Review
Oncology
Hassan Mesgari, Samar Esmaelian, Kamyar Nasiri, Shabnam Ghasemzadeh, Parisa Doroudgar, Zahra Payandeh
Summary: This review emphasizes the importance of epigenetics in oral squamous cell carcinoma (OSCC). The study highlights the role of DNA methylation, histone modifications, and miRNAs in the development and progression of OSCC. Researchers are exploring targeted therapies, such as DNMT and HDAC inhibitors, to modify abnormal gene expression patterns. However, challenges remain in identifying reliable biomarkers and developing effective combination treatments.
Review
Biochemistry & Molecular Biology
Heinrich Botha, Camile S. Farah, Kendrick Koo, Nicola Cirillo, Michael McCullough, Rita Paolini, Antonio Celentano
Summary: Research shows that in oral squamous cell carcinoma, glucose transporter 1 (GLUT-1) and GLUT-3 expression levels are correlated with tumor stage, treatment resistance, and poor prognosis. Other glucose transporters (GLUTs) are relatively understudied and may have the potential to improve patient care with further analysis.
Article
Chemistry, Medicinal
Pragya Kumari, Subhashis Ghosh, Sourav Acharya, Paromita Mitra, Souryadip Roy, Shilpendu Ghosh, Moumita Maji, Sandeep Singh, Arindam Mukherjee
Summary: This study reveals a new class of drugs targeting oral squamous cell carcinoma stem cells, which inhibit the growth and differentiation of cancer stem cells by suppressing the expression of stemness genes and inducing differentiation markers.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Omprakash Shriwas, Rakesh Arya, Sibasish Mohanty, Pallavi Mohapatra, Sugandh Kumar, Rachna Rath, Sandeep Rai Kaushik, Falak Pahwa, Krushna Chandra Murmu, Saroj Kumar Das Majumdar, Dillip Kumar Muduly, Anshuman Dixit, Punit Prasad, Ranjan K. Nanda, Rupesh Dash
Summary: The study identified RRBP1 as a major driver of cisplatin-resistance in oral squamous cell carcinoma, regulating YAP1 expression to mediate chemoresistance, and demonstrated that targeting RRBP1 could reverse cisplatin-induced chemoresistance.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Ke Huang, Xiaoting Gu, Huimei Xu, Hui Li, Mingxuan Shi, Defang Wei, Shiqi Wang, Yao Li, Bin Liu, Yi Li
Summary: This study explored the link between necroptosis and oral squamous cell carcinoma (OSCC), and identified HPRT1 as a novel independent prognostic factor for OSCC. Knockdown of HPRT1 was found to inhibit tumor cell proliferation and migration. These findings contribute to the understanding of the mechanisms underlying OSCC and provide guidance for clinical diagnosis, targeted therapy, and prognosis evaluation.
Review
Biochemistry & Molecular Biology
Qin Niu, Qiannan Sun, Rushui Bai, Yunfan Zhang, Zimeng Zhuang, Xin Zhang, Tianyi Xin, Si Chen, Bing Han
Summary: Oral squamous cell carcinoma (OSCC) is a prevalent cancer worldwide with current treatment models presenting limitations. Nanomaterial-based photothermal therapy (PTT) has attracted research attention as a promising alternative. This paper reviews the latest progress in applying biological nanomaterials for PTT in OSCC and discusses different categories of photothermal nanomaterials and drug delivery systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Inorganic & Nuclear
Souryadip Roy, Paromita Mitra, Sourav Acharya, Shantanu Saha Roy, Shilpendu Ghosh, Moumita Maji, Niladri Modak, Nirmalya Ghosh, Moulinath Acharya, Sandeep Singh, Arindam Mukherjee
Summary: The researchers developed a novel photosensitizer to treat cancer, which exhibited excellent efficacy against oral squamous cell carcinoma cells. The photosensitizer was found to inhibit the formation of tumor stem cells and significantly affect the stemness-related genes in multiple cancer cells.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Biochemistry & Molecular Biology
Tatjana Zejc, Jorg Piontek, Jorg-Dieter Schulzke, Michael Fromm, Jurgen Ervens, Rita Rosenthal
Summary: The study compares the expression of claudins in oral squamous cell carcinoma (OSCC) and healthy oral epithelium, and finds that the expression levels of claudin-2, -4, and -7 are associated with the diagnosis and prognosis of OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Karolina Golabek, Grzegorz Raczka, Jadwiga Gazdzicka, Katarzyna Miskiewicz-Orczyk, Natalia Zieba, Lukasz Krakowczyk, Maciej Misiolek, Joanna Katarzyna Strzelczyk
Summary: This study found no significant differences in the expression levels of CDKN2A, MDM2, E2F2, and LTF genes in OSCC patients, except for the association between E2F2 expression level and tumor grade. Further research on the changes in E2F2 expression profile may be useful in describing the invasiveness and dynamics of OSCC development.
Article
Medicine, General & Internal
Petr Posta, Andreas Kolk, Kristyna Pivovarcikova, Jan Liska, Jiri Gencur, Omid Moztarzadeh, Christos Micopulos, Adam Penkava, Maria Frolo, Oliver Bissinger, Lukas Hauer
Summary: This study investigated the effect of autofluorescence on the success rate of surgical treatment in oral squamous carcinoma. The findings showed that preoperative autofluorescence assessment significantly increased the ability to achieve pathological negative margins.
Article
Multidisciplinary Sciences
Yui Hatanaka, Takeshi Niinuma, Hiroshi Kitajima, Koyo Nishiyama, Reo Maruyama, Kazuya Ishiguro, Mutsumi Toyota, Eiichiro Yamamoto, Masahiro Kai, Akira Yorozu, Shohei Sekiguchi, Kazuhiro Ogi, Hironari Dehari, Masashi Idogawa, Yasushi Sasaki, Takashi Tokino, Akihiro Miyazaki, Hiromu Suzuki
Summary: DLEU1, an overexpressed lncRNA, exerts oncogenic effects in oral squamous cell carcinoma by activating a series of interferon-stimulated genes (ISGs).
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Shuxia Cui, Hanzhe Liu, Guanglin Cui
Summary: Oral squamous cell carcinoma (OSCC) is a common malignancy worldwide. Current medical therapies for OSCC, such as chemotherapy, radiotherapy, and immunotherapy, are not ideal due to their low efficiency. To overcome this limitation, nanotechnology has been utilized to develop nanoparticles (NPs) as a more effective drug delivery system (DDS). NPs formulated with anticancer drugs have shown promising results in improving drug release and concentration at the tumor site, suggesting their potential as DDSs for the treatment of OSCC.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Simin Li, Zhaoyi Mai, Wenli Gu, Anthony Chukwunonso Ogbuehi, Aneesha Acharya, George Pelekos, Wanchen Ning, Xiangqiong Liu, Yupei Deng, Hanluo Li, Bernd Lethaus, Vuk Savkovic, Rudiger Zimmerer, Dirk Ziebolz, Gerhard Schmalz, Hao Wang, Hui Xiao, Jianjiang Zhao
Summary: Deep learning identified two survival subtypes of OSCC, which can assist clinicians in categorizing immunocompromised patients into two subpopulations for targeted drug therapy, ultimately improving survival rates and offering novel therapeutic strategies in precision medicine.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mi Seong Kim, Sei Hoon Yang, Min Seuk Kim
Summary: Lysosomal exocytosis is essential for remodeling the extracellular matrix and drug resistance. The study identified differentially expressed SNPs, including ABCA2, in gefitinib-sensitive and -resistant oral squamous carcinoma cell lines. ABCA2 and its SNPs play a crucial role in drug resistance and could be potential targets for overcoming multi-drug resistance and enhancing chemotherapy efficacy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Neha Khera, Asvika Soodhalaagunta Rajkumar, Khlood Abdulkader M. Alkurdi, Zhiao Liu, Hong Ma, Ahmad Waseem, Muy-Teck Teh
Summary: Through transcriptome datamining, 10 multidrug chemoresistance genes were identified in head and neck squamous cell carcinoma. Among them, NEK2 and INHBA showed significant prognostic values in multiple cancer types. Drug library screens discovered two compounds targeting INHBA and NEK2, which resensitized cisplatin-resistant cells.
Article
Plant Sciences
Rajiniraja Muniyan, Jayaraman Gurunathan
PHARMACEUTICAL BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Muniyan Rajiniraja, Akella Sivaramakrishna, Varatharajan Sabareesh, Gurunathan Jayaraman
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2018)
Article
Biology
Panchaksaram Muthukumaran, Muniyan Rajiniraja
JOURNAL OF THEORETICAL BIOLOGY
(2018)
Article
Biology
Panchaksaram Muthukumaran, Muniyan Rajiniraja
JOURNAL OF THEORETICAL BIOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Sadhana Sundararajan, Rajiniraja Muniyan
Summary: Tuberculosis (TB) is a major global health concern, with the complex physiology of Mycobacterium tuberculosis making control efforts challenging. The emergence of drug-resistant and latent TB further complicates the situation, as the bacterium successfully modulates genes to evade the host immune system and affect key cellular processes.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Engineering, Multidisciplinary
Himadri Shekhaar Baul, Muniyan Rajiniraja
JOURNAL OF COMPUTATIONAL METHODS IN SCIENCES AND ENGINEERING
(2018)
Review
Biotechnology & Applied Microbiology
Rajiniraja Muniyan, Jayaraman Gurunathan
RESEARCH JOURNAL OF BIOTECHNOLOGY
(2017)
