4.7 Article

Michael Addition with an Olefinic Pyridine: Organometallic Nucleophiles and Carbon Electrophiles

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 85, Issue 19, Pages 12740-12746

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c00823

Keywords

-

Funding

  1. NIGMS-NIH [1R15GM126498-01]
  2. NSF MRI program [CHE:1726931]
  3. Northern Illinois University

Ask authors/readers for more resources

The conjugate addition reactions of trans-1,2-di(2-pyridyl)ethylene have been studied. This substrate reacts with organolithium nucleophiles, and the resulting anionic intermediates may be trapped by proton or various carbonyl-based electrophiles. It is suggested that the dipyridyl structure stabilizes the intermediate carbanion, allowing the Michael adduct to be captured by an added electrophile.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available