Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity

Triethylenetetramine modulates polyamine and energy metabolism and inhibits cancer cell proliferation

(2016) M. T. Hyvonen et al.   BIOCHEMICAL JOURNAL

Hypoxia-activated prodrugs: paths forward in the era of personalised medicine

(2016) Francis W Hunter et al.   BRITISH JOURNAL OF CANCER

Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases

(2016) Nancy Chan et al.   CLINICAL CANCER RESEARCH

Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs

(2015) F. W. Hunter et al.   CANCER RESEARCH

The Clinical Significance of Hypoxia in Human Cancers

(2015) Neesha Dhani et al.   SEMINARS IN NUCLEAR MEDICINE

Fragmentation of the quinoxaline N-oxide bond to the ˙OH radical upon one-electron bioreduction

(2014) Pooja Yadav et al.   CHEMICAL COMMUNICATIONS

The Meaning, Measurement and Modification of Hypoxia in the Laboratory and the Clinic

(2014) E.M. Hammond et al.   CLINICAL ONCOLOGY

The promise of copper lowering therapy with tetrathiomolybdate in the cure of cancer and in the treatment of inflammatory disease

(2014) George J. Brewer   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Dual Targeting of Hypoxia and Homologous Recombination Repair Dysfunction in Triple-Negative Breast Cancer

(2014) F. W. Hunter et al.   MOLECULAR CANCER THERAPEUTICS

FSL-61 is a 6-nitroquinolone fluorogenic probe for one-electron reductases in hypoxic cells

(2013) Jiechuang Su et al.   BIOCHEMICAL JOURNAL

Zinc Finger Nuclease Knock-out of NADPH:Cytochrome P450 Oxidoreductase (POR) in Human Tumor Cell Lines Demonstrates That Hypoxia-activated Prodrugs Differ in POR Dependence

(2013) Jiechuang Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is copper chelation an effective anti-angiogenic strategy for cancer treatment?

(2013) V. Antoniades et al.   MEDICAL HYPOTHESES

Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors

(2010) K. O. Hicks et al.   CLINICAL CANCER RESEARCH

Oxidatively generated DNA damage after Cu(II) catalysis of dopamine and related catecholamine neurotransmitters and neurotoxins: Role of reactive oxygen species

(2010) Wendy A. Spencer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prognostic Significance of p16INK4Aand Human Papillomavirus in Patients With Oropharyngeal Cancer Treated on TROG 02.02 Phase III Trial

(2010) Danny Rischin et al.   JOURNAL OF CLINICAL ONCOLOGY

Tirapazamine, Cisplatin, and Radiation Versus Cisplatin and Radiation for Advanced Squamous Cell Carcinoma of the Head and Neck (TROG 02.02, HeadSTART): A Phase III Trial of the Trans-Tasman Radiation Oncology Group

(2010) Danny Rischin et al.   JOURNAL OF CLINICAL ONCOLOGY

Critical Impact of Radiotherapy Protocol Compliance and Quality in the Treatment of Advanced Head and Neck Cancer: Results From TROG 02.02

(2010) Lester J. Peters et al.   JOURNAL OF CLINICAL ONCOLOGY

Radical production by hydrogen peroxide/bicarbonate and copper uptake in mammalian cells: Modulation by Cu(II) complexes

(2010) Larissa C. Carvalho do Lago et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Characterization of Radicals Formed Following Enzymatic Reduction of 3-Substituted Analogues of the Hypoxia-Selective Cytotoxin 3-Amino-1,2,4-Benzotriazine 1,4-Dioxide (Tirapazamine)

(2010) Sujata S. Shinde et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spin Trapping of Radicals Other Than the•OH Radical upon Reduction of the Anticancer Agent Tirapazamine by Cytochrome P450Reductase

(2009) Sujata S. Shinde et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224)

(2008) F Doñate et al.   BRITISH JOURNAL OF CANCER

Homologous Recombination Is the Principal Pathway for the Repair of DNA Damage Induced by Tirapazamine in Mammalian Cells

(2008) J. W. Evans et al.   CANCER RESEARCH

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

Initiation of DNA Strand Cleavage by 1,2,4-Benzotriazine 1,4-Dioxide Antitumor Agents: Mechanistic Insight from Studies of 3-Methyl-1,2,4-benzotriazine 1,4-Dioxide

(2008) Venkatraman Junnotula et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design of anticancer prodrugs for reductive activation

(2008) Yu Chen et al.   MEDICINAL RESEARCH REVIEWS