Article
Multidisciplinary Sciences
Jing Qi, Feiyang Jin, Yuchan You, Yan Du, Di Liu, Xiaoling Xu, Jun Wang, Luwen Zhu, Minjiang Chen, Gaofeng Shu, Liming Wu, Jiansong Ji, Yong-Zhong Du
Summary: The study introduces E-selectin-modified thermal-sensitive micelles loaded with doxorubicin and an adenosine A2 receptor antagonist to enhance chemotherapy-induced anti-tumor immune responses. This strategy not only increases the tumor accumulation of drugs by hitchhiking with leukocytes, but also improves the immunotherapeutic effects of chemotherapy drugs.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Zhenkun Ren, Xibin Han, Lixin Wang, Yi Wang
Summary: The study found that AS/GOD@HAZnO nanoparticles could effectively inhibit tumors and improve drug efficacy through responsive release. These nanoparticles, which can be efficiently taken in by tumor cells through the affinity between hyaluronic acid and CD44 receptors, release drugs in an acidic environment, thereby inhibiting tumor growth.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
K. Laxmi Swetha, Milan Paul, Kavya Sree Maravajjala, Soniya Kumbham, Swati Biswas, Aniruddha Roy
Summary: Previous studies have shown that breast cancer cells employ various strategies to resist anticancer drugs, such as docetaxel, through drug-resistance mechanisms like overexpression of P-glycoprotein and cancer stem cells. By inhibiting both P-glycoprotein and cancer stem cells, the combination of docetaxel and disulfiram shows potential in sensitizing drug-resistant breast cancer cells. This study developed a pH-responsive nanoparticle system for the co-delivery of docetaxel and disulfiram, which demonstrated improved drug release, penetration, and cytotoxic efficacy against drug-resistant breast cancer cells in vitro, as well as enhanced tumor drug delivery and anti-tumor efficacy in vivo.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Ashok Bora, Dimpee Sarmah, Muzamil Ahmad Rather, Manabendra Mandal, Niranjan Karak
Summary: In this study, a bio-based hydrogel nanocomposite (HNC) was successfully prepared and used to evaluate pH-sensitive drug release properties. The HNC exhibited sustained drug release and pH responsive behavior. Additionally, it showed antibacterial activity and photocatalytic degradation of dyes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Saman Emami Gerami, Mehrab Pourmadadi, Hooman Fatoorehchi, Fatemeh Yazdian, Hamid Rashedi, Mona Navaei Nigjeh
Summary: In this study, nanocomposites of hematite/chitosan/polyvinylpyrrolidone were synthesized as a drug carrier for doxorubicin, exhibiting pH-sensitive and controlled release properties. The chemical and physical interactions within the nanocomposites were confirmed through analyses, and they demonstrated good cytotoxicity and anticancer effects in cell experiments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Qing-Hua Lan, Chu-Chu Du, Run-Jie Yu, Jiaoyuan Zhai, Yannan Shi, Longfa Kou, Jian Xiao, Cui-Tao Lu, Ying-Zheng Zhao, Qing Yao
Summary: The study investigated the use of Tf-DSF/CuS nanocomplex for glioma therapy, demonstrating high cytotoxic effect in vitro and effective tumor growth suppression in vivo. The UTMD technique facilitated selective accumulation of the nanocomplex in the tumor, contributing to the successful treatment outcome.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Nanoscience & Nanotechnology
Xiangshi Sun, Kongtong Yu, Yulin Zhou, Shiyan Dong, Wenji Hu, Yating Sun, Yuhuan Li, Jing Xie, Robert J. Lee, Fengying Sun, Yifan Ma, Shengnian Wang, Betty Y. S. Kim, Yifan Wang, Zhaogang Yang, Wen Jiang, Youxin Li, Lesheng Teng
Summary: The newly synthesized amphiphilic polymers can self-assemble into micellar nanoparticles with favorable hydrolysis kinetics, biocompatibility, and long circulation time. These materials not only exhibit better inflammation-targeting effects, but also do not induce an acidic microenvironment during degradation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Md Aquib, Hang Zhang, Faisal Raza, Parikshit Banerjee, Rohit Bavi, Samuel Kesse, Kofi Oti Boakye-Yiadom, Mensura Sied Filli, Muhammad Asim Farooq, Bo Wang
Summary: Aminated mesoporous silica nanoparticles (AMPSNPs) were developed as a nanocarrier for disulfiram (DSF) delivery in cancer therapies. The optimized AMPSNPs showed excellent properties and compatibility, providing potential for effective drug delivery.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Polymer Science
Nour M. AlSawaftah, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Summary: Stimuli-responsive nanoparticles have shown promising potential in overcoming the limitations of conventional chemotherapy. pH-sensitive nanoparticles, in particular, have proven to be highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review summarizes the different strategies used to develop pH-sensitive nanoparticles for cancer therapy.
Article
Pharmacology & Pharmacy
Kandasamy Vinothini, Sathish Sundar Dhilip Kumar, Heidi Abrahamse, Mariappan Rajan
Summary: This study developed a functionalized graphene oxide (GO) carrier system for combined chemo-photodynamic therapeutic effects. Doxorubicin (DOX) and rose bengal (RB) were successfully entrapped on the GO surface with high entrapment efficiency and loading capacities. The co-loaded carrier showed effective cytotoxicity on MCF-7 cells, indicating improved therapeutic efficacy. The carrier also demonstrated RB-mediated photodynamic action in response to laser irradiation, enabling on-demand dual-payload release for the eradication of cancer cells with a synergistic effect.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Materials Science, Biomaterials
Li Zhou, Wei Li, Yilin Wen, Xiaoxue Fu, Feng Leng, Jiaxin Yang, Lu Chen, Xiaojuan Yu, Chao Yu, Zhangyou Yang
Summary: The study presents an innovative method to improve the hypoxic tumor microenvironment using modified hollow ceria nanozymes, demonstrating effective drug delivery and significant anticancer effects in vitro and in vivo.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Biomaterials
Niping Chen, Yakun Wang, Yaoxun Zeng, Yushan Li, Zhenxing Pan, Haihong Li, Jingman Chen, Zefeng Chen, Jiongpeng Yuan, Wen Yan, Yu-Jing Lu, Xujie Liu, Yan He, Kun Zhang
Summary: The study demonstrates the use of a novel nanoparticle CFOT for tumor therapy, utilizing photothermal and chemodynamic therapies to achieve a good antitumor effect.
BIOMATERIALS SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Haibin Zhang, Zhiyang Gu, Wenya Li, Lili Guo, Litong Wang, Lan Guo, Saibo Ma, Baoqin Han, Jing Chang
Summary: Oral drug delivery is the most preferred mode of treatment due to its convenience and non-invasiveness. However, delivering protein drugs orally has been a challenge. This study developed a novel OCMC/SA nanohydrogel that solves this problem, with high drug loading capacity and passive drug targeting function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Marie Piantino, Masahiko Nakamoto, Michiya Matsusaki
Summary: Efficient and selective drug delivery systems (DDS) in cancer therapy remain a major challenge. A recent study introduced a molecular block (MB) therapy targeting the cancer cell microenvironment, which induced cancer cell death through self-aggregation and cell membrane disruption. The optimized MB showed increased sensitivity to the cancer microenvironment and avoided off-target accumulation in the bloodstream, making it a promising approach for improved cancer cell targeting.
Article
Materials Science, Biomaterials
Ziwen Zhang, Jinxia Wang, Yu Luo, Chunlin Li, Yangang Sun, Kaiyang Wang, Guoying Deng, Linjing Zhao, Chunping Yuan, Jie Lu, Ying Chen, Jian Wan, Xijian Liu
Summary: A multifunctional hydrogel composed of chitosan quaternary ammonium salts/polyvinyl alcohol/polyethylene glycol loaded with ZnO@CeO2 nanoparticles was constructed. The hydrogel exhibited antibacterial and antioxidant properties, promoting wound healing.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Nanoscience & Nanotechnology
Qing Yao, Zhi-Wei Huang, Yuan-Yuan Zhai, Meng Yue, Lan-Zi Luo, Peng-Peng Xue, Yong-Hui Han, He-Lin Xu, Longfa Kou, Ying-Zheng Zhao
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Pharmacology & Pharmacy
Qing Yao, Ya-Wen Zheng, Qing-Hua Lan, Li-Fen Wang, Zhi-Wei Huang, Rui Chen, Yang Yang, He-Lin Xu, Longfa Kou, Ying-Zheng Zhao
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Oncology
Zhiwei Chen, Aimin Cai, Hailun Zheng, Huirong Huang, Rui Sun, Xiao Cui, Weijian Ye, Qing Yao, Ruijie Chen, Longfa Kou
Review
Biochemistry & Molecular Biology
Longfa Kou, Xinyu Jiang, Xinlu Lin, Huirong Huang, Jun Wang, Qing Yao, Ruijie Chen
Summary: Matrix Metalloproteinases (MMPs) are zinc-containing enzymes that are involved in breaking down the Extracellular Matrix (ECM) and play crucial roles in cell migration, aging, and other physiological processes. Research on the functions and mechanisms of MMPs in bone health and diseases has gained increasing attention, providing new insights into the treatment of bone-related diseases.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Qing Yao, Xue Jiang, Yuan-Yuan Zhai, Lan-Zi Luo, He-Lin Xu, Jian Xiao, Longfa Kou, Ying-Zheng Zhao
JOURNAL OF CONTROLLED RELEASE
(2020)
Review
Chemistry, Multidisciplinary
Qing Yao, Ruijie Chen, Vadivel Ganapathy, Longfa Kou
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Pharmacology & Pharmacy
Qing-Hua Lan, Chu-Chu Du, Run-Jie Yu, Jiaoyuan Zhai, Yannan Shi, Longfa Kou, Jian Xiao, Cui-Tao Lu, Ying-Zheng Zhao, Qing Yao
Summary: The study investigated the use of Tf-DSF/CuS nanocomplex for glioma therapy, demonstrating high cytotoxic effect in vitro and effective tumor growth suppression in vivo. The UTMD technique facilitated selective accumulation of the nanocomplex in the tumor, contributing to the successful treatment outcome.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Engineering, Biomedical
Longfa Kou, Xinyu Jiang, Yingying Tang, Xing Xia, Yingtao Li, Aimin Cai, Hailun Zheng, Hailin Zhang, Vadivel Ganapathy, Qing Yao, Ruijie Chen
Summary: Reprogramming cellular metabolism in cancer is a significant characteristic. This study developed a nanoplatform to target two essential transporters involved in amino acid metabolism in cancer cells. Blocking amino acid entry enhanced the anticancer effect of a kinase inhibitor by interfering with signaling pathways, promoting apoptosis, and suppressing cell proliferation and metastasis.
BIOACTIVE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Ruijie Chen, Yuan-Yuan Zhai, Lining Sun, Zeqing Wang, Xing Xia, Qing Yao, Longfa Kou
Summary: Psoriasis is an immune-mediated skin disease characterized by keratinocyte hyperproliferation and aberrant differentiation. The constitutive activation of STAT3 exacerbates psoriasis by promoting cell proliferation and cytokine production. The study developed ALT-loaded nanoparticles that effectively attenuated hyperactivation of STAT3, inhibited inflammation, and restricted immune cell recruitment, showing great potential for psoriasis therapy.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Huirong Huang, Yujie Lin, Yiling Jiang, Qing Yao, Ruijie Chen, Ying-Zheng Zhao, Longfa Kou
Summary: Osteoarthritis (OA) is a common chronic degenerative joint disease that weakens motor function and has a significant economic burden. Current medications for OA do not meet the needs for treatment. Recombinant protein drugs (RPDs) show promise as disease-modifying OA drugs (DMOADs) by inhibiting inflammation, regulating metabolism, and promoting cartilage repair. However, their short half-life and rapid clearance in the joint cavity restrict their clinical translation. Reliable drug delivery systems are necessary for their further development.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Medicine, Research & Experimental
Qing Yao, Qing-Hua Lan, Xinyu Jiang, Chu-Chu Du, Yuan-Yuan Zhai, Xiaohan Shen, He-Lin Xu, Jian Xiao, Longfa Kou, Ying-Zheng Zhao
Article
Pharmacology & Pharmacy
Xue Jiang, Ya-Wen Zheng, Shihui Bao, Hailin Zhang, Ruijie Chen, Qing Yao, Longfa Kou