Review
Nutrition & Dietetics
Hikari Takeshita, Koichi Yamamoto
Summary: The severity of COVID-19 is characterized by systemic damage to organs, including skeletal muscle, due to excessive secretion of inflammatory cytokines. Clinical studies have found that tryptophan metabolism is selectively enhanced in patients with severe COVID-19.
FRONTIERS IN NUTRITION
(2022)
Review
Cell Biology
Seyed Ali Ziai, Mitrasadat Rezaei, Sajad Fakhri, Ramin Pouriran
Summary: COVID-19, caused by the novel coronavirus, has posed a global challenge and highlights the urgent need for an effective vaccine. Understanding the virus's structure, entry mechanism, and pathogenesis is crucial in developing treatment strategies.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Immunology
Jieqiong Wang, Huiying Zhao, Youzhong An
Summary: ACE2 is a crucial component of the RAS and serves as the receptor for SARS-COV-2. The role of sACE2 in the pathology of the disease is not completely understood. Recent studies have shown that sACE2 also acts as a receptor for SARS-COV-2 and elevated concentrations of sACE2 are associated with the disease. Recombinant human ACE2 may be a potential treatment for COVID-19, but further research is needed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Medicine, General & Internal
Joseph Adu-Amankwaah, Richard Mprah, Adebayo Oluwafemi Adekunle, Marie Louise Ndzie Noah, Gabriel Komla Adzika, Jeremiah Ong'achwa Machuki, Hong Sun
Summary: COVID-19 pandemic caused by SARS-CoV-2 has major health implications globally, with the virus entering hosts through ACE2 and affecting the cardiovascular system. Understanding the cardiovascular aspects of COVID-19 is crucial for improving cardiac health during and after the pandemic.
ANNALS OF MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Guyi Wang, Jiayi Deng, Jinxiu Li, Chenfang Wu, Haiyun Dong, Shangjie Wu, Yanjun Zhong
Summary: The COVID-19 pandemic presents challenges in managing acutely ill patients, with dysregulated immune responses and abnormal coagulation function being key pathophysiological features. Decreased levels of HDL in COVID-19 patients are associated with disease severity and mortality but the specific role and mechanism of HDL in COVID-19 remain unclear. Reviewing evidence on pathophysiological characteristics of COVID-19, pleiotropic properties of HDL, changes in HDL in COVID-19, and potential of HDL-targeting therapy in COVID-19 can provide insight on the role of HDL in COVID-19 pathogenesis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tatsuya Maruhashi, Yukihito Higashi
Summary: COVID-19 caused by SARS-CoV-2 poses a worldwide challenge to healthcare systems, with thromboembolism being a major complication contributing to high morbidity and mortality in severe cases. Studies suggest that the direct infection of endothelial cells by SARS-CoV-2 may lead to endothelial dysfunction, resulting in thrombotic complications and severe outcomes in COVID-19 patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Atila Duque Rossi, Joao Locke Ferreira de Araujo, Tailah Bernardo de Almeida, Marcelo Ribeiro-Alves, Camila de Almeida Velozo, Jessica Maciel de Almeida, Isabela de Carvalho Leitao, Samila Natiane Ferreira, Jessica da Silva Oliveira, Hugo Jose Alves, Helena Toledo Scheid, Debora Souza Faffe, Rafael Mello Galliez, Renata Eliane de Avila, Gustavo Gomes Resende, Mauro Martins Teixeira, Orlando da Costa Ferreira Junior, Terezinha Marta P. P. Castineiras, Renan Pedra Souza, Amilcar Tanuri, Renato Santana de Aguiar, Shana Priscila Coutinho Barroso, Cynthia Chester Cardoso
Summary: ACE2 and TMPRSS2 levels are positively correlated with age, which is strongly associated with respiratory distress. Increased ACE2 levels have a protective effect against this outcome, while the TMPRSS2/ACE2 ratio is associated with risk. In modeling COVID-19 severity, the TMPRSS2/ACE2 ratio outperforms ACE2.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Jennifer Yin Yee Kwan, Liang-Tzung Lin, Rachel Bell, Jeffrey P. Bruce, Christopher Richardson, Trevor J. Pugh, Fei-Fei Liu
Summary: Multiple studies have reported a doubling in the risk of COVID-19 among cancer patients, which may be attributed to the increased expression of critical viral entry genes in cancer states and the transient dysregulation of innate viral defenses during radiation treatments, especially in pediatric samples.
SCIENTIFIC REPORTS
(2021)
Review
Urology & Nephrology
Jordana B. Cohen, Andrew M. South, Hossam A. Shaltout, Matthew R. Sinclair, Matthew A. Sparks
Summary: During the early months of the COVID-19 pandemic, controversy arose over the hypothesis that pharmacologic inhibitors of the renin-angiotensin system (RAS) may exacerbate COVID-19 severity. While some evidence suggests potential protective effects of ACE2 and RAS blockade on acute lung injury, there are risks associated with discontinuing these medications. Further research and examination of this topic are warranted to improve understanding of these complex relationships.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Cell Biology
Yanliang Zhang, Yangyang Sun, Kang Liu, Raphael N. Alolga, Xueqiang Xu, Ganzhu Feng, Pingxi Xiao
Summary: Patients with diabetes may have lower plasma levels of ACE2, which could increase their susceptibility to severe COVID-19 infections.
Article
Environmental Sciences
Nguyen Thanh Tung, Po-Ching Cheng, Kai-Hsien Chi, Ta-Chi Hsiao, Timothy Jones, Kelly BeruBe, Kin-Fai Ho, Hsiao-Chi Chuang
Summary: COVID-19 caused by SARS-CoV-2 has become a global pandemic. Particulate matter (PM) may act as a carrier for SARS-CoV-2 transmission, with PM increasing the expression of ACE2 in the lungs, facilitating viral adhesion. This suggests that PM could be a direct and indirect transmission model for SARS-CoV-2 infection.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Otorhinolaryngology
Ahmet Doblan, Mehmet Erkan Kaplama, Semih Ak, Nazli Basmaci, Emine Zeynep Tarini, Seniz Engur Goktas, Suleyman Guler, Togay Muderris
Summary: The study found that COVID-19 can cause symptoms of cranial nerve involvement, which are more common and severe than previous diseases. These results may indicate a greater degree of neuroinvasion in COVID-19. While sensory functions are significantly affected, motor functions are rarely impacted.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Francesca Lunardi, Francesco Fortarezza, Luca Vedovelli, Federica Pezzuto, Annalisa Boscolo, Marco Rossato, Roberto Vettor, Anna Maria Cattelan, Claudia Del Vecchio, Andrea Crisanti, Paolo Navalesi, Dario Gregori, Fiorella Calabrese
Summary: This study found that ACE-2 levels were decreased in lung tissue of smokers, and smoking was the most probable risk factor associated with low ACE-2 expression. Additionally, there was a direct relationship between viral quantity and ACE-2 expression, with high ACE-2 expressors more likely to show vascular injury.
Review
Endocrinology & Metabolism
Yue Hu, Lihuan Liu, Xifeng Lu
Summary: ACE2, a negative regulator of the renin-angiotensin system, is the receptor for SARS-CoV-2 and plays a crucial role in the pathophysiology of COVID-19. It is implicated in tissue injury, chronic conditions such as hypertension, diabetes, and cardiovascular disease, and may be a potential therapeutic target for COVID-19.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Sadaf Noor, Yuliya Semenova, Alexandru Dosa, Joeri J. Pen, Alain Menzel, Salva Piscopo, Nicolas Wirth, Daniel-Ovidiu Costea
Summary: This article discusses alternative treatments for prostate disorders, with a particular focus on the role of nutrients. By providing an overview of the characteristics of the prostate organ and the most prevalent diseases, nutrition-based treatment methods are proposed, with an emphasis on their potential effectiveness in surgery. The article advocates for the recognition of this form of alternative treatment as a fully recognized therapy for prostate disorders.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Pavan Kumar Mujawdiya, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Joeri J. Pen, Asma Gasmi Benahmed, Daniel Ovidiu Costea
Summary: Bariatric surgery is an effective method for significant weight loss in patients who have not achieved weight loss through pharmacological interventions. Post-surgery, sustained weight loss offers metabolic advantages and improves glucose and lipid metabolism. However, bariatric surgery is associated with deficiencies in vitamins and minerals, requiring monitoring and supplementation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Pavan Kumar Mujawdiya, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Joeri J. Pen, Asma Gasmi Benahmed, Daniel-Ovidiu Costea
Summary: Gut microbes play a crucial role in bariatric surgery outcomes, as they can be altered by the surgery and have beneficial effects on therapeutic results.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Cell Biology
Marina Izmailovich, Yuliya Semenova, Gulzada Abdushukurova, Ainur Mukhamejanova, Azhar Dyussupova, Raida Faizova, Meruert Gazaliyeva, Leila Akhvlediani, Natalya Glushkova, Sundetgali Kalmakhanov, Geir Bjorklund
Summary: A systematic review was conducted to explore the use of component-resolved diagnosis in identifying polysensitization in patients with seasonal allergic rhinitis. A total of 568 publications were identified and 12 were included in the review, with 3302 patients enrolled. The findings showed that component-resolved diagnostics changed the choice of relevant allergens for immunotherapy in at least 50% of cases and sensitization differed based on age, disease type, and disease duration.
Article
Microbiology
Maryam Dadar, Saeed Alamian, Hanka Brangsch, Mohamed Elbadawy, Ahmed R. Elkharsawi, Heinrich Neubauer, Gamal Wareth
Summary: This study investigated antimicrobial resistance (AMR) and virulence-associated factors in Brucella isolates from humans and animals in Iran. B. melitensis was the most common species, while B. abortus was isolated from only one human case. The isolates showed intermediate or resistant phenotype patterns for certain antibiotics. Whole genome sequencing (WGS) identified several virulence-associated genes, but failed to determine classical AMR genes. The findings suggest a need for further investigation into the proteomic and transcriptomic levels of phenotypic resistance mechanisms.
Review
Infectious Diseases
Asma Gasmi Benahmed, Amin Gasmi, Torsak Tippairote, Pavan Kumar Mujawdiya, Oleksandr Avdeev, Yurii Shanaida, Geir Bjorklund
Summary: Dental implants are commonly used to replace lost teeth, and titanium implants have a high success rate. However, there is an increasing risk of peri-implantitis, an inflammatory disease that affects the tissues around the implant. This review highlights the impact of different metabolic conditions on peri-implantitis and emphasizes the importance of considering both local and systemic factors in dental implant procedures and treatment.
Review
Chemistry, Medicinal
Amin Gasmi, Pavan Kumar Mujawdiya, Amine Nehaoua, Mariia Shanaida, Yuliya Semenova, Salva Piscopo, Alain Menzel, Volodymyr Voloshyn, Olena Voloshyn, Volodymyr Shanaida, Geir Bjorklund
Summary: The obesity pandemic is a pressing public health concern, with a projected increase in the number of obese or overweight individuals by 2025. Current strategies for treating obesity focus on patient-centered approaches including diet, behavior, medication, and surgery. However, there is a need for novel and more effective pharmaceutical drugs to assist with lifestyle modifications and better manage obesity.
Review
Chemistry, Medicinal
Amin Gasmi, Mariia Shanaida, Oleksandra Oleshchuk, Yuliya Semenova, Pavan Kumar Mujawdiya, Yana Ivankiv, Olena Pokryshko, Sadaf Noor, Salva Piscopo, Stepan Adamiv, Geir Bjorklund
Summary: The immune system protects the body from infectious agents, and a well-balanced immunity is crucial for maintaining human health. Nutritional and micronutrient deficiencies can compromise the immune system, while certain bioactive compounds from plants, fungi, animals, microorganisms, and other natural sources have shown immunomodulatory properties and can enhance the immune response.
Review
Health Care Sciences & Services
Laura Kassym, Assiya Kussainova, Yuliya Semenova, Almas Kussainov, Damir Marapov, Marat Zhanaspayev, Zhanar Urazalina, Almira Akhmetova, Madi Tokanov, Yerbol Smail, Geir Bjorklund
Summary: Drunk driving is a significant risk factor for traffic accidents and their lethality. This meta-analysis provides estimates of the prevalence of drunk driving in non-lethally injured drivers, considering factors such as the world region, blood alcohol concentration, and study quality. The pooled prevalence of drunk driving in injured drivers was found to be 16.6%.
Article
Multidisciplinary Sciences
Faranak Abnaroodheleh, Anahita Emadi, Shojaat Dashtipour, Tariq Jamil, Amin Mousavi Khaneghah, Maryam Dadar
Summary: A cross-sectional study in industrial dairy cattle farms in Iran revealed the presence of Brucella spp., including Brucella abortus and Brucella melitensis, in the Alborz and Tehran provinces. The seroprevalence of brucellosis in these farms was significant, and the shedding of Brucella in the milk of seropositive cows posed a serious risk of transmission to humans. Therefore, comprehensive bacteriological and serological tests, including analysis of blood and milk samples, should be conducted in order to control the spread of the disease.
Article
Health Policy & Services
Valeriy Zub, Yuliya Semenova, Oleksandr Tolstanov, Andrii Kotuza, Taras Gutor, Oksana Matsyura, Roman Lysiuk, Geir Bjorklund
Summary: This study assessed the challenges faced by oncologists in providing cancer care in Ukraine after the armed conflict. The findings showed that physicians in regions occupied by the Russian army experienced a significant decline in patient numbers, while most physicians were satisfied with the availability of medicines and equipment.
INTERNATIONAL JOURNAL OF HEALTHCARE MANAGEMENT
(2023)
Article
Neurosciences
Neluwa-Liyanage R. Indika, Udara D. Senarathne, Antonio Malvaso, Dhanushka Darshana, Susan C. Owens, Borhan Mansouri, Yuliya Semenova, Geir Bjorklund
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by early-onset social interaction and communication deficits, along with repetitive and restricted patterns of activities, behavior, and interests. Heavy metal exposure, abnormal metabolism, and genetic susceptibility may play a role in the pathogenesis of ASD. Altered porphyrin metabolism in ASD may be associated with deficiencies in vitamins and minerals, and potential metabolic therapies such as supplementation with vitamins, minerals, cofactors, and antioxidants need to be explored in future research.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Maryam Dadar, Ramin Tabibi, Saeed Alamian, Yohama Caraballo-Arias, Ezra Jonathan Mrema, Jane Mlimbila, Sashikala Chandrasekar, Kenesh Dzhusupov, Cholpon Sulaimanova, Lyailya Zh Alekesheva, Smagul A. Manar, Karlygash K. Toguzbayeva, Aseni Wickramatillake, Bahman Mirzaei
Summary: This review highlights the risk factors associated with brucellosis among different occupational groups and emphasizes the need for a One Health policy to evaluate the complex challenges of brucellosis. However, implementing One Health strategies in developing countries has proven to be challenging.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2023)
