Article
Neurosciences
Grazia Menna, Alessandro Rapisarda, Alessandro Izzo, Manuela D'Ercole, Quintino Giorgio D'Alessandris, Alessandro Olivi, Nicola Montano
Summary: Microvascular decompression (MVD) is a safe and effective surgical procedure for elderly patients with trigeminal neuralgia (TN), with no significant differences in surgical outcomes compared to non-elderly patients.
Article
Clinical Neurology
Risheng Xu, Sumil K. Nair, Joshua Materi, Divyaansh Raj, Giho Park, Ravi Medikonda, Safwan Alomari, Timothy Kim, Yuanxuan Xia, Judy Huang, Michael Lim, Chetan Bettegowda
Summary: Microvascular decompression (MVD) is an effective surgical intervention for severe facial pain, and discharging carefully selected patients within 1 day post-operation can lead to cost savings without compromising patient outcomes.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Risheng Xu, Sumil K. Nair, Joshua Materi, Divyaansh Raj, Giho Park, Ravi Medikonda, Safwan Alomari, Timothy Kim, Yuanxuan Xia, Judy Huang, Michael Lim, Chetan Bettegowda
Summary: This study examined the safety and cost-benefits of discharging patients with microvascular decompression (MVD) within 1 day of admission for severe facial pain. The results showed that discharging carefully selected patients within 1 day of admission was safe and resulted in reduced hospital admissions, complications, and total hospital costs.
WORLD NEUROSURGERY
(2022)
Review
Clinical Neurology
Junwei Sun, Mingyu Wang, Li Zhang, Yanbing Yu
Summary: This meta-analysis compared the effectiveness and safety of microvascular decompression (MVD) in elderly and young patients with trigeminal neuralgia (TN). The results showed that elderly patients had significantly better long-term efficacy compared to younger patients, and there were no significant differences in complication rates between the two age groups. Therefore, MVD is an effective and safe treatment for TN in the elderly patient population.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Raymond J. J. So, Anita L. L. Kalluri, Stanley Zhu, Joshua Materi, Sumil K. K. Nair, Michael Lim, Judy Huang, Chetan Bettegowda, Risheng Xu
Summary: The presence of multiple compressive vessels in trigeminal neuralgia (TN) patients is associated with higher pain scores preoperatively and an increased risk for pain recurrence after microvascular decompression (MVD), compared to patients with a single compressive vessel.
Review
Clinical Neurology
Liwu Jiao, Hao Ye, Jibo Lv, Yong Xie, Wei Sun, Guolin Ding, Simin Cui
Summary: This study analyzed literature regarding the feasibility of repeat MVD for recurrent or persistent trigeminal neuralgia. It found that the effective rate of repeat MVD was 91.66% with a postoperative complication rate of 37.31%, mainly related to postoperative adhesions around the nerve and nerve injury caused by partial sensory rhizotomy.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
James Mooney, Nicholas Erickson, Adeel Ilyas, Ethan Tabibian, Barton L. Guthrie
Summary: The majority of North American neurosurgeons prioritize clinical symptomatic presentation over imaging evidence of neurovascular compression when deciding to perform microvascular decompression for trigeminal neuralgia. High-volume surgeons tend to consider imaging findings of vascular compression more heavily in their decision-making process compared to low-volume surgeons.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Zhaoli Shen, Feng Yu, Fei Xue, Yuhai Wang, Sze Chai Kwok, Jia Yin
Summary: This study retrospectively analyzed the rates and patterns of intraneural offending vessels in patients with TGN undergoing MVD and discussed the corresponding management strategies. The results showed that intraneural offending vessels requiring treatment are uncommon in patients undergoing MVD for TGN. Decompression by shredded Teflon wrapping interposition is recommended for intraneural offending arteries. The management of intraneural offending veins depends on individual situations.
Article
Clinical Neurology
Collin B. Kilgore, Raymond J. So, Kaitlyn Storm, Sumil K. Nair, Kathleen R. Ran, Anita L. Kalluri, Michael Lim, Judy Huang, Chetan Bettegowda, Risheng Xu
Summary: Trigeminal neuralgia is more prevalent in women, and microvascular decompression is the most effective surgical treatment for it. This study aims to investigate the relationship between sex and pain outcomes following microvascular decompression for trigeminal neuralgia.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Wenhao Zheng, Xiaoqiao Dong, Din Wang, Qiang Hu, Quan Du
Summary: The study showed that both MVD and MVD+IN are effective in treating recurrent TN, with no significant difference in efficacy and recurrence rate. However, MVD+IN can improve the pain cure rate for patients with severe arachnoid adhesions, without increasing the incidence of long-term facial numbness and other complications.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2021)
Article
Surgery
Mustaqim Prasetya, Peter Adidharma, Takuro Inoue, Adi Sulistyanto, Fadhil, Selfy Oswari, Ryan Rhiveldi Keswani, Muhammad Kusdiansah, Yunus Kuntawi Aji, Abrar Arham
Summary: Trigeminal Neuralgia is usually triggered by stimuli in the area of the trigeminal nerve innervation. However, we reported an exceptional case of a 61-year-old woman who experienced recurrent trigeminal neuralgia solely triggered by seeing a bright light. The Teflon felt placed on the nerve root during the initial surgery was suspected to be the cause of this rare type of pain.
FRONTIERS IN SURGERY
(2022)
Review
Clinical Neurology
Gui Yu, Jingxing Leng, Yinghua Xia, Feixiang Min, Hui Xiang
Summary: Classical trigeminal neuralgia is a severe facial pain disease, and microvascular decompression is the most effective surgical method. Imaging plays an important role in accurate diagnosis, and endoscopic techniques improve surgical visualization.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Haotian Jiang, Dewei Zou, Pan Wang, Longwei Zeng, Jie Liu, Chao Tang, Gang Zhang, Xiaorong Tan, Nan Wu
Summary: Fully endoscopic microvascular decompression is a safe and effective method for the treatment of trigeminal neuralgia, with excellent surgical outcomes and no obvious complications or recurrence after follow-up.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Giorgio Lambru, Susie Lagrata, Andrew Levy, Sanjay Cheema, Indran Davagnanam, Khadija Rantell, Neil Kitchen, Ludvic Zrinzo, Manjit Matharu
Summary: Trigeminal microvascular decompression may be a safe and effective long-term treatment for patients with short-lasting unilateral neuralgiform headache attacks, especially those with MRI evidence showing neurovascular conflict with morphological changes. The study found that the majority of patients showed significant improvement in pain frequency after surgery, with no severe adverse events reported. MRI results indicated the presence of ipsilateral neurovascular conflict with morphological changes in most symptomatic nerves, supporting the efficacy of the surgical intervention.
Article
Clinical Neurology
Yoshifumi Mizobuchi, Shinji Nagahiro, Akinori Kondo, Kazunori Arita, Isao Date, Yukihiko Fujii, Takamitsu Fujimaki, Ryosuke Hanaya, Mitsuhiro Hasegawa, Toru Hatayama, Tooru Inoue, Hidetoshi Kasuya, Masahito Kobayashi, Eiji Kohmura, Toshio Matsushima, Jun Masuoka, Akio Morita, Shigeru Nishizawa, Yoshihiro Okayama, Taku Shigeno, Hiroshi Shimano, Hideo Takeshima, Iwao Yamakami
Summary: MVD performed by experienced neurosurgeons for TGN can achieve high long-term curative effects with uncommon and transient complications.
Article
Clinical Neurology
Tobias Greve, Maximilian Sukopp, Maria Wostrack, Egon Burian, Claus Zimmer, Benjamin Friedrich
Summary: The independent risk factors for aneurysm recurrence after coil embolization are postinterventional modified Raymond-Roy occlusion classification and aneurysm diameter, while packing density and neck width are not associated with recurrence.
CLINICAL NEURORADIOLOGY
(2021)
Article
Clinical Neurology
Annamaria Biczok, Philipp Karschnia, Raffaela Vitalini, Markus Lenski, Tobias Greve, Jun Thorsteinsdottir, Rupert Egensperger, Franziska Dorn, Joerg-Christian Tonn, Christian Schichor
Summary: The study found that a history of tumors unrelated to meningioma may be associated with an increased risk of meningioma recurrence. A detailed pre-surgical evaluation of patients' medical history may help identify those at risk for early recurrence.
ACTA NEUROCHIRURGICA
(2021)
Article
Oncology
Tobias Greve, Felix Ehret, Theresa Hofmann, Jun Thorsteinsdottir, Franziska Dorn, Viktor Svigelj, Anita Resman-Gaspersic, Joerg-Christian Tonn, Christian Schichor, Alexander Muacevic
Summary: The study analyzed a large series of cerebral AVMs treated by the frameless CyberKnife stereotactic radiosurgery system. Most AVMs were classified as Spetzler-Martin grade I to III. The occurrence of new neurological deficits after treatment was 5.1%, with almost all patients recovering.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Egon Burian, Lioba Grundl, Tobias Greve, Daniela Junker, Nico Sollmann, Maximilian Loeffler, Marcus R. Makowski, Claus Zimmer, Jan S. Kirschke, Thomas Baum
Summary: The study found that measuring bone mineral density at specific vertebral levels in multi-detector computed tomography examinations is more suitable for predicting the risk of vertebral fractures compared to standard average BMD measurements.
Article
Medicine, General & Internal
Long Yu Yeung, Ni Thin Manohar Rayudu, Maximilian Loeffler, Anjany Sekuboyina, Egon Burian, Nico Sollmann, Michael Dieckmeyer, Tobias Greve, Jan S. Kirschke, Karupppasamy Subburaj, Thomas Baum
Summary: By combining FE analysis with BMD measurements from routine thoracic/abdominal MDCT, the prediction of incidental fractures at vertebral-specific level can be improved. This study found that certain normalized FE and BMD parameters showed higher discriminative power in identifying incidental fractures compared to standard mean BMD measurements.
Article
Radiology, Nuclear Medicine & Medical Imaging
Egon Burian, Nico Sollmann, Kai Mei, Michael Dieckmeyer, Daniela Juncker, Maximilian Loeffler, Tobias Greve, Claus Zimmer, Jan S. Kirschke, Thomas Baum, Peter B. Noel
Summary: This study evaluated the performance of different methods of radiation dose reduction for paravertebral muscle composition assessment using MDCT scans. Results showed that sparse sampling approach may be more promising and potentially superior to tube current reduction for dose reduction in assessing the composition of the paravertebral musculature.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tobias Greve, Egon Burian, Agnes Zoffl, Georg Feuerriegel, Sarah Schlaeger, Michael Dieckmeyer, Nico Sollmann, Elisabeth Klupp, Dominik Weidlich, Stephanie Inhuber, Maximilian Loffler, Federica Montagnese, Marcus Deschauer, Benedikt Schoser, Sarah Bublitz, Claus Zimmer, Dimitrios C. Karampinos, Jan S. Kirschke, Thomas Baum
Summary: Chemical shift encoding-based water-fat MRI can quantitatively evaluate proton density fat fraction (PDFF) in thigh muscles. Patients with DM2, LGMD2A, and LOPD showed increased muscle fat replacement compared to healthy controls, with PDFF variations related to disease duration. Regional differences in PDFF within and between diseases and controls are important for longitudinal monitoring in clinical or research settings.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Medicine, General & Internal
Sarah Schlaeger, Nico Sollmann, Agnes Zoffl, Edoardo Aitala Becherucci, Dominik Weidlich, Elisabeth Kottmaier, Isabelle Riederer, Tobias Greve, Federica Montagnese, Marcus Deschauer, Benedikt Schoser, Claus Zimmer, Dimitrios C. Karampinos, Jan S. Kirschke, Thomas Baum
Summary: The study aimed to assess the diagnostic value of PDFF in correlation to Mercuri grading and clinically determined muscle strength in patients with DM2, LGMD2A, and Pompe disease. The results showed a strong correlation between Mercuri grading and PDFF values for almost all muscles, and significant correlations between PDFF values and muscle strength for muscle groups responsible for knee flexion. This suggests that PDFF could be further considered as an MRI-based biomarker in the assessment of fatty infiltration of muscle tissue in NMD, with advantages such as greater dynamic range, amplified objectivity, and potential direct correlation to muscle function.
Article
Endocrinology & Metabolism
Tobias Greve, Nithin Manohar Rayudu, Michael Dieckmeyer, Christof Boehm, Stefan Ruschke, Egon Burian, Christopher Kloth, Jan S. Kirschke, Dimitrios C. Karampinos, Thomas Baum, Karupppasamy Subburaj, Nico Sollmann
Summary: The purpose of this study was to investigate whether osteoporotic and osteoblastic metastatic changes in lumbar vertebrae could be differentiated based on parameters such as vBMD, PDFF, and measures from FEA, and how these parameters correlate with each other. The results showed that PDFF, as well as failure displacement and load, allowed for the distinction between osteoporotic and diffuse osteoblastic vertebrae, with strong associations between PDFF and failure displacement and load.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yannik Leonhardt, Michael Dieckmeyer, Florian Zoffl, Georg C. Feuerriegel, Nico Sollmann, Daniela Junker, Tobias Greve, Christina Holzapfel, Hans Hauner, Karupppasamy Subburaj, Jan S. Kirschke, Dimitrios C. Karampinos, Claus Zimmer, Marcus R. Makowski, Thomas Baum, Egon Burian
Summary: This study investigated the associations between vertebral bone marrow and paraspinal muscle texture features derived from CSE-MRI-based PDFF maps in healthy subjects. The results showed differences in texture features between males and females, as well as a significant correlation between vertebral bone marrow and paraspinal muscles, indicating a metabolic interrelationship.
Article
Clinical Neurology
Moritz Ueberschaer, Katharina Breitkopf, Sebastian Siller, Sophie Katzendobler, Jonathan Weller, Tobias Greve, Stefan Zausinger, Joerg-Christian Tonn, Andrea Szelenyi
Summary: In surgery for intramedullary spinal cord tumors, the distortion of anatomy makes it difficult to visually identify dorsal columns for midline myelotomy. This study compares the application and feasibility of dorsal column mapping and spinal cord stimulation. The results show that both methods can help confirm and correct the midline for myelotomy, but spinal cord stimulation is superior in terms of applicability, cost-effectiveness, and time expenditure.
ACTA NEUROCHIRURGICA
(2023)
Article
Clinical Neurology
Sebastian Niedermeyer, Tobias Greve, Ludwig-Maximilian Lamm, Jun Thorsteinsdottir, Christian Schichor, Joerg-Christian Tonn, Andrea Szelenyi
Summary: This case report presents a rare occurrence of hiccups during the resection of a vestibular schwannoma. Intraoperative neuromonitoring (IONM) helped to differentiate the hiccups from other potential causes of sudden upper body movements.
OPERATIVE NEUROSURGERY
(2022)
Letter
Clinical Neurology
Tobias Greve, Joerg-Christian Tonn, Christian Schichor
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Tobias Greve, Nico Sollmann, Andreas Hock, Claus Zimmer, Jan S. Kirschke
Summary: This study compared the image and diagnostic quality of TOF-Spiral-short, TOF-CS, and CTA in intracranial vessel imaging, finding that TOF-Spiral-short improved delineation of small vessels compared to CTA, with slightly reduced image quality at the skull base. TOF-Spiral-short enabled the correct identification of all vessel pathologies.
JOURNAL OF NEUROIMAGING
(2021)