Article
Infectious Diseases
Mohamed Rhouma, Michelle Tessier, Cecile Aenishaenslin, Pascal Sanders, Helene Carabin
Summary: Experts are concerned about the potential increase in antimicrobial resistance during the COVID-19 pandemic due to increased use of antimicrobials globally. The impact of the pandemic on antimicrobial use and resistance in animals has not been discussed and evaluated. This crisis could be an opportunity to implement global collaborative solutions to address the complex challenges of antimicrobial resistance.
Review
Infectious Diseases
Tsegahun Asfaw, Deribew Genetu, Demissew Shenkute, Tassew Tefera Shenkutie, Yosef Eshetie Amare, Berhanu Yitayew
Summary: Foodborne pathogens are the leading cause of foodborne diseases globally, with a more severe problem in low-income countries like Ethiopia. Current studies in Ethiopia have focused on human, animal, and environmental samples using conventional culture-based diagnostic methods. Antimicrobial resistance is a serious issue, with high rates observed in foodborne bacterial pathogens in Ethiopia.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Infectious Diseases
Ioana Ghiga, Anna Sidorchuk, Emma Pitchforth, Cecilia Stalsby Lundborg, Anna Machowska
Summary: This systematic review synthesizes the evidence on the value of community-based behavior change interventions to improve antibiotic use. The findings show positive emerging evidence of the benefits of such interventions, especially multifaceted ones. Combining education with persuasion may be more effective than solely educational interventions. However, standardized approaches are needed in study design and outcome measurements.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Kayley D. McCubbin, John W. Ramatowski, Esther Buregyeya, Eleanor Hutchinson, Harparkash Kaur, Anthony K. Mbonye, Ana L. P. Mateus, Sian E. Clarke
Summary: The misuse and cross-use of antibiotics has led to a global issue of antibiotic resistance, but policymakers face challenges in low-income countries due to lack of surveillance data. Additionally, the mixed use of animal and human antibiotics in communities poses serious public health risks.
JOURNAL OF ANTIBIOTICS
(2021)
Review
Microbiology
Eleonora Cella, Marta Giovanetti, Francesca Benedetti, Fabio Scarpa, Catherine Johnston, Alessandra Borsetti, Giancarlo Ceccarelli, Taj Azarian, Davide Zella, Massimo Ciccozzi
Summary: Antibiotic resistance is a significant global health concern that requires a collaborative One Health approach. It poses a threat to human and animal health, as well as the effectiveness of medical treatments and veterinary interventions.
Article
Computer Science, Information Systems
Andrew Zhang, Ling Teng, Gil Alterovitz
Summary: The study aims to use machine learning technology to rapidly diagnose tuberculosis resistance and identify genetic features causing resistance. The results show that the machine learning platform can accurately predict resistance and identify relevant genes and mutations, potentially aiding in timely diagnosis and effective control of drug-resistant tuberculosis.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Review
Pharmacology & Pharmacy
Vasundhra Bhandari, Akash Suresh
Summary: This article discusses the emergence of resistance in bacterial species over time and the various protective mechanisms employed by bacterial cells. Additionally, it highlights the importance of new approaches and practices for tackling antimicrobial resistance and identifying new treatment options.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Samir K. Saha, Nazifa Tabassum, Senjuti Saha
Summary: Typhoid is endemic in many countries in South Asia and sub-Saharan Africa, putting a high burden on their health systems. With increasing antimicrobial resistance in treating typhoid, rapid implementation of typhoid conjugate vaccines is essential to reduce the burden of the disease.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Pharmacology & Pharmacy
Muhammad Usman Munir, Muhammad Masood Ahmad
Summary: This review focuses on different approaches to inhibiting bacterial infection using nanoparticles and emphasizes the functionality of nanomaterial surface design and fabrication for antimicrobial cargo.
Review
Biochemistry & Molecular Biology
Rajib Dey, Sudip Mukherjee, Swagatam Barman, Jayanta Haldar
Summary: The global threat of rising population of multidrug-resistant pathogens and their biofilm forming ability has stimulated the scientific community to search for smart and innovative alternatives to combat against drug-resistant superbugs. Membrane targeting antimicrobial polymers inspired from antimicrobial peptides can form nanoaggregates with superior antimicrobial efficacy, which can be utilized to design smart drug delivery systems to increase local antibiotic concentration and reduce off-target toxicity. This review article highlights the recent developments in macromolecular architecture for designing nanostructures with broad-spectrum antimicrobial activity and their application as antibiotic adjuvants to overcome antimicrobial resistance, with discussions on current challenges and future prospects.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Infectious Diseases
Chidozie Declan Iwu, Sean Mark Patrick
Summary: The study evaluated the implementation of the Global Action Plan on antimicrobial resistance in WHO African countries, finding that the overall performance score was low with some thematic scores appearing relatively good but lacking progress and implementation on closer inspection. Some threats and opportunities were identified to inform a practical roadmap for action.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Review
Infectious Diseases
Ayako Wendy Fujita, Kaitlyn Werner, Jesse T. Jacob, Rea Tschopp, Gezahegne Mamo, Adane Mihret, Alemseged Abdissa, Russell Kempker, Paulina A. Rebolledo
Summary: This study reviewed the prevalence of antimicrobial resistance (AMR) in humans, animals, and the environment in Ethiopia from 2016 to 2020. High prevalence of AMR was observed, with Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus being the most common bacteria in humans. Gram-negative organisms showed high rates of resistance to third-generation cephalosporins, fluoroquinolones, and sulfamethoxazole-trimethoprim. Humans had the highest resistance rates, followed by environmental isolates.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Nan Zhou, Zile Cheng, Xiaoxi Zhang, Chao Lv, Chaoyi Guo, Haodong Liu, Ke Dong, Yan Zhang, Chang Liu, Yunfu Chang, Sheng Chen, Xiaokui Guo, Xiao-Nong Zhou, Min Li, Yongzhang Zhu
Summary: This study developed a comprehensive tool for assessing global antimicrobial resistance (AMR) status and evaluated AMR in 146 countries. The study found that high-income countries performed better in terms of AMR, while low-income countries unexpectedly performed well in certain indicators. The study also identified correlations between AMR and socioeconomic factors such as GDP and life expectancy.
INFECTIOUS DISEASES OF POVERTY
(2022)
Article
Fisheries
Andrew P. Desbois, Maria Garza, Mahmoud Eltholth, Yamen M. Hegazy, Ana Mateus, Alexandra Adams, David C. Little, Erling Hog, Chadag Vishnumurthy Mohan, Shimaa E. Ali, Lucy A. Brunton
Summary: This study applies participatory systems-thinking approach to Nile tilapia production in the Nile Delta of Egypt, identifying potential short-term interventions to effectively reduce antibiotic use, mainly focusing on improving culture water quality parameters, feed storage conditions, and training programs for stakeholders.
Editorial Material
Fisheries
Felipe C. Cabello, Henry P. Godfrey
Summary: Dr. Avendano-Herrera's comments on our review are mostly marginal and do not weaken our hypothesis. We believe that infections caused by P. salmonis can be prevented by improving husbandry practices, and that excessive use of antimicrobials is detrimental to health.
Editorial Material
Fisheries
M. Troell, P. J. G. Henriksson, A. H. Buschmann, T. Chopin, S. Quahe
Summary: Seaweed farming has been promoted as a climate solution, but the carbon sink function is diminished due to consumption and alternative applications. Seaweeds can reduce greenhouse gas emissions through carbon offset and potentially through reducing enteric methane emissions from ruminants and bioenergy production. However, further research is needed to understand seaweeds' carbon cycling and contributions.
REVIEWS IN FISHERIES SCIENCE & AQUACULTURE
(2023)
Article
Biodiversity Conservation
Diana Sinclair, Craig Stephen, E. Jane Parmley, Andria Jones-Bitton, Zvonimir Poljak, Claire M. Jardine
Summary: This study aims to investigate and compare how wildlife health data and information are shared in the conservation and animal health fields in Ontario, Canada. The results demonstrate that there is more sharing of data and information between people from different institutions, highlighting opportunities for improved networking between wildlife conservation and health practitioners in Ontario.
HUMAN DIMENSIONS OF WILDLIFE
(2023)
Article
Environmental Sciences
Bhumika Jena, Swati Sucharita Singh, Susanta Kumar Behera, Smrutirekha Mishra, Sankha Chakrabortty, Dayanidhi Meher, Bansidhar Mulia, Suraj K. Tripathy, Ramesh Kumar, Byong-Hun Jeon, Cecilia Stalsby Lundborg, Amrita Mishra
Summary: Globally, Methicillin-Resistant Staphylococcus aureus bacteraemia is a common bloodstream infection associated with complications and high mortality. This study demonstrates the biosynthesis of Ag nanoparticles using a phytochemical agent from Urginea indica bulb extract. The synthesized nanoparticles show potential antibacterial and anti-biofilm activity against S. aureus and MRSA. They also exhibit biocompatibility and future clinical potential against Staphylococcus infections.
ENVIRONMENTAL RESEARCH
(2023)
Article
Microbiology
Irene Anna Lambraki, Mohan Vishnumurthy Chadag, Melanie Cousins, Tiscar Graells, Anais Leger, Patrik John Gustav Henriksson, Max Fredrik Troell, Stephan Harbarth, Didier Wernli, Peter Sogaard Jorgensen, Carolee Anne Carson, Elizabeth Jane Parmley, Shannon E. E. Majowicz
Summary: By integrating the perspectives of experts from the region, this study identified factors influencing antimicrobial resistance (AMR) in the food system of Southeast Asia and pinpointed potential places for intervention. The causal loop diagram constructed based on the experts' insights illustrated the complexity of AMR in the region and highlighted the need for comprehensive, multi-pronged interventions across multiple sectors.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Engineering, Environmental
Pranjal, Soujanya Ghosh, A. P. Habeeb Rahman, Sankha Chakrabortty, Shirsendu Banerjee, Ramesh Kumar, Amrita Mishra, Byong-Hun Jeon, Cecilia Stalsby Lundborg, Suraj K. Tripathy
Summary: A systematic study was conducted to understand the bactericidal mechanism of ultrasound assisted Fenton reaction (Sono-Fenton) against multidrug resistant Acinetobacter baumannii. The study found that SF achieved approximately 99% inactivation efficiency against A. baumannii within 90 minutes under weak acidic conditions. The combination of ultrasound and H2O2 was found to be more efficient, and the generation of multiple reactive oxygen species (ROS) may have led to the membrane damage of the bacteria.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Infectious Diseases
Ioana Ghiga, Anna Sidorchuk, Emma Pitchforth, Cecilia Stalsby Lundborg, Anna Machowska
Summary: This systematic review synthesizes the evidence on the value of community-based behavior change interventions to improve antibiotic use. The findings show positive emerging evidence of the benefits of such interventions, especially multifaceted ones. Combining education with persuasion may be more effective than solely educational interventions. However, standardized approaches are needed in study design and outcome measurements.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Veterinary Sciences
Ali Mostafaei, Hamid Akbari, Cecilia Stalsby Lundborg, Neda Kabiri, Nafiseh Vahed, Sakineh Hajebrahimi, Leila Doshmangir
Summary: Actions to preserve effective antibacterial agents and eliminate transmission of resistant organisms are crucial to prevent a catastrophic postantibiotic era. This systematic review gathered and appraised texts and expert opinions to determine effective strategies to tackle bacterial resistance worldwide. The findings emphasize the importance of strengthening surveillance, developing guidelines, improving public awareness, enhancing hygiene, improving prescribing patterns, enhancing laboratory capacity, promoting innovation and research, and strengthening coordination.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Didier Wernli, Jean-Luc Falcone, Stephan Davidshofer, Kelley Lee, Bastien Chopard, Nicolas Levrat
Summary: From a complexity perspective, multilateral diplomacy is built on interactions between people, ideas, norms, policies, and institutions. Using a computer-assisted methodology, this article analyzes World Health Assembly (WHA) resolutions from 1948 to 2022 to understand the network of norms in governance systems. The findings reveal a complex network of interconnected global health issues, characterized by different community patterns. This research highlights the relevance of network analysis in understanding global health norms and suggests extending the computational approach to explore the impact of regime complexity on global health diplomacy.
Letter
Pharmacology & Pharmacy
Saibal Das, Shambo Samrat Samajdar, Shatavisa Mukherjee, Sougata Sarkar, Sumalya Sen, Ashish Pathak, Cecilia Stalsby Lundborg, Sandhiya Selvarajan, Santanu Kumar Tripathi, Jyotirmoy Pal, Nandini Chatterjee, Shashank R. Joshi
INTERNATIONAL JOURNAL OF PHARMACY PRACTICE
(2023)
Article
International Relations
Didier Wernli, Lucas Boettcher, Flore Vanackere, Yuliya Kaspiarovich, Maria Masood, Nicolas Levrat
Summary: This article examines the impact of growing interconnections among societies on the emergence of systemic crises and discusses the importance of the interdisciplinary field of complexity in understanding these crises. It applies an analytical framework to the 2008 global financial crisis and the COVID-19 pandemic, highlighting the unsustainability of relying on reactive and recovery capacities. The article calls for a multipronged strategy to strengthen our capacities to face systemic crises and address fundamental mismatches between global challenges and collective action.
Article
Environmental Sciences
Nada Hanna, Ashok J. Tamhankar, Cecilia Stalsby Lundborg
Summary: Environmental contamination with antibiotic residues is a significant concern. This study developed a prioritisation system for antibiotics based on their integrated environmental and human health risks, to implement eco-pharmacovigilance and develop targeted policies.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Didier Wernli, Peter Sogaard Jorgensen, E. Jane Parmley, Shannon E. Majowicz, Irene Lambraki, Carolee A. Carson, Melanie Cousins, Tiscar Graells, Patrik J. G. Henriksson, Anais Leger, Stephan Harbarth, Max Troell
Summary: Social-ecological resilience is crucial in understanding and addressing the challenges posed by antimicrobial resistance. It provides a framework to comprehend the impacts, diversity of strategies, and conditions of intervention success or failure. Resilience thinking is essential for human societies to cope, adapt, and transform in the face of growing global antimicrobial resistance.
LANCET PLANETARY HEALTH
(2023)
Review
Environmental Sciences
Nada Hanna, Ashok J. Tamhankar, Cecilia Stalsby Lundborg
Summary: This study aimed to determine the antibiotic residue levels that are likely to select for resistance and the relative contributions from different aquatic sources in the WHO Western Pacific region and the WHO South-East Asia region. The highest risk for the development of resistance was observed in tap or drinking water with ciprofloxacin in these regions.
LANCET PLANETARY HEALTH
(2023)
Article
Environmental Sciences
Jena Webb, Sergio Raez-Villanueva, Paul Carriere, Audrey -Anne Beauchamp, Isaac Bell, Angela Day, Sarah Elton, Mathieu Feagan, Jolene Giacinti, Jean Paul Kabemba Lukusa, Celia Kingsbury, Paola A. Torres-Slimming, Martin Bunch, Katie Clow, Maya K. Gislason, Margot W. Parkes, E. Jane Parmley, Blake Poland, Cathy Vaillancourt
Summary: This paper presents the work and insights from the Canadian Community of Practice in Ecosystem Approaches to Health (CoPEH-Canada) and 15 years of land-based, transdisciplinary, learner-centered, transformative learning and training. The learning approaches have included cognitive, psychomotor, and affective learning, which are essential for enacting structural changes and reestablishing healthier relationships with nature and each other. The development of teaching techniques and resources, integration of different approaches and ways of knowing, and the creation of a networked Community of Practice highlight the importance of ecohealth teaching and learning in informing planetary health education approaches.
LANCET PLANETARY HEALTH
(2023)
Article
Primary Health Care
Ioana Ghiga, Emma Pitchforth, Cecilia Stalsby Lundborg, Anna Machowska
Summary: This qualitative study conducted semi-structured interviews with 12 family doctors in Romania to explore their perceptions of antibiotic resistance. The findings revealed differences in their perceptions and highlighted the lack of patient education and awareness as a major driver of antibiotic consumption. Potential interventions, particularly focused on patient education, were identified to address this issue.
