Article
Oncology
Daniel R. Schmidt, Rutulkumar Patel, David G. Kirsch, Caroline A. Lewis, Matthew G. Vander Heiden, Jason W. Locasale
Summary: Cancer has complex effects on cellular and systemic metabolism, with metabolomics playing a crucial role in providing insights for cancer diagnosis, monitoring, and therapy. Advances in technology have expanded the applications of metabolomics in clinical research, with the potential to further enhance cancer patient management in the future.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Review
Biochemistry & Molecular Biology
Hiromichi Sato, Kazuki Sasaki, Tomoaki Hara, Yoshiko Tsuji, Yasuko Arao, Chihiro Otsuka, Yumiko Hamano, Mirei Ogita, Shogo Kobayashi, Eric di Luccio, Takaaki Hirotsu, Yuichiro Doki, Hidetoshi Eguchi, Taroh Satoh, Shizuka Uchida, Hideshi Ishii
Summary: This article describes the causes and complexity of pancreatic ductal adenocarcinoma (PDAC), emphasizing the importance of early diagnosis and the multifaceted characteristics of PDAC in terms of cancer cell metabolism, mesenchymal cells, and metagenomics. The article also mentions various pathway alterations associated with PDAC treatment refractoriness and prospects for the application of new technologies.
Review
Oncology
Yibing Bai, Jiani Yang, Ying Cui, Yuanfei Yao, Feng Wu, Caiqi Liu, Xiaona Fan, Yanqiao Zhang
Summary: Sirtuins are a conserved family of protein lysine deacylases, with SIRT4 playing a crucial role in mitochondria and various biological processes such as energy metabolism, oxidative stress, and aging. It also has an impact on tumorigenesis.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Wenqing Zhang, Kunpeng Zhang, Peng Zhang, Juanjuan Zheng, Congcong Min, Xiaoyu Li
Summary: Pancreatic cancer is difficult to diagnose early due to lack of specific symptoms, but recent studies have shown a close relationship between microorganisms colonized in pancreatic cancer tissues and the development of the cancer, highlighting the importance of researching microbiome and immunotherapy approaches to improve treatment effectiveness and patient prognosis. Microbial diversity plays a crucial role in the occurrence, treatment, and prognosis of pancreatic cancer, and targeting the pancreatic microbiome may be a new focus in the diagnosis and treatment of the disease.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Pegah Farhadi, Reza Yarani, Elahe Valipour, Sarah Kiani, Zohreh Hoseinkhani, Kamran Mansouri
Summary: Metabolic reprogramming is a potential characteristic of tumor cells for continuous proliferation, with metabolic heterogeneity in breast cancer patients driving tumor progression and resistance to anticancer drugs. Identifying distinct metabolic alterations in breast cancer subtypes could provide new perspectives for faster diagnosis and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Oncology
Bin Xiong, Qiaoyi Huang, Huida Zheng, Shu Lin, Jianhua Xu
Summary: Colorectal cancer (CRC) is the most common and deadly cancer, and gene expression alteration is its main pathophysiological mechanism, leading to disrupted signaling pathways and cellular metabolic processes. MicroRNAs are closely related to CRC metabolism, proliferation, and chemotherapy resistance. Metabolic reprogramming is strongly associated with the development and prognosis of CRC, and microRNAs play a regulatory role by targeting enzymes involved in metabolic processes.
FRONTIERS IN ONCOLOGY
(2023)
Editorial Material
Oncology
Mariia Yuneva
Summary: Increasing glucose catabolism in brown adipose tissue through cold exposure reduces blood glucose and insulin tolerance, thereby decreasing glucose catabolism in tumors and arresting tumor progression, providing a novel approach for metabolism-based cancer therapy.
Review
Biochemistry & Molecular Biology
Xin He, Xinyu Gao, Weidong Xie
Summary: This article reviews the interaction between skin metabolism and aging, covering glucose, protein, and lipid metabolism, and explores relevant strategies for regulating skin metabolism. It is found that skin aging affects the metabolism of glucose, protein, and lipids, and the metabolism of these substances also affects the process of skin aging. Regulating specific metabolic disorders in the skin is an important anti-aging strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Zhengming Wu, Kun-Liang Guan
Summary: In this study, Park et al. (2022) demonstrate that reduced cellular acetyl-CoA levels and protein hypoacetylation contribute to the growth and dedifferentiation of liver cancer.
Article
Oncology
Qian Shen, Chuanlong Zhang, Xiaochen Jiang, Junchen Li, Fudong Liu, Xiyuan Zhang, Ge'er En, Bo Pang
Summary: Pancreatic cancer metabolism, as a research field, has attracted increasing attention in recent years. The number of publications on this topic has been continuously increasing. The United States, China, and Italy are the top three countries with the highest number of publications, showing close collaboration among researchers worldwide. The main research areas in this field include nutriment-deficient environment, cancer chemoprevention, and targeting cancer stem cells. Immunotherapy, ferroptosis, and targeted therapy are identified as hot keywords in recent years.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Cell Biology
Skirmantas Kriaucionis
Summary: Through chromatin accessibility analysis, the researchers found that inactivation of LKB1 resulted in overexpression of the Sox17 gene, which promotes lung cancer metastasis.
NATURE CELL BIOLOGY
(2021)
Editorial Material
Multidisciplinary Sciences
Katie Langin
Summary: Interviews with Science reveal that the history of mental health treatment can be a disqualifier.
Article
Chemistry, Multidisciplinary
Qishuai Feng, Wenming Fang, Yuedong Guo, Ping Hu, Jianlin Shi
Summary: Cancer stem cells (CSCs) play a critical role in the initiation and progression of early lung cancer. By modulating the communication between tumor-associated macrophages (TAMs) and CSCs, we developed a nebulized therapeutic strategy that triggers CSC ferroptosis, leading to the suppression of early lung cancer.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Oncology
Derek W. Stouth, Paul F. Lebeau, Richard C. Austin
Summary: Statins are drugs that lower cholesterol by inhibiting the rate-limiting enzyme of the mevalonate pathway. Recent research showed that caffeine enhances the antitumor activity of statins by suppressing statin-induced feedback activation of the mevalonate pathway. This finding suggests that combining caffeine and statin drugs could be a potential strategy to potentiate anticancer activity.
Review
Chemistry, Multidisciplinary
Rabin Dhakal, Mohammad Yosofvand, Hanna Moussa
Summary: This study provides an overview of polymer gel dosimetry using MAGIC-f gel, discussing its composition, manufacture, imaging, and calibration. The review also presents the history of polymer gel development and highlights the important experiments and applications of MAGIC-f polymer gel. Future works and potential research directions are also suggested based on the past and present works on MAGIC-f gel.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Monica Vara-Perez, Matteo Rossi, Chris van den Haute, Hannelore Maes, Maria Livia Sassano, Vivek Venkataramani, Bernhard Michalke, Erminia Romano, Kristine Rillaerts, Abhishek D. Garg, Corentin Schepkens, Francesca M. Bosisio, Jasper Wouters, Ana Isabel Oliveira, Peter Vangheluwe, Wim Annaert, Johannes Swinnen, Jean Marie Colet, Joost J. van den Oord, Sarah-Maria Fendt, Massimiliano Mazzone, Patrizia Agostinis
Summary: The study revealed that elevated BNIP3 levels correlated with poorer melanoma patient survival, and depletion of BNIP3 compromised tumor growth. Moreover, BNIP3-deprived melanoma cells displayed increased intracellular iron levels, affecting HIF-1 alpha stabilization.
Editorial Material
Cell Biology
H. Furkan Alkan, Patricia Altea-Manzano, Sarah-Maria Fendt
Summary: A recent study published in Nature reveals that dietary palmitic acid can induce an epigenetic memory in cancer cells, leading to enhanced metastasis.
Editorial Material
Cell Biology
Sarah-Maria Fendt
NATURE CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Tom Van Nyen, Melanie Planque, Lilian van Wagensveld, Joao A. G. Duarte, Esther A. Zaal, Ali Talebi, Matteo Rossi, Pierre-Rene Korner, Lara Rizzotto, Stijn Moens, Wout De Wispelaere, Regina E. M. Baiden-Amissah, Gabe S. Sonke, Hugo M. Horlings, Guy Eelen, Emanuele Berardi, Johannes Swinnen, Celia R. Berkers, Peter Carmeliet, Diether Lambrechts, Ben Davidson, Reuven Agami, Sarah-Maria Fendt, Daniela Annibali, Frederic Amant
Summary: Metabolic reprogramming is associated with cancer development and therapy resistance. In this study, the downregulation of serine biosynthesis enzyme PHGDH in a subset of patients is shown to be associated with relapse in platinum-treated ovarian cancers, as well as upregulation of NAD(+) and PARP activity. These findings reveal metabolic vulnerabilities with clinical implications for a subset of platinum-resistant ovarian cancers.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Guillaume Tournaire, Shauni Loopmans, Steve Stegen, Gianmarco Rinaldi, Guy Eelen, Sophie Torrekens, Karen Moermans, Peter Carmeliet, Bart Ghesquiere, Bernard Thienpont, Sarah -Maria Fendt, Nick van Gastel, Geert Carmeliet
Summary: Stem cells bypass mitochondrial oxidative phosphorylation blockade and maintain self-renewal ability by adjusting metabolic pathways.
Article
Oncology
Sied Kebir, Vivien Ullrich, Pia Berger, Celia Dobersalske, Sarah Langer, Laurel Rauschenbach, Daniel Trageser, Andreas Till, Franziska K. Lorbeer, Anja Wieland, Timo Wilhelm-Buchstab, Ashar Ahmad, Holger Froehlich, Igor Cima, Shruthi Prasad, Johann Matschke, Verena Jendrossek, Marc Remke, Barbara M. Gruener, Alexander Roesch, Jens T. Siveke, Christel Herold-Mende, Tobias Blau, Kathy Keyvani, Frank K. H. van Landeghem, Torsten Pietsch, Jorg Felsberg, Guido Reifenberger, Michael Weller, Ulrich Sure, Oliver Bruestle, Matthias Simon, Martin Glas, Bjoern Scheffler
Summary: This study aimed to identify and target tumor cells that can survive, adapt, and expand under primary therapy in glioblastoma. The researchers found that ALDH1A1+/pAKT+ subclones accumulate and acquire drug resistance in response to temozolomide treatment. They propose a combination therapy of temozolomide and AKT inhibitors as a potential treatment strategy.
CLINICAL CANCER RESEARCH
(2023)
Correction
Multidisciplinary Sciences
Matteo Rossi, Patricia Altea-Manzano, Margherita Demicco, Ginevra Doglioni, Laura Bornes, Marina Fukano, Anke Vandekeere, Alejandro M. Cuadros, Juan Fernandez-Garcia, Carla Riera-Domingo, Cristina Jauset, Melanie Planque, H. Furkan Alkan, David Nittner, Dongmei Zuo, Lindsay A. Broadfield, Sweta Parik, Antonino Alejandro Pane, Francesca Rizzollo, Gianmarco Rinaldi, Tao Zhang, Shao Thing Teoh, Arin B. Aurora, Panagiotis Karras, Ines Vermeire, Dorien Broekaert, Joke Van Elsen, Maximilian M. L. Knott, Martin F. Orth, Sofie Demeyer, Guy Eelen, Lacey E. Dobrolecki, Ayse Bassez, Thomas Van Brussel, Karl Sotlar, Michael T. Lewis, Harald Bartsch, Manfred Wuhrer, Peter van Veelen, Peter Carmeliet, Jan Cools, Sean J. Morrison, Jean-Christophe Marine, Diether Lambrechts, Massimiliano Mazzone, Gregory J. Hannon, Sophia Y. Lunt, Thomas G. P. Grunewald, Morag Park, Jacco van Rheenen, Sarah-Maria Fendt
Article
Oncology
Emma Phillips, Jorg Balss, Frederic Bethke, Stefan Pusch, Stefan Christen, Thomas Hielscher, Martina Schnoelzer, Michael N. C. Fletcher, Antje Habel, Claudia Tessmer, Lisa-Marie Brenner, Mona Goettmann, David Capper, Christel Herold-Mende, Andreas von Deimling, Sarah-Maria Fendt, Violaine Goidts
Summary: The study reveals the crucial role of PFKFB4 in glioblastoma growth, showing its involvement in regulating the degradation of HIF-1α. Furthermore, the overexpression of PFKFB4 in other cancer entities suggests its potential as a target for cancer therapy.
Review
Oncology
Yawen Liu, Anke Vandekeere, Min Xu, Sarah-Maria Fendt, Patricia Altea-Manzano
Summary: Malignant growth is characterized by aberrant cellular features, including metabolic rewiring, inactivation of tumor suppressors and activation of oncogenes which have mutual regulatory relationships. Changes in gene expression/activity impact cellular metabolism and protein modifications, highlighting the importance of understanding the crosstalk between tumor suppressors/oncogenes and metabolism-induced alterations.
FRONTIERS IN ONCOLOGY
(2022)
Meeting Abstract
Oncology
A. I. Tuens, C. S. L. Ho, H. -U. Schildhaus, M. Wiesweg, B. M. Gruener, B. Hegedues, M. Schuler, A. Schramm, S. Oeck
JOURNAL OF THORACIC ONCOLOGY
(2022)
Meeting Abstract
Endocrinology & Metabolism
Guillaume Tournaire, Shauni Loopmans, Steve Stegen, Guy Eelen, Sophie Torrekens, Karen Moermans, Peter Carmeliet, Bart Ghesquiere, Bernard Thienpont, Sarah-Maria Fendt, Nick van Gastel, Geert Carmeliet
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ana P. Gomes, Didem Ilter, Vivien Low, Stanislav Drapela, Tanya Schild, Edouard Mullarky, Julie Han, Ilaria Elia, Dorien Broekaert, Adam Rosenzweig, Michal Nagiec, Joana B. Nunes, Bethany E. Schaffer, Anders P. Mutvei, John M. Asara, Lewis C. Cantley, Sarah-Maria Fendt, John Blenis
Summary: The study reveals that alterations in propionate metabolism contribute to cancer aggressiveness by causing the accumulation of methylmalonic acid, a by-product of propionate metabolism. Dysregulation of propionate metabolism leads to a pro-aggressive signature in breast and lung cancer cells, increasing their metastatic potential. The downregulation of methylmalonyl coenzyme A epimerase (MCEE) is mediated by an extracellular signal-regulated kinase 2-driven transcription factor Sp1/early growth response protein 1 transcriptional switch driven by metastatic signaling at its promoter level.
Article
Endocrinology & Metabolism
Daniela Annibali, Sarah-Maria Fendt
Summary: The study demonstrates the transition of PHGDH to the nucleus following nutrient stress, impacting the activity of c-Jun and contributing to sustained cancer cell proliferation.
Review
Oncology
Erica Pranzini, Elisa Pardella, Paolo Paoli, Sarah-Maria Fendt, Maria Letizia Taddei
Summary: This study emphasizes the important role of amino acid metabolic reprogramming in cancer therapy, with amino acids playing a crucial role in acquiring resistance to anticancer drugs, especially in terms of the resistance of cancer stem cells.
Article
Cell & Tissue Engineering
Katrien Neyrinck, Johanna Van den Daele, Tim Vervliet, Jonathan De Smedt, Keimpe Wierda, Melissa Nijs, Tom Vanbokhoven, Astrid D'hondt, Melanie Planque, Sarah-Maria Fendt, Pei-Yu Shih, Frederik Seibt, Juan Pita Almenar, Mohamed Kreir, Devesh Kumar, Vania Broccoli, Geert Bultynck, Andreas Ebneth, Alfredo Cabrera-Socorro, Catherine Verfaillie
Summary: By overexpressing SOX9 in pluripotent stem cells, functionally mature human astrocytes can be generated, displaying comparable functional properties to primary human astrocytes. The electrophysiological properties of neurons co-cultured with these astrocytes are similar to murine primary cultures. This method allows for scaled-up production for high-throughput analysis, aiding in drug development and reducing animal use in biomedical research.
STEM CELL REVIEWS AND REPORTS
(2021)
