Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 64, Issue 23, Pages -Publisher
WILEY
DOI: 10.1002/mnfr.202000437
Keywords
calcidiol; calcitriol; DNA methylation; epigenetics; vitamin D
Categories
Funding
- NHMRC/Multiple Sclerosis Research Australia/Trish MS Foundation scholarship
- NSW Health Pathology Postgraduate Fellowship
- Multiple Sclerosis Research Australia Postdoctoral Fellowship
- Trish MS Research Foundation Project Grant
Ask authors/readers for more resources
DNA methylation is increasingly being recognized as a mechanism through which environmental exposures confer disease risk. Several studies have examined the association between vitamin D and changes in DNA methylation in areas as diverse as human and animal development, genomic stability, chronic disease risk, and malignancy. In many cases, they have demonstrated clear associations between vitamin D and DNA methylation in candidate disease pathways. Despite this, a clear understanding of the mechanisms by which these factors interact is unclear. This paper reviews the current understanding of the effects of vitamin D on DNA methylation. In light of current knowledge in the field, the potential mechanisms mediating vitamin D effects on DNA methylation are discussed, as are the limiting factors and future avenues for research into this exciting area.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available