Article
Chemistry, Multidisciplinary
Sherif Ashraf Fahmy, Soad Nasr, Asmaa Ramzy, Abdelhameed S. Dawood, Anwar Abdelnaser, Hassan Mohamed El-Said Azzazy
Summary: Loading ascorbic acid (AA) and geranium oil (GO) into niosomal nanovesicles can improve their physicochemical properties and enhance their cytotoxic effects on breast cancer cells. The AA-GO niosomal vesicles showed higher inhibitory effects on cancer cell growth and induced apoptosis compared to free AA or GO, suggesting their potential as a treatment strategy for breast cancer.
Article
Pharmacology & Pharmacy
Abdullah Alshememry, Mohd Abul Kalam, Abdulhadi Almoghrabi, Abdulwahab Alzahrani, Mudassar Shahid, Azmat Ali Khan, Anzarul Haque, Raisuddin Ali, Musaed Alkholief, Ziyad Binkhathlan, Aws Alshamsan
Summary: The present study investigates the simultaneous encapsulation and delivery of DOX and NAR using PLGA-NPs and CS-coated PLGA-NPs to enhance their efficacy and synergistic anticancer activity, while reducing toxicity. The results demonstrate that F4 exhibits the best drug release and cytotoxicity, indicating its potential as an effective nano-carrier for DOX and NAR.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Xinbang Jiang, Boya Ma, Momo Sun, Chen Guo, Zhuang Liu, Yunzheng Du, Biao Wang, Nan Li, Mengya Chen, Yanjia Zhang, Jie Shen, Lailiang Ou
Summary: In this study, a novel IMNs platform was developed by biomimetic protein corona precoating and polyethylene glycol (PEG) spacer, forming PEG and corona-coated IMNs (IP-CMNs). The IP-CMNs demonstrated a dual stealth effect, reducing nonspecific protein adsorption and cell binding, and enhancing capture performance towards tumor cells.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Kammila Martins Nicolau Costa, Rafaella Moreno Barros, Emmily Oliveira Jorge, Mariana Rillo Sato, Marlus Chorilli, Bolivar Ponciano Goulart de Lima Damasceno, Dean Nicholas, John F. Callan, Joao Augusto Oshiro
Summary: Nanostructured lipid carriers (NLCs) containing folic acid were developed for the targeted delivery of doxorubicin (DOX) to breast cancer cells. The NLCs showed promising characteristics for further preclinical studies to evaluate their toxicity and antitumor activities.
JOURNAL OF NANOPARTICLE RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Agata Noelia Traverso, David Jose Fragale, Diego Luis Viale, Octavio Garate, Pablo Torres, Gaston Valverde, Alejandro Berra, Ana Vanesa Torbidoni, Juan Sebastian Yakisich, Mariano Grasselli, Martin Radrizzani
Summary: In this study, a two-step procedure for preparing biohybrid nanoparticles with a hydrophobic quantum dot core and a multilayer coating of human serum albumin is reported. These nanoparticles, decorated with proteins like human serum albumin or human transferrin, retained their fluorescent properties and showed no corona effect in the presence of serum. They were selectively taken up by lung cancer and neuroblastoma cells but not by non-cancerous cells or differentiated neurons. Moreover, digitoxin-loaded transferrin-decorated nanoparticles specifically reduced the number of lung cancer cells. Finally, the in vivo uptake of these biohybrid nanoparticles by retinal cells in mice demonstrated their excellent targeting and traceability.
Article
Chemistry, Multidisciplinary
Ahmed S. Doghish, Gharieb S. El-Sayyad, Al-Aliaa M. Sallam, Waleed F. Khalil, Waleed M. A. El Rouby
Summary: The synthesized GO-based nanocomposites showed significant anticancer activity, especially against the MCF-7 breast cancer cell line, with GO-EDTA exhibiting the strongest cytotoxic effect. Through various analytical techniques and cytotoxicity assays, the anticancer effects of the nanocomposites were confirmed.
Article
Chemistry, Analytical
Runrun Li, Thea A. Vedelaar, Alina Sigaeva, Yue Zhang, Kaiqi Wu, Hui Wang, Xixi Wu, Peter Olinga, Malgorzata K. Wlodarzyk-Biegun, Romana Schirhagl
Summary: Polymer nanoparticles are widely used in drug delivery and cause potential concerns regarding the increase in nano- or microplastics in the environment. To understand their mechanism of action and ensure safe usage, it is important to know their localization within cells and tissues. We labeled polymer nanoparticles with nanodiamond particles, allowing long-term imaging and tracking, and demonstrated this principle in both cells and liver tissues.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Birnur Akkaya, Recep Akkaya, Arife Nazlim
Summary: In this study, new target-specific adsorbents, S-Cho-SA and M-S-Cho-SA, were fabricated by modifying Fe3O4 nanoparticles with oleic acid. These magnetic adsorbents have the potential for selective targeting in cancer therapy due to their ability to transport therapeutic agents to the target site and maintain them there for a longer period of time under an external magnetic field. Characterization techniques including SEM, ATR FT-IR spectroscopy, NMR, XRD, VSM, and TG/DTA were used to analyze the adsorbents. Cisplatin-loaded magnetic adsorbents showed high drug loading efficiency (>50%) and released more drug at pH 4.5 compared to pH 7.4 at 37 degrees C. The biocompatibility of the adsorbents was demonstrated using the XTT assay in MCF-7 cell lines, and the results showed that S-Cho-SA and M-S-Cho-SA were biocompatible and exhibited an antiproliferative effect. These cisplatin-loaded magnetic nanoparticles (M-S-Cho-SA) have the potential to be used in thermotherapy for cancer treatment in the future due to their site-specific targeting and magnetic properties.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Chemistry, Analytical
Yan Gong, Wei Yuan, Xinjie Guo, Qian Zhang, Peng Zhang, Caifeng Ding
Summary: The study developed a multifunctional nanocomposite based on gold nanorods for cancer therapy and microRNA-21 detection, showing high selectivity and sensitivity. This approach provides a promising strategy for cell imaging, treatment, and detection in the field of biomedical research.
Article
Chemistry, Physical
Haofei Zhou, Ye Yuan, Zhexu Wang, Zexin Ren, Mixia Hu, JingKun Lu, Hongxia Gao, Cheng Pan, Wenjie Zhao, Baohua Zhu
Summary: This study has developed a novel nanoplatform for delivering chemotherapy drugs and overcoming multidrug resistance. By using a combination strategy of quercetin and doxorubicin and utilizing the high-speed motion of the motor, this nanoplatform can increase the intracellular accumulation of drugs and enhance the killing effect on multidrug-resistant cells.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Review
Polymer Science
Viktoria Hornok
Summary: This paper summarizes the research results on serum albumin-based nanoparticles for drug delivery purposes, focusing on their preparation techniques, synthesis parameters, and successful clinical applications. Despite promising possibilities, products made from different types of albumin nanoparticles, with the exception of a few, have not been invented yet. The paper also discusses promising applications of serum albumin nanoparticles for various biomedical purposes, such as carriers, delivery systems, and contrast agents.
Article
Chemistry, Multidisciplinary
Syed Farooq Adil, Mohammed Rafi Shaik, Fahd A. Nasr, Ali S. Alqahtani, Mohammad Z. Ahmed, Wajhul Qamar, Mufsir Kuniyil, Adibah Almutairi, Abdulrahman Alwarthan, Mohammed Rafiq H. Siddiqui, Mohammad Rafe Hatshan, Mujeeb Khan
Summary: The study revealed that functionalized graphene nanocomposites have enhanced anticancer properties against human breast cancer cells, demonstrating improved physical stability and dispersibility.
Article
Chemistry, Applied
Saeed Siavashy, M. Soltani, Fatemeh Ghorbani-Bidkorbeh, Newsha Fallah, Golrokh Farnam, Seyed Alireza Mortazavi, Farshad H. Shirazi, Mohammad Hassan Houshdar Tehrani, Mohammad Hossein Hamedi
Summary: The magnetic core/chitosan shell nanoparticles containing cisplatin were successfully synthesized using microfluidic technology, resulting in monodisperse particles with optimal size and morphology. These nanoparticles showed higher encapsulation efficiency, controlled release, and lower IC50 values when exposed to cancer cells, indicating their potential for more efficient drug delivery. The developed microfluidic platform provides valuable features for the clinical translation of nanoparticles in drug delivery.
CARBOHYDRATE POLYMERS
(2021)
Article
Engineering, Environmental
Han Luo, Jianyong Sheng, LinLin Shi, Xiaoyu Yang, Jitang Chen, Tianhao Peng, Qibing Zhou, Jiangling Wan, Xiangliang Yang
Summary: The one-step Fenton method offers a unique and green solution to produce protein NPs, which demonstrated promising antitumor efficacy, pharmacokinetic profiles, and safety. This approach is applicable not only to BSA NPs but also to other proteins, providing a novel strategy for effective drug delivery carrier production in biomedical applications.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Applied
Nastaran Hashemzadeh, Ayuob Aghanejad, Elaheh Dalir Abdolahinia, Mitra Dolatkhah, Mohammad Barzegar-Jalali, Yadollah Omidi, Jaleh Barar, Khosro Adibkia
Summary: This study aimed to develop therapeutic nanostructures encapsulating MET and ER for combinational therapy in breast cancer. The developed NSs showed a synergistic inhibitory impact on MCF-7 cells.
JOURNAL OF MICROENCAPSULATION
(2021)
Review
Pharmacology & Pharmacy
Vikas Pandey, Tanweer Haider, Priyanka Jain, Prem N. Gupta, Vandana Soni
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Vikas Pandey, Tanweer Haider, Ashok R. Chandak, Avik Chakraborty, Sharmila Banerjee, Vandana Soni
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Vikas Pandey, Tanweer Haider, Ashok R. Chandak, Avik Chakraborty, Sharmila Banerjee, Vandana Soni
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Pharmacology & Pharmacy
Tanweer Haider, Vikas Pandey, Chittaranjan Behera, Pradeep Kumar, Prem N. Gupta, Vandana Soni
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Chemistry, Medicinal
Kumud Soni, Vishal Gour, Poornima Agrawal, Tanweer Haider, Indu Lata Kanwar, Avijit Bakshi, Vandana Soni
Summary: This study aimed to prepare and evaluate a doxycycline hyclate-containing bigel for treating acne effectively. The bigel microstructure and rheological studies suggested that stability decreases with higher organogel concentration. In vitro drug release studies showed that formulation F2 was more effective compared to F3, and in vivo studies on a rabbit ear model demonstrated that the bigel reduced acne diameter significantly.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Review
Instruments & Instrumentation
Avijit Kumar Bakshi, Tanweer Haider, Rahul Tiwari, Vandana Soni
Summary: This article discusses the crucial role of multivalency in biochemical interactions and highlights the challenges and recent advances in designing and developing multivalent nanoconstructs for drug delivery.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Kavita R. Gajbhiye, Vandana Soni
Summary: The study aimed to investigate the potential of ascorbic acid grafted PLGA-b-PEG NPs in enhancing the transport of rivastigmine (RSM) to the brain via SVCT2 transporters. Results revealed that using ascorbic acid grafted PLGA-b-PEG NPs is a potential strategy for delivering bioactives to the brain.
CURRENT DRUG DELIVERY
(2023)
Article
Chemistry, Medicinal
Tanweer Haider, Vikas Pandey, Chittaranjan Behera, Pradeep Kumar, Prem N. Gupta, Vandana Soni
Summary: This research aims to overcome the rapid enzymatic degradation and limited permeation across the cell membrane of nisin, an antibacterial peptide with anticancer properties, by developing nisin-loaded nanoparticles (NPN) with improved cytotoxic effects. The findings suggest that nisin delivery via PLGA nanoparticles can treat cancer without significant effects on healthy cells.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2022)
Article
Pharmacology & Pharmacy
Tanweer Haider, Vandana Soni
Summary: This study developed PS-targeted nanoparticles for efficient delivery of methotrexate to tumor sites. The nanoparticles showed good drug entrapment and loading rates, and the ANX-MNP formulation exhibited better cellular uptake and cytotoxic effects compared to MNP17. The study demonstrates the potential of ANX-MNP as a carrier for improved drug delivery in cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Poornima Agrawal, Vandana Soni
Summary: This study proposes the buccal administration of the water-insoluble anti-cancer drug docetaxel (DTX) with an adjuvant C6 ceramide (Cer) to overcome the challenges of wet site of administration and inadequate drug availability on-site, by increasing the residence time of mucoadhesive film. Mucoadhesive films were prepared and chitosan, HEC, and PVA were selected as suitable polymers based on the percentage swelling index, residence time, and dissolution data modelling. CHeP10 with optimized polymer composition showed enhanced anti-cancer activity against oral cancer in vitro.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2023)
Article
Biochemistry & Molecular Biology
Zaffar Azam, Vikas Pandey, Navita Gupta, Leena Sapra, Hamid Y. Dar, Niti Shokeen, Asha Bhardwaj, Ayaan Ahmad, Vandana Soni, Rupesh K. Srivastava
FRONTIERS IN BIOSCIENCE-LANDMARK
(2020)
Review
Materials Science, Biomaterials
Tanweer Haider, Kamalpreet Kaur Sandha, Vandana Soni, Prem N. Gupta
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Review
Pharmacology & Pharmacy
Ravishankar Yadav, Indu Lata Kanwar, Tanweer Haider, Vikas Pandey, Vishal Gour, Vandana Soni
FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)