Article
Chemistry, Multidisciplinary
Qian Wang, Meng Xiao, Dianyu Wang, Xiaoxue Hou, Jie Gao, Jinjian Liu, Jianfeng Liu
Summary: This study introduces a synergistic Pt(IV) prodrug that combines dual responsive behavior and dual drug resistance-related pathways deactivation, effectively overcoming drug resistance and improving the efficacy of anticancer drugs through multiple mechanisms.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Yue Yu, Liping Sun, Yanfei Tang, Huixia Zhu, Huai Wang, Hua Xiao, Feng Wang, Wei Tao
Summary: Encapsulating cisplatin in calcium phosphate nanoparticles is challenging due to its low solubility and weak binding affinity. This study presents a unique strategy using a polymer bearing numerous carboxyl side groups and incorporating redox-sensitive cisplatin prodrugs for encapsulation in CPNPs. The encapsulated CPNPs showed enhanced stability and efficacy against cancerous cells compared to free cisplatin and the prodrug alone.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Materials Science, Biomaterials
Peng Xie, Qiao Jin, Yifan Li, Jinbo Zhang, Xiang Kang, Jialin Zhu, Xinzhan Mao, Peiguo Cao, Chaoyong Liu
Summary: This study reports a triple action nanoplatinum drug based on artesunate and cantharidin, which enhances ROS generation, induces DNA damage, and inhibits DNA repair to achieve a high-efficiency killing effect in a single tumor cell.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Inorganic & Nuclear
Ran Zhang, Yueyue Zhang, Liumei Tang, Yixing Xu, Hao Li, Xueping Jiang, Xiangdong Xin, Zhongzheng Gui
Summary: A series of Pt(IV) prodrugs containing a microtubule inhibitor paclitaxel were synthesized and evaluated for their antitumor activity. One of the prodrugs, named Ptxplatin, effectively entered cancer cells and induced DNA damage, cell cycle arrest, and inhibition of cell migration. Furthermore, Ptxplatin caused mitochondrial dysfunction and triggered endoplasmic reticulum stress, ultimately leading to cancer cell death.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Beatriz Brito, Maria Rosaria Ruggiero, Thomas W. Price, Milene da Costa Silva, Nuria Genicio, Annah J. Wilson, Olga Tyurina, Veronika Rosecker, Thomas R. Eykyn, Manuel Banobre-Lopez, Graeme J. Stasiuk, Juan Gallo
Summary: Manganese dioxide (MnO2)-based nanostructures were prepared using a one-pot reaction, and Pt(iv) prodrugs were used as redox-responsive theranostics for cancer therapy. The cytotoxicity of these nanostructures was evaluated and found to be as effective as the clinical chemotherapeutic drug cisplatin in 3D cell models. The nanostructures also exhibited strong ON/OFF magnetic resonance (MR) contrast in response to reducing agents and induced a significant and long-lasting T-1 signal enhancement in tumor-bearing mice.
Article
Chemistry, Multidisciplinary
Dachuan Qi, Lei Xing, Lijun Shen, Wenshuang Sun, Cheng Cai, Chunhua Xue, Xuwei Song, Hua Yu, Hulin Jiang, Chengjun Li, Qingri Jin, Zhiqi Zhang
Summary: This study developed a GSH-depleted drug for breast cancer, which can effectively treat breast cancer by increasing oxidative stress and inducing ferroptosis.
CHINESE CHEMICAL LETTERS
(2022)
Review
Medicine, Research & Experimental
Rahul Bhattacharjee, Tanima Dey, Lamha Kumar, Sulagna Kar, Ritayan Sarkar, Mimosa Ghorai, Sumira Malik, Niraj Kumar Jha, Balachandar Vellingiri, Kavindra Kumar Kesari, Jose M. Perez de la Lastra, Abhijit Dey
Summary: This review discusses the causes, mechanisms, and potential therapeutic strategies for cisplatin resistance in cervical cancer. Strategies such as the use of nanocarriers, miRNA, CRISPR/Cas system, and combination therapy with chemotherapeutics show promise in overcoming drug resistance and improving the efficacy of cisplatin. Furthermore, the review examines the signaling network of cisplatin-resistant cells in cervical cancer and the impact of tumor microenvironment on drug resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Congcong Lin, Yuxiu Chen, Mengli Zhu, Junping Pei, Yang Zhou, Maling Gou, Liang Ouyang
Summary: A nano-delivery system based on a novel sulfhydryl blocking reagent was developed for the CDDP prodrug, which can deplete GSH in tumor cells and increase the cytotoxicity of CDDP. This system promotes the distribution of CDDP in tumors, reduces inactivation, and enhances the efficacy of CDDP.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Oncology
Cheng Ming, Xuelian Bai, Lifeng Zhao, Dedong Yu, Xiaomin Wang, Yun Wu
Summary: This study found that the expression of RPL24 is closely associated with the treatment and prognosis of cervical carcinoma, and it can be considered as a potential biomarker for predicting the prognosis of cervical carcinoma patients and assessing treatment efficacy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Alessandra Barbanente, Valentina Gandin, Chiara Donati, Carmela Ilaria Pierro, Giovanni Natile, Nicola Margiotta
Summary: Platinum-based drugs have been successful in treating solid tumors, but toxicity and resistance limit their outcomes. Natural products, such as 10-HDA found in royal jelly, are being explored as safe and easily available anti-cancer drugs. In this study, the researchers aimed to combine the functionality of 10-HDA with platinum to develop new compounds with potential anti-cancer activity. The synthesized compounds were characterized and tested for their cytotoxicity against human tumor cell lines. The results showed that some of the new compounds exhibited promising activity against specific tumor cell lines.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Engineering, Biomedical
Wei Jiang, Zuoxiu Tie, Chi Yu, Yu Chen, Dan Liu, Bin Li
Summary: This study constructs a glutathione (GSH)-responsive nanoplatform to inhibit the energy metabolism and lysosomal activity of tumor cells, making tumor cells remain sensitive to cisplatin. By inhibiting the energy metabolism and autophagy-lysosome pathway of tumor cells, the nanoplatform prevents tumor cells from entering a low-energy dormancy state and enhances the chemotherapeutic effect of cisplatin.
Article
Engineering, Biomedical
Xiaohui Xiao, Yupeng Wang, Jieyao Chen, Peng Qin, Peiyao Chen, Dongfang Zhou, Yue Pan
Summary: This study presents a self-targeting nano-assembly strategy based on platinum(IV)-lactose amphiphilic prodrug for synergistic and safe chemoradiotherapy of hepatocellular carcinoma (HCC). The nano-assembly targets HCC cells and releases cisplatin to induce DNA damage and cell apoptosis. Under X-ray irradiation, the assembly enhances the cell-killing effect of radiotherapy.
Article
Pharmacology & Pharmacy
Elizabeth Mahapatra, Debomita Sengupta, Ravindra Kumar, Budheswar Dehury, Salini Das, Madhumita Roy, Sutapa Mukherjee
Summary: Acquired cisplatin resistance in cervical cancer is mainly caused by reduced intracellular drug accumulation, which is a result of hyperactivation of the PI3K/Akt signaling pathway and overexpression of related proteins. The study suggests that PEITC may be a potential sensitizing agent that can restore the effectiveness of cisplatin.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Dongbo Guo, Josh Haipeng Lei, Dade Rong, Tesen Zhang, Bohan Zhang, Zikang Tang, Han-Ming Shen, Chu-Xia Deng, Songnan Qu
Summary: This study reports a novel orange light-triggered anti-tumor therapeutic agent based on photoactivatable Pt(IV)-coordinated carbon dots. These carbon dots release cytotoxic Pt(II) species and promote hydroxy radical generation under orange light, efficiently killing cancer cells.
Review
Chemistry, Multidisciplinary
Larasati Larasati, Witri Wahyu Lestari, Maulidan Firdaus
Summary: The conversion of cisplatin Pt(II) into a Pt(IV) complex is a strategy to overcome resistance and side effects. Ligands with bioactivity could target specific cancer cells and enhance cellular uptake. Self-assembled MOFs with high porosity can load drugs and enable controlled release. Combined with prodrugs, MOFs could generate a triple-acting anticancer agent for enhanced treatment.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2022)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)