Article
Chemistry, Applied
Xinyu Bai, Ping Liu, Hengyan Shen, Qiaoyue Zhang, Tao Zhang, Xuejun Jin
Summary: WLJP was found to improve allergic rhinitis through various mechanisms, such as reducing inflammation levels, modulating immune responses, maintaining gut microbiota balance, repairing damaged barriers, and alleviating AR symptoms. Additionally, significant interaction between WLJP and the NLRP3 inhibitor CY-09 was observed.
CARBOHYDRATE POLYMERS
(2022)
Article
Plant Sciences
Jia-jun Zhang, Xue-cheng He, Min Zhou, Qin-dong Liu, Wei-zhen Xu, Ya-jie Yan, Yan Ruan
Summary: XQLT has a therapeutic effect on OVA-induced AR by alleviating nasal symptoms and reducing inflammation. It regulates ILC2s through the IL-33/ST2 and JAK/STAT pathways to ameliorate type 2 inflammation in AR.
Article
Allergy
Nicholas J. Campion, Sergio Villazala-Merino, Ryan S. Thwaites, Victoria Stanek, Helen Killick, Eleftheria Pertsinidou, Mohammed Zghaebi, Josef Toth, Renate Froschl, Thomas Perkmann, Katharina Gangl, Sven Schneider, Robin Ristl, Ian C. Scott, Emma Suzanne Cohen, Magnus Molin, Margit Focke-Tejkl, Guenther Regelsberger, Trevor T. Hansel, Rudolf Valenta, Verena Niederberger-Leppin, Julia Eckl-Dorna
Summary: This study aimed to characterize the immunologic and clinical nasal responses to birch pollen allergen challenge, with a special focus on the late allergic response.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
He Zhao, Zhaowei Gu, Yunxiu Wang, Meng Wang, Yue Zhan, Xin Zhao, Zhiwei Cao
Summary: Allergic rhinitis is a common nasal mucosa disease that is mainly mediated by IgE after exposure to allergens. IL-9 may play an important role in the development of allergic rhinitis by inhibiting the expression of certain cytokines and signaling pathways. Inhibition of IL-9 activity can significantly reduce the symptoms of allergic rhinitis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Allergy
Kathleen R. Bartemes, Hirohito Kita
Summary: ILC2, a type of innate lymphoid cell, responds rapidly to allergen exposure and environmental insults in mucosal organs by producing type 2 cytokines. In addition to being activated by epithelium-derived cytokines, ILC2s are regulated by other cytokines, eicosanoids, and neuropeptides.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Weiwei Chen, Dengming Lai, Yuehua Li, Xueke Wang, Yihang Pan, Xiangming Fang, Jie Fan, Qiang Shu
Summary: In sepsis, NMU acts through NMUR1 in lung ILC2s to initiate ILC2 activation, which promotes IL-17A-producing gamma delta T cell expansion and secretion of IL-17A. ILC2-derived IL-9 plays a crucial role in mediating gamma delta T cell expansion and IL-17A production. This study explores a novel mechanism in the neuronal regulation of innate immunity in sepsis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Naoya Imahashi, Masashi Satoh, Emanuela Clemente, Kazuhisa Yoshino, Mario Di Gioacchino, Kazuya Iwabuchi
Summary: Major histocompatibility complex (MHC) class Ib molecules present antigens to subsets of T cells involved in host defense and immune-mediated diseases. MHC-related protein 1 (MR1) selects MR1-restricted T cells, including mucosal-associated invariant T (MAIT) cells, and presents ligands to them. This study found that MR1-deficient mice exhibited exaggerated allergic contact dermatitis (ACD) lesions with increased recruitment of neutrophils. Additionally, MR1-deficient mice lacking MAIT cells showed an increase in IL-17-producing αβ and γδ T cells in the skin.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Manabu Kitano, Seiya Fukuoka, Naoki Adachi, Tadashi Hisamitsu, Masataka Sunagawa
Summary: Shoseiryuto (SST), a traditional herbal medicine, alleviates symptoms of toluene diisocyanate (TDI)-induced allergic rhinitis (AR) and inhibits IL-33 release from nasal epithelial cells.
Article
Microbiology
Yung Jin Jeon, Chan Hee Gil, Jina Won, Ara Jo, Hyun Jik Kim
Summary: Allergic rhinitis (AR) is characterized by airway inflammation in nasal mucosa from inhaled allergens and Staphylococcus epidermidis reduces allergic inflammation by suppressing IL-33 production, which is a key mechanism of reduction of IL-33 and Th2 inflammation.
Article
Microbiology
Bhawna Yadav, Charles A. Specht, Chrono K. Lee, Maria Pokrovskii, Jun R. Huh, Dan R. Littman, Stuart M. Levitz
Summary: Exposure to mold, Aspergillus, is generally harmless to healthy individuals but can lead to invasive and allergic aspergillosis in immunocompromised and atopic individuals. In murine models of pulmonary aspergillosis, lung eosinophils express IL-17, ROR gamma t, and IL-23R. However, IL-23 is not necessary for the production of IL-17 and ROR gamma t in this context.
Article
Endocrinology & Metabolism
C. Yang, N. Chen, X. L. Tang, X. H. Qian, C. P. Cai
Summary: Both IL-33 and IL-25 contribute to the pathogenesis of allergic rhinitis, with IL-33 playing a greater role. Neutralization of IL-33 may be a potential therapeutic approach for allergic rhinitis.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Multidisciplinary Sciences
Siti Muhamad Nur Husna, Norasnieda Md Shukri, Noor Suryani Mohd Ashari, Kah Keng Wong
Summary: This review discusses the role of interleukin IL-4 and IL-13 in allergic rhinitis and asthma, as well as the feasibility of using therapeutic antibodies targeting these cytokines and their receptors to treat these diseases.
Article
Medicine, Research & Experimental
Maya E. Kotas, Jeremie Dion, Steven Van Dyken, Roberto R. Ricardo-Gonzalez, Claire J. Danel, Camille Taille, Luc Mouthon, Richard M. Locksley, Benjamin Terrier
Summary: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and poorly understood disease characterized by elevated levels of TSLP, IL-25, and soluble ST2 in patients, alongside reduced circulating ILC2s. A mouse model study revealed the important roles of IL-33, ILC2s, and IL4R alpha signaling in the pathogenesis of EGPA.
Article
Immunology
Jutamas Suwanpradid, Min Jin Lee, Peter Hoang, Jeffery Kwock, Lauren P. Floyd, Jeffrey S. Smith, Zhinan Yin, Amber R. Atwater, Sudarshan Rajagopal, Ross M. Kedl, David L. Corcoran, Jennifer Y. Zhang, Amanda S. MacLeod
Summary: The crosstalk between T cells, dendritic cells, and macrophages in leukocyte clusters within barrier tissues provides a new concept for T cell activation in the skin. It was found that macrophages produce IL-27 which induces IL-15 production from other cells within leukocyte clusters, enhancing the survival of skin T cells. Blocking the IL-27 pathway in CHS mice led to decreased expression of the T cell survival gene BCL2, resulting in a decline in dermal CD8(+) T cells and T cell cluster numbers.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yanlu Che, Nan Wang, Qianzi Ma, Junjie Liu, Zhaonan Xu, Qiuying Li, Jingting Wang, Yanan Sun
Summary: This study investigated the differences in nasal flora composition between patients with allergic rhinitis (AR) and non-allergic rhinitis (nAR) and their role in pathogenesis. The results showed that AR patients had a significantly higher abundance of Vibrio vulnificus and Acinetobacter baumanni in the nasal cavity compared to nAR patients, while the abundance of Lactobacillus murinus, Lactobacillus iners, Proteobacteria, Pseudomonadales, and Escherichia coli was lower. The study also identified specific bacterial models associated with AR and nAR, providing new insights for their treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)