUS DISEASES

An interactive web-based dashboard to track COVID-19 in real time

(2020) Ensheng Dong et al.   LANCET INFECTIOUS DISEASES

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Co‐expression of human calreticulin significantly improves the production of HIV gp140 and other viral glycoproteins in plants

(2020) E Margolin et al.   PLANT BIOTECHNOLOGY JOURNAL

The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak

(2020) Matteo Chinazzi et al.   SCIENCE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Feasibility of controlling COVID-19 outbreaks by isolation of cases and contacts

(2020) Joel Hellewell et al.   Lancet Global Health

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

(2020) Xiaobo Yang et al.   Lancet Respiratory Medicine

Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak

(2020) Tao Zhang et al.   CURRENT BIOLOGY

COVID ‐19 infection may cause ketosis and ketoacidosis

(2020) Juyi Li et al.   DIABETES OBESITY & METABOLISM

An alternative workflow for molecular detection of SARS-CoV-2 – escape from the NA extraction kit-shortage, Copenhagen, Denmark, March 2020

(2020) Anna S. Fomsgaard et al.   Eurosurveillance

SARS-CoV-2 Vaccines: Status Report

(2020) Fatima Amanat et al.   IMMUNITY

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

(2020) Philippe Gautret et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Deployment of convalescent plasma for the prevention and treatment of COVID-19

(2020) Evan M. Bloch et al.   JOURNAL OF CLINICAL INVESTIGATION

Co‐infection of SARS‐CoV‐2 and HIV in a patient in Wuhan city, China

(2020) Feng Zhu et al.   JOURNAL OF MEDICAL VIROLOGY

COVID-19 in Europe: the Italian lesson

(2020) Andrea Saglietto et al.   LANCET

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial

(2020) Feng-Cai Zhu et al.   LANCET

Kawasaki-like disease: emerging complication during the COVID-19 pandemic

(2020) Russell M Viner et al.   LANCET

Developing antibody tests for SARS-CoV-2

(2020) Anna Petherick   LANCET

Hyperinflammatory shock in children during COVID-19 pandemic

(2020) Shelley Riphagen et al.   LANCET

African nations missing from coronavirus trials

(2020) Antoaneta Roussi et al.   NATURE

Let Africa into the market for COVID-19 diagnostics

(2020) John Nkengasong   NATURE

Human neutralizing antibodies elicited by SARS-CoV-2 infection

(2020) Bin Ju et al.   NATURE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

CRISPR–Cas12-based detection of SARS-CoV-2

(2020) James P. Broughton et al.   NATURE BIOTECHNOLOGY

Antibody responses to SARS-CoV-2 in patients with COVID-19

(2020) Quan-Xin Long et al.   NATURE MEDICINE

The COVID-19 vaccine development landscape

(2020) Tung Thanh Le et al.   NATURE REVIEWS DRUG DISCOVERY

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 Infection in Children

(2020) Xiaoxia Lu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

(2020) Kai Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Race to find COVID-19 treatments accelerates

(2020) Kai Kupferschmidt et al.   SCIENCE

Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2)

(2020) Ruiyun Li et al.   SCIENCE

DNA vaccine protection against SARS-CoV-2 in rhesus macaques

(2020) Jingyou Yu et al.   SCIENCE

Covid-19: Keep essential malaria services going during pandemic, urges WHO

(2020) Jacqui Thornton   BMJ-British Medical Journal

Distribution of the SARS-CoV-2 Pandemic and Its Monthly Forecast Based on Seasonal Climate Patterns

(2020) Nicola Scafetta   International Journal of Environmental Research and Public Health

Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy

(2020) Peter M George et al.   Lancet Respiratory Medicine

Seasonality of Respiratory Viral Infections

(2020) Miyu Moriyama et al.   Annual Review of Virology

COVID-19 in patients with HIV: clinical case series

(2020) Jose L Blanco et al.   Lancet HIV

A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques

(2020) Neeltje van Doremalen et al.   Science Advances

Emergence of SARS-CoV-2 through recombination and strong purifying selection

(2020) Xiaojun Li et al.   Science Advances

Species distribution models are inappropriate for COVID-19

(2020) Colin J. Carlson et al.   Nature Ecology & Evolution

Diabetic Ketoacidosis in COVID-19: Unique Concerns and Considerations

(2020) Nadine E Palermo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

COVID-19 vaccine development pipeline gears up

(2020) Asher Mullard   LANCET

Retraction—Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis

(2020) Mandeep R Mehra et al.   LANCET

ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques

(2020) Neeltje van Doremalen et al.   NATURE

Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates

(2020) Pauline Maisonnasse et al.   NATURE

Rapid Decay of Anti–SARS-CoV-2 Antibodies in Persons with Mild Covid-19

(2020) F. Javier Ibarrondo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques

(2020) Wei Deng et al.   SCIENCE

Potential impact of the COVID-19 pandemic on HIV, tuberculosis, and malaria in low-income and middle-income countries: a modelling study

(2020) Alexandra B Hogan et al.   Lancet Global Health

The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

(2020) Lakshmanane Premkumar et al.   Science Immunology

The Impact of Influenza and Tuberculosis Interaction on Mortality Among Individuals Aged ≥15 Years Hospitalized With Severe Respiratory Illness in South Africa, 2010–2016

(2019) Sibongile Walaza et al.   Open Forum Infectious Diseases

Randomized clinical trial examining safety and immunogenicity of heterologous prime-boost Ebola vaccines, Ad26.ZEBOV and MVA-BN-Filo: 12-month data from Nairobi, Kenya

(2019) Gaudensia Mutua et al.   JOURNAL OF INFECTIOUS DISEASES

Non-specific effects of BCG vaccine on viral infections

(2019) S.J.C.F.M. Moorlag et al.   CLINICAL MICROBIOLOGY AND INFECTION

Aiming for protective T-cell responses: a focus on the first generation conserved-region HIVconsv vaccines in preventive and therapeutic clinical trials

(2019) Tomáš Hanke   Expert Review of Vaccines

Phase 3 Efficacy Trial of Modified Vaccinia Ankara as a Vaccine against Smallpox

(2019) Phillip R. Pittman et al.   NEW ENGLAND JOURNAL OF MEDICINE

BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design

(2019) Camila Covián et al.   Frontiers in Immunology

Molecular Pharming for low and middle income countries

(2019) Sheeba Murad et al.   CURRENT OPINION IN BIOTECHNOLOGY

Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry

(2019) Yushun Wan et al.   JOURNAL OF VIROLOGY

Vaccinia-based vaccines to biothreat and emerging viruses

(2018) Les P. Nagata et al.   Biotechnology & Genetic Engineering Reviews

Residual T cell activation and skewed CD8+ T cell memory differentiation despite antiretroviral therapy-induced HIV suppression

(2018) Ramla F. Tanko et al.   CLINICAL IMMUNOLOGY

Novel Vaccine Technologies

(2018) Barney S. Graham et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Influenza Viral Shedding in a Prospective Cohort of HIV-Infected and Uninfected Children and Adults in 2 Provinces of South Africa, 2012–2014

(2018) Claire von Mollendorf et al.   JOURNAL OF INFECTIOUS DISEASES

Bacillus Calmette-Guérin (BCG) vaccine: A global assessment of demand and supply balance

(2018) Tania Cernuschi et al.   VACCINE

New Vaccine Technologies to Combat Outbreak Situations

(2018) Susanne Rauch et al.   Frontiers in Immunology

Expression of Rift Valley fever virus N-protein in Nicotiana benthamiana for use as a diagnostic antigen

(2018) Sandiswa Mbewana et al.   BMC BIOTECHNOLOGY

Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion

(2017) Alexandra C. Walls et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chimpanzee adenoviral vectors as vaccines for outbreak pathogens

(2017) Katie Ewer et al.   Human Vaccines & Immunotherapeutics

Subtype C gp140 Vaccine Boosts Immune Responses Primed by the South African AIDS Vaccine Initiative DNA-C2 and MVA-C HIV Vaccines after More than a 2-Year Gap

(2016) Glenda E. Gray et al.   Clinical and Vaccine Immunology

Safety and Immunogenicity of the Recombinant Mycobacterium bovis BCG Vaccine VPM1002 in HIV-Unexposed Newborn Infants in South Africa

(2016) André G. Loxton et al.   Clinical and Vaccine Immunology

Effect of Antiretroviral Therapy on the Memory and Activation Profiles of B Cells in HIV-Infected African Women

(2016) Ramla F. Tanko et al.   JOURNAL OF IMMUNOLOGY

Plant-produced Crimean-Congo haemorrhagic fever virus nucleoprotein for use in indirect ELISA

(2016) Richard Atkinson et al.   JOURNAL OF VIROLOGICAL METHODS

The host immune response in respiratory virus infection: balancing virus clearance and immunopathology

(2016) Amy H. Newton et al.   Seminars in Immunopathology

Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses

(2016) Shuo Su et al.   TRENDS IN MICROBIOLOGY

Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus

(2016) Anurodh Shankar Agrawal et al.   Human Vaccines & Immunotherapeutics

Impact of HIV on the severity of influenza

(2016) Daniel Alberto González Álvarez et al.   Expert Review of Respiratory Medicine

When plant virology metAgrobacterium: the rise of the deconstructed clones

(2015) Hadrien Peyret et al.   PLANT BIOTECHNOLOGY JOURNAL

Review: Capripoxvirus Diseases: Current Status and Opportunities for Control

(2015) E. S. M. Tuppurainen et al.   Transboundary and Emerging Diseases

The Evolution of Poxvirus Vaccines

(2015) Lucas Sánchez-Sampedro et al.   Viruses-Basel

Vaccination in HIV-Infected Adults

(2014) Nancy F. Crum-Cianflone et al.   AIDS PATIENT CARE AND STDS

Systematic review and meta-analysis of the current evidence on the duration of protection by bacillus Calmette–Guérin vaccination against tuberculosis

(2014) I Abubakar et al.   HEALTH TECHNOLOGY ASSESSMENT

Virus-Specific Memory CD8 T Cells Provide Substantial Protection from Lethal Severe Acute Respiratory Syndrome Coronavirus Infection

(2014) R. Channappanavar et al.   JOURNAL OF VIROLOGY

Correction: Absolute Humidity and the Seasonal Onset of Influenza in the Continental United States

(2014) Jeffrey Shaman et al.   PLOS BIOLOGY

Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions

(2013) N van Doremalen et al.   Eurosurveillance

Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study

(2013) Abdullah Assiri et al.   LANCET INFECTIOUS DISEASES

A Phase IIa Trial of the New Tuberculosis Vaccine, MVA85A, in HIV- and/orMycobacterium tuberculosis–infected Adults

(2012) Thomas J. Scriba et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Setting up a platform for plant-based influenza virus vaccine production in South Africa

(2012) Elizabeth Mortimer et al.   BMC BIOTECHNOLOGY

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Correction: Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

(2012) Chien-Te Tseng et al.   PLoS One

A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

(2011) M. Bolles et al.   JOURNAL OF VIROLOGY

A novel candidate HIV vaccine vector based on the replication deficient Capripoxvirus, Lumpy skin disease virus (LSDV)

(2011) Yen-Ju Shen et al.   Virology Journal

Epidemiology and Clinical Presentations of the Four Human Coronaviruses 229E, HKU1, NL63, and OC43 Detected over 3 Years Using a Novel Multiplex Real-Time PCR Method

(2010) E. R. Gaunt et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza

(2010) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Immunization for HIV-positive individuals

(2009) Anna Maria Geretti et al.   CURRENT OPINION IN INFECTIOUS DISEASES

The Poxvirus Vectors MVA and NYVAC as Gene Delivery Systems for Vaccination Against Infectious Diseases and Cancer

(2008) Carmen Gomez et al.   CURRENT GENE THERAPY