Disease Modification in Emphysema Related to Alpha-1 Antitrypsin Deficiency

Elastin Degradation: An Effective Biomarker in COPD

(2016) Gerard M. Turino et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Hospitalized Exacerbations of COPD

(2015) Hana Müllerova et al.   CHEST

The Impact of Smoke Exposure on the Clinical Phenotype of Alpha-1 Antitrypsin Deficiency in Ireland: Exploiting a National Registry to Understand a Rare Disease

(2015) M. Emmet O’Brien et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Challenges and Prospects for Alpha-1 Antitrypsin Deficiency Gene Therapy

(2015) Joanna Wozniak et al.   HUMAN GENE THERAPY

Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial

(2015) Kenneth R Chapman et al.   LANCET

One-year change in health status and subsequent outcomes in COPD

(2015) Sarah Wilke et al.   THORAX

Variation of Densitometry on Computed Tomography in COPD – Influence of Different Software Tools

(2014) Mark O. Wielpütz et al.   PLoS One

Prognostic evaluation of COPD patients: GOLD 2011 versus BODE and the COPD comorbidity index COTE

(2014) Juan P de Torres et al.   THORAX

Alpha-1 Antitrypsin Augmentation Therapy

(2013) Mark D. Wewers et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Characteristics, stability and outcomes of the 2011 GOLD COPD groups in the ECLIPSE cohort

(2013) Alvar Agusti et al.   EUROPEAN RESPIRATORY JOURNAL

Antisense oligonucleotide treatment ameliorates alpha-1 antitrypsin–related liver disease in mice

(2013) Shuling Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Lessons from ECLIPSE: a review of COPD biomarkers

(2013) Rosa Faner et al.   THORAX

The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study

(2013) Harvey O Coxson et al.   Lancet Respiratory Medicine

Modifying the Course of Chronic Obstructive Pulmonary Disease: Looking Beyond the FEV1

(2012) Richard L. ZuWallack et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Randomised controlled trial for emphysema with a selective agonist of the γ-type retinoic acid receptor

(2012) Jan Stolk et al.   EUROPEAN RESPIRATORY JOURNAL

Alpha-1 antitrypsin deficiency PI*Z and PI*S gene frequency distribution using on maps of the world by an inverse distance weighting (IDW) multivariate interpolation method

(2012) Ignacio Blanco et al.   Hepatitis Monthly

Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease

(2011) John E. McDonough et al.   NEW ENGLAND JOURNAL OF MEDICINE

Changes in Forced Expiratory Volume in 1 Second over Time in COPD

(2011) Jørgen Vestbo et al.   NEW ENGLAND JOURNAL OF MEDICINE

The discovery of α1-antitrypsin and its role in health and disease

(2011) Sabina M. Janciauskiene et al.   RESPIRATORY MEDICINE

Predictors of mortality in COPD

(2010) Bartolome R. Celli   RESPIRATORY MEDICINE

An Autophagy-Enhancing Drug Promotes Degradation of Mutant  1-Antitrypsin Z and Reduces Hepatic Fibrosis

(2010) T. Hidvegi et al.   SCIENCE

Diagnostic delay and clinical modifiers in alpha-1 antitrypsin deficiency

(2010) Thomas Köhnlein et al.   Therapeutic Advances in Respiratory Disease

Endpoints and Analyses to Discern Disease-Modifying Drug Effects in Early Parkinson’s Disease

(2009) Venkatesh Atul Bhattaram et al.   AAPS Journal

Augmentation Therapy for α1Antitrypsin Deficiency: A Meta-Analysis

(2009) Kenneth R. Chapman et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Defining Disease Modification in Chronic Obstructive Pulmonary Disease

(2009) David M.G. Halpin et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Exploring the role of CT densitometry: a randomised study of augmentation therapy in  1-antitrypsin deficiency

(2009) A. Dirksen et al.   EUROPEAN RESPIRATORY JOURNAL

The Delayed-Start Study Design

(2009) Ralph B. D'Agostino   NEW ENGLAND JOURNAL OF MEDICINE

A Double-Blind, Delayed-Start Trial of Rasagiline in Parkinson's Disease

(2009) C. Warren Olanow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alpha-1 Antitrypsin Deficiency: Pathogenesis, Clinical Presentation, Diagnosis, and Treatment

(2008) Thomas Köhnlein et al.   AMERICAN JOURNAL OF MEDICINE

Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE)

(2008) J. Vestbo et al.   EUROPEAN RESPIRATORY JOURNAL

Endpoints for trials in Alzheimer's disease: a European task force consensus

(2008) Bruno Vellas et al.   LANCET NEUROLOGY

A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease

(2008) Donald P. Tashkin et al.   NEW ENGLAND JOURNAL OF MEDICINE