Article
Engineering, Environmental
Yaqi Fan, Caixia Li, Xiaoni Liu, Junfeng Ren, Yu Zhang, Jingqi Chi, Lei Wang
Summary: Sodium-ion hybrid capacitors (SIHCs) combine the advantages of batteries and supercapacitors, offering low cost and abundant reserves. Researchers synthesized interconnected anode materials with Co-MOF-74 nanoparticles dispersed on functionalization graphene oxide (FGO). The Co-MOF-74|FGO-180 electrode displayed a reversible capacity of 416 mA h g-1 after 100 cycles in the Na-ion half-cell, and the SIHC device achieved a high energy density of 240 Wh kg-1 and power density of 10 kW kg-1.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Chemical
Xueli Luo, Chunyan Wang, Gengli Huang, Youwen Tan, Wenzhi Tang, Jia Kong, Zhonghong Li
Summary: This study developed a separation-free shapable adsorbent by enveloping a COF hybrid into chitosan aerogel, and successfully removed 2,4-D and glyphosate herbicides. The adsorbent exhibited rapid adsorption equilibrium, high adsorption capacities, and satisfactory recyclability.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Evi B. Struble, Jonathan M. O. Rawson, Tzanko Stantchev, Dorothy Scott, Marjorie A. Shapiro
Summary: Viral diseases pose a significant threat to public health and can lead to global pandemics. Antiviral antibody therapeutics have emerged as valuable options for prevention and treatment, both alone and in combination with other therapies. This article discusses the unique biochemical and physiological properties of polyclonal and monoclonal antiviral antibodies that make them effective as therapeutic agents. It also explores methods of antibody characterization and potency assessment, compares polyclonal and monoclonal products, and examines the benefits and challenges of combining antiviral antibodies with other therapeutics. Additionally, novel approaches to the development and characterization of antiviral antibodies are discussed, along with areas that require further research.
Article
Multidisciplinary Sciences
Fabian Schmidt, Yiska Weisblum, Magdalena Rutkowska, Daniel Poston, Justin DaSilva, Fengwen Zhang, Eva Bednarski, Alice Cho, Dennis J. Schaefer-Babajew, Christian Gaebler, Marina Caskey, Michel C. Nussenzweig, Theodora Hatziioannou, Paul D. Bieniasz
Summary: The number and variability of neutralizing epitopes targeted by polyclonal antibodies in individuals who have recovered from SARS-CoV-2 or been vaccinated play a crucial role in determining the breadth of neutralization and the genetic barrier to viral escape. Studying HIV-1 pseudotypes and plasma selection experiments, it was found that human polyclonal antibodies target multiple neutralizing epitopes within and outside the receptor-binding domain, and antibody targets coincide with spike sequences enriched for diversity in natural SARS-CoV-2 populations. Combining plasma-selected spike substitutions led to the generation of 'polymutant' spike protein pseudotypes that resist neutralization by polyclonal antibodies to a similar extent as circulating variants of concern. Plasma from individuals who had been infected with SARS-CoV-2 and subsequently received mRNA vaccination was able to neutralize highly resistant SARS-CoV-2 variants, suggesting that optimally elicited polyclonal antibodies can provide protection against future SARS-CoV-2 variations and potential sarbecovirus pandemics.
Review
Medicine, Research & Experimental
Kyung-Han Lee, Kyung-Ho Jung, Jin Hee Lee
Summary: Monoclonal antibodies have revolutionized lymphoma management and the development of new antibody therapeutics and radioimmunotherapy can further enhance treatment efficacy. Immuno-PET with radiolabeled antibodies can facilitate the development of new treatments and provide valuable information for patient selection and treatment response assessment, showing great potential in lymphoma management.
MOLECULAR PHARMACEUTICS
(2022)
Article
Oncology
Jonatan Dewulf, Christel Vangestel, Yannick Verhoeven, Jorrit De Waele, Karen Zwaenepoel, Peter A. van Dam, Filipe Elvas, Tim van den Wyngaert
Summary: RANKL has been recognized as an important target in the tumor microenvironment for promoting an immunosuppressive environment and resistance to immunotherapy. Assessment of RANKL expression is challenging due to its heterogeneous nature, but the development of anti-RANKL immuno-PET tracers shows promise in non-invasively monitoring RANKL expression.
Article
Chemistry, Applied
Qing Sun, Jingfeng Zhao, Zhibo Hu, Jian Zhang, Jun Yan, Jiawei Sheng
Summary: In this study, rod-like CoAl2O4/halloysite hybrid pigment was successfully designed and synthesized for the first time using a two-step route. The nanostructures were characterized and the color performance was evaluated, demonstrating the potential of the pigment in ceramic glazes and water-borne coatings.
Review
Agriculture, Multidisciplinary
Danial Abdollahdokht, Yunhao Gao, Sanaz Faramarz, Alireza Poustforoosh, Mojtaba Abbasi, Gholamreza Asadikaram, Mohammad Hadi Nematollahi
Summary: Pesticides are classified into different categories based on their structure, and they are toxic to both humans and pests. They have adverse effects on the environment, beneficial biota, and public health. Pesticide exposure can occur through various means, and the use of nanotechnology and biopesticides offers potential for developing environmentally friendly, safe, and efficient pesticides.
CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE
(2022)
Article
Mathematics
Jagdish S. Thakur, Archana Thakur, Lawrence G. Lum
Summary: Mathematical models play a crucial role in exploring the complexities of biological systems at the cellular level. In this study, a model was presented to investigate the interactions between immune cells for in vitro polyclonal antibody synthesis. The model incorporates interactions of various cells and predicts time-dependent trajectories of these cells and antibody synthesis stimulated by pokeweed mitogen.
Article
Physics, Condensed Matter
Hannes Rijckaert, Simona Premcheska, Sonali Mohanty, Joost Verduijn, Andre Skirtach, Anna M. Kaczmarek
Summary: This study demonstrates that UiO-66-NH2 can serve as a host for nano thermometers and gold nanoparticles, resulting in a hybrid material with good biocompatibility.
PHYSICA B-CONDENSED MATTER
(2022)
Article
Green & Sustainable Science & Technology
Roberta A. dos Reis, Lila A. M. Mahmoud, Evdokiya H. Ivanovska, Richard Telford, Matthew A. Addicoat, Lui R. Terry, Valeska P. Ting, Sanjit Nayak
Summary: Metal-Organic Frameworks (MOFs) have great potential for extraction and delivery of agrochemicals, but their granular form can limit their application in wider agricultural context. This study explores the use of biodegradable polymer-MOF composites to overcome this limitation and achieve controlled release of the pesticide 2,4-dichloropheoxycetic acid (2,4-D). The results demonstrate high loading capacity and sustained release of 2,4-D from the MOFs over a period of 16 days, with the NH2-functionalized MOF showing a more controlled release compared to the UiO-66 MOF.
ADVANCED SUSTAINABLE SYSTEMS
(2023)
Article
Engineering, Environmental
Chunyan Li, Jun Wang, Yan Yan, Pengwei Huo, Xinkun Wang
Summary: This study reports a porous 2D-3D NiZnCo-P electrode with highly exposed active sites for high-capacitance supercapacitors. The electrode structure increases the contact with electrolyte ions, facilitating charge transportation and ion diffusion. The electrode exhibits a high capacitance, making it the highest reported for TMP electrodes. The assembled NiZnCo-P//Zn-modified carbon nano-sheets device shows excellent performance in terms of energy density and durability.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Computer Science, Interdisciplinary Applications
Tamas Pfeil, Blanka Herbaly
Summary: This article models polyclonal antibody-antigen reactions assuming constant free antibody clone concentrations and monovalent reactants using a system of linear differential equations. The positive invariance of the simplex of immunologically meaningful points is demonstrated, the unique equilibrium point is determined, and its global asymptotic stability is proven. Numerical simulations illustrate the obtained results.
MATHEMATICS AND COMPUTERS IN SIMULATION
(2022)
Review
Immunology
Kandasamy Saravanakumar, Sathiyaseelan Anbazhagan, Janandi Pujani Usliyanage, Kumar Vishven Naveen, Udari Wijesinghe, Hu Xiaowen, Veeraraghavan Vishnu Priya, Gobika Thiripuranathar, Myeong-Hyeon Wang
Summary: Nanosized drug carriers, specifically immunonanomedicine, have shown promise in targeting cancer cells. Understanding nanotechnology, cancer biology, immunomedicine, and nanoparticle surface chemistry is crucial for the preparation of effective immuno-nanomedicine. Factors such as nanoparticle type and composition, drug loading, size, shape, and ligand conjugation play important roles in cancer cell targeting and drug release. The selection of specific receptors and their ligand is essential for the development of active immuno-nanomedicines. This review focuses on the fundamental factors and technical challenges in the fabrication of antibody alone or drug conjugated nanoparticles for breast cancer treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Alyaa Farid
Summary: In many tropical regions, schistosomiasis is a major parasitic disease that causes significant morbidity and mortality, second only to malaria. Diagnostic methods include microscopy, radiography, and serology. Proteases have been investigated as targets for immunological or chemotherapeutic anti-Schistosoma agents due to their importance in the parasitic life cycle.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Sheetal K. Bhardwaj, Tinku Basu
Article
Biotechnology & Applied Microbiology
Tithi Mehrotra, Abhinav Srivastava, R. Pragadeeshwara Rao, Rachana Singh
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2019)
Article
Chemistry, Analytical
Pragadeeshwara R. Rao, Shalini Sharma, Tithi Mehrotra, Rajashree Das, Ranjit Kumar, Rachana Singh, Indrajit Roy, Tinku Basu
ANALYTICAL CHEMISTRY
(2020)
Article
Engineering, Biomedical
Shreyas Vasantham, Ruby Alhans, Chaitali Singhal, Shalini Nagabooshanam, Sumaya Nissar, Tinku Basu, Sekhar C. Ray, Shikha Wadhwa, Jagriti Narang, Ashish Mathur
BIOMEDICAL MICRODEVICES
(2019)
Article
Chemistry, Multidisciplinary
Chansi, Shikha Upreti, Punya, Jay Singh, Madhumita P. Ghosh, Tinku Basu
Summary: The major challenges in ophthalmic treatment include limited residence time of drugs in the ocular surface, poor bioavailability, and side effects. This study demonstrates the potential of using mucoadhesive FeMOF as a drug delivery system to enhance preocular retention of ophthalmic drugs. The results from in-vitro studies suggest that TM@FeMOF could be a successful biocompatible, biodegradable, and sustainable ophthalmic drug delivery system with enhanced drug release capabilities.
Article
Chemistry, Inorganic & Nuclear
R. Pragadeeshwara Rao, Sanya Mishra, R. M. Tripathi, Sudhir Kumar Jain
Summary: The study presents a green synthesis method for polydisperse Bismuth Oxide nanorods using Ficus benghalensis leaf extract, with detailed characterization of their properties through XRD, UV, SEM, and FTIR. The synthesized BONRs were confirmed to have a single-phase (alpha - Bi2O3) crystalline structure, with a wide bandgap of 3.13 eV and an average diameter of 388 nm, demonstrating the role of leaf extract as a reducing and stabilizing agent.
INORGANIC AND NANO-METAL CHEMISTRY
(2021)
Article
Engineering, Environmental
Isha Fuletra, Chansi, Sumaya Nisar, Rashi Bhardwaj, Punya Saluja, Sheetal K. Bhardwaj, K. Asokan, Tinku Basu
Summary: The experiment successfully developed an electrochemical sensor for trace level arsenic detection in water by integrating gold nano islands with the substrate ITO surface, fixed with 1, 4-dithiothreitol (DTT). The sensor showed wide linearity, low detection limit, good selectivity against various interfering substances, and demonstrated sensitive, rapid, and reliable characteristics, with potential for commercialization.
GROUNDWATER FOR SUSTAINABLE DEVELOPMENT
(2021)
Article
Chemistry, Multidisciplinary
Chansi, R. Pragadeeshwara Rao, Irani Mukherjee, Tinku Basu, Lalit M. Bharadwaj
Article
Materials Science, Biomaterials
Ravi Mani Tripathi, Pearlin Hameed, R. Pragadeeshwara Rao, Neeraj Shrivastava, Jagjiwan Mittal, Swarti Mohapatra
Article
Materials Science, Biomaterials
Sheetal K. Bhardwaj, Ruchika Chauhan, Premlata Yadav, Subhasis Ghosh, Ajit K. Mahapatro, Jay Singh, Tinku Basu
BIOMATERIALS SCIENCE
(2019)
Article
Chemistry, Multidisciplinary
R. M. Tripathi, R. Pragadeeshwara Rao, Takuya Tsuzuki
