Article
Multidisciplinary Sciences
Sanduni Madawala, Narelle Warren, Christian Osadnik, Chris Barton
Summary: This study investigated the healthcare experiences of patients living independently in the community with COPD who smoked or had recently quit. The findings revealed that patients desired proactive and empathetic care from healthcare providers and wanted to avoid stigma and judgement.
Review
Medicine, General & Internal
Amanda J. Cross, Jenifer Liang, Dennis Thomas, Elida Zairina, Michael J. Abramson, Johnson George
Summary: There is conflicting evidence for the efficacy of educational interventions for health professionals managing COPD in the primary care setting. These interventions may improve influenza vaccination rates among patients with COPD and patient satisfaction with care, but there is uncertainty regarding the proportion of COPD diagnoses confirmed with spirometry, the proportion of patients participating in pulmonary rehabilitation, and the proportion prescribed guideline-recommended medications. Further well-designed RCTs are needed to assess the effects of educational interventions on COPD management.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Medicine, General & Internal
Fernando J. Martinez, MeiLan K. Han, Camden Lopez, Susan Murray, David Mannino, Stacey Anderson, Randall Brown, Rowena Dolor, Nancy Elder, Min Joo, Irfan Khan, Lyndee M. Knox, Catherine Meldrum, Elizabeth Peters, Cathie Spino, Hazel Tapp, Byron Thomashow, Linda Zittleman, Barry Make, Barbara P. Yawn
Summary: Chronic obstructive pulmonary disease (COPD) is often undiagnosed in primary care. The CAPTURE screening tool is effective in identifying US primary care patients with clinically significant, undiagnosed COPD.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Health Care Sciences & Services
Martine W. J. Huygens, Helene R. Voogdt-Pruis, Myrah Wouters, Maaike M. Meurs, Britt van Lettow, Conchita Kleijweg, Roland D. Friele
Summary: The uptake of telemonitoring in Dutch chronic care remained stable during 2014-2019 but increased among medical specialists. According to both patients and professionals, telemonitoring improves the quality of life and quality of care. Professionals mentioned that monitoring data and tracking alerts can take up significant time.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Medicine, General & Internal
Alvise Casara, Graziella Turato, Marta Marin-Oto, Umberto Semenzato, Davide Biondini, Mariaenrica Tine, Nicol Bernardinello, Elisabetta Cocconcelli, Pablo Cubero, Elisabetta Balestro, Paolo Spagnolo, Jose M. Marin, Manuel G. Cosio, Marina Saetta, Erica Bazzan
Summary: Chronic bronchitis (CB) significantly affects symptoms, quality of life, and survival in smokers without COPD, with 27% of noCOPD smokers having CB. CB does not impact FEV1 decline in noCOPD but does significantly in COPD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Z. Lahmar, E. Ahmed, A. Fort, I. Vachier, A. Bourdin, A. Bergougnoux
Summary: COPD is a chronic airway disease that affects millions of people worldwide and is ranked as the third leading cause of death. Genetic susceptibility, environmental factors, and the combined effects of these factors play important roles in the development of COPD. The Hedgehog signaling pathway and its inhibitor HHIP are potential targets for therapeutic interventions in COPD.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Estela Camus-Garcia, Ana Isabel Gonzalez-Gonzalez, Monique Heijmans, Ena Nino de Guzman, Claudia Valli, Jessica Beltran, Hector Pardo-Hernandez, Lyudmil Ninov, Valentina Strammiello, Kaisa Immonen, Dimitris Mavridis, Marta Ballester, Rosa Sunol, Carola Orrego
Summary: By developing the COPD COS for the evaluation of SMIs, consistency in outcome measurement and reporting across trials will be increased. This will lead to more personalized healthcare and informed health decisions in clinical practice, as patients' preferences regarding COPD outcomes are more systematically included.
Review
Microbiology
Yehudis Rosenwasser, Irene Berger, Zvi G. Loewy
Summary: This article discusses the pharmacotherapeutic approaches for COPD exacerbation, including antimicrobials, bronchodilators, and anti-inflammatory drugs, as well as the connection between the oral cavity and the lungs.
Review
Microbiology
Bryn Short, Stephen Carson, Anna-Claire Devlin, James A. Reihill, Anne Crilly, William MacKay, Gordon Ramage, Craig Williams, Fionnuala T. Lundy, Lorcan P. McGarvey, Keith D. Thornbury, S. Lorraine Martin
Summary: Haemophilus influenzae is a common cause of bacterial infection in the lungs of COPD patients, leading to acute exacerbations. Its ability to adhere to host epithelial cells, form biofilms, and persist through immune evasion and antibiotic tolerance plays a crucial role in the pathogenesis of COPD.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Review
Psychology, Multidisciplinary
Hernan Anllo, Francois Larue, Bertrand Herer
Summary: This article introduces the potential of hypnosis therapy in the treatment of anxiety and breathlessness in COPD patients, and evaluates the application of hypnosis in anxiety, depression, and respiratory diseases. The article discusses the potential of hypnosis for improving health-related quality of life and self-management of COPD.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Medicine, General & Internal
Stephanie A. Christenson, Benjamin M. Smith, Mona Bafadhel, Nirupama Putcha
Summary: Chronic obstructive pulmonary disease (COPD) is a global health problem that leads to high morbidity, mortality, and healthcare utilization. Its main causes are exposure to harmful particles, such as tobacco smoke and pollutants. Recent research has shown that various factors throughout the life course increase the risk of developing COPD. Innovations in omics and imaging techniques have provided greater understanding of the disease's pathophysiology, potentially leading to advancements in its prevention, diagnosis, and treatment. This review focuses on recent advances in the epidemiology, pathophysiology, imaging, diagnosis, and treatment of COPD.
Article
Multidisciplinary Sciences
Florian Hofer, Jonas Schreyogg, Tom Stargardt
Summary: This study evaluated the effects of a structured home telemonitoring program implemented by a statutory health insurer in Germany on COPD patients. The results showed that the telemonitoring program was associated with higher healthcare expenditures, particularly in the first year. However, participants in the program had significantly improved survival rates compared to non-participants.
Article
Cardiac & Cardiovascular Systems
Astrid K. Wahl, Richard H. Osborne, Marie H. Larsen, Marit H. Andersen, Ingrid A. Holter, Christine R. Borge
Summary: This study highlights the importance of psychological factors in determining the health literacy needs among people with COPD. The results showed that higher levels of psychological well-being and education were associated with higher levels of health literacy.
Article
Allergy
Janwillem W. H. Kocks, Hui Cao, Bjorn Holzhauer, Alan Kaplan, J. Mark FitzGerald, Konstantinos Kostikas, David Price, Helen K. Reddel, Ioanna Tsiligianni, Claus F. Vogelmeier, Sebastien Bostel, Paul Mastoridis
Summary: The AC/DC tool showed superior diagnostic accuracy compared to primary care physicians and pulmonologists in diagnosing asthma and COPD. It has the potential to support physicians in the diagnosis of these conditions in clinical practice.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Thilo Bracht, Daniel Kleefisch, Karin Schork, Kathrin E. Witzke, Weiqiang Chen, Malte Bayer, Jan Hovanec, Georg Johnen, Swetlana Meier, Yon-Dschun Ko, Thomas Behrens, Thomas Bruning, Jana Fassunke, Reinhard Buettner, Julian Uszkoreit, Michael Adamzik, Martin Eisenacher, Barbara Sitek
Summary: Chronic obstructive pulmonary disease (COPD) is a major risk factor for the development of lung adenocarcinoma (AC). In this study, mass-spectrometry-based proteomics analysis and machine learning algorithms were used to identify potential biomarkers for differentiation between AC and COPD. The results showed promising performance for distinguishing AC from COPD and AC with COPD from COPD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nursing
Julia Wells, Catriona Kennedy, Heather Bain, Siew Hwa Lee
JOURNAL OF CLINICAL NURSING
(2020)
Review
Peripheral Vascular Disease
J. P. Sheppard, K. L. Tucker, W. J. Davison, R. Stevens, W. Aekplakorn, H. B. Bosworth, A. Bove, K. Earle, M. Godwin, B. B. Green, P. Hebert, C. Heneghan, N. Hill, F. D. R. Hobbs, I. Kantola, S. M. Kerry, A. Leiva, D. J. Magid, J. Mant, K. L. Margolis, B. McKinstry, M. A. McLaughlin, K. McNamara, S. Omboni, O. Ogedegbe, G. Parati, J. Varis, W. J. Verberk, B. J. Wakefield, R. J. McManus
AMERICAN JOURNAL OF HYPERTENSION
(2020)
Article
Public, Environmental & Occupational Health
Willem Odendaal, Simon Lewin, Brian McKinstry, Mark Tomlinson, Esme Jordaan, Mikateko Mazinu, Pam Haig, Anna Thorson, Salla Atkins
GLOBAL HEALTH ACTION
(2020)
Article
Medicine, General & Internal
Vicky Hammersley, Richard Parker, Mary Paterson, Janet Hanley, Hilary Pinnock, Paul Padfield, Andrew Stoddart, Hyeon Gyeong Park, Aziz Sheikh, Brian McKinstry
Review
Cardiac & Cardiovascular Systems
Alice Pearsons, Coral L. Hanson, Robyn Gallagher, Ronan E. O'Carroll, Sahar Khonsari, Janet Hanley, Fiona E. Strachan, Nicholas L. Mills, Terence J. Quinn, Brian McKinstry, Sheona McHale, Stacey Stewart, Mengying Zhang, Siobhan O'Connor, Lis Neubeck
Summary: This review aimed to assess commercially available atrial fibrillation (AF) self-management apps, finding that these apps had limited functions, lacked intuitive operations, and had difficult-to-read privacy policies, failing to meet the standards for use in healthcare settings.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2021)
Article
Health Care Sciences & Services
Chi Yan Hui, Brian McKinstry, Olivia Fulton, Mark Buchner, Hilary Pinnock
Summary: The study found that most asthma patients preferred an automated system that could log their asthma control status, provide real-time advice to help them understand asthma, identify triggers, and adjust treatment. Patients wanted data types such as peak flow, environmental factors (pollen, humidity, air temperature), and asthma symptoms. Clinicians desired automated objective data about patients' conditions during consultations.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Medicine, General & Internal
Guo-Qiang Zhang, Jin-Liang Chen, Ying Luo, Maya B. Mathur, Panagiotis Anagnostis, Ulugbek Nurmatov, Madar Talibov, Jing Zhang, Catherine M. Hawrylowicz, Mary Ann Lumsden, Hilary Critchley, Aziz Sheikh, Bo Lundback, Cecilia Lasser, Hannu Kankaanranta, Siew Hwa Lee, Bright Nwaru
Summary: The study comprehensively summarized 60 systematic reviews on the use of menopausal hormone therapy in women, revealing a complex balance of benefits and harms across multiple health outcomes. The findings suggest potential health risks associated with MHT, highlighting the importance of further research in this area.
Article
Health Care Sciences & Services
Chi Yan Hui, Brian McKinstry, Olivia Fulton, Mark Buchner, Hilary Pinnock
Summary: This study used the McKnight model to explore the trust of patients and clinicians in IoT systems for providing self-management support. Most patients believed that IoT systems had broad functionality to support various self-management tasks and wanted the system to provide customized advice involving AI. While they trusted the system to reliably log their condition and provide action plan advice, they were less confident in the system's continuous operation and error-free advice provision. Clinicians preferred clinical evidence before trusting the system and were hesitant to trust AI to generate new advice.
JMIR MHEALTH AND UHEALTH
(2021)
Article
Health Care Sciences & Services
Carolyn Steele Gray, Edward Chau, Farah Tahsin, Sarah Harvey, Mayura Loganathan, Brian McKinstry, Stewart W. Mercer, Jason Xin Nie, Ted E. Palen, Tim Ramsay, Kednapa Thavorn, Ross Upshur, Walter P. Wodchis
Summary: The study evaluated the implementation and effectiveness of an electronic Patient-Reported Outcome (ePRO) mobile app and portal system in enabling goal-oriented care delivery in interprofessional primary care practices. Despite challenges in recruitment and engagement, the impact of ePRO on quality of life could not be definitively assessed due to underpowering, but a decrease in quality of life was observed in the intervention group. Ethnographic data highlighted the importance of the technology's meaningfulness to individuals' lives and work in driving adoption and tool appraisal.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Health Care Sciences & Services
Anne Canny, Eddie Donaghy, Victoria Murray, Leo Campbell, Carol Stonham, Andrew Bush, Brian McKinstry, Heather Milne, Hilary Pinnock, Luke Daines
Summary: Diagnosing asthma can be uncertain for patients due to lack of consultation time and poor communication. A clinical decision support system (CDSS) could improve the diagnostic process by providing resources, prompting dialogue, and encouraging patient involvement.
HEALTH EXPECTATIONS
(2023)
Article
Health Care Sciences & Services
Farah Tahsin, Tujuanna Austin, Brian McKinstry, Stewart W. Mercer, Mayura Loganathan, Kednapa Thavorn, Ross Upshur, Carolyn Steele Gray
Summary: This study explores the social and behavioral factors contributing to patients' use behavior of an mHealth app called ePRO. The patient-provider relationship, personal and social circumstances, perceived usefulness, patients' previous experience with goal-related behaviors, and confidence in one's capability were identified as key factors influencing patients' decision to continue using the app. Long-term users perceived the app to be more useful and their goals to be more meaningful than short-term users.
JMIR HUMAN FACTORS
(2022)
Article
Allergy
Luke Daines, Eddie Donaghy, Anne Canny, Victoria Murray, Leo Campbell, Carol Stonham, Andrew Bush, Brian Mckinstry, Heather Milne, David Price, Aziz Sheikh, Hilary Pinnock
Summary: ObjectiveAsthma diagnosis can be challenging in primary care. This study aimed to explore health professionals' perspectives on the value of a clinical decision support system (CDSS) for asthma diagnosis and the barriers and facilitators for its use in UK primary care. Qualitative interviews were conducted with doctors and nurses who had experience diagnosing asthma, and the findings revealed that participants recognized the potential benefits of a CDSS in structuring consultations, extracting relevant information from health records, and visually communicating findings to patients. Key factors for successful implementation included evidence-based content, regular updates, integration with existing software, and ease of use. Experienced clinicians expressed skepticism about the usefulness of a CDSS in routine practice, but believed it would be beneficial for trainees or less experienced colleagues.
Article
Health Care Sciences & Services
Chi Yan Hui, Brian McKinstry, Susannah Mclean, Mark Buchner, Hilary Pinnock
Summary: This study aimed to explore how a connected system for asthma support patients in self-management. The results indicated that patients found the system easy to use, and they tended to use devices based on trust in accuracy and needs; clinicians hoped the report could provide asthma score/status and reliever usage.
Article
Health Care Sciences & Services
Brian McKinstry, Helen Alexander, Gabriela Maxwell, Lesley Blaikie, Sameer Patel, Bruce Guthrie
Summary: This study aimed to design, implement, and evaluate a telemonitoring system for people with COVID-19 who are self-managing at home and are considered at significant risk of deterioration. Patients were able to record symptoms, pulse oximetry, and temperature through the system, and receive alerts if their readings breached targets. The study found that supported self-monitoring of COVID-19 patients at home is reassuring to patients, acceptable to clinicians, and can detect important signs of deterioration. However, some patients occasionally ignored important signs of deterioration because they felt well, highlighting the need for emphasis on early investigation and treatment.
JMIR FORMATIVE RESEARCH
(2021)