Article
Cardiac & Cardiovascular Systems
Karl-Patrik Kresoja, Karl-Philipp Rommel, Christian Lucke, Matthias Unterhuber, Christian Besler, Maximilian von Roeder, Anne Rebecca Schober, Thilo Noack, Matthias Gutberlet, Holger Thiele, Philipp Lurz
Summary: Global RV dysfunction is a predictor of outcomes among TTVR patients, who can be stratified into three types of RV contraction, in which a loss of longitudinal function can be compensated by increasing circumferential function, preserving RVEF and leading to favorable outcomes.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Andrada C. Guta, Kinan C. El-Tallawi, Duc T. Nguyen, Fatima Qamar, Thuy Nguyen, William A. Zoghbi, Gerald Lawrie, Edward A. Graviss, Dipan J. Shah
Summary: In this study, diagnostic criteria for tricuspid valve prolapse (TVP) were proposed using cardiac magnetic resonance. It was found that TVP is associated with severe tricuspid regurgitation (TR) in patients with primary mitral regurgitation (MR). A comprehensive assessment of tricuspid anatomy should be an important component of the preoperative evaluation for mitral valve surgery.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Erwan Donal, Guillaume Leurent, Anne Ganivet, Philip Lurz, Augustin Coisne, Pascal De Groote, Stephane Lafitte, Lionel Leroux, Nicole Karam, Loic Biere, Frederic Rouleau, Catherine Sportouch, Julien Dreyfus, Mohammed Nejjari, Jean-Michel Josselin, Amedeo Anselmi, Elena Galli, Emma Bajeux, Patrice Guerin, Jean-Francois Obadia, Jean-Noel Trochu, Emmanuel Oger
Summary: The Tri.fr trial is a multicentre, randomized controlled study aiming to investigate the impact of non-surgical treatment for tricuspid regurgitation on clinical outcomes. The study will follow 300 patients with severe secondary TR and use the Packer composite clinical endpoint as the primary outcome measure.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Rebecca T. Hahn, Matthew K. Lawlor, Charles J. Davidson, Vinay Badhwar, Anna Sannino, Ernest Spitzer, Philipp Lurz, Brian R. Lindman, Yan Topilsky, Suzanne J. Baron, Scott Chadderdon, Omar K. Khalique, Gilbert H. L. Tang, Maurizio Taramasso, Paul A. Grayburn, Luigi Badano, Jonathon Leipsic, Joann Lindenfeld, Stephan Windecker, Sreekanth Vemulapalli, Bjorn Redfors, Maria C. Alu, David J. Cohen, Josep Rodes-Cabau, Gorav Ailawadi, Michael Mack, Ori Ben-Yehuda, Martin B. Leon, Joerg Hausleiter
Summary: Interest in TR has grown due to progressively worse outcomes associated with increasing TR severity. The aim of the Tricuspid Valve Academic Research Consortium document is to standardize definitions and endpoints for trials addressing knowledge gaps in TR management. Another document will focus on defining trial endpoints and discussing trial design options.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Rebecca T. Hahn, Matthew K. Lawlor, Charles J. Davidson, Vinay Badhwar, Anna Sannino, Ernest Spitzer, Philipp Lurz, Brian R. Lindman, Yan Topilsky, Suzanne J. Baron, Scott Chadderdon, Omar K. Khalique, Gilbert H. L. Tang, Maurizio Taramasso, Paul A. Grayburn, Luigi Badano, Jonathon Leipsic, Joann Lindenfeld, Stephan Windecker, Sreekanth Vemulapalli, Bjorn Redfors, Maria C. Alu, David J. Cohen, Josep Rodes-Cabau, Gorav Ailawadi, Michael Mack, Ori Ben-Yehuda, Martin B. Leon, Joerg Hausleiter
Summary: Interest in the pathophysiology, etiology, management, and outcomes of patients with tricuspid regurgitation (TR) has grown. The aim of this document is to standardize definitions of disease etiology and severity, as well as endpoints for trials, to address the gaps in our knowledge related to identification and management of patients with TR.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Fabio Fazzari, Francesco Cannata, Matteo Maurina, Renato Maria Bragato, Marco Francone
Summary: This review describes the role of multimodality imaging in the assessment of tricuspid valve disease, emphasizing the importance of transcatheter treatment and the need for careful patient selection and anatomical evaluation.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Yang Zhan, Dipan Shah
Summary: This review highlights the role of cardiovascular magnetic resonance (CMR) in tricuspid valve disease, showing its advantages in dynamic anatomical assessment, accurate leaflet identification, and volumetric calculation. CMR can be used to evaluate tricuspid regurgitation volume and fraction, as well as optimize the assessment of adverse right heart prognostic factors.
CURRENT OPINION IN CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Federico Fortuni, Kensuke Hirasawa, Jeroen J. Bax, Victoria Delgado, Nina Ajmone Marsan
Summary: Severe tricuspid regurgitation has a significant negative impact on morbidity and mortality, but there are now various treatment options available, including transcatheter procedures for high surgical risk patients. Accurate assessment of the tricuspid valve and its surrounding structures is crucial for the management of TR patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Yura Ahn, Hyun Jung Koo, Joon-Won Kang, Dong Hyun Yang
Summary: Cardiac CT and CMR can provide detailed information about the anatomy and function of the tricuspid valve and right ventricle, which has prognostic implications. With transcatheter treatment options for tricuspid valve diseases, evaluating the tricuspid valve using CT and CMR is important for patient selection and procedural guidance. Additionally, CT can help investigate post-procedural causes of valve dysfunction such as pannus or thrombus.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Susheel K. Kodali, Rebecca T. Hahn, Charles J. Davidson, Akhil Narang, Adam Greenbaum, Patrick Gleason, Samir Kapadia, Rhonda Miyasaka, Firas Zahr, Scott Chadderdon, Robert L. Smith, Paul Grayburn, Robert M. Kipperman, Leo Marcoff, Brian Whisenant, Mike Gonzales, Raj Makkar, Moody Makar, William O'Neill, Dee Dee Wang, William A. Gray, Sandra Abramson, James Hermiller, Lucas Mitchel, D. Scott Lim, Dale Fowler, Mathew Williams, Sorin V. Pislaru, Abdellaziz Dahou, Michael J. Mack, Martin B. Leon, Mackram F. Eleid
Summary: The PASCAL system has shown promising results in reducing mortality and heart failure hospitalization rates, as well as improving TR severity, functional status, and quality of life in patients with severe TR.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Heemoon Lee, Dong Seop Jeong, Wook Sung Kim, Kiick Sung, Keumhee Chough Carriere, Sung-Ji Park, Pyo Won Park
Summary: The study found that prophylactic TAP in patients with mild TR who underwent mitral valve repair may not have a beneficial effect on TR progression. Further large studies are necessary to define the role of prophylactic TAP in mild TR.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas P. P. Craven, Pei G. G. Chew, Laura E. E. Dobson, Miroslawa Gorecka, Martine Parent, Louise A. E. Brown, Christopher E. D. Saunderson, Arka Das, Amrit Chowdhary, Nicholas Jex, David M. M. Higgins, Erica Dall'Armellina, Eylem Levelt, Dominik Schlosshan, Peter P. P. Swoboda, Sven Plein, John P. P. Greenwood
Summary: By using serial CMR, we investigated cardiac reverse remodeling and residual MR post-MVr vs MVR with chordal preservation in patients with primary MR. The results showed that MVR with chordal preservation may offer comparable cardiac reverse remodeling and functional benefits at 6-months compared to MVr.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)
Article
Cardiac & Cardiovascular Systems
Guillem Muntane-Carol, Maurizio Taramasso, Mizuki Miura, Mara Gavazzoni, Alberto Pozzoli, Hannes Alessandrini, Azeem Latib, Adrian Attinger-Toller, Luigi Biasco, Daniel Braun, Eric Brochet, Kim A. Connelly, Horst Sievert, Paolo Denti, Edith Lubos, Sebastian Ludwig, Daniel Kalbacher, Rodrigo Estevez-Loureiro, Neil Fam, Christian Frerker, Edwin Ho, Jean-Michel Juliard, Ryan Kaple, Susheel Kodali, Felix Kreidel, Claudia Harr, Alexander Lauten, Julia Lurz, Karl-Patrik Kresoja, Vanessa Monivas, Michael Mehr, Tamim Nazif, Georg Nickening, Giovanni Pedrazzini, Francois Philippon, Fabien Praz, Rishi Puri, Ulrich Schafer, Joachim Schofer, Gilbert H. L. Tang, Ahmed A. Khattab, Martin Andreas, Marco Russo, Holger Thiele, Matthias Unterhuber, Dominique Himbert, Marina Urena, Ralph Stephan von Bardeleben, John G. Webb, Marcel Weber, Mirjam Winkel, Michel Zuber, Jorg Hausleiter, Philipp Lurz, Francesco Maisano, Martin B. Leon, Rebecca T. Hahn, Josep Rodes-Cabau
Summary: The study found that TTVI in PLVS patients had a high rate of procedural success and low early mortality, with most patients maintaining good functional status and TR grade in midterm follow-up. Poor right ventricular function and history of heart failure hospitalization were associated with increased risk of procedural failure and poorer outcomes in follow-up.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Susheel Kodali, Rebecca T. Hahn, Isaac George, Charles J. Davidson, Akhil Narang, Firas Zahr, Scott Chadderdon, Robert Smith, Paul A. Grayburn, William W. O'Neill, Dee Dee Wang, Howard Herrmann, Frank Silvestry, Sammy Elmariah, Ignacio Inglessis, Jonathan Passeri, D. Scott Lim, Michael Salerno, Moody Makar, Michael J. Mack, Martin B. Leon, Raj Makkar
Summary: The TRISCEND study evaluated the feasibility and safety of transcatheter tricuspid valve replacement in patients with clinically significant tricuspid regurgitation and elevated surgical risk. The study found that the procedure resulted in a reduction in tricuspid regurgitation and an improvement in symptoms and quality of life at 30 days with an acceptable safety profile.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Review
Cardiac & Cardiovascular Systems
Emmanuelle Vermes, Laura Iacuzio, Franck Levy, Yohann Bohbot, Cedric Renard, Bernhard Gerber, Sylvestre Marechaux, Christophe Tribouilloy
Summary: Valvular regurgitation is a common condition in developed countries, especially with an aging population and improved diagnostic imaging methods. Echocardiography is the standard method for assessing the severity of valvular regurgitation, but cardiovascular magnetic resonance (CMR) has emerged as an additional tool for evaluating aortic and mitral valve regurgitation when echocardiography results are inconclusive. CMR is also useful for assessing ventricular volume and flow, which are important in calculating regurgitant volume and regurgitant fraction for various types of valvular regurgitation. However, there is a lack of studies comparing CMR to echocardiography in determining the severity and prognosis of valvular regurgitation. Further research is needed to validate the prognostic relevance of CMR in assessing valvular regurgitation severity. This review discusses the use of CMR in clinical practice for determining the severity of valvular regurgitation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Moritz C. Wyler von Ballmoos, Michael J. Reardon
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Michael J. Reardon
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Tian-Yuan Xiong, Walid Ben Ali, Yuan Feng, Kentaro Hayashida, Hasan Jilaihawi, Azeem Latib, Michael Kang-Yin Lee, Martin B. Leon, Raj R. Makkar, Thomas Modine, Christoph Naber, Yong Peng, Nicolo Piazza, Michael J. Reardon, Simon Redwood, Ashok Seth, Lars Sondergaard, Edgar Tay, Didier Tchetche, Wei-Hsian Yin, Mao Chen, Bernard Prendergast, Darren Mylotte
Summary: The indications for transcatheter aortic valve implantation (TAVI) have expanded to include low surgical risk and bicuspid aortic valve (BAV) patients, although BAV patients have been excluded from major randomized trials due to anatomical considerations. Despite advances in device design, BAV presents anatomical challenges and geographical variations, making it a challenging cohort for TAVI procedures.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hemal Gada, Amit N. Vora, Gilbert H. L. Tang, Mubashir Mumtaz, John K. Forrest, Roger J. Laham, Steven J. Yakubov, G. Michael Deeb, Chad Rammohan, Jian Huang, Michael J. Reardon
Summary: We investigated predictors of permanent pacemaker implantation (PPI) after self-expanding transcatheter aortic valve replacement (TAVR), explored the variability of PPI rates across different sites, and examined the impact of implantation methods on PPI. Despite the advantages of TAVR compared to surgical aortic valve replacement, increased PPI remains a limitation. The study included 699 patients without baseline PPI and analyzed their clinical, echocardiographic, and procedural characteristics. The results showed significant site-to-site variability in PPI rates and identified baseline conduction disorders and implant depth as important predictors of PPI in low-risk TAVR patients with Evolut valves.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2023)
Article
Immunology
Ashton A. Connor, Ashish Saharia, Constance M. Mobley, Mark J. Hobeika, David W. Victor, Sudha Kodali, Elizabeth W. Brombosz, Edward A. Graviss, Duc T. Nguyen, Linda W. Moore, A. Osama Gaber, R. Mark Ghobrial
Summary: The study retrospectively evaluated the outcomes of liver retransplantation and found that overall and graft survival rates were comparable to those of primary liver transplantation, indicating that modern liver retransplantation is a safer option for patients with liver graft failure.
Article
Cardiac & Cardiovascular Systems
Daniel O'Hair, Steven J. Yakubov, Kendra J. Grubb, Jae K. Oh, Saki Ito, G. Michael Deeb, Nicolas M. Van Mieghem, David H. Adams, Tanvir Bajwa, Neal S. Kleiman, Stanley Chetcuti, Lars Sondergaard, Hemal Gada, Mubashir Mumtaz, John Heiser, William M. Merhi, George Petrossian, Newell Robinson, Gilbert H. L. Tang, Joshua D. Rovin, Stephen H. Little, Renuka Jain, Sarah Verdoliva, Tim Hanson, Shuzhen Li, Jeffrey J. Popma, Michael J. Reardon
Summary: This study aimed to evaluate the 5-year incidence and clinical outcomes of hemodynamic structural valve deterioration (SVD) in patients undergoing self-expanding transcatheter aortic valve implantation (TAVI) or surgery. The results showed a lower rate of SVD in the TAVI group and its association with worse clinical outcomes.
Article
Cardiac & Cardiovascular Systems
Sukhdeep Bhogal, Toby Rogers, Amer Aladin, Itsik Ben-Dor, Jeffrey E. Cohen, Christian C. Shults, Jason P. Wermers, Gaby Weissman, Lowell F. Satler, Michael J. Reardon, Steven J. Yakubov, Ron Waksman
Summary: Since the first transcatheter delivery of an aortic valve prosthesis in 2002, the treatment options for aortic stenosis (AS) have undergone significant changes. Transcatheter aortic valve replacement (TAVR) has become the frontline therapy for severe symptomatic AS, applicable to patients across all risk categories. However, there are still patients who are not suitable for TAVR due to certain anatomical and procedural factors. This study focuses on these scenarios and explores the reasons for referring selected patients for surgical aortic valve replacement in 2023.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Maan Malahfji, Danai Kitkungvan, Alpana Senapati, Duc T. Nguyen, Carlos El-Tallawi, Bhupendar Tayal, Dany Debs, Valentina Crudo, Edward A. Graviss, Michael J. Reardon, Miguel Quinones, William A. Zoghbi, Dipan J. Shah
Summary: Cardiac magnetic resonance identified significant differences in remodeling patterns and tissue characteristics between patients with aortic regurgitation and primary mitral regurgitation. Aortic regurgitation led to more pronounced increases in ventricular volume and mass, while mitral regurgitation patients had normal geometry followed by myocardial thinning. Furthermore, mitral regurgitation patients had a higher prevalence of myocardial scarring and higher extracellular volume with increasing regurgitant volume.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Bart J. J. Velders, Michiel D. Vriesendorp, Rob A. F. De Lind Van Wijngaarden, Vivek Rao, Michael J. Reardon, Malakh Shrestha, Michael W. A. Chu, Joseph F. Sabik III, Fang Liu, Robert J. M. Klautz
Summary: This study compared the perioperative management of patients undergoing surgical aortic valve replacement (SAVR) between North America and Europe. The results showed that European patients were older, had lower body mass index, and more severe aortic stenosis at baseline. In Europe, anticoagulant therapy at discharge was more aggressive, length of stay was longer, and discharges directly to home were less common. Rehospitalisation risk differed between continents and countries.
Editorial Material
Cardiac & Cardiovascular Systems
Sachin S. Goel, Michael J. Reardon
Article
Cardiac & Cardiovascular Systems
Saki Ito, Roger Laham, Vuyisile T. Nkomo, John K. Forrest, Michael J. Reardon, Stephen H. Little, Mubashir Mumtaz, Hemal Gada, Tanvir Bajwa, David Langholz, John Heiser, Atul Chawla, Bart Jenson, Guilherme Attizanni, Alan H. Markowitz, Jian Huang, Jae K. Oh
Summary: This study aimed to evaluate the impact of transcatheter or surgical aortic valve replacement (TAVR or SAVR) on clinical and haemodynamic outcomes in symptomatic patients with moderately-severe aortic stenosis (AS). The analysis showed that both TAVR and SAVR had significant effects on the treatment outcomes of symptomatic patients with moderately-severe AS.
Article
Cardiac & Cardiovascular Systems
Safi U. Khan, Salman Zahid, Mohamad A. Alkhouli, Usman Ali Akbar, Syed Zaid, Hassaan B. Arshad, Stephen H. Little, Michael J. Reardon, Neal S. Kleiman, Sachin S. Goel
Summary: The use of cerebral embolic protection (CEP) in patients undergoing transcatheter aortic valve intervention (TAVI) may reduce the risk of disabling stroke, especially in high and intermediate surgical risk patients.
STRUCTURAL HEART-THE JOURNAL OF THE HEART TEAM
(2023)
Article
Cardiac & Cardiovascular Systems
Kees H. van Bergeijk, Joanna J. Wykrzykowska, Nicolas M. van Mieghem, Stephan Windecker, Lars Sondergaard, Hemal Gada, Shuzhen Li, Tim Hanson, Michael Deeb, Adriaan A. Voors, Michael J. Reardon
Summary: This study aimed to develop preprocedural risk scores for 5-year clinical outcomes after transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR). The risk predictors differed between TAVI and SAVR. The simple risk scoring systems performed better than the contemporary risk scores.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Maan Malahfji, Duc T. Nguyen, Edward A. Graviss, Dipan J. Shah
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Luis Augusto P. Dallan, Gilbert Tang, John K. Forrest, Michael J. Reardon, Wilson Y. Szeto, Susheel K. Kodali, Cristian Baeza, Ruth Eisenberg, Guilherme F. Attizzani
Summary: Research indicates that in transcatheter aortic valve replacement procedures, device oversizing within the range of >12% delivers better clinical outcomes compared to below-range (0%-12%) device oversizing, with lower mortality, reintervention, and readmission rates.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)