Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 397, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jhazmat.2020.122724
Keywords
Indoxacarb; MWCNTs; Altered enantioselective toxicity; Zebrafish
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Funding
- National Natural Science Foundation of China [21607084]
- Natural Science Foundation of Inner Mongolia [2015BS0204]
- Applied Technology Research and Development Foundation of Inner Mongolia [2019MS02008]
- Incentive Fund Plan for Scientific and Technological Innovation of Inner Mongolia [201502097]
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The mass production and usage of carbon nanotubes (CNTs) have led to the inevitable release into the environment, and the effects of CNTs on the toxicity of co-existing pollutants have been well documented. However, knowledge of the effects of CNTs on the enantioselective toxicity of chiral compounds is limited. Using zebrafish as an experimental model, the enantioselective expression of the apoptosis, CYP3C and EAAT-related genes were analyzed following exposure to multi-walled carbon nanotubes (MWCNTs) (0.05 and 0.5 mg/L), rac-/R-/S-indoxacarb (0.01 mg/L), or the combination of rac-/R-/S-indoxacarb mixed with MWCNTs for 28d. Sex-specific differences were observed in both the liver and brain of zebrafish. The expression of apoptosis and CYP3C-related genes was 16.55-44.29 times higher in the livers of males treated with R-indoxacarb than in S-indoxacarb treated groups. The EAAT-related genes were expressed at 1.38-2.56 times higher levels in the brain of females treated with R-indoxacarb than in S-indoxacarb-treated groups. In the presence of MWCNTs, the expression of caspase-3, cyp3c3, cyp3c4, eaat1a, eaat1b and eaat2 in the livers of males and brains of females treated with S-indoxacarb were 1.65-15.33 times higher than in fish treated with R-indoxacarb. Based on these results, MWCNTs affected the enantioselective toxicity of indoxacarb toward zebrafish.
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