Article
Infectious Diseases
Itai Chitungo, Tafadzwa Dzinamarira, Tinashe K. Nyazika, Helena Herrera, Godfrey Musuka, Grant Murewanhema
Summary: The global COVID-19 pandemic has led to a surge in antimicrobial use, which has the potential to increase antimicrobial resistance. Adopting antimicrobial stewardship principles and improving regulatory oversight can help limit the occurrence of antimicrobial resistance during this pandemic.
Review
Public, Environmental & Occupational Health
Rasha Abdelsalam Elshenawy, Nkiruka Umaru, Amal Bandar Alharbi, Zoe Aslanpour
Summary: This systematic literature review investigates the AMS interventions and measures before and during the COVID-19 pandemic. The proper selection of AMS strategies and measures appeared to be effective in maintaining the appropriate use of antibiotics and decreasing the threat of AMR. Further studies are needed to evaluate the effectiveness of these strategies and measures before and during the pandemic.
Article
Immunology
Joanna M. Kimball, Connor R. Deri, Whitney J. Nesbitt, George E. Nelson, Milner B. Staub
Summary: This study investigated successful antimicrobial stewardship interventions at Vanderbilt University Medical Center, identifying key strategies such as continuous provider-level education and the implementation of division and department algorithms to reduce the use of concomitant vancomycin and piperacillin-tazobactam. The TASE framework and ASIR analysis were effective in identifying pivotal interventions for achieving and sustaining change, suggesting potential for wider application in similar settings.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Akane Ono, Ryuji Koizumi, Shinya Tsuzuki, Yusuke Asai, Masahiro Ishikane, Yoshiki Kusama, Norio Ohmagari
Summary: The study found that the COVID-19 pandemic had a significant impact on antimicrobial use trends in Japan in 2020, resulting in a substantial reduction in AU. This reduction may be partly attributed to the pandemic itself and recent efforts to improve AU. Therefore, continued surveillance and research on antimicrobial use are necessary.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Olivier Friedli, Michael Gasser, Alexia Cusini, Rosamaria Fulchini, Danielle Vuichard-Gysin, Roswitha Halder Tobler, Nasstasja Wassilew, Catherine Pluss-Suard, Andreas Kronenberg
Summary: This study analyzed inpatient antibiotic consumption during the first 16 months of the COVID-19 pandemic in Switzerland. The findings showed that overall inpatient antibiotic consumption remained stable during the first year of the pandemic, with a slight increase in ICUs. The consumption of broad-spectrum antibiotics increased significantly, especially in ICUs.
Article
Infectious Diseases
Alexandre Castro-Lopes, Sofia Correia, Catia Leal, Ines Resende, Pedro Soares, Ana Azevedo, Jose-Artur Paiva
Summary: The COVID-19 pandemic led to a significant increase in antimicrobial consumption in 2020, with different impacts on the usage of various types of antibiotics. A correlation was found between antibacterial consumption and patient or admission type.
Review
Infectious Diseases
Jeroen Schouten, Jan De Waele, Christian Lanckohr, Despoina Koulenti, Nisrine Haddad, Nesrine Rizk, Fredrik Sjovall, Souha S. Kanj
Summary: Issues surrounding antimicrobial stewardship in the context of COVID-19 patients include the challenge of distinguishing between infectious and non-infectious causes of respiratory deterioration, the relevance of biomarkers like procalcitonin, the consideration of cytomegalovirus reactivation, and the complexities in diagnosing COVID-19-associated invasive aspergillosis. Additionally, there is a need to take into account altered pharmacokinetic/pharmacodynamic properties when prescribing antimicrobial therapy in this population, emphasizing the importance of further research to address unknowns in this area.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Immunology
Laila Carolina Abu Esba, Faisal Aqeel Al Sehli
Summary: The estimated incidence of antimicrobial-associated anaphylaxis is around 18.6 cases per 100,000 exposures, with hospitalization required in 23.8% of cases and ICU admission in 19% of cases. The implications of these episodes may extend beyond the event itself and be associated with poor clinical outcomes such as infection-related mortality and hospitalization.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Infectious Diseases
Braden D. Knight, Jayson Shurgold, Glenys Smith, Derek R. MacFadden, Kevin L. Schwartz, Nick Daneman, Denise Gravel Tropper, James Brooks
Summary: During the COVID-19 pandemic, the dispensing of antibiotics in the community in Canada decreased by 26.5%, with the most significant decrease in prescription rates observed in children and older adults.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Microbiology
Timothy J. Savage, Shun Rao, Jill Joerger, Al Ozonoff, Alexander J. McAdam, Thomas J. Sandora
Summary: The study has identified that direct disk diffusion testing is highly predictive of susceptibility for many common organism-antibiotic combinations and provides actionable information one day earlier than standard susceptibility approaches. However, the negative predictive value of dDD is variable and frequently lower than the positive predictive value. Antibiotics were narrowed in 30% of cases after a dDD result and a further 25% of cases after AST result.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Immunology
Kathryn Sine, Haley Appaneal, David Dosa, Kerry L. LaPlante
Summary: This article proposes a tailored and sustainable approach to antimicrobial stewardship in primary care settings using telehealth. The use of telehealth presents unique challenges for antimicrobial stewardship, such as limited physical examination and changes to the patient-provider relationship. With the increased use of telehealth due to the COVID-19 pandemic, there is a need for innovative antimicrobial stewardship strategies.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Amelia Andrews, Emma L. Budd, Aoife Hendrick, Diane Ashiru-Oredope, Elizabeth Beech, Susan Hopkins, Sarah Gerver, Berit Muller-Pebody
Summary: During the COVID-19 pandemic, there was a decrease in antibacterial prescribing in the community, while overall antibacterial use in hospitals decreased, with increases observed in specific antibacterials. This emphasizes the importance of antimicrobial stewardship during pandemics to ensure appropriate prescribing and prevent negative consequences on patient outcomes and antimicrobial resistance.
Article
Medicine, General & Internal
Maria Costantino, Valeria Conti, Graziamaria Corbi, Alessandra Anna Iannelli, Francesco Marongiu, Martina Torsiello, Antonio Della Vecchia, Carmine Sellitto, Armando Genovese, Giuseppina Moccia, Amelia Filippelli, Francesco De Caro
Summary: This study aimed to evaluate the impact of antimicrobial stewardship (AMS) on antibiotic consumption trends. The results showed a decreasing trend in antibiotic consumption at the University Hospital, but an overall increase in total antibiotic consumption. AMS also led to a reduction in antibiotic therapy costs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Immunology
Ibrahim Omer, Noorah Abuthiyab, Nura Al Zaid, Raghad Alkanani, Reema Abualnaja, Ghadeer Khan
Summary: This systematic review aimed to evaluate the potential appropriateness of Procalcitonin as an antimicrobial stewardship tool in COVID-19 patients. Despite variations in Procalcitonin cut-off values, the majority of studies indicated the appropriateness of using Procalcitonin as an antimicrobial stewardship tool in COVID-19 patients.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Medical Laboratory Technology
Selina Wolfisberg, Claudia Gregoriano, Philipp Schuetz
Summary: Procalcitonin (PCT) can differentiate between viral and bacterial infections, reducing unnecessary antibiotic use. While recent trials found no significant benefit, key considerations for the optimal use of PCT have been learned, particularly in differentiating infections based on clinical settings and pretest probability.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2022)
Letter
Immunology
Chris Lynch, Steve Green, Nicolas Lewis, Chris Megson, Helena Parsons
CLINICAL INFECTIOUS DISEASES
(2020)
Editorial Material
Public, Environmental & Occupational Health
C. Lynch, N. Mahida, B. Oppenheim, J. Gray
JOURNAL OF HOSPITAL INFECTION
(2020)
Editorial Material
Public, Environmental & Occupational Health
C. Fears, N. Mahida, B. Oppenheim, C. Lynch, J. Gray
JOURNAL OF HOSPITAL INFECTION
(2020)
Editorial Material
Public, Environmental & Occupational Health
C. Lynch, N. Mahida, B. Oppenheim, J. Gray
JOURNAL OF HOSPITAL INFECTION
(2020)
Letter
Public, Environmental & Occupational Health
C. Lynch, K. Choudhari, R. Townsend, S. Whittaker, C. Bates
JOURNAL OF HOSPITAL INFECTION
(2020)
Article
Public, Environmental & Occupational Health
K. Prescott, E. Baxter, C. Lynch, S. Jassal, A. Bashir, J. Gray
JOURNAL OF HOSPITAL INFECTION
(2020)
Editorial Material
Public, Environmental & Occupational Health
B. Poller, C. Lynch, R. Ramsden, K. Jessop, C. Evans, K. Tweed, C. Drew, C. Bates
JOURNAL OF HOSPITAL INFECTION
(2020)
