Glucose-sensing abilities of mixed-metal (Ni-Co) Prussian blue analogs hollow nanocubes

Ni-Co Prussian blue analogs (PBA) with a structure of hollow nanocubes (Ni-Co PBA HNCs) are successfully prepared by simple static settlement at room temperature and ammonia etching method. The Ni-Co PBA HNCs exhibit an enhanced catalytic activity towards glucose oxidation. The three-dimensional Ni-Co PBA IINCs modified electrode form a novel glucose sensor which not involved the enzyme. The properties of glucose sensor based on Ni-Co PBA HNCs are explored by electrochemical technique, for instance, cyclic voltammetry (CV), differential impulse voltammetry (DPV) and typical amperometric-time method (i-t). As compared to pure Ni PBA HNCs and pure Co PBA HNCA, the Ni-Co PBA HNCs exhibit outstanding catalytic performance for electro-oxidation of glucose. The bimetal synergetic catalyst of Ni and Co in the Ni-Co PBA HNCs causes this sensor with superior oxidation capacity for glucose. The analysis of the experimental data prove that this glucose sensor based on Ni-Co PBA HNCs possesses wide linear range: 0.002 mM - 3.79 mM, low detection limit: 1.2 mu M (S/N = 3), high sensitivity: 149 mu A.mM(-1).cm(-2), as well as good selectivity. We further find that the proposed glucose sensors can be successfully applied to detect glucose levels in drinks experiment.