Bacterial virulence mediated by orthogonal post-translational modification

FICD activity and AMPylation remodelling modulate human neurogenesis

(2020) Pavel Kielkowski et al.   Nature Communications

A Chemical Probe for Dehydrobutyrine

(2020) Kaitlin A. Chambers et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways

(2019) Joshua PM Newson et al.   MOLECULAR & CELLULAR PROTEOMICS

Exploring the substrate scope of the phosphocholine transferase AnkX for versatile protein functionalisation

(2019) Christian Hedberg   CHEMBIOCHEM

Structural and Functional Insights into Host Death Domains Inactivation by the Bacterial Arginine GlcNAcyltransferase Effector

(2019) Jingjin Ding et al.   MOLECULAR CELL

Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases

(2019) Miles H. Black et al.   SCIENCE

A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy

(2019) Yue Xu et al.   CELL

Inhibition of bacterial ubiquitin ligases by SidJ–calmodulin-catalysed glutamylation

(2019) Sagar Bhogaraju et al.   NATURE

Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB

(2019) Donghyuk Shin et al.   MOLECULAR CELL

Deubiquitination of phosphoribosyl-ubiquitin conjugates by phosphodiesterase-domain–containing Legionella effectors

(2019) Min Wan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thinking outside the box - novel antibacterials to tackle the resistance crisis

(2018) Markus Lakemeyer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selectivity within a Family of Bacterial Phosphothreonine Lyases

(2018) Kaitlin A. Chambers et al.   BIOCHEMISTRY

Structural Insights into Non-canonical Ubiquitination Catalyzed by SidE

(2018) Yong Wang et al.   CELL

Discovery of Ubiquitin Deamidases in the Pathogenic Arsenal of Legionella pneumophila

(2018) Dylan Valleau et al.   Cell Reports

Protein AMPylation by an Evolutionarily Conserved Pseudokinase

(2018) Anju Sreelatha et al.   CELL

Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination

(2018) Sissy Kalayil et al.   NATURE

Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector

(2018) Anil Akturk et al.   NATURE

Structural basis of ubiquitin modification by the Legionella effector SdeA

(2018) Yanan Dong et al.   NATURE

Technologies to address antimicrobial resistance

(2018) Stephen J. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioorthogonal Engineering of Bacterial Effectors for Spatial–Temporal Modulation of Cell Signaling

(2018) Jingyi Zhao et al.   ACS Central Science

Legionella pneumophila inhibits immune signalling via MavC-mediated transglutaminase-induced ubiquitination of UBE2N

(2018) Ninghai Gan et al.   Nature Microbiology

Isopeptide and ester bond ubiquitination both regulate degradation of the human dopamine receptor 4

(2017) Jennifer C. Peeler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance

(2017) Seth W. Dickey et al.   NATURE REVIEWS DRUG DISCOVERY

Unraveling the Phosphocholination Mechanism of the Legionella pneumophila Enzyme AnkX

(2016) Konstantin Gavriljuk et al.   BIOCHEMISTRY

Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination

(2016) Sagar Bhogaraju et al.   CELL

Major Histocompatibility Complex (MHC) Class I Processing of the NY-ESO-1 Antigen Is Regulated by Rpn10 and Rpn13 Proteins and Immunoproteasomes following Non-lysine Ubiquitination

(2016) Richard Golnik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Distinct Substrate-binding Domain in the Bacterial Cysteine Methyltransferase Effectors NleE and OspZ

(2016) Ying Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YopJ Family Effectors Promote Bacterial Infection through a Unique Acetyltransferase Activity

(2016) Ka-Wai Ma et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Ubiquitination independent of E1 and E2 enzymes by bacterial effectors

(2016) Jiazhang Qiu et al.   NATURE

Structure of a pathogen effector reveals the enzymatic mechanism of a novel acetyltransferase family

(2016) Zhi-Min Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of a pathogen effector reveals the enzymatic mechanism of a novel acetyltransferase family

(2016) Zhi-Min Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Covalent Protein Labeling by Enzymatic Phosphocholination

(2015) Katharina Heller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bacterial Internalization, Localization, and Effectors Shape the Epithelial Immune Response during Shigella flexneri Infection

(2015) Juliane Lippmann et al.   INFECTION AND IMMUNITY

A Novel Link between Fic (Filamentation Induced by cAMP)-mediated Adenylylation/AMPylation and the Unfolded Protein Response

(2015) Anwesha Sanyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach

(2015) Malgorzata Broncel et al.   MOLECULAR & CELLULAR PROTEOMICS

Secretion systems in Gram-negative bacteria: structural and mechanistic insights

(2015) Tiago R. D. Costa et al.   NATURE REVIEWS MICROBIOLOGY

Oscillatory stress stimulation uncovers an Achilles heel of the yeast MAPK signaling network

(2015) A. Mitchell et al.   SCIENCE

The Bacterial Type III Secretion System as a Target for Developing New Antibiotics

(2014) Andrew C. McShan et al.   Chemical Biology & Drug Design

Unfolded Protein Response-regulatedDrosophilaFic (dFic) Protein Reversibly AMPylates BiP Chaperone during Endoplasmic Reticulum Homeostasis

(2014) Hyeilin Ham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting virulence: can we make evolution-proof drugs?

(2014) Richard C. Allen et al.   NATURE REVIEWS MICROBIOLOGY

Structure and Specificity of the Bacterial Cysteine Methyltransferase Effector NleE Suggests a Novel Substrate in Human DNA Repair Pathway

(2014) Qing Yao et al.   PLoS Pathogens

Inhibiting AMPylation: A Novel Screen To Identify the First Small Molecule Inhibitors of Protein AMPylation

(2013) Daniel M. Lewallen et al.   ACS Chemical Biology

What Pathogens Have Taught Us About Posttranslational Modifications

(2013) Dor Salomon et al.   Cell Host & Microbe

Structure of the Legionella effector AnkX reveals the mechanism of phosphocholine transfer by the FIC domain

(2013) Valérie Campanacci et al.   EMBO JOURNAL

Systems-Level Overview of Host Protein Phosphorylation DuringShigella flexneriInfection Revealed by Phosphoproteomics

(2013) Christoph Schmutz et al.   MOLECULAR & CELLULAR PROTEOMICS

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

(2013) Shan Li et al.   NATURE

A type III effector antagonizes death receptor signalling during bacterial gut infection

(2013) Jaclyn S. Pearson et al.   NATURE

Bacterial Subversion of Host Innate Immune Pathways

(2013) L. A. Baxt et al.   SCIENCE

Yersinia pseudotuberculosis Effector YopJ Subverts the Nod2/RICK/TAK1 Pathway and Activates Caspase-1 to Induce Intestinal Barrier Dysfunction

(2012) Ulrich Meinzer et al.   Cell Host & Microbe

Reversible phosphocholination of Rab proteins byLegionella pneumophilaeffector proteins

(2012) Philip R Goody et al.   EMBO JOURNAL

Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells

(2012) Ping Wei et al.   NATURE

Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins

(2012) Philipp Engel et al.   NATURE

The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response

(2012) Takahito Sanada et al.   NATURE

Serine/threonine acetylation of TGF -activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling

(2012) N. Paquette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type III Effector VopC Mediates Invasion for Vibrio Species

(2012) Lingling Zhang et al.   Cell Reports

Protection of Mice From a Chlamydia trachomatis Vaginal Infection Using a Salicylidene Acylhydrazide, a Potential Microbicide

(2011) A. Slepenkin et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular Mechanism for Eliminylation, a Newly Discovered Post-Translational Modification

(2011) Zhihong Ke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Chemical Reporter for Protein AMPylation

(2011) Markus Grammel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation

(2011) Li Zhang et al.   NATURE

Modulation of Rab GTPase function by a protein phosphocholine transferase

(2011) Shaeri Mukherjee et al.   NATURE

A Burkholderia pseudomallei Toxin Inhibits Helicase Activity of Translation Factor eIF4A

(2011) A. Cruz-Migoni et al.   SCIENCE

Modulation of Host Cell Function byLegionella pneumophilaType IV Effectors

(2010) Andree Hubber et al.   Annual Review of Cell and Developmental Biology

Post-translational modifications in host cells during bacterial infection

(2010) David Ribet et al.   FEBS LETTERS

The Legionella Effector Protein DrrA AMPylates the Membrane Traffic Regulator Rab1b

(2010) M. P. Muller et al.   SCIENCE

Glutamine Deamidation and Dysfunction of Ubiquitin/NEDD8 Induced by a Bacterial Effector Family

(2010) J. Cui et al.   SCIENCE

The Fic Domain: Regulation of Cell Signaling by Adenylylation

(2009) Carolyn A. Worby et al.   MOLECULAR CELL

Targeting of immune signalling networks by bacterial pathogens

(2009) Igor E. Brodsky et al.   NATURE CELL BIOLOGY

A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the host cell cycle

(2009) Q. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Inhibition of Type III Secretion Activated Signaling by the Salmonella Effector AvrA

(2009) Fangyong Du et al.   PLoS Pathogens

Salmonella AvrA Coordinates Suppression of Host Immune and Apoptotic Defenses via JNK Pathway Blockade

(2008) Rheinallt M. Jones et al.   Cell Host & Microbe

Bacterial cyclomodulin Cif blocks the host cell cycle by stabilizing the cyclin-dependent kinase inhibitors p21waf1and p27kip1

(2008) Ascel Samba-Louaka et al.   CELLULAR MICROBIOLOGY

Structure of the Cyclomodulin Cif from Pathogenic Escherichia coli

(2008) Yun Hsu et al.   JOURNAL OF MOLECULAR BIOLOGY

The Legionella pneumophila replication vacuole: making a cosy niche inside host cells

(2008) Ralph R. Isberg et al.   NATURE REVIEWS MICROBIOLOGY

AMPylation of Rho GTPases by Vibrio VopS Disrupts Effector Binding and Downstream Signaling

(2008) M. L. Yarbrough et al.   SCIENCE