Review
Biochemistry & Molecular Biology
Yanggu Shi, Jindong Shang
Summary: Circular RNAs are covalently circularized RNA loops with unique biochemical properties. Their biological functions and clinical indications continue to be discovered. They are increasingly being used as biomarkers due to their unusual specificities and stable circular form. Profiling circRNA expression is crucial in advancing circRNA research and we will review the use of circRNA microarrays in biological and clinical labs, sharing valuable experiences and significant findings.
Review
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Mohammad Taheri, Bashdar Mahmud Hussen, Jamshid Vafaeimanesh, Atefe Abak, Reza Vafaee
Summary: Circular RNAs (circRNAs) play critical roles in the formation and progression of neoplasms, and have the potential for clinical outcome prediction.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Atefe Rahmati, Alireza Mafi, Firooze Soleymani, Zahra Babaei Aghdam, Niloufar Masihipour, Behrooz Ghezelbash, Reza Asemi, Michael Aschner, Omid Vakili, Mina Homayoonfal, Zatollah Asemi, Mehran Sharifi, Abbas Azadi, Hamed Mirzaei, Esmat Aghadavod
Summary: Acute myeloid leukemia (AML) is a aggressive hematological malignancy with poor overall survival rates. Circular RNAs (circRNAs), a class of non-coding RNAs with a unique loop structure, have been found to be dysregulated in AML patients. These dysregulated circRNAs have been shown to regulate leukemia cell proliferation, stemness, and apoptosis in both positive and negative ways. Furthermore, circRNAs show potential as biomarkers and therapeutic targets in AML.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cell Biology
Takahiro Seimiya, Motoyuki Otsuka, Mitsuhiro Fujishiro
Summary: Circular RNAs play significant roles in the pathogenesis of pancreatic cancer and have the potential to serve as novel diagnostic biomarkers and therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Sajad Najafi
Summary: Ovarian cancer is a common gynecologic malignancy and the leading cause of death in this field. Circular RNAs (circRNAs) are a group of non-coding RNAs with circular structure, and they play important roles in regulating gene expression and various biological processes including tumorigenesis. In ovarian cancer, circRNAs are involved in regulating cell growth, metastasis, angiogenesis, and chemoresistance, and they also show potential as diagnostic, prognostic, and therapeutic targets.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Medical Laboratory Technology
Xiaoni Huang, Yuwen Zhao, Huijiao Zhou, Yongqiang Li
Summary: This article reviews the biogenesis, classification, and functions of circRNA, and summarizes the research on circRNA as a diagnostic biomarker for AS. Additionally, it describes the regulatory capacity of circRNA in the pathogenesis of AS and demonstrates its potential therapeutic role.
CLINICA CHIMICA ACTA
(2022)
Review
Immunology
Qinglan Wang, Danni Yang, Yinan Zuo, Dan Wang, Weimin Li
Summary: Tuberculosis is a global health issue, and circRNAs are a new class of noncoding RNAs that can regulate host anti-TB immune responses, potentially serving as diagnostic biomarkers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yingcheng Lyu, Binghua Tan, Lin Li, Ruihao Liang, Kai Lei, Kefeng Wang, Duoguang Wu, Huayue Lin, Minghui Wang
Summary: In this study, a highly expressed circRNA with protein-coding ability, circUBE4B, was identified in esophageal squamous carcinoma (ESCC) tissues. The expression level of circUBE4B was correlated with tumor size and differentiation level of ESCC patients, and higher levels were associated with poorer prognosis. Functionally, circUBE4B promoted ESCC cell proliferation by encoding a novel cancer-promoting protein, circUBE4B-173aa. Mechanistically, circUBE4B-173aa interacted with MAPK1, leading to increased phosphorylation and activation of the MAPK/ERK signaling pathway. In a xenograft model, overexpression of circUBE4B-173aa significantly promoted tumor growth. This study provides new insights into the role of circRNAs in ESCC development and suggests circUBE4B-173aa as a potential biomarker and therapeutic target for ESCC.
CELL DEATH & DISEASE
(2023)
Review
Cell Biology
Cheng Wen, Bowei Li, Lei Nie, Ling Mao, Yuanpeng Xia
Summary: This review summarizes the emerging roles of extracellular vesicle-derived circular RNAs in atherosclerosis and their mechanism in the development of this disease. Extracellular vesicle-derived circular RNAs play an important role in the pathological process of atherosclerosis and have great potential as diagnostic biomarkers and novel therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Geriatrics & Gerontology
Xin Chen, Shuzhe Yang, Junhua Yang, Qingyuan Liu, Maogui Li, Jun Wu, Hao Wang, Shuo Wang
Summary: CircRNAs play a crucial role in various diseases, but their involvement in intracranial aneurysm remains unknown. This study identified differential expression of circRNAs in intracranial aneurysm compared to superficial temporal arteries, with circDUS2 being a potential molecular marker for the condition.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Cell Biology
Arunagiri Kuha Deva Magendhra Rao, Vittal Rangan Arvinden, Deepa Ramasamy, Krishna Patel, Balaiah Meenakumari, Priya Ramanathan, Shirley Sundersingh, Velusami Sridevi, Thangarajan Rajkumar, Zdenko Herceg, Harsha Gowda, Samson Mani
Summary: This study identified 26 differentially expressed circular RNAs associated with early-stage breast cancer, as well as potential interactions between circRNAs and miRNAs. The results showed that certain circRNAs have diagnostic implications in breast cancer, and observed circRNA-miRNA interactions that may be involved in breast cancer development.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Cell Biology
Dean Rao, Chengpeng Yu, Jiaqi Sheng, Enjun Lv, Wenjie Huang
Summary: Circular RNAs (circRNAs) are a class of stable and resistant non-coding RNAs widely expressed in eukaryotic cells, playing important roles in various diseases. CircRNA Foxhead box O3 (circFOXO3) has been studied extensively in cancers as a molecular sponge. Understanding the roles of circFOXO3 can enrich our knowledge of circRNA functions in cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Jing Han, Nannan Han, Zhimin Xu, Chunye Zhang, Jiannan Liu, Min Ruan
Summary: This study identified the profile of circRNA expression in SACC, with 5 up-regulated and 26 down-regulated circRNAs. The establishment of circRNA-miRNA system revealed an interaction between circRNA ABCA13 and cancer-related miRNA (miR-138-5p), suggesting circRNA ABCA13 may promote SACC through inhibition of miR-138-5p, providing a potential therapeutic target in SACC treatment.
CANCER CELL INTERNATIONAL
(2021)
Review
Cell Biology
Ming-Che Kuo, Sam Chi-Hao Liu, Ya-Fang Hsu, Ruey-Meei Wu
Summary: The article discusses the discovery of various noncoding RNAs and their roles in regulating gene expression and modifying metabolic pathways. It highlights the importance of studying these ncRNAs in neurodegenerative diseases using diverse sequencing technologies and bioinformatic analytical tools. The review also emphasizes the association of numerous ncRNAs with Parkinson's disease and the potential use of exosome-transferred microRNAs and long ncRNAs in diagnosing and understanding the pathophysiology of PD.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Claudia Pisanu, Alessio Squassina
Summary: In this narrative review, the potential use of messenger RNAs and noncoding transcripts as peripheral markers of bipolar disorder (BD) and/or response to lithium and other mood stabilizers are summarized. Studies have investigated specific targets or pathways and there is heterogeneity in the type of cells or biofluids included. However, there is a growing number of hypothesis-free designs and integration of coding and noncoding RNAs data. Studies conducted in cellular models provide promising findings for investigating the molecular determinants of BD and clinical response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)