Article
Chemistry, Multidisciplinary
Hairong Wang, Yu Chao, He Zhao, Xiuxia Zhou, Fuyong Zhang, Zheng Zhang, Zhiheng Li, Jian Pan, Jian Wang, Qian Chen, Zhuang Liu
Summary: In this study, a BBB-crossing copolymer was successfully fabricated using a choline analogue MPC, leading to efficient delivery of ICB therapy in a glioma model and significantly prolonging animal survival.
Article
Chemistry, Multidisciplinary
Guangbao Yang, Dongdong Wang, Soo Zeng Fiona Phua, Anivind Kaur Bindra, Cheng Qian, Rui Zhang, Liang Cheng, Guofeng Liu, Hongwei Wu, Zhuang Liu, Yanli Zhao
Summary: A nanoscale therapeutic system was fabricated by coassembly of human serum albumin and glucose oxidase, which effectively eliminates tumor cells through the combination of catalysis and chemotherapeutic prodrug conversion, demonstrating high therapeutic efficacy.
Article
Chemistry, Multidisciplinary
Jiaying Li, Fengxuan Han, Jinjin Ma, Huan Wang, Jun Pan, Guangbao Yang, He Zhao, Jiayue Zhao, Jinbo Liu, Zhuang Liu, Bin Li
Summary: This study visualizes the spatial and temporal profile of ROS in the bone injury microenvironment using photoacoustic imaging technique for the first time. It demonstrates that the levels of H2O2 increase significantly upon bone injury, peak at a certain stage of bone healing, and gradually decrease towards baseline level. Regulating ROS with hollow manganese dioxide nanoparticles (hMNPs) can promote cell growth and repair in bone injury environments.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Chunjie Wang, Ziliang Dong, Yu Hao, Yujie Zhu, Jing Ni, Quguang Li, Bo Liu, Yikai Han, Zhijuan Yang, Jianmei Wan, Kai Yang, Zhuang Liu, Liangzhu Feng
Summary: The pH-responsive nanomedicine prepared in this study has shown promising results in enhancing the therapeutic efficacy of radiotherapy against tumors by neutralizing tumor acidity and inhibiting IDO1, resulting in robust antitumor immunity and suppression of tumor metastasis and recurrence.
ADVANCED MATERIALS
(2022)
Article
Engineering, Environmental
Yan Liu, Xinxing Ma, Yujie Zhu, Xiang Lv, Peipei Wang, Liangzhu Feng
Summary: This study developed a pH-responsive nanomedicine that inhibits EGFR and normalizes tumor vasculature, improving tumor oxygenation and reducing tumor growth. It demonstrated the therapeutic efficacy of combined chemotherapy and photodynamic therapy in TNBC models, offering a potential treatment advantage for TNBC patients.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Lele Sun, Fengyun Shen, Zijian Xiong, He Yang, Ziliang Dong, Jian Xiang, Qingyang Gu, Qunsheng Ji, Chunhai Fan, Zhuang Liu
Summary: This study successfully constructed lymphocyte-based homologous targeting aAPCs (LC-aAPCs) that mimic the characteristics of natural antigen-presenting cells through lipid-DNA-mediated noninvasive live cell surface engineering. These LC-aAPCs can optimize T cell activation and effectively inhibit tumor growth.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Materials Science, Multidisciplinary
Yu Hao, Lei Zhang, Ziliang Dong, Chunjie Wang, Yu Chao, Dongxu Zhao, Yujie Zhu, Zhijuan Yang, Nailin Yang, Yikai Han, Liangzhu Feng, Zhuang Liu
Summary: This article proposes an alternative locoregional treatment strategy using percutaneously implanted catalytic couple fueled by orally administrated ethanol to effectively ablate tumors. It is shown that this strategy has a great inhibitory effect on liver and breast tumors in mice and rats, comparable to the traditional percutaneous ethanol injection therapy.
Article
Chemistry, Multidisciplinary
Yu Yang, Bo Liu, Yuan Liu, Jingqi Chen, Yujia Sun, Xiaoshu Pan, Jun Xu, Shujuan Xu, Zhuang Liu, Weihong Tan
Summary: Metal X Frameworks (MXFs) constructed from metal ions and biomacromolecules via coordination interactions exhibit crystalline structures and diverse functionalities. This study showcases the application of a specific MXF composed of Hf4+ and CpG oligodeoxynucleotides in high-Z elements-enhanced photon radiotherapy and immune responses, leading to efficient tumor suppression. The findings highlight the potential of MXFs in fabricating various functional materials and stimulating systemic immune responses through localized radiotherapy.
Review
Chemistry, Multidisciplinary
Wei-Hai Chen, Qi-Wen Chen, Qian Chen, Chunyan Cui, Shun Duan, Yongyuan Kang, Yang Liu, Yun Liu, Wali Muhammad, Shiqun Shao, Chengqiang Tang, Jinqiang Wang, Lei Wang, Meng-Hua Xiong, Lichen Yin, Kuo Zhang, Zhanzhan Zhang, Xu Zhen, Jun Feng, Changyou Gao, Zhen Gu, Chaoliang He, Jian Ji, Xiqun Jiang, Wenguang Liu, Zhuang Liu, Huisheng Peng, Youqing Shen, Linqi Shi, Xuemei Sun, Hao Wang, Jun Wang, Haihua Xiao, Fu-Jian Xu, Zhiyuan Zhong, Xian-Zheng Zhang, Xuesi Chen
Summary: This review summarizes the recent advances in the synthesis and application of biomedical polymers, discussing their property-function relationship for corresponding biomedical applications. It highlights emerging bioactive polymers as potential biomaterials for cancer precision therapy. The challenges and outlook for the development of more efficient, healthier, and safer biomedical polymers are also discussed.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Nailin Yang, Fei Gong, Bo Liu, Yu Hao, Yu Chao, Huali Lei, Xiaoyuan Yang, Yuehan Gong, Xianwen Wang, Zhuang Liu, Liang Cheng
Summary: The researchers developed magnesium galvanic rods that continuously produce hydrogen and found that hydrogen can be used as an anti-cancer treatment. By implanting these rods into tumors, hydrogen molecules can be generated within the tumor, leading to tumor inhibition. This hydrogen therapy based on implantable metals may be a safe and effective cancer treatment.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Chen Xue, Jiaxin Zheng, Guangli Wang, Liang Feng, Feng Li
Summary: A functional strain BD2 with improved degradation efficiency of chlorothalonil (CTN) and carbendazim (MBC) was obtained through protoplast fusion, and the genetic relationship between BD2 and its parental strains was confirmed by SEM, RAPD, and 16S rRNA gene sequences analysis. BD2 showed better degradation rates of CTN and MBC compared to its parental strains, indicating its potential for bioremediation of CTN and MBC contaminated sites.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yikai Han, Ziliang Dong, Chunjie Wang, Quguang Li, Yu Hao, Zhijuan Yang, Wenjun Zhu, Yunyun Zhang, Zhuang Liu, Liangzhu Feng
Summary: In this study, a pH-responsive Fe2+ delivery nanocarrier was prepared to suppress tumor growth through inducing ferroptosis. The results showed that the nanocarrier exhibited high efficacy in tumor chemotherapy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Yujie Zhu, Zhijuan Yang, Zijian Pan, Yu Hao, Chunjie Wang, Ziliang Dong, Quguang Li, Yikai Han, Longlong Tian, Liangzhu Feng, Zhuang Liu
Summary: The study demonstrates that Ca2+-surplus alginate hydrogel can enhance microwave ablation (MWA) therapy by increasing heating efficiency and inducing immunogenic cell death. Synergizing with Mn2+, it can also strengthen antitumor immunity and suppress tumor growth. This finding is of great significance for clinical translation.
Article
Engineering, Biomedical
Qiaofeng Li, Yu Chao, Bo Liu, Zhisheng Xiao, Zhijuan Yang, Yuzhe Wu, Zhuang Liu
Summary: This study developed pH-responsive lipid-coated calcium phosphate nanoparticles (LCP NPs) that co-loaded with disulfiram (DSF) and copper ions (Cu2+). The nanoparticles selectively accumulated in tumors and released DSF and Cu2+ in the acidic tumor microenvironment, inducing cytotoxicity and immunogenic cell death (ICD) of cancer cells. These findings demonstrate the potential of repurposing DSF as a new ICD inducer for improved tumor-responsive therapy and enhanced immune checkpoint blockade (ICB) therapy.