Article
Rheumatology
Jasvinder A. Singh
Summary: This study examined the frequency and rates of common drug/substance use disorder hospitalizations in five musculoskeletal diseases, with each drug use disorder hospitalization increasing from 1998 to 2014 in each of the five MSDs.
CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
J. Denise Power, Anthony Perruccio, J. Michael Paterson, Mayilee Canizares, Christian Veillette, Peter C. Coyte, Elizabeth M. Badley, Nizar N. Mahomed, Y. Raja Rampersaud
Summary: This study examined the magnitude and costs of ambulatory primary care, specialist physician care, and hospital service use for musculoskeletal disorders (MSDs) in Ontario, Canada. The results showed that MSDs place a significant and costly burden on the healthcare system.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Primary Health Care
Victoria K. Welsh, Kayleigh J. Mason, James Bailey, Ram Bajpai, Kelvin P. Jordan, Christian Mallen, Claire Burton
Summary: The COVID-19 pandemic resulted in changes in primary healthcare consultations and analgesic prescribing for rheumatic and musculoskeletal diseases (RMDs) in the UK. The number of consultations dropped significantly after the introduction of pandemic-related restrictions and had not fully recovered by October 2021. The proportion of RMD consultations with analgesic prescriptions, including strong opioids, increased during the pandemic. Higher proportions of strong opioid prescriptions were observed in the most deprived areas.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Review
Rheumatology
Rasmi Ranjan Sahoo, Anupam Wakhlu, Vikas Agarwal
Summary: Dealing with rheumatic diseases in tropical countries is complex due to limited healthcare infrastructure, lack of diagnostic and therapeutic facilities, impact of dominant prevalent diseases, and challenges in differentiating from infectious and non-infectious disease mimics. Several tropical diseases present with musculoskeletal and rheumatic manifestations, leading to delayed diagnosis or misdiagnosis and poor patient outcomes.
CLINICAL RHEUMATOLOGY
(2022)
Article
Psychology, Clinical
Colin T. Mahoney, Samantha J. Moshier, Terence M. Keane, Brian P. Marx
Summary: This study found that Veterans with comorbid PTSD and OUD have higher likelihood of emergency room and inpatient care, probable somatoform and major depressive disorders, and greater functional impairment compared to other groups. Both the PTSD/OUD group and PTSD/non-opioid SUD group demonstrate increased suicidality, urgent care utilization, and probable generalized anxiety disorder relative to Veterans with PTSD only or non-opioid SUD only. These findings support the importance of concentrated and sustained efforts to improve prevention and intervention strategies for Veterans struggling with PTSD symptoms and opioid misuse.
ADDICTIVE BEHAVIORS
(2021)
Review
Medicine, General & Internal
Livia Roseti, Brunella Grigolo
Summary: Joint pain and arthralgia can be symptoms of COVID-19, and there is evidence suggesting a possible relationship between the virus and the development of inflammatory arthritis. Viral infections and rheumatic diseases have documented associations, and they share genetic and environmental risk factors. The interaction between viruses and the immune system plays a role in the development of rheumatic diseases, and infections may contribute to autoimmune rheumatic diseases and patient mortality. Therefore, understanding the interaction between viral infections and rheumatic diseases is crucial.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Yumeko Kawano, Naomi J. Patel, Xiaosong Wang, Claire E. Cook, Kathleen Mm Vanni, Emily N. Kowalski, Emily P. Banasiak, Grace Qian, Michael DiIorio, Tiffany Y-T Hsu, Michael E. Weinblatt, Derrick J. Todd, Zachary S. Wallace, Jeffrey A. Sparks
Summary: This study investigated temporal trends in the incidence and severity of COVID-19 among patients with systemic autoimmune rheumatic diseases. The proportion of patients with severe COVID-19 has decreased over time, particularly during the most recent time periods, including the initial Omicron wave. Unvaccinated individuals had a higher proportion of severe cases compared to vaccinated individuals.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Critical Care Medicine
Mohammad Alrawashdeh, Michael Klompas, Simeon Kimmel, Marc R. Larochelle, Runa H. Gokhale, Raymund B. Dantes, Brooke Hoots, Kelly M. Hatfield, Sujan C. Reddy, Anthony E. Fiore, Edward J. Septimus, Sameer S. Kadri, Russell Poland, Kenneth Sands, Chanu Rhee, Cdc Prevention Epicenters Program
Summary: Limited knowledge exists about the association between opioid use and sepsis, but opioid-related hospitalizations are significantly associated with morbidity and mortality in patients, particularly younger individuals. Public health agencies should focus on raising awareness about sepsis among patients who use opioids and their healthcare providers, in addition to efforts to combat the opioid crisis.
CRITICAL CARE MEDICINE
(2021)
Article
Surgery
Na Lin, Eashita Dabas, May Lynn Quan, Winson Y. Cheung, Colleen Cuthbert, Yuanchao Feng, Shiying Kong, Khara M. Sauro, Darren R. Brenner, Lin Yang, Mingshan Lu, Yuan Xu
Summary: The study aimed to compare the health outcomes and resource use of cancer patients who were new persistent opioid users with those who were not, after undergoing curative intent surgery for cancer. The results showed that new persistent opioid use among cancer patients undergoing surgery was associated with a higher risk of opioid overdose within 3 years, increased hospitalization and emergency department visits in the first year after surgery, and worse survival. Therefore, avoiding the persistent use of opioids is crucial for cancer patients undergoing surgery.
Article
Rheumatology
Karin Melsens, Maurizio Cutolo, Dieneke Schonenberg-Meinema, Ivan Foeldvari, Maria C. Leone, Yora Mostmans, Valerie Badot, Rolando Cimaz, Joke Dehoorne, Ellen Deschepper, Tracy Frech, Johanna Hernandez-Zapata, Francesca Ingegnoli, Archana Khan, Dorota Krasowska, Hartwig Lehmann, Ashima Makol, Miguel A. Mesa-Navas, Malgorzata Michalska-Jakubus, Ulf Muller-Ladner, Laura Nuno-Nuno, Rebecca Overbury, Carmen Pizzorni, Mislav Radic, Divya Ramadoss, Angelo Ravelli, Silvia Rosina, Clara Udaondo, Merlijn J. van den Berg, Ariane L. Herrick, Alberto Sulli, Vanessa Smith
Summary: This study aimed to standardly assess and describe nailfold videocapillaroscopy (NVC) assessment in children and adolescents with juvenile rheumatic and musculoskeletal diseases (jRMD) vs healthy controls (HCs). The results showed significant differences in NVC assessment between jRMD subgroups and HCs.
Review
Biology
Joaquim H. L. Branco, Ruy L. L. Branco, Thais C. Siqueira, Loiane C. de Souza, Keyla M. S. Dalago, Alexandro Andrade
Summary: This systematic review summarized the clinical applicability of infrared thermography (IT) in rheumatic diseases (RD). The findings from 12 included studies demonstrated that IT is an effective tool for assessing the health status of individuals with RD, providing clinical information relevant to diagnosis and treatment.
JOURNAL OF THERMAL BIOLOGY
(2022)
Review
Ergonomics
Beatrice Albanesi, Michela Piredda, Marco Bravi, Federica Bressi, Raffaella Gualandi, Anna Marchetti, Gabriella Facchinetti, Andrea Ianni, Francesca Cordella, Loredana Zollo, Maria Grazia De Marinis
Summary: This study aims to provide a comprehensive description of interventions for preventing and reducing work-related musculoskeletal injuries and/or pain among healthcare professionals, and to assess the methodological quality of studies. The results suggest that multifactorial interventions are effective in reducing injuries and pain, while individual and task-specific interventions also have some preventive effects. Further research is needed to study interventions targeted at different healthcare professional groups.
JOURNAL OF SAFETY RESEARCH
(2022)
Article
Orthopedics
Nathan Blanchard, Simon Deslauriers, Jonathan Gervais-Hupe, Anne Hudon, Jean-Sebastien Roy, Sasha Bernatsky, Debbie E. Feldman, Anne Marie Pinard, Mary-Ann Fitzcharles, Francois Desmeules, Kadija Perreault
Summary: This study explored healthcare utilization of individuals living with rheumatic pain conditions while waiting to access pain clinics. Findings revealed that individuals faced challenges in accessing and maintaining services, lacked guidance in addressing their complex needs, but also displayed resilience in seeking sustainable self-management strategies.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Review
Rheumatology
Amanda E. Nelson, Liubov Arbeeva
Summary: There has been rapid growth in the use of artificial intelligence (AI) analytics in medicine, including in rheumatic and musculoskeletal diseases (RMDs). However, the black box nature of most algorithms and the unfamiliarity of the terms pose challenges for clinicians, patients, and researchers. This review aims to provide relevant insights into the strengths and limitations of AI analytics in RMDs, as well as recent examples and future directions in diagnosis, phenotyping, prognosis, and precision medicine.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Daniel I. Rhon, Chad E. Cook, Joshua A. Cleland, Suzanne J. Snodgrass
Summary: Prior opioid use was associated with higher downstream medical costs and recurrent episodes of knee pain compared to individuals without prior opioid use. Patients with prior opioid use who used opioids with a higher risk of misuse or dependency had greater medical costs and recurrent episodes of knee pain compared to those who used lower-risk opioids.
CLINICAL RHEUMATOLOGY
(2021)
Letter
Rheumatology
Jasvinder A. Singh
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Letter
Rheumatology
Jasvinder A. Singh
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Letter
Rheumatology
Jasvinder A. Singh
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Health Policy & Services
Larry Hearld, Allyson Hall, Reena Joseph Kelly, Aizhan Karabukayeva, Jasvinder Singh
Summary: The study found that most clinics reported strong positive learning and change readiness climates, but more complex organizations and members with longer tenure may have less supportive learning and change readiness climates.
JOURNAL OF HEALTH ORGANIZATION AND MANAGEMENT
(2022)
Article
Peripheral Vascular Disease
Brittany Butts, Jamelle A. Brown, Thomas S. Denney, Scott Ballinger, Steven G. Lloyd, Suzanne Oparil, Paul Sanders, Tony R. Merriman, Angelo Gaffo, Jasvinder Singh, Eric E. Kelley, David A. Calhoun, Louis J. Dell'Italia
Summary: Racial differences in XO activity and mtDNA DAMPs were observed in Black and White adults with resistant hypertension. Black resistant hypertension patients had higher XO activity, worse diastolic dysfunction, and greater mtDNA DAMPs than White patients. Urinary sodium excretion was correlated with left ventricular function in Black patients. These findings highlight the importance of further investigating the role of XO and mtDNA DAMPs in cardiac remodeling and heart failure in Black adults with resistant hypertension.
Article
Rheumatology
Kathleen L. Carluzzo, Erin M. Knight, Karen E. Schifferdecker, Rebecca L. Butcher, Guy S. Eakin, Julie A. Eller, Jasvinder A. Singh
Summary: This study aimed to identify differences in patient empowerment among arthritis patients and found that factors such as gender, age, education, income, arthritis type, emotional support, and physical function are associated with patient empowerment. Among these factors, emotional support has the most significant impact on patient empowerment.
JOURNAL OF RHEUMATOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Jasvinder A. Singh
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Editorial Material
Rheumatology
Michael Putman, Kevin Kennedy, Emily Sirotich, Jean W. Liew, Sebastian E. Sattui, Tarin T. Moni, Akpabio A. Akpabio, Deshire Alpizar-Rodriguez, Saskya Angevare, Richard P. Beesley, Francis Berenbaum, Inita Bulina, Yu Pei Eugenia Chock, Richard Conway, Ali Duarte-Garcia, Aman Dev Singh, Eimear Duff, Karen L. Durrant, Tamer A. Gheita, Catherine L. Hill, Richard Howard, Bimba F. Hoyer, Evelyn Hsieh, Lina el Kibbi, Adam Kilian, Alfred H. J. Kim, David F. L. Liew, Chieh Lo, Elsa F. Mateus, Bruce Miller, Serena Mingolla, Michal Nudel, Jasvinder A. Singh, Namrata Singh, Manuel F. Ugarte-Gil, John Wallace, Kristen J. Young, Erick Adrian Zamora-Tehozol, Suleman Bhana, Wendy Costello, Rebecca Grainger, Pedro M. Machado, Philip C. Robinson, Paul Sufka, Zachary S. Wallace, Jinoos Yazdany, Carly Harrison, Maggie J. Larche, Mitchell Levine, Gary Foster, Lehana Thabane, Jonathan S. Hausmann, Jeffrey A. Sparks, Julia F. Simard
LANCET RHEUMATOLOGY
(2022)
Article
Rheumatology
Lisa K. Stamp, Christopher Frampton, Melanie B. Morillon, William J. Taylor, Nicola Dalbeth, Jasvinder A. Singh, Michael Doherty, Weiya Zhang, Helen Richardson, Aye Sarmanova, Robin Christensen
Summary: Analyzing data from two randomized trials on urate-lowering therapies, this study found that achieving an average serum urate concentration less than 6 mg/dL is associated with reduced gout flares in the subsequent 12 months, supporting the use of a treat-to-target serum urate approach in gout management.
LANCET RHEUMATOLOGY
(2022)
Article
Rheumatology
Kathleen M. Andersen, Benjamin A. Bates, Emaan S. Rashidi, Amy L. Olex, Roslyn B. Mannon, Rena C. Patel, Jasvinder Singh, Jing Sun, Paul G. Auwaerter, Derek K. Ng, Jodi B. Segal, Brian T. Garibaldi, Hemalkumar B. Mehta, G. Caleb Alexander
Summary: This study found that the use of immunosuppressive medications in hospitalized COVID-19 patients was associated with a reduced risk of invasive ventilation, but overall no association with in-hospital death. Some medication classes may be associated with an increased risk of death for specific diseases, such as rituximab for rheumatological disease and cancer. Careful medication selection is needed for COVID-19 patients with long-term immunosuppression.
LANCET RHEUMATOLOGY
(2022)
Article
Rheumatology
Namrata Singh, Vithal Madhira, Chen Hu, Amy L. Olex, Timothy Bergquist, Kathryn C. Fitzgerald, Jared D. Huling, Rena C. Patel, Jasvinder A. Singh
Summary: This study assessed the association between rituximab (RTX) use and COVID-19 outcomes in rheumatoid arthritis (RA) patients. The results showed that compared to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), RTX use was associated with increased odds of COVID-19-related hospitalization, ICU admission, and invasive ventilation. These findings can provide guidance for decision-makers, healthcare providers, and patients during the COVID-19 pandemic.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Review
Oncology
Jasvinder A. A. Singh
Summary: Janus kinase inhibitor (JAKi) medications are highly effective oral drugs for treating rheumatic diseases. They have similar safety concerns to biologic therapies but also have distinct differences. Recent data comparing JAKi with tumor necrosis factor inhibitors (TNFi) led to new warnings about cardiovascular and cancer risks by the FDA. This review summarizes the current published data on the safety of JAKi in rheumatic diseases, including risk differences between agents and indications.
Meeting Abstract
Rheumatology
Simon Helfgott, Kent Kwas Huston, Jasvinder Singh, Nehad Soloman, Jeremy Broestl, Kimmi Cox, Kelsey Milligan, Colin Edgerton
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Kent Kwas Huston, Christopher Adams, Simon Helfgott, Jasvinder Singh, Nehad Soloman, Dan Persons, Scott Milligan, Colin Edgerton
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
John Bridges, Jing Li, Melissa Mannion, Gabriela Schmajuk, Jasvinder Singh
ARTHRITIS & RHEUMATOLOGY
(2022)