Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 120, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2020.111671
Keywords
Diabetic wound healing; Exosomes; PVA; Alginate; Nanohydrogel; Angiogenesis
Categories
Funding
- National Natural Science Foundation of China [82072076,81771987, 81871556]
- Special program for guiding local science and technology development by the central government of China [2018201002]
- Innovative Talents Program of Liaoning Provincial Universities [LR2017075]
- Liaoning Revitalization Talents Program [XLYC1807183, XLYC1902108]
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The study showed that exosomes derived from HUCMSCs encapsulated in a nanohydrogel could promote proliferation, migration, and angiogenesis of endothelial cells, as well as accelerate diabetic wound healing. The nanohydrogel also upregulated the expression of wound healing-related molecules and increased VEGF levels through the ERK1/2 pathway, significantly enhancing the healing of diabetic wounds in rats by promoting angiogenesis.
Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSCs) were helpful for injury repair, but whether HUCMSCs-derived exosomes could be encapsulated in a novel nanohydrogel to regulate diabetic wound healing was unclear. Here, HUCMSCs-derived exosomes encapsulated in a bioactive scaffold composed of polyvinyl alcohol (PVA)/alginate (Alg) nanohydrogel (exo@H) was applied to wound healing of diabetic rats. Results found that exo@H could facilitate the proliferation, migration and angiogenesis of HUVECs and sped up the process of diabetic wound healing. We confirmed that exo@H contributed to the expression of the molecules related to wound healing, including SMA, SR-B1 and CD31. Besides, we also found that exo@H up regulated VEGF level via regulating ERK1/2 pathway. These data demonstrated that exo@H significantly accelerated healing of diabetic wounds in rats by promoting angiogenesis.
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