Article
Infectious Diseases
Qiong Liao, Yangming Zheng, Yanchun Wang, Leping Ye, Xiaomei Liu, Weiwei Jiao, Yang Liu, Yu Zhu, Jihang Jia, Lin Sun, Adong Shen, Chaomin Wan
Summary: BCG vaccination in Chinese children can reduce the risk of severe tuberculosis. Children who received BCG vaccination at birth, regardless of the presence of a BCG scar, have a lower risk of severe tuberculosis.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Bhupendra Singh Rawat, Deepak Kumar, Vijay Soni, Eric H. Rosenn
Summary: Metabolomics is a useful tool for understanding immunometabolism and developing effective therapies. It can provide valuable insights into the impact of immune metabolism on diseases and vaccinations. By integrating with other biology tools, metabolomics can enhance treatment outcomes and control drug-resistant strains.
Article
Immunology
Amit Rawat, Pandiarajan Vignesh, Murugan Sudhakar, Madhubala Sharma, Deepti Suri, Ankur Jindal, Anju Gupta, Jitendra Kumar Shandilya, Sathish Kumar Loganathan, Gurjit Kaur, Sanchi Chawla, Pratap Kumar Patra, Alka Khadwal, Biman Saikia, Ranjana Walker Minz, Vaishali Aggarwal, Prasad Taur, Ambreen Pandrowala, Vijaya Gowri, Mukesh Desai, Manasi Kulkarni, Gauri Hule, Umair Bargir, Priyanka Kambli, Manisha Madkaikar, Sagar Bhattad, Chetan Ginigeri, Harish Kumar, Ananthvikas Jayaram, Deenadayalan Munirathnam, Meena Sivasankaran, Revathi Raj, Ramya Uppuluri, Fouzia Na, Biju George, Harsha Prasada Lashkari, Manas Kalra, Anupam Sachdeva, Shishir Seth, Tapas Sabui, Aman Gupta, Karin van Leeuwen, Martin de Boer, Koon Wing Chan, Kohsuke Imai, Osamu Ohara, Shigeaki Nonoyama, Yu Lung Lau, Surjit Singh
Summary: Chronic granulomatous disease (CGD) is a rare genetic disorder in India, with a higher proportion of autosomal recessive (AR) CGD compared to Western countries, and regional variations in types of AR-CGD. Clinical profiles and mortality rates are similar in both X-linked and AR-CGD, possibly due to milder forms of AR-CGD being overlooked.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Karin Dijkman, Thomas Lindenstrom, Ida Rosenkrands, Rikke Soe, Joshua S. S. Woodworth, Cecilia S. Lindestam S. Arlehamn, Rasmus Mortensen
Summary: The licensed TB vaccine, BCG, is inadequate in protecting adolescents and adults from pulmonary TB, leading to millions of deaths each year. Subunit vaccines have shown potential against TB, but their multiple administrations pose logistical challenges. Co-administration of BCG with a single dose of the expression-optimized H107e/CAF((R))01 vaccine improved protection and triggered BCG-specific immune responses. This supports the strategy of combining BCG with subunit vaccines for an improved TB vaccine with fewer vaccination visits.
Article
Oncology
Lei Zhang, Yuqing Li, Lingli Zhou, Houhong Zhou, Liefu Ye, Tong Ou, Huaishan Hong, Shiwen Zheng, Ziyu Zhou, Kang Wu, Zeqin Yan, Jean Paul Thiery, Jun Cui, Song Wu
Summary: YTHDF2 is upregulated in bladder cancer and promotes tumor growth by inhibiting RIG-I-mediated immune signaling, highlighting the significance of m(6)A modifications in bladder cancer and providing therapeutic opportunities.
Article
Immunology
Takashi Ishikawa, Masashi Okai, Emi Mochizuki, Toru Uchiyama, Masafumi Onodera, Toshinao Kawai
Summary: Despite X-CGD patients developing severe infections at a younger age than AR-CGD patients, our data suggests that BCG infections occur at a high frequency in both AR-CGD and X-CGD patients, regardless of genotype and mutant forms.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Huanhuan Ning, Jian Kang, Yanzhi Lu, Xuan Liang, Jie Zhou, Rui Ren, Shan Zhou, Yong Zhao, Yanling Xie, Lu Bai, Linna Zhang, Yali Kang, Xiaojing Gao, Mingze Xu, Yanling Ma, Fanglin Zhang, Yinlan Bai
Summary: In this study, researchers constructed a recombinant BCG vaccine (rBCG-DisA) with di-adenylate cyclase (DisA) and found that it induced enhanced immune responses in mice, leading to trained immunity and adaptive immunity. Additionally, rBCG-DisA showed promising potential in protecting against M. tuberculosis infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Hend M. Moghawry, Mohamed E. Rashed, Kareeman Gomaa, Sameh AbdelGhani, Tarek Dishisha
Summary: In the field of vaccine production, the Bacillus Calmette-Guerin (BCG) vaccine has become widely used in 157 countries. However, the current potency test based on colony-forming unit (CFU) assay has several limitations. To address this issue, a flow cytometry assay and a colorimetric technique were developed in this study, both of which showed promising results in terms of precision and correlation with the CFU assay. These methods not only reduced the analysis time significantly but also eliminated the need for human intervention.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Boli Ma, Xueyi Nie, Lei Liu, Mengyuan Li, Qi Chen, Yueyang Liu, Yuxin Hou, Yi Yang, Jinrui Xu
Summary: The inhibition of PERK alleviated pyroptosis induced by BCG infection, showing an effect of resistance against infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Maria A. Duarte C., Jeismar M. Carballo O., Yetsenia M. De Gouveia, Angie Garcia, Diana Ruiz, Teresa Gledhill, Eglys Gonzalez-Marcano, Ana F. Convit
Summary: ConvitVax is a personalized vaccine for breast cancer treatment, which has been shown to be safe and effective in preclinical studies on BALB/c mice.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Susan Martins Pereira, Florisneide Rodrigues Barreto, Ramon Andrade de Souza, Carlos Antonio de Souza Teles Santos, Marcos Pereira, Enny Santos da Paixao, Carla Cristina Oliveira de Jesus Lima, Marcio Santos da Natividade, Ana Angelica Bulcao Portela Lindoso, Eder Gatti Fernandes, Evonio Barros Campelo Campelo Junior, Julia Moreira Pescarini, Kaio Vinicius Freitas de Andrade, Fernanda Mattos de Souza, Elisangela Alves de Britto, Ceuci Nunes, Maria Yuri Ichihara, Margareth Dalcolmo, Anete Trajman, Manoel Barral-Netto, Ibrahim Abubakar, Mauricio Lima Barreto, Ricardo Arraes de Alencar Ximenes, Laura Cunha Rodrigues
Summary: This study investigated the association between previous BCG vaccination and the severity of COVID-19 clinical progression. The results showed that BCG vaccination was highly protective against clinical progression of COVID-19, especially in individuals aged 60 or younger.
Article
Veterinary Sciences
Saraswathi Subramanian, Sreenidhi Srinivasan, Kathiravan Ramaiyan Selvaraju, Priyadharshini Michael Vinoli, Suganya Selladurai, Boominathan Ramasamy, Karthik Kumaragurubaran, Douwe Bakker, Martin Vordermeier, Vivek Kapur, Dhinakar Raj Gopal
Summary: The BCG vaccine provides partial protection against bovine tuberculosis in cattle. A peptide-based defined antigen skin test (DST) has been developed to differentiate between BCG-vaccinated and bTB-infected animals. This study demonstrates that DST retains its diagnostic specificity even after revaccination with BCG.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Ola Nakken, Trygve Holmoy, Hein Stigum, Kjell-Morten Myhr, Jesper Dahl, Einar Heldal, Haakon E. Meyer
Summary: The study found that a strong in vivo immune response to BCG vaccine is associated with a reduced risk of developing MS more than 30 years later. The strength of TST reactivity is linked to decreased MS risk, suggesting a potential protective mechanism against the disease.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jiang Pi, Zhiyi Zhang, Enzhuo Yang, Lingming Chen, Lingchan Zeng, Yiwei Chen, Richard Wang, Dan Huang, Shuhao Fan, Wensen Lin, Hongbo Shen, Jun-Fa Xu, Gucheng Zeng, Ling Shen
Summary: Engineering Mycobacterium tuberculosis into nanoscale particles improves the safety and efficacy of the TB vaccine, providing better protection against TB infection.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Eduardo Moreo, Aitor Jarit-Cabanillas, Inaki Robles-Vera, Santiago Uranga, Claudia Guerrero, Ana Belen Gomez, Pablo Mata-Martinez, Luna Minute, Miguel Araujo-Voces, Maria Jose Felgueres, Gloria Esteso, Iratxe Uranga-Murillo, Maykel Arias, Julian Pardo, Carlos Martin, Mar Vales-Gomez, Carlos del Fresno, David Sancho, Nacho Aguilo
Summary: Intravenous administration of BCG shows potential in the treatment of lung tumors, reducing tumor growth and enhancing immune responses. It also enhances the efficacy of immune checkpoint blockade.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Tomotaka Okamura, Yusuke Tsujimura, Shogo Soma, Ichiro Takahashi, Kazuhiro Matsuo, Yasuhiro Yasutomi
JOURNAL OF GENERAL VIROLOGY
(2016)
Article
Immunology
Shogo Soma, Satoru Kawai, Hiroyasu Inada, Kenta Watanabe, Satoru Mizuno, Seiichi Kato, Kazuhiro Matsuo, Yasuhiro Yasutomi
INFECTION AND IMMUNITY
(2018)
Article
Cell Biology
Mohammad A. J. Bapary, Jun-ichiro Takano, Shogo Soma, Tadashi Sankai
CELL BIOLOGY INTERNATIONAL
(2019)
Article
Immunology
Satoru Mizuno, Shogo Soma, Hiroyasu Inada, Tomohiro Kanuma, Kazuhiro Matsuo, Yasuhiro Yasutomi
JOURNAL OF IMMUNOLOGY
(2019)
Article
Cell Biology
Kofi A. Mensah, Jeff W. Chen, Jean-Nicolas Schickel, Isabelle Isnardi, Natsuko Yamakawa, Andrea Vega-Loza, Jennifer H. Anolik, Richard A. Gatti, Erwin W. Gelfand, Ruth R. Montgomery, Mark C. Horowitz, Joe E. Craft, Eric Meffre
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Parasitology
Satoru Kawai, Takeshi Annoura, Tamasa Araki, Yumiko Shiogama, Shogo Soma, Jun-ichiro Takano, Marcello Otake Sato, Osamu Kaneko, Yasuhiro Yasutomi, Yuichi Chigusa
PARASITOLOGY INTERNATIONAL
(2020)
Editorial Material
Critical Care Medicine
Shogo Soma, Melanie J. Harriff
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Immunology
Shogo Soma, Deborah A. Lewinsohn, David M. Lewinsohn
Summary: DURTs, characterized by invariant antigen presentation molecules, can recognize diverse mycobacterial antigens, potentially serving as vaccination targets or enabling traditional immune responses.
Article
Biology
Erin W. Meermeier, Christina L. Zheng, Jessica G. Tran, Shogo Soma, Aneta H. Worley, David Weiss, Robert L. Modlin, Gwendolyn Swarbrick, Elham Karamooz, Sharon Khuzwayo, Emily B. Wong, Marielle C. Gold, David M. Lewinsohn
Summary: Human lung-resident MAIT cells are polycytotoxic, secrete antimicrobial molecules, express genes associated with persistence, and selectively express cytokine and chemokine-related molecules. These characteristics make MAIT cells early sensors in the defense of the respiratory barrier.
COMMUNICATIONS BIOLOGY
(2022)