Article
Peripheral Vascular Disease
Alexandra M. Garvin, Matthew D. De Both, Joshua S. Talboom, Merry L. Lindsey, Matthew J. Huentelman, Taben M. Hale
Summary: Transient ACE inhibition in spontaneously hypertensive rats leads to a persistent shift in cardiac fibroblast subpopulations, resulting in reduced fibrogenic phenotype.
Article
Cell Biology
Michael P. Czubryt, Taben M. Hale
Summary: Cardiac fibrosis is a characteristic of end-stage heart disease, but there are no approved therapies directly targeting the extracellular matrix. Research on cardiac fibroblasts is hindered by the lack of a clear marker.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Ratchanee Duangrat, Warisara Parichatikanond, Sutharinee Likitnukul, Supachoke Mangmool
Summary: Endothelin-1 (ET-1) plays a role in cardiac fibrosis through fibroblast activation and myofibroblast differentiation. This study reveals that ET-1 induces proliferation and synthesis of myofibroblast markers, alpha-SMA and collagen I, through the ETAR receptor subtype and G(alpha q) protein-mediated signaling. ERK1/2 is also involved in these processes. ETR antagonists, ambrisentan and bosentan, inhibit ET-1-induced effects and promote the reversal of myofibroblasts, suggesting their potential as therapeutic strategies for ET-1-induced cardiac fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Hui Xu, Jingwen Yang, Mengyun Tu, Jie Weng, Mengying Xie, Zhiliang Zhou, Peisen Zhou, Liang Wang, Chan Chen, Zhiyi Wang
Summary: This study demonstrated that VCR promoted the differentiation of fibroblasts into myofibroblasts through the MAPK signal pathway, suggesting a potential therapeutic target for VCR-induced PF.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Hiroyuki Arai, Yuki Sato, Motoko Yanagita
Summary: Fibroblasts play important roles in maintaining tissue structure and homeostasis under physiological conditions, but their phenotypic alterations can lead to various pathological conditions. Recent research has shown that fibroblasts consist of heterogeneous subpopulations with both beneficial and detrimental effects in a context-dependent manner, particularly in the development of chronic kidney disease in the kidney.
IMMUNOLOGICAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Yunna Zhang, Jiafeng Fu, Yang Han, Dandan Feng, Shaojie Yue, Yan Zhou, Ziqiang Luo
Summary: This study reveals that TREK-1 plays a pivotal role in BLM-induced lung fibrosis by inhibiting the FAK/p38/YAP signaling pathway and reducing the differentiation of fibroblasts to myofibroblasts. These findings provide a theoretical basis for utilizing TREK-1 inhibition as a potential therapeutic approach for lung fibrosis.
Article
Oncology
Yuchen Liu, Pengxiang Chen, Tianyu Liu, Bo Cheng, Changhua Sun, Huixian Xin, Zhihua Wen, Yufeng Cheng
Summary: This study aimed to explore the roles of endothelin-1 (ET-1) in radiation-induced myocardial fibrosis (RIMF) and the potential of docosahexaenoic acid (DHA) in preventing RIMF. The results showed that radiation increased ET-1 expression and secretion, promoting the activation of cardiac fibroblasts. DHA effectively inhibited fibroblast activation by targeting the p38/ET-1 pathway and attenuated cardiac fibrosis caused by radiation.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Yan Zhou, Yunna Zhang, Haipeng Cheng, Xiaohong Li, Dandan Feng, Shaojie Yue, Jianping Xu, Hui Xie, Ziqiang Luo
Summary: Omentin-1 has been found to alleviate bleomycin-induced lung fibrosis by preventing fibroblast activation. Therefore, omentin-1 may be a promising therapeutic agent for the treatment of lung fibrosis.
Article
Pharmacology & Pharmacy
Changlong An, Baihai Jiao, Hao Du, Melanie Tran, Bo Song, Penghua Wang, Dong Zhou, Yanlin Wang
Summary: This study identifies JMJD3 as a critical regulator of myeloid fibroblast activation, macrophage polarization, and renal fibrosis development, suggesting it as a potential therapeutic target for chronic kidney disease.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Min Kyung Kim, Jong-Uk Lee, Sun Ju Lee, Hun Soo Chang, Jong-Sook Park, Choon-Sik Park
Summary: Genetic and epigenetic factors have been identified in the development and prognosis of idiopathic pulmonary fibrosis (IPF). In this study, the role of erythrocyte membrane protein band 4.1-like 3 (EPB41L3) was investigated in IPF. It was found that EPB41L3 expression was significantly increased in lung fibroblasts from IPF patients compared to controls. The upregulation of EPB41L3 was also observed during epithelial-mesenchymal transition (EMT) and fibroblast-to-myofibroblast transition (FMT).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Huamin Zhang, Yutong Zhou, Dada Wen, Jie Wang
Summary: Myofibroblasts escape apoptosis and proliferate abnormally under pathological conditions, especially fibrosis. Non-coding RNAs have been found to play a vital role in regulating fibroblast to myofibroblast transition (FMT), mainly through the regulation of signaling pathways. They have the potential to be a new therapeutic target for FMT-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Alexandra M. Garvin, Laxmansa C. Katwa
Summary: Primary cardiac fibroblast tissue culture is a necessary tool for studying the signaling mechanisms in heart diseases. Traditional culture methods may induce cell activation and complicate result interpretation. Recent studies focus on the interaction between CF and its environment. This review discusses the factors that impact CF activation in tissue culture.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ravi Kumar, Hitesh Soni, Jeremiah M. Afolabi, Praghalathan Kanthakumar, Pratheesh D. Mankuzhy, Samson A. Iwhiwhu, Adebowale Adebiyi
Summary: Mechanical stretch-induced generation of reactive oxygen species stimulates the production of vasoactive endothelin in neonatal pig renal epithelial cells. Endothelin activates TRPC3 channels in renal microvascular smooth muscle, leading to persistent vasoconstriction and reduction in renal blood flow. These mechanisms may explain the development of renal insufficiency in acute reversible renal tubular cell stretch and obstruction.
Article
Biochemistry & Molecular Biology
Ravi Kumar, Hitesh Soni, Jeremiah M. Afolabi, Praghalathan Kanthakumar, Pratheesh D. Mankuzhy, Samson A. Iwhiwhu, Adebowale Adebiyi
Summary: This study demonstrates that mechanical stretch-induced oxyradical generation stimulates endothelin production in neonatal pig renal epithelial cells, leading to persistent vasoconstriction and reduction in renal blood flow, which may underlie early acute kidney injury.
Article
Biochemistry & Molecular Biology
Cai-Xia Ma, Zhi-Ru Wei, Tong Sun, Ming-Hui Yang, Yu-Qie Sun, Kun-Lun Kai, Jia-Chen Shi, Meng-Jiao Zhou, Zi-Wei Wang, Jing Chen, Wei Li, Tian-Qi Wang, Shan-Feng Zhang, Lixiang Xue, Min Zhang, Qianqian Yin, Ming-Xi Zang
Summary: The transdifferentiation from cardiac fibroblasts to myofibroblasts is a crucial step in the development of cardiac fibrosis. However, the mechanism behind this process is not fully understood. In this study, we identified a novel circular RNA called circ-sh3rf3, which was down-regulated in isoproterenol-treated rat cardiac fibroblasts and cardiomyocytes as well as during fibroblast differentiation into myofibroblasts. We further revealed that circ-sh3rf3 could interact with GATA-4 proteins and regulate the expression of miR-29a, thereby inhibiting fibroblast-myofibroblast differentiation and myocardial fibrosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ratih Paramita Suprapto, Yoko Suzuki, Tatsuya Nagano, Ken-Ichi Hirata, Noriaki Emoto
Summary: Lung adenocarcinoma, the leading cause of cancer-related deaths worldwide, was found to have increased expression of endothelin-2 (ET-2) which was associated with poor overall survival. Silencing ET-2 inhibited proliferation, migration, and invasion, and enhanced apoptosis in lung adenocarcinoma cells.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Biology
Keisuke Miwa, Yu Taniguchi, Hiroyuki Fujii, Yoichiro Matsuoka, Hiroyuki Onishi, Kenichi Yanaka, Yu Izawa, Yasunori Tsuboi, Atsushi Kono, Noriaki Emoto, Kenichi Hirata
Summary: Poor subpleural perfusion (PSP) on dual-energy computed tomography (DE-CT) is a specific imaging finding in chronic thromboembolic pulmonary hypertension (CTEPH) and suggests a different mechanism of microvasculopathy from that in pulmonary arterial hypertension (PAH).
Article
Medicine, Research & Experimental
Rochmy Istikharah, Dwi Aris Agung Nugrahaningsih, Ahmad Hamim Sadewa, Mae Sri Hartati Wahyuningsih
Summary: This study examined the effects of Tithonia diversifolia leaf extracts on insulin resistance and mitochondrial DNA copy number. The results showed that the extract improved blood glucose levels, insulin resistance, and increased mitochondrial DNA copy number.
MALAYSIAN JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Medicine, Research & Experimental
Dita Maria Virgina, Iwan Dwiprahasto, Mae Sri Hartati Wahyuningsih, Dwi Aris Agung Nugrahaningsih
Summary: This study analyzed the association between PRKAA2 gene variation and the risk of type 2 diabetes mellitus, finding that the G allele may be the main contributing factor to increased susceptibility to T2DM.
MALAYSIAN JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Neurosciences
Shoji Kawauchi, Taiji Mizoguchi, Sayo Horibe, Toru Tanaka, Naoto Sasaki, Koji Ikeda, Noriaki Emoto, Ken-ichi Hirata, Yoshiyuki Rikitake
Summary: This study investigated the effects of aging-related changes on the neurovascular unit (NVU). It was found that senescence in the vascular endothelial cells led to morphological alterations in astrocytes and affected the localization of the water channel AQP4 at the gliovascular interface.
Article
Cardiac & Cardiovascular Systems
Hiroyuki Fujii, Yu Taniguchi, Sachiyo Yoneda, Keisuke Miwa, Yoichiro Matsuoka, Kenichi Yanaka, Yasunori Tsuboi, Noriaki Emoto, Kenichi Hirata
Summary: In this study, data from 149 patients with chronic thromboembolic pulmonary hypertension (CTEPH) were analyzed. The results showed that the efficacy and safety of balloon pulmonary angioplasty (BPA) for CTEPH with concurrent chronic obstructive pulmonary disease (COPD) were similar to those without COPD. Oxygenation and forced expiratory volume in 1 second/forced vital capacity showed improvement in patients with COPD. Therefore, BPA should be considered as a treatment option for CTEPH patients with concurrent COPD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Biochemistry & Molecular Biology
Gusty Rizky Teguh Ryanto, Ahmad Musthafa, Tetsuya Hara, Noriaki Emoto
Summary: Advances in technology and biomedical knowledge have improved the diagnosis and treatment of rare diseases, including pulmonary arterial hypertension (PAH). This article explores the role of activins and inhibins in PAH development and their connection to signaling pathways implicated in the pathogenesis of PAH. It also discusses the potential therapeutic benefits of activin/inhibin-targeting drugs, such as sotatercep, in improving patient outcomes. Overall, this article highlights the importance of activin/inhibin signaling as a critical mediator in PAH development and its potential as a target for future treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Sayo Horibe, Takuo Emoto, Taiji Mizoguchi, Toru Tanaka, Shoji Kawauchi, Naoto Sasaki, Tomoya Yamashita, Koji Ikeda, Noriaki Emoto, Ken-ichi Hirata, Yoshiyuki Rikitake
Summary: Alzheimer's disease is a common neurodegenerative disease associated with aging. Endothelial cell senescence has been found in the brains of Alzheimer's disease patients, but its role in the pathogenesis of the disease is unclear. The study revealed that endothelial cell senescence alters microglial morphology and function, providing a potential clue for the prevention and treatment of Alzheimer's disease.
Article
Cardiac & Cardiovascular Systems
Muhammad R. Hadwiono, Anggoro B. Hartopo, Widya Wasityastuti, Dyah W. Anggrahini, Gusty R. T. Ryanto, Noriaki Emoto, Lucia K. Dinarti
Summary: This study found that Activin A may have a role in the development and progression of pulmonary artery hypertension (PAH) caused by uncorrected congenital heart disease (CHD-PAH). Serum levels of Activin A were significantly increased in subjects with uncorrected CHD, and were even more significantly elevated in CHD-PAH patients compared to controls. Therefore, the measurement of serum Activin A shows promise in identifying uncorrected CHD patients with PAH development and progression.
PULMONARY CIRCULATION
(2023)
Article
Medicine, General & Internal
Anggoro Budi Hartopo, Dyah Wulan Anggrahini, Lucia Kris Dinarti, Anne-Kathrin Schaefer, Andreas Bergmann, Jajah Fachiroh, Salvatore Di Somma
Summary: The plasma level of bioactive adrenomedullin (bio-ADM) is significantly elevated in patients with both atrial septal defects-associated pulmonary artery hypertension (ASD-PAH) and idiopathic/hereditary pulmonary arterial hypertension (I/H-PAH), and is associated with a higher mortality rate. This suggests that bio-ADM may serve as an important predictor of mortality risk in patients with PAH.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Anggoro Budi Hartopo, Dyah Wulan Anggrahini, Muhammad G. Satwiko, Arditya Damarkusuma, Armalya Pritazahra, Muhammad Reyhan Hadwiono, Vera C. Dewanto, Salvatore Di Somma, Noriaki Emoto, Lucia Kris Dinarti
Summary: This study aims to assess the value of NT-proBNP and TTE parameters in screening for PH in adult ASD patients. The results showed that the combined values of NT-proBNP level >140pg/mL and RA diameter >46.0mm had a better performance in detecting PH compared to single values.
ACTA MEDICA INDONESIANA
(2022)
Article
Health Care Sciences & Services
Yampa Eksa Daidella Ghilari, Arik Iskandar, Bayu Satria Wiratama, Anggoro Budi Hartopo
Summary: This study investigated the joint effect of diabetes mellitus and hypertension on in-hospital mortality among COVID-19 patients. The findings showed that patients with both diabetes mellitus and hypertension were more likely to have higher in-hospital mortality rates compared to those without these comorbidities.
Article
Medicine, General & Internal
Anggoro Budi Hartopo, Ira Puspitawati, Vita Yanti Anggraeni
Summary: This study found that the elevated level of midregional proadrenomedullin (MR-proADM) during the acute phase of ST-segment elevation myocardial infarction (STEMI) and its change intensity can predict adverse cardiac events within 90 days.
MEDICINA-LITHUANIA
(2022)
Meeting Abstract
Peripheral Vascular Disease
Mutiara Putri, Anggoro Budi Hartopo, Maria Patricia Inggriani, Jajah Fachiroh, Fatwa Sari Tetra Dewi
JOURNAL OF HYPERTENSION
(2022)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
