Article
Immunology
Tomonori Kaifu, Takumi Maruhashi, Soo-Hyun Chung, Kenji Shimizu, Akira Nakamura, Yoichiro Iwakura
Summary: Dendritic cell immunoreceptor (DCIR) is an inhibitory C-type lectin receptor that negatively regulates the immune system and bone metabolism. Previous research has shown that DCIR deficiency enhances osteoclastogenesis and antigen presentation by dendritic cells, and that the interaction between asialo-biantennary N-glycan (NA2) and DCIR suppresses osteoclastogenesis. In this study, the researchers found that DCIR regulates osteoclastogenesis by downregulating M-CSF and RANKL signaling, and that DCIR-mediated signaling may control the expression of glycosylation enzymes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Shojiro Haji, Taiki Ito, Carla Guenther, Miyako Nakano, Takashi Shimizu, Daiki Mori, Yasunori Chiba, Masato Tanaka, Sushil K. Mishra, Janet A. Willment, Gordon D. Brown, Masamichi Nagae, Sho Yamasaki
Summary: This study reports that human Dectin-1 acts as a ligand for CLEC-2 and highlights the importance of glycosylation in its function as a CLEC-2 ligand. Furthermore, it is shown that expression of human Dectin-1 can rescue the lethality and lymphatic defect resulting from a deficiency of Podoplanin.
Article
Immunology
Tianhang Li, Tianyao Liu, Zihan Zhao, Yuchen Pan, Xinyan Xu, Yulin Zhang, Shoubin Zhan, Shengkai Zhou, Wenjie Zhu, Hongqian Guo, Rong Yang
Summary: Immunotherapies offer new treatment options for urothelial bladder cancer, but their efficacy is limited by heterogeneity and therapeutic resistance. Research has shown that the commensal microbiota and its interactions with host immunity play a crucial role in bladder cancer. The urinary mycobiome and C-type lectin receptors (CLRs) may be potential targets for immunotherapy in bladder cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Xinyu Xiong, Zhe Cheng, Yi Zhou, Fan Wu, Linglin Xie, Lauren Lawless, Ruolan Dong, Yan Zhao, Lingling Yu, Guang Chen
Summary: HuanglianGanjiang Tang (HGT), a classic prescription of traditional Chinese medicine, has been used for treating ulcerative colitis (UC) with good curative effect. This study aimed to evaluate the therapeutic potential of HGT and explore its molecular mechanism in a mouse model of UC. The results showed that HGT could alleviate UC symptoms by inhibiting colonic necroptosis through upregulating the level of VDR.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Huixia Wu, Zhengchun Wu, Yilan Qiu, Fangjian Zhao, Minjing Liao, Zhihong Zhong, Jian Chen, Yiliang Zeng, Rushi Liu
Summary: This study found that a specific synbiotic intervention can protect the intestinal barrier, inhibit the occurrence of colitis-associated cancer (CAC), and improve the intestinal microecological environment. The synbiotic upregulates tight junction proteins and anti-inflammatory cytokines, while downregulating pro-inflammatory cytokines. It also improves the disorder of the colonic microbiota, promotes the formation of SCFAs and the production of secondary bile acids, and alleviates the accumulation of primary bile acids in CAC mice. Additionally, it inhibits the abnormal activation of the intestinal Wnt/β-catenin signaling pathway related to IL-23.
Article
Integrative & Complementary Medicine
Yuanbing Zhu, Zhiqi Zhuang, Qiaofeng Wu, Sirui Lin, Na Zhao, Qun Zhang, Lushuang Xie, Shuguang Yu
Summary: This study found that moxibustion can improve ulcerative colitis by regulating the expression of immune cells and adenosine receptors, affecting the ATP purine signal metabolism pathway, and alleviating gut inflammation in mice.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Guozhen Wang, Yongshuai Qi, Jia Xu, Yun Huang, Feng Xiong, Weichang Huang, Xiaoxin Ma, Shuanghu Wang, Changxiong Wang, Yunfang Zhou, Lisheng Wang
Summary: The incidence and prevalence of ulcerative colitis (UC) are increasing worldwide. Hydrocortisone enema (HC) is widely used in UC treatment but its effectiveness is limited by degradation and low uptake in the intestines. This study developed neutrophil membrane-coated MSN loaded with HC to improve targeting efficiency. The MSN-HC@NM NPs showed promising results in alleviating DSS-induced colitis in mice, reducing apoptosis and inflammation. This research provides a safe and potentially translatable hydrocortisone delivery system.
ACS APPLIED NANO MATERIALS
(2023)
Article
Environmental Sciences
Wanfa Dong, Dan Liu, Tingting Zhang, Qi You, Fengjie Huang, Jie Wu
Summary: Oral administration of ALG-SNase can reduce intestinal NET levels in UC mice, alleviate clinical colitis and tissue inflammation, and decrease intestinal permeability. Furthermore, SNase nanoparticles regulate the expression levels of proinflammatory cytokines, suggesting a potential therapeutic role for UC treatment.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Sijing Dong, Min Zhu, Ke Wang, Xiaoye Zhao, Longlong Hu, Wanghui Jing, Haitao Lu, Sicen Wang
Summary: Recent studies have shown that DHM can alleviate IBD by modulating gut microbiota and microbial BA metabolism, leading to improvements in intestinal barrier integrity. This research provides insights into the development of novel DHM-derived drugs for the management of inflammatory bowel disease.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biotechnology & Applied Microbiology
Jan Dohnalek, Tereza Skalova
Summary: The C-type lectin-like fold (CTL fold) is a versatile structural motif found in many proteins, and its interactions play significant roles in various biological processes. Understanding the rules governing these interactions can aid in the development of new protein binders for biomedical and biotechnological applications.
BIOTECHNOLOGY ADVANCES
(2022)
Article
Fisheries
Yang Liu, Zuzhen Wang, Wenjun Wang, Bing Liu, Chunfang Li, Yuandong Sun, Jiri Cao, Kuanyu Xia, Moci Yang, Jinpeng Yan
Summary: In this study, a novel C-type lectin (MaCTL) was cloned and characterized, which plays significant roles in innate immune response through binding to the pathogen-associated molecular patterns (PAMPs) on microorganisms. The results showed that MaCTL is widely expressed in various tissues and upregulated after LPS stimulation and Aeromonas hydrophila challenge, suggesting its involvement in innate immune response. Furthermore, MaCTL can bind to various bacteria and carbohydrates, and exhibit antimicrobial effects.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Xiaohan Liu, Jiqing Gao, Xiao Wei, Xinze Zhang, Liping You, Yuanjin Liu, Lizhu Chen, Caili Liu, Chunxiao Sun, Xiuhui Tian, Quanli Zhou, Xiaomin Zhang
Summary: In this study, the potential mechanisms of PAMP binding and opsonic activities of a c-type lectin and a sialic acid-binding lectin from manila clam were investigated. The results showed that both lectins could bind to various pathogen-associated molecular patterns (PAMPs) and enhance the phagocytosis and encapsulation ability of hemocytes. These lectins may function as pattern recognition receptors (PRRs) involved in the innate immune responses of the clam.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Danfeng Dong, Tongxuan Su, Wei Chen, Daosheng Wang, YiLun Xue, Qiuya Lu, Cen Jiang, Qi Ni, Enqiang Mao, Yibing Peng
Summary: Clostridioides difficile exacerbates the severity of colitis in mice with inflammatory bowel disease by altering the gut microbiota and enhancing neutrophil recruitment. Inhibition of neutrophil migration or interleukin-1 beta production can ameliorate inflammation. This study provides insights into the complex interaction between microbiota and immune responses in C. difficile-induced inflammation.
Article
Cell Biology
Qianqian Li, Xuan Sun, Kaiyuan Yu, Junqiang Lv, Chunhui Miao, Jianming Yang, Song Wang, Zheng Fu, Yamin Sun, Hong Zhang, Zhi-Song Zhang, Evan T. Keller, Zhi Yao, Quan Wang
Summary: This study reveals the important role of commensal intestinal bacteria E. ludwigii in regulating host immune tolerance. Choline, a metabolite of E. ludwigii, is identified to increase immune tolerance and promote Treg differentiation, suggesting potential therapeutic approaches for inflammatory bowel diseases (IBDs).
Article
Microbiology
Axel Dietschmann, Sebastian Schruefer, Stefanie Westermann, Fiona Henkel, Kirstin Castiglione, Ralf Willebrand, Jasmin Adam, Jurgen Ruland, Roland Lang, Donald C. Sheppard, Julia Esser-von-Bieren, Daniel Radtke, Sven Krappmann, David Voehringer
Summary: Eosinophilia is associated with various inflammatory diseases, such as allergic bronchopulmonary aspergillosis (ABPA). It has been shown that direct interaction between eosinophils and Aspergillus fumigatus is essential for the activation of eosinophils, which then secrete multiple proinflammatory mediators. The PI3K-AKT-mTOR pathway plays a crucial role in A. fumigatus-induced eosinophil activation.
Article
Biotechnology & Applied Microbiology
Tomoyuki Shimazu, Mai Suzuki, Ryo Takasaki, Asuka Besshi, Yuna Suzuki, Yoichiro Iwakura
Summary: This study investigated the relationship between lactic acid bacteria (LAB) and innate immune receptors. The researchers found that C-type lectin receptors (CLRs) are involved in the immune-stimulating function of LAB. The interaction between LAB and CLRs can reduce the levels of certain cytokines and is only observed in heat-killed LAB. These findings contribute to a better understanding of the immunomodulatory effects of LAB.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Engineering, Biomedical
Suyoung Lee, Seohyun Byun, Changhon Lee, Sun Hee Park, Dipayan Rudra, Yoichiro Iwakura, You Jeong Lee, Sin-Hyeog Im, Dong Soo Hwang
Summary: This study reveals the impact of bending stiffness on the immune regulatory properties of chitosan, indicating the potential of low molecular weight chitosan as a pharmaceutical ingredient for treating various inflammatory disorders.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Immunology
Anne-Charlotte Jonckheere, Sven F. Seys, Brecht Steelant, Tatjana Decaesteker, Kaat Dekoster, Jonathan Cremer, Ellen Dilissen, Dominique Schols, Yoichiro Iwakura, Greetje Vande Velde, Christine Breynaert, Rik Schrijvers, Jeroen Vanoirbeek, Jan L. Ceuppens, Lieven J. Dupont, Dominique M. A. Bullens
Summary: This study developed a murine model for non-allergic neutrophilic asthma and found that ILC play a key role in inducing airway hyperreactivity. ILC are also associated with inflammatory response and cytokine release.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Haiyang Sun, Ce Tang, Soo-Hyun Chung, Xiao-Qi Ye, Yulia Makusheva, Wei Han, Masato Kubo, Shigeyuki Shichino, Satoshi Ueha, Koji Matsushima, Kazuho Ikeo, Masahide Asano, Yoichiro Iwakura
Summary: DCIR plays important roles in regulating the immune and bone systems, but its role in the intestine is unclear. Blocking DCIR signaling can improve colitis and suppress the development of colonic tumors, indicating that DCIR may be a potential target for the treatment of these diseases.
Article
Immunology
Ryota Yamagishi, Fumitaka Kamachi, Masaru Nakamura, Shota Yamazaki, Tomonori Kamiya, Masaki Takasugi, Yi Cheng, Yoshiki Nonaka, Yoshimi Yukawa-Muto, Le Thi Thanh Thuy, Yohsuke Harada, Tatsuya Arai, Tze Mun Loo, Shin Yoshimoto, Tatsuya Ando, Masahiro Nakajima, Hayao Taguchi, Takamasa Ishikawa, Hisaya Akiba, Sachiko Miyake, Masato Kubo, Yoichiro Iwakura, Shinji Fukuda, Wei-Yu Chen, Norifumi Kawada, Alexander Rudensky, Susumu Nakae, Eiji Hara, Naoko Ohtani
Summary: In this study, the release mechanism of senescence-associated secretory phenotype (SASP) factors from senescent hepatic stellate cells (HSCs) was identified in a mouse model of obesity-induced hepatocellular carcinoma (HCC). IL-33 release from HSCs promoted HCC development via the activation of ST2-positive T-reg cells in the liver tumor microenvironment. These findings highlight the therapeutic potential of inhibitors of gasdermin D-mediated pore formation for HCC treatment.
SCIENCE IMMUNOLOGY
(2022)
Article
Developmental Biology
Tomoaki Iwayama, Mizuho Iwashita, Kazuya Miyashita, Hiromi Sakashita, Shuji Matsumoto, Kiwako Tomita, Phan Bhongsatiern, Tomomi Kitayama, Kentaro Ikegami, Takashi Shimbo, Katsuto Tamai, Masanori A. Murayama, Shuhei Ogawa, Yoichiro Iwakura, Satoru Yamada, Lorin E. Olson, Masahide Takedachi, Shinya Murakami
Summary: Periodontal ligament cells have the ability to differentiate into osteoblasts and cementoblasts. Other cell populations, such as mural cells and Schwann cells, also exist in the periodontal ligament. This study further elucidates the importance of periodontal ligament cells in periodontal tissue homeostasis and repair.
Correction
Immunology
Anne-Charlotte Jonckheere, Sven F. Seys, Brecht Steelant, Tatjana Decaesteker, Kaat Dekoster, Jonathan Cremer, Ellen Dilissen, Dominique Schols, Yoichiro Iwakura, Greetje Vande Velde, Christine Breynaert, Rik Schrijvers, Jeroen Vanoirbeek, Jan L. Ceuppens, Lieven J. Dupont, Dominique M. A. Bullens
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Toxicology
Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa
Summary: In the study of polymicrobial sepsis, pro-inflammatory cytokines play a vital role in regulating hepatic drug transporter expression. The research found that both CLP and LPS can reduce the expression of drug transporters, but IL-6 is the major factor in the downregulation of hepatic multidrug transporters caused by polymicrobial sepsis.
TOXICOLOGY LETTERS
(2023)
Article
Multidisciplinary Sciences
Zhengping Huang, Xiaomeng You, Liang Chen, Yan Du, Kailey Brodeur, Hyuk Jee, Qiang Wang, Grace Linder, Roxane Darbousset, Pierre Cunin, Margaret H. Chang, Alexandra Wactor, Brian M. Wauford, Marc J. C. Todd, Kevin Wei, Ying Li, Anais Levescot, Yoichiro Iwakura, Virginia Pascual, Nicole E. Baldwin, Pierre Quartier, Tianwang Li, Maria T. Gianatasio, Robert P. Hasserjian, Lauren A. Henderson, David B. Sykes, Elizabeth D. Mellins, Scott W. Canna, Julia F. Charles, Peter A. Nigrovic, Pui Y. Lee
Summary: This study reveals the involvement of mTORC1 in the pathogenesis of Still's disease and macrophage activation syndrome. Activation of mTORC1 was found to be preferential in monocytes, and inhibiting mTORC1 or depleting monocytes attenuated disease severity. Additionally, decreased expression of mTORC1 inhibitors TSC1/TSC2 was observed in patients with Still's disease and correlated with disease activity and treatment response.
NATURE COMMUNICATIONS
(2022)
Correction
Oncology
Chunyan Yu, Xiulong Niu, Yongrui Du, Yan Chen, Xiaomei Liu, Lingling Xu, Yoichiro Iwakura, Xiaoxia Ma, Yan Li, Zhi Yao, Weimin Deng
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Immunology
Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa
Summary: Sepsis affects drug metabolism and the expression of cytochrome P450s. The study shows that cecal ligation and puncture (CLP) induces the expression of proinflammatory cytokines and leads to decreased survival in IL-6(-/-) mice. CLP also downregulates the expression of Cyp2c and Cyp3a11 genes, but this effect is abolished by IL-6 depletion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Takehisa Nakanishi, Shohei Iida, Junko Maruyama, Hayato Urushima, Masako Ichishi, Yoshiaki Matsushima, Kento Mizutani, Yuichi Nakayama, Kyoko Sugioka, Mai Nishimura, Ai Umaoka, Yoichiro Iwakura, Makoto Kondo, Koji Habe, Daisuke Tsuruta, Osamu Yamamoto, Yasutomo Imai, Keiichi Yamanaka
Summary: The skin is a major immune organ that produces inflammatory cytokines in response to stimuli, leading to systemic inflammation. Inflammatory skin diseases like psoriasis and atopic dermatitis can cause vascular disorders like arteriosclerosis. However, the mechanism of arteriosclerosis in dermatitis and the role of cytokines are not fully understood. This study investigates the pathophysiology of arteriosclerosis and treatment options for inflammatory skin conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Rebecca A. Drummond, Jigar V. Desai, Amy P. Hsu, Vasileios Oikonomou, Donald C. Vinh, Joshua A. Acklin, Michael S. Abers, Magdalena A. Walkiewicz, Sarah L. Anzick, Muthulekha Swamydas, Simon Vautier, Mukil Natarajan, Andrew J. Oler, Daisuke Yamanaka, Katrin D. Mayer-Barber, Yoichiro Iwakura, David Bianchi, Brian Driscoll, Ken Hauck, Ahnika Kline, Nicholas S. P. Viall, Christa S. Zerbe, Elise M. N. Ferre, Monica M. Schmitt, Tom DiMaggio, Stefania Pittaluga, John A. Butman, Adrian M. Zelazny, Yvonne R. Shea, Cesar A. Arias, Cameron Ashbaugh, Maryam Mahmood, Zelalem Temesgen, Alexander G. Theofiles, Masayuki Nigo, Varsha Moudgal, Karen C. Bloch, Sean G. Kelly, M. Suzanne Whitworth, Ganesh Rao, Cindy J. Whitener, Neema Mafi, Juan Gea-Banacloche, Lawrence C. Kenyon, William R. Miller, Katia Boggian, Andrea Gilbert, Matthew Sincock, Alexandra F. Freeman, John E. Bennett, Rodrigo Hasbun, Constantinos M. Mikelis, Kyung J. Kwon-Chung, Yasmine Belkaid, Gordon D. Brown, Jean K. Lim, Douglas B. Kuhns, Steven M. Holland, Michail S. Lionakis
Summary: The study explores the immune protection mechanisms against subcutaneous phaeohyphomycosis caused by viral particles. The researchers found that CLEC7A gene mutations are associated with susceptibility to the disease. Animal experiments further confirmed the importance of this gene in immune defense against phaeohyphomycosis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Meeting Abstract
Dermatology
S. Iida, T. Nakanishi, F. Momose, M. Ichishi, K. Mizutani, Y. Matsushima, A. Umaoka, M. Kondo, K. Habe, Y. Hirokawa, M. Watanabe, Y. Iwakura, Y. Miyahara, Y. Imai, K. Yamanaka
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Meeting Abstract
Respiratory System
A. Jonckheere, B. Steelant, S. Seys, T. Decaesteker, J. Cremer, E. Dilissen, D. Schols, Y. Iwakura, J. Vanoirbeek, L. Dupont, D. Bullens
EUROPEAN RESPIRATORY JOURNAL
(2022)