Role of carbonate electrolytes on interaction of quinolone drug with anionic surfactant at various temperatures: A conductometric study

The role of different carbonate salts on the interaction of anionic surfactant sodium dodecyl sulfate (SDS) with employed quinolone antibiotic drug (ciprofloxacin hydrochloride [CFH]) was explosively inspected through measuring specific conductivity (kappa) of the investigated system. The drug, CFH, is an excellent antibiotic for the treatment of different bacterial infections like skin, urinary tract, and respiratory infections. The estimated critical micelle concentrations (cmc) of SDS were observed to be dwindled in the attendance of electrolytes andcmcreduction continues with the escalation of the electrolyte's concentration. The magnitudes ofcmcfor the SDS + CFH mixture were reduced with the elevation of temperature in K(2)CO(3)and CaCO(3)medium while increased with the rise of the temperature in the Na(2)CO(3)medium. The magnitudes of counterion binding to micelles (beta) were increased with the increase of the concentration of Na(2)CO(3)and K(2)CO(3)up to definite value and then reduced with the increase of successive rise of concentration of both salts at all temperatures while decreased monotonically with the rise of electrolyte concentration in CaCO(3)medium. The values of standard free energy ( increment Gmo) were achieved to be negative in each case suggesting spontaneous self-assembly formation. The standard entropy change ( increment Smo) along with enthalpy change ( increment Hmo) was also assessed and discussed elaborately.

Automated summary

The research demonstrated significant effects of carbonate salts on the interaction between different drugs and surfactants, especially under temperature conditions. In various mediums, the formation of micelles and ion binding showed different trends with the increase of electrolyte concentration.