Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway

Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium

(2019) Raphael Brandt et al.   Nature Communications

Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control

(2017) Maxwell Z. Wilson et al.   MOLECULAR CELL

Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy

(2017) Heeseon An et al.   NATURE CELL BIOLOGY

Linear Integration of ERK Activity Predominates over Persistence Detection in Fra-1 Regulation

(2017) Taryn E. Gillies et al.   Cell Systems

Optimal Regulatory Circuit Topologies for Fold-Change Detection

(2017) Miri Adler et al.   Cell Systems

Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway

(2016) Tujin Shi et al.   Science Signaling

Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway

(2016) Tujin Shi et al.   Science Signaling

Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs

(2016) Steven S. Andrews et al.   Cell Systems

Phosphatase Specificity and Pathway Insulation in Signaling Networks

(2015) Michael A. Rowland et al.   BIOPHYSICAL JOURNAL

Receptor Level Mechanisms Are Required for Epidermal Growth Factor (EGF)-stimulated Extracellular Signal-regulated Kinase (ERK) Activity Pulses

(2015) Breanne Sparta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

(2015) J. C. Hunter et al.   MOLECULAR CANCER RESEARCH

High-Sensitivity Measurements of Multiple Kinase Activities in Live Single Cells

(2014) Sergi Regot et al.   CELL

A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics

(2014) Apirat Chaikuad et al.   Nature Chemical Biology

Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells

(2013) Wai Leong Tam et al.   CANCER CELL

Encoding and Decoding Cellular Information through Signaling Dynamics

(2013) Jeremy E. Purvis et al.   CELL

Oncogenic K-Ras requires activation for enhanced activity

(2013) H Huang et al.   ONCOGENE

NMR-based functional profiling of RASopathies and oncogenic RAS mutations

(2013) M. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a Novel ERK Inhibitor with Activity in Models of Acquired Resistance to BRAF and MEK Inhibitors

(2013) E. J. Morris et al.   Cancer Discovery

A Quantitative Model of ERK MAP Kinase Phosphorylation in Crowded Media

(2013) Kazuhiro Aoki et al.   Scientific Reports

Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise

(2012) Marc R Birtwistle et al.   BMC Systems Biology

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals

(2012) John G. Albeck et al.   MOLECULAR CELL

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling

(2011) R. Fritsche-Guenther et al.   Molecular Systems Biology

Linear Approaches to Intramolecular Förster Resonance Energy Transfer Probe Measurements for Quantitative Modeling

(2011) Marc R. Birtwistle et al.   PLoS One

Ligand-Specific c-Fos Expression Emerges from the Spatiotemporal Control of ErbB Network Dynamics

(2010) Takashi Nakakuki et al.   CELL

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival

(2010) Matthias Drosten et al.   EMBO JOURNAL

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders

(2010) Lothar Gremer et al.   HUMAN MUTATION

Cell signaling: What is the signal and what information does it carry?

(2009) Roger Brent   FEBS LETTERS

KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer

(2009) J. J. Yeh et al.   MOLECULAR CANCER THERAPEUTICS

Dynamics and Variability of ERK2 Response to EGF in Individual Living Cells

(2009) Cellina Cohen-Saidon et al.   MOLECULAR CELL

Cytokine-Induced Signaling Networks Prioritize Dynamic Range over Signal Strength

(2008) Kevin A. Janes et al.   CELL

Robust single-particle tracking in live-cell time-lapse sequences

(2008) Khuloud Jaqaman et al.   NATURE METHODS

A genetically encoded fluorescent sensor of ERK activity

(2008) C. D. Harvey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA