Journal
MOLECULES
Volume 25, Issue 17, Pages -Publisher
MDPI
DOI: 10.3390/molecules25173841
Keywords
canataxpropellane; taxane diterpene; waihoensene; ortho-photo-cycloaddition; natural products; total synthesis
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Contiguous quaternary carbons in terpene natural products remain a major challenge in total synthesis. Synthetic strategies to overcome this challenge will be a pivotal prerequisite to the medicinal application of natural products and their analogs or derivatives. In this review, we cover syntheses of natural products that exhibit a dense assembly of quaternary carbons and whose syntheses were uncompleted until recently. While discussing their syntheses, we not only cover the most recent total syntheses but also provide an update on the status quo of modern syntheses of complex natural products. Herein, we review (+/-)-canataxpropellane, (+)-waihoensene, (-)-illisimonin A and (+/-)-11-O-debenzoyltashironin as prominent examples of natural products bearing contiguous quaternary carbons.
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