Review
Medicine, Research & Experimental
Aysan Moeinafshar, Niloufar Yazdanpanah, Nima Rezaei
Summary: COVID-19 is a viral disease caused by a coronavirus. The immune system plays a crucial role in the pathogenesis of COVID-19, making immune-based therapeutic approaches an interesting field of research.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Virology
Sana Shabbir, Muhammad Hassan Raza, Muhammad Arshad, Muhammad Jawad Khan
Summary: The global population has been significantly impacted by COVID-19, caused by SARS-CoV-2 with no effective treatment options available. Research has shown that patients exhibit active immune responses, potentially leading to issues like cytokine storm syndrome.
ARCHIVES OF VIROLOGY
(2021)
Review
Immunology
Masoomeh Masoomikarimi, Behzad Garmabi, Javad Alizadeh, Erfan Kazemi, Amirhossein Azari Jafari, Seyyedmohammadsadeq Mirmoeeni, Motahareh Dargahi, Niloofar Taheri, Reza Jafari
Summary: COVID-19 is a global pandemic caused by SARS-COV-2, with immunopathological features including elevated CRP and IL-6 levels, decreased CD4+ and CD8+ T cells, and increased inflammatory cytokines. Specific immunotherapies like CP for COVID-19 lack definitive evidence of effectiveness.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Salmaan Sharif, Aamer Ikram, Adnan Khurshid, Muhammad Salman, Nayab Mehmood, Yasir Arshad, Jamal Ahmed, Rana Muhammad Safdar, Lubna Rehman, Ghulam Mujtaba, Jaffar Hussain, Johar Ali, Mehar Angez, Muhammad Masroor Alam, Ribqa Akthar, Muhammad Wasif Malik, Mirza Zeeshan Iqbal Baig, Muhammad Suleman Rana, Muhammad Usman, Muhammad Qaisar Ali, Abdul Ahad, Nazish Badar, Massab Umair, Sana Tamim, Asiya Ashraf, Faheem Tahir, Nida Ali
Summary: The study found 27% of wastewater samples tested positive for SARs-CoV-2, indicating the potential for monitoring viral spread through wastewater surveillance. Additionally, the detection of virus sequence data in wastewater highlights the importance of surveillance for early warning signs.
Review
Respiratory System
J. L. Boechat, I. Chora, A. Morais, L. Delgado
Summary: SARS-CoV-2 is a new beta coronavirus responsible for COVID-19, declared a pandemic by the World Health Organization. Control of the pandemic has been hindered by limited knowledge of the virus-host interactions. The rapid clinical course of COVID-19 is linked to innate immune response in asymptomatic or mild cases.
Article
Multidisciplinary Sciences
Viviane Fongaro Botosso, Soraia Attie Calil Jorge, Renato Mancini Astray, Ana Marcia de Sa Guimaraes, Monica Beatriz Mathor, Patricia dos Santos de Carneiro, Edison Luiz Durigon, Dimas Covas, Danielle Bruna Leal de Oliveira, Ricardo das Neves Oliveira, Durvanei Augusto Maria, Silas Fernandes Eto, Neuza Maria Frazatti Gallina, Giselle Pidde, Carla Cristina Squaiella-Baptistao, Dilza Trevisan Silva, Isadora Maria Villas-Boas, Dayanne Carla Fernandes, Aline Vivian Vatti Auada, Alexandre Campos Banari, Antonio Francisco de Souza Filho, Camila Bianconi, Carla Lilian de Agostini Utescher, Denise Cristina Andre Oliveira, Douglas Oscar Ceolin Mariano, Flavia Ferreira Barbosa, Giuliana Rondon, Josana Kapronezai, Juliana Galvao da Silva, Mauricio Barbugiani Goldfeder, Priscila Comone, Regis Edgar Castilho Junior, Taiana Taina Silva Pereira, Fan Hui Wen, Denise Tambourgi, Ana Marisa Chudzinski-Tavassi
Summary: The new outbreak of COVID-19 has caused millions of deaths worldwide. Efforts are being made to find effective treatments, such as using immunoglobulin from immunized animals or plasma from convalescent patients. Clinical trials using anti-SARS-CoV-2 immunoglobulins from horses immunized with spike protein are underway. Researchers have developed an anti-SARS-CoV-2 equine F(ab ')(2) immunoglobulin that successfully neutralizes the virus, is safe in animal models, and reduces the severity of the disease in a hamster model of SARS-CoV-2 infection.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Lowell Ling, Zigui Chen, Grace Lui, Chun Kwok Wong, Wai Tat Wong, Rita W. Y. Ng, Eugene Y. K. Tso, Kitty S. C. Fung, Veronica Chan, Apple C. M. Yeung, David S. C. Hui, Paul K. S. Chan
Summary: The study found that as disease severity increases in COVID-19 patients, certain cytokine levels also increase progressively. IL-8, IP-10, and MDC in the early stage are the best predictors of disease severity. MCP-1 can predict clinical outcomes in critically ill patients, including duration of mechanical ventilation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Nhu Ngoc Nguyen, Linda Houhamdi, Van Thuan Hoang, Jeremy Delerce, Lea Delorme, Philippe Colson, Philippe Brouqui, Pierre-Edouard Fournier, Didier Raoult, Philippe Gautret
Summary: The reinfection rate of SARS-CoV-2 is low, and the severity of the first and second episodes of infection is similar. The severity of the second episode of COVID-19 is not higher than that of the first infection, even for patients with antibodies.
EMERGING MICROBES & INFECTIONS
(2022)
Review
Physiology
Silvia D'Ippolito, Francesca Turchiano, Amerigo Vitagliano, Gennaro Scutiero, Antonio Lanzone, Giovanni Scambia, Pantaleo Greco
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has posed a serious challenge to physicians. The long-term impact of SARS-CoV-2 infection on the reproductive system is still unclear. ACE2, which is abundantly expressed in the reproductive system, plays a role in the production of Ang-(1-7), which is involved in follicle growth, maturation, and ovulation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Microbiology
Christina M. Kackos, Sherri L. Surman, Bart G. Jones, Robert E. Sealy, Trushar Jeevan, Christopher J. H. Davitt, Sergei Pustylnikov, Tamarand L. Darling, Adrianus C. M. Boon, Julia L. Hurwitz, Marcelo M. Samsa, Richard J. Webby
Summary: SARS-CoV-2 continues to disrupt everyday life and cause excess morbidity and mortality worldwide. Vaccination has been key to quelling the impact of this respiratory pathogen, and mRNA vaccines have led the charge on this front. The emergence of SARS-CoV-2 variants has threatened vaccine efficacy, but the mRNA vaccines developed by GreenLight Biosciences have shown robust protective efficacy against the wild-type virus and its variants.
MICROBIOLOGY SPECTRUM
(2023)
Review
Microbiology
Jessica A. Plante, Brooke M. Mitchell, Kenneth S. Plante, Kari Debbink, Scott C. Weaver, Vineet D. Menachery
Summary: Despite the development of vaccines, COVID-19 caused by SARS-CoV-2 continues to be a global concern due to the emergence of new variants, raising worries about increased spread and potential impacts on immunity.
CELL HOST & MICROBE
(2021)
Review
Biochemistry & Molecular Biology
Xuewen Deng, Hiroshi Terunuma, Mie Nieda
Summary: NK cells play a crucial role in determining the course of COVID-19, and their dysregulation may contribute to disease progression. NK cell-based therapies with antiviral and antifibrotic activity could be a potential strategy for the treatment of COVID-19.
Article
Medicine, Research & Experimental
Suhana Ahmad, Ma'mon M. Hatmal, Lidawani Lambuk, Mohammad A. Al-Hatamleh, Walhan Alshaer, Rohimah Mohamud
Summary: COVID-19 is a complex disease with various manifestations, primarily affecting the lungs and potentially other organs, with immune dysregulation contributing to disease severity. Regulatory T cells (Tregs) and their hallmark TNFR2 are suggested to play a significant role in COVID-19 management.
Review
Chemistry, Multidisciplinary
Han Dai, Jie Han, Eric Lichtfouse
Summary: Prevention is better than cure. The emergence of epidemics and pandemics caused by the transmission of pathogens from animals to humans in the past two decades, especially COVID-19, has highlighted the limitations of traditional solutions and the need for more intelligent, cheaper, and preventive therapies to combat future pandemics.
ENVIRONMENTAL CHEMISTRY LETTERS
(2021)
Article
Virology
Chen Jia, Zhiguo Zhou, Wenjing Pan, Pan Zhang, Ming Yang, Mingming Zhao, Bo Li, Ping Liu, Qianqian Zhang, Xianglong Kong, Keyu Li, Tingting Yue, Ting Cai, Zijun Wang, Erik De Clercq, Song Li, Guangdi Li, Jiyang Liu, Haijing Wu, Qianjin Lu
Summary: Accumulating evidence shows that SARS-CoV-2 impairs the adaptive immune system during acute infection, but it is unclear whether T and B cell frequencies and functions return to normal after COVID-19 recovery. This study analyzed immune repertoires and neutralization antibodies in COVID-19 survivors with a 6-month follow-up and found abnormal T and B cell expression and function, decreased diversity, and abnormal class-switch recombination. Survivors had a decreased number of B cells but an increased proportion of CD19(+)CD138(+) B cells, an increased proportion of CD4(+) T cells, and a decreased frequency of CD3(+)CD4(-) T cells. SARS-CoV-2-specific neutralization antibodies were detectable after 6 months, suggesting the need for extended medical care for immune abnormalities and tissue damage.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Clinical Neurology
Amirmohammad Khalaji, Amir Hossein Behnoush, Parnian Shobeiri, Behrad Saeedian, Antonio L. Teixeira, Nima Rezaei
Summary: The study found no significant difference in BDNF levels between patients with OSA and controls, as well as no statistically significant impact of CPAP treatment on BDNF levels. Therefore, BDNF peripheral levels are not significantly altered in OSA or by its related treatment, preventing its use as a biomarker.
SLEEP AND BREATHING
(2023)
Review
Neurosciences
Mobina Amanollahi, Melika Jameie, Arash Heidari, Nima Rezaei
Summary: Adult neurogenesis plays a critical role in various neurological disorders, and neuroinflammation is a key factor that can affect this process by regulating multiple steps of neurogenesis. Understanding the effects of immune components on adult neurogenesis can provide insights into potential therapeutic candidates for these disorders.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Virology
Amene Saghazadeh, Nima Rezaei
Summary: An immunocompromised status increases the risk of monkeypox virus infection and severe disease, highlighting the importance of immune competence for controlling and clearing the virus. Studies have shown various effects of monkeypox virus on the immune system, including stimulation, modulation, and memory, affecting immune cells and molecules such as natural killer cells, macrophages, neutrophils, lymphocytes, cytokines, interferons, chemokines, and complement.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Review
Pharmacology & Pharmacy
Mandana Azari, Farbod Bahreini, Vladimir N. Uversky, Nima Rezaei
Summary: Breast cancer is a malignancy that occurs in the mammary glands, with triple-negative breast cancer (TNBC) being the most aggressive subtype. TNBC is resistant to hormone therapy and targeted therapies, making chemotherapy the primary treatment. However, resistance to chemotherapy can lead to treatment failure, cancer recurrence, and distant metastasis. Targeting chemoresistant metastases-initiating cells with specific therapeutic agents is a promising approach in TNBC management. Peptides, with their specificity, low immunogenicity, and efficacy, can be used to design drugs that enhance the effectiveness of chemotherapy for targeting drug-tolerant TNBC cells.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Hematology
Hanieh Kolahi Azar, Aylar Imanpour, Hanieh Rezaee, Fatemeh Ezzatifar, Zeinab Zarei-Behjani, Mohammadreza Rostami, Mahmoud Azami, Nima Behestizadeh, Nima Rezaei
Summary: This article discusses the importance of two core elements, mesenchymal stromal cells (MSCs) and chimeric antigen receptor (CAR)-T cells, in cell therapy procedures. It analyzes multiple parameters that affect cell homing and the impact of several chemokines in the tumor microenvironment on the homing process. Emerging comprehensive mechanistic strategies and their significant role in cell therapy remodeling are reviewed, and the development of combination therapies incorporating MSCs and CAR-T cells for cancer treatment is discussed.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Immunology
Niloufar Yazdanpanah, Arezou Rezaei, Vahid Ziaee, Nima Rezaei
Summary: Juvenile systemic lupus erythematosus (JSLE) is a complex disorder with unclear causes. Environmental factors, genetic factors, and immune system dysregulation are believed to play a role in JSLE etiology. The NLRP3 inflammasome, an important mediator of inflammation, is thought to be involved in JSLE etiology. This study found that the CT genotype of the NLRP3 rs3806265 gene was more common in patients with JSLE compared to healthy controls.
IMMUNOLOGICAL INVESTIGATIONS
(2023)
Review
Immunology
Soren Nooraei, Alireza Sarkar Lotfabadi, Milad Akbarzadehmoallemkolaei, Nima Rezaei
Summary: Vaccination is the most effective method for preventing and reducing the impact of infectious diseases in animals and humans. Adjuvants are substances that enhance the immune response and can improve the body's immune reactions. Nanoparticles have shown promise as more effective adjuvants due to their ability to target antigen-presenting cells and easily cross biological barriers.
Article
Allergy
Negar Moradian, Samaneh Zoghi, Elham Rayzan, Simin Seyedpour, Raul Jimenez Heredia, Kaan Boztug, Nima Rezaei
Summary: This article reports a male patient with SCN4 caused by G6PC3 gene deficiency, manifested as recurrent bacterial infections and multi-systemic complications, and showed rare large platelets on peripheral blood smear. The authors recommend considering G6PC3 gene mutation in cases of congenital, unexplained neutropenia.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Soodeh Ghadimi, Mahnaz Jamee, Hassan Abolhassani, Nima Parvaneh, Nima Rezaei, Samaneh Delavari, Mahnaz Sadeghi-Shabestari, Sedigheh Rafiei Tabatabaei, Alireza Fahimzad, Shahnaz Armin, Zahra Chavoshzadeh, Samin Sharafian
Summary: DCLRE1C gene mutation leads to severe combined immunodeficiency (SCID) with recurrent infections, impaired immune system development, and radiosensitivity. This study identified 9 Iranian patients with confirmed DCLRE1C mutation, most of whom were born in consanguineous families. The patients presented with early-onset respiratory tract infections, chronic diarrhea, and autoimmune disorders, along with reduced B cell and CD4+ cell counts and IgA deficiency.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2023)
Review
Oncology
Kimia Kazemzadeh, Sadra Behrouzieh, Nima Rezaei
Summary: This article reviews the potential immune-related side effects of immunotherapy in treating leukemia, including effects on different body systems such as cardiovascular and neurologic systems. Being aware of these side effects can lead to better clinical decision-making and proactive management in case of occurrence.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Review
Oncology
Sara Mahdiabadi, Sara Momtazmanesh, Amirali Karimi, Nima Rezaei
Summary: This study conducted a meta-analysis of randomized controlled trials to evaluate the efficacy of immune checkpoint inhibitors (ICIs) for metastatic melanoma. The results showed that ICIs are associated with improved overall survival and can assist clinicians in choosing the optimal treatment approach.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Review
Virology
Hanie Karimi, Vahid Mansouri, Nima Rezaei
Summary: This paper discusses the hypothesis of antibody transmission through the placenta and breast milk following SARS-CoV-2 infection or vaccination, while considering the potential harm and benefits to the fetus/infant.
Review
Multidisciplinary Sciences
Mahdi Masrour, Shaghayegh Khanmohammadi, Parisa Fallahtafti, Nima Rezaei
Summary: The study found that lncRNAs could be used as diagnostic biomarkers for HNSCC, but further investigation is needed to validate clinical efficacy and elucidate mechanisms. High-throughput sequencing and bioinformatics should be used to ascertain expression profiles.
Article
Neurosciences
Mahsa Golshani Nasab, Arash Heidari, Mohammadreza Sedighi, Narges Shakerian, Mona Mirbeyk, Amene Saghazadeh, Nima Rezaei
Summary: This article discusses the relationship between dietary inflammatory index (DII) and neuropsychiatric disorders (NPDs), finding that a proinflammatory diet is associated with depression, anxiety, stress, and sleep disorders. The effects of genetic backgrounds, dietary patterns, and the gut microbiome on DII are also discussed. Future research should evaluate causality through RCTs and explore personalized medicine interventions using information about DII in NPDs.
REVIEWS IN THE NEUROSCIENCES
(2023)
Review
Neurosciences
Ghazaleh Ghaffaripour Jahromi, Sepideh Razi, Nima Rezaei
Summary: This comprehensive review explores the pathophysiological models of depression and the relationship between NLRP3 inflammasome activation and depression. By adopting the inflammatory theory, the central role of NLRP3 inflammasome activation in depression is explained and supported by evidence from human studies and animal models. The activation of the inflammasome is not limited to the central nervous system, but extends to the gut and peripheral immune systems, affecting the balance of the microbiota-gut-brain axis.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
