Journal
NATURAL PRODUCT RESEARCH
Volume 36, Issue 9, Pages 2239-2245Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1826481
Keywords
Pilea cavaleriei; Urticaceae; sesquiterpenoid; antimycobacterial activity
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Funding
- Beijing Natural Science Foundation [7132129]
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Fourp-coumaroylated sesquiterpenoids were isolated from Pilea cavaleriei. Three of them are new compounds. Compounds 2 and 4 showed antimycobacterial activity against Mycobacterium tuberculosis H(37)Rv.
Fourp-coumaroylated sesquiterpenoids (1-4), including three new ones (1,2, and 4), were isolated from the whole plants ofPilea cavaleriei. Their structures were established on the basis of comprehensive spectroscopic analysis and comparison with data reported in the literature. Compounds 1-4 were evaluated for their antimycobacterial activities, and 2 and 4 were active againstMycobacterium tuberculosis H(37)Rv with the MIC values of 19.6 +/- 0.19 and 17.4 +/- 0.12 mu g/mL, respectively.
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