SMN-primed ribosomes modulate the translation of transcripts related to spinal muscular atrophy

High-Resolution Ribosome Profiling Defines Discrete Ribosome Elongation States and Translational Regulation during Cellular Stress

(2019) Colin Chih-Chien Wu et al.   MOLECULAR CELL

Robust Comparison of Protein Levels Across Tissues and Throughout Development Using Standardized Quantitative Western Blotting

(2019) Yu-Ting Huang et al.   Jove-Journal of Visualized Experiments

mRNP assembly, axonal transport, and local translation in neurodegenerative diseases

(2018) Bilal Khalil et al.   BRAIN RESEARCH

Temporal and tissue-specific variability of SMN protein levels in mouse models of spinal muscular atrophy

(2018) Ewout J N Groen et al.   HUMAN MOLECULAR GENETICS

Advances in therapy for spinal muscular atrophy: promises and challenges

(2018) Ewout J. N. Groen et al.   Nature Reviews Neurology

Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression

(2018) Matthew M. Parks et al.   Science Advances

High-affinity RNA targets of the Survival Motor Neuron protein reveal diverse preferences for sequence and structural motifs

(2018) Eric W Ottesen et al.   NUCLEIC ACIDS RESEARCH

riboWaltz: Optimization of ribosome P-site positioning in ribosome profiling data

(2018) Fabio Lauria et al.   PLoS Computational Biology

Decoding the Function of Expansion Segments in Ribosomes

(2018) Kotaro Fujii et al.   MOLECULAR CELL

Endogenous rRNA Sequence Variation Can Regulate Stress Response Gene Expression and Phenotype

(2018) Chad M. Kurylo et al.   Cell Reports

Active Ribosome Profiling with RiboLace

(2018) Massimiliano Clamer et al.   Cell Reports

Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide

(2017) Zhen Shi et al.   MOLECULAR CELL

Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus

(2017) Olga Tapia et al.   NEUROBIOLOGY OF DISEASE

The Actin Cytoskeleton in SMA and ALS: How Does It Contribute to Motoneuron Degeneration?

(2017) Niko Hensel et al.   NEUROSCIENTIST

Ubiquitination of stalled ribosome triggers ribosome-associated quality control

(2017) Yoshitaka Matsuo et al.   Nature Communications

Converging Mechanisms of p53 Activation Drive Motor Neuron Degeneration in Spinal Muscular Atrophy

(2017) Christian M. Simon et al.   Cell Reports

Cellular and Molecular Anatomy of the Human Neuromuscular Junction

(2017) Ross A. Jones et al.   Cell Reports

Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons

(2016) Claudia Fallini et al.   JOURNAL OF NEUROSCIENCE

Commonality amid diversity: Multi-study proteomic identification of conserved disease mechanisms in spinal muscular atrophy

(2016) Heidi R. Fuller et al.   NEUROMUSCULAR DISORDERS

The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation

(2016) Rosario Francisco-Velilla et al.   NUCLEIC ACIDS RESEARCH

Systematic discovery of cap-independent translation sequences in human and viral genomes

(2016) Shira Weingarten-Gabbay et al.   SCIENCE

Translation and cancer

(2015) Ivan Topisirovic et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Three distinct ribosome assemblies modulated by translation are the building blocks of polysomes

(2015) Gabriella Viero et al.   JOURNAL OF CELL BIOLOGY

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

Differential Stoichiometry among Core Ribosomal Proteins

(2015) Nikolai Slavov et al.   Cell Reports

Transcriptional profiling of differentially vulnerable motor neurons at pre-symptomatic stage in the Smn 2b/- mouse model of spinal muscular atrophy

(2015) Lyndsay M. Murray et al.   Acta Neuropathologica Communications

Ribosome profiling reveals sequence-independent post-initiation pausing as a signature of translation

(2014) Yan Han et al.   CELL RESEARCH

Label-Free Quantitative Proteomic Profiling Identifies Disruption of Ubiquitin Homeostasis As a Key Driver of Schwann Cell Defects in Spinal Muscular Atrophy

(2014) Arwin Aghamaleky Sarvestany et al.   JOURNAL OF PROTEOME RESEARCH

Fragile X Mental Retardation Protein Regulates Translation by Binding Directly to the Ribosome

(2014) Eileen Chen et al.   MOLECULAR CELL

Subcellular transcriptome alterations in a cell culture model of spinal muscular atrophy point to widespread defects in axonal growth and presynaptic differentiation

(2014) Lena Saal et al.   RNA

Distinct stages of the translation elongation cycle revealed by sequencing ribosome-protected mRNA fragments

(2014) Liana F Lareau et al.   eLife

SMN Is Essential for the Biogenesis of U7 Small Nuclear Ribonucleoprotein and 3′-End Formation of Histone mRNAs

(2013) Sarah Tisdale et al.   Cell Reports

Widespread uncoupling between transcriptome and translatome variations after a stimulus in mammalian cells

(2012) Toma Tebaldi et al.   BMC GENOMICS

An SMN-Dependent U12 Splicing Event Essential for Motor Circuit Function

(2012) Francesco Lotti et al.   CELL

A novel function for the survival motoneuron protein as a translational regulator

(2012) Gabriel Sanchez et al.   HUMAN MOLECULAR GENETICS

Synaptic defects in type I spinal muscular atrophy in human development

(2012) Rebeca Martínez-Hernández et al.   JOURNAL OF PATHOLOGY

The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments

(2012) Nicholas T Ingolia et al.   Nature Protocols

Specialized ribosomes: a new frontier in gene regulation and organismal biology

(2012) Shifeng Xue et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning

(2011) Nadya Kondrashov et al.   CELL

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy

(2011) J. N. Sleigh et al.   Disease Models & Mechanisms

The spinal muscular atrophy disease protein SMN is linked to the rho-kinase pathway via profilin

(2011) Anna Nölle et al.   HUMAN MOLECULAR GENETICS

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy

(2010) Markus Riessland et al.   HUMAN MOLECULAR GENETICS

Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line

(2010) Christine Vogel et al.   Molecular Systems Biology

Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?

(2009) Arthur H. M. Burghes et al.   NATURE REVIEWS NEUROSCIENCE

Alternative Splicing Events Are a Late Feature of Pathology in a Mouse Model of Spinal Muscular Atrophy

(2009) Dirk Bäumer et al.   PLoS Genetics

Rare Missense and Synonymous Variants in UBE1 Are Associated with X-Linked Infantile Spinal Muscular Atrophy

(2008) Juliane Ramser et al.   AMERICAN JOURNAL OF HUMAN GENETICS

SMN Deficiency Causes Tissue-Specific Perturbations in the Repertoire of snRNAs and Widespread Defects in Splicing

(2008) Zhenxi Zhang et al.   CELL

Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy

(2008) Shingo Kariya et al.   HUMAN MOLECULAR GENETICS