Article
Biophysics
Byung-Sik Cho, Gi-June Min, Sung-Soo Park, Silvia Park, Young-Woo Jeon, Seung-Hwan Shin, Seung-Ah Yahng, Jae-Ho Yoon, Sung-Eun Lee, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Chang-Ki Min, Seok-Goo Cho, Dong-Wook Kim, Jong Wook Lee, Myungshin Kim, Yonggoo Kim, Hee-Je Kim
Summary: This study retrospectively evaluated 88 AML patients who underwent either Allo-HSCT or Auto-HSCT, revealing a significant association between D816V KIT mutation and post-transplant relapse, as well as the predictive value of CBFB-MYH11 MRD assessments for post-transplant outcomes.
BONE MARROW TRANSPLANTATION
(2021)
Review
Biochemistry & Molecular Biology
Annalisa Talami, Francesca Bettelli, Valeria Pioli, Davide Giusti, Andrea Gilioli, Corrado Colasante, Laura Galassi, Rachele Giubbolini, Hillary Catellani, Francesca Donatelli, Rossana Maffei, Silvia Martinelli, Patrizia Barozzi, Leonardo Potenza, Roberto Marasca, Tommaso Trenti, Enrico Tagliafico, Patrizia Comoli, Mario Luppi, Fabio Forghieri
Summary: Despite the favorable risk category of AML carrying inv(16)/t(16;16) with fusion transcript CBFB-MYH11, approximately 30% of cases eventually relapse after obtaining morphological complete remission after induction. Measurable residual disease (MRD) monitoring by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) has a significant independent prognostic impact, especially in predicting relapse, surpassing other prognostic factors. Controversies exist regarding the frequency of subsequent serial monitoring, significant MRD thresholds (most commonly 0.1%), and the best source to be analyzed (bone marrow or peripheral blood samples).
Article
Medicine, Research & Experimental
Gabriele Lo Iudice, Eleonora De Bellis, Arianna Savi, Luca Guarnera, Alice Massacci, Francesca De Nicola, Frauke Goeman, Tiziana Ottone, Mariadomenica Divona, Matteo Pallocca, Maurizio Fanciulli, Maria Teresa Voso, Gennaro Ciliberto
Summary: The article discusses a case of Acute Myeloid Leukaemia with both CBFB-MYH11 rearrangement and FLT3-ITD gene mutation, resulting in an extremely aggressive phenotype. Somatic and germline Whole Exome Sequencing revealed additional mutations in LTK, BCAS2, and LGAS9, but they were unlikely to be causative of the observed clinical phenotype.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Weijun Zhou, Jinyi Yu, Yilu Li, Kankan Wang
Summary: Neoantigens derived from non-synonymous somatic mutations are considered ideal targets for T cell receptor (TCR)-based immunotherapy. High-avidity TCRs specific for neoantigens expressed on AML cells have been identified and show great potential as safe and effective therapies. TCR-based immunotherapies also demonstrate encouraging anti-leukemic effects in early-phase clinical trials for AML.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Fabio Forghieri, Giovanni Riva, Ivana Lagreca, Patrizia Barozzi, Francesca Bettelli, Ambra Paolini, Vincenzo Nasillo, Beatrice Lusenti, Valeria Pioli, Davide Giusti, Andrea Gilioli, Corrado Colasante, Laura Galassi, Hillary Catellani, Francesca Donatelli, Annalisa Talami, Rossana Maffei, Silvia Martinelli, Leonardo Potenza, Roberto Marasca, Enrico Tagliafico, Rossella Manfredini, Tommaso Trenti, Patrizia Comoli, Mario Luppi
Summary: The C-terminal aminoacidic sequence from NPM1-mutated protein may serve as a leukemia-specific antigen, and different in silico instruments have identified the most immunogenic epitopes. Spontaneous development of endogenous NPM1-mutated-specific cytotoxic T cells has been observed in patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Niklas Baumann, Christian Arndt, Judith Petersen, Marta Lustig, Thies Roesner, Katja Klausz, Christian Kellner, Miriam Bultmann, Lorenz Bastian, Fotini Vogiatzi, Jeanette H. W. Leusen, Renate Burger, Denis M. Schewe, Matthias Peipp, Thomas Valerius
Summary: Antibody-based immunotherapy is increasingly used to treat acute lymphoblastic leukemia (ALL) patients. This study investigates the effects of CD38 antibodies, targeting T-ALL cells expressing CD38, on tumor cell killing through antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cell-mediated cytotoxicity (ADCC). The study shows that IgA2 variants of CD38 antibodies are more effective in killing tumor cells through myeloid cells. The interactions between CD47 and SIRP alpha negatively regulate ADCP and ADCC. Additionally, treatment with all-trans retinoic acid (ATRA) enhances CD38 expression and further enhances ADCP and ADCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Wei Qin, Xiayu Chen, Hong Jie Shen, Zheng Wang, Xiaohui Cai, Naike Jiang, Haiying Hua
Summary: This study retrospectively analyzed the gene mutations in 134 patients with CBF-AML. The most common mutations were found in c-KIT and NRAS, while mutations related to epigenetic modification were less frequent. Patients with different chromosomal translocations exhibited different mutation profiles, and the frequencies of mutations in signaling pathways and cohesin varied among different chromosomal translocation types. AML patients with chromosomal translocations had significantly higher white blood cell counts if they had c-KIT or NRAS mutations.
TURKISH JOURNAL OF HEMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Nichole Owen, Irina G. Minko, Samantha A. Moellmer, Sydney K. Cammann, R. Stephen Lloyd, Amanda K. McCullough
Summary: Human clinical trials suggest that inhibition of enzymes in the DNA base excision repair (BER) pathway, such as PARP1 and APE1, can be useful in anticancer strategies when combined with certain DNA-damaging agents. Specifically, in acute myeloid leukemia (AML), AML cell lines deficient in OGG1 have enhanced sensitivity to cytarabine (Ara-C) treatment. This enhanced cytotoxicity is likely due to the insertion of Ara-C opposite unrepaired 8-oxo-dG in OGG1-deficient AML cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Joseph S. Dolina, Joey Lee, Spencer E. Brightman, Sara McArdle, Samantha M. Hall, Rukman R. Thota, Karla S. Zavala, Manasa Lanka, Ashmitaa Logandha Ramamoorthy Premlal, Jason A. Greenbaum, Ezra E. W. Cohen, Bjoern Peters, Stephen P. Schoenberger
Summary: This study explores how the response to immune checkpoint blockade can be improved for aggressive low-TMB squamous cell tumors by combining intermolecular epitope spreading and immune checkpoint blockade, leading to the eradication of established large tumors.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Hematology
Anthony G. Mansour, Kun-Yu Teng, Zhiyao Li, Zheng Zhu, Hanyu Chen, Lei Tian, Aliya Ali, Jianying Zhang, Ting Lu, Shoubao Ma, Chih-Min Lin, Michael A. Caligiuri, Jianhua Yu
Summary: A new approach for treating AML has been developed, using engineered human NK cells to target and attack leukemia-associated antigens, which can increase survival rate without causing toxicity to healthy cells.
Article
Chemistry, Analytical
Wenjie Ma, Huanhuan Sun, Biao Chen, Ruichen Jia, Jin Huang, Hong Cheng, Xiaoxiao He, Mingmin Huang, Kemin Wang
Summary: The pH and membrane receptor dual-activatable aptamer therapeutic, pH-Apt-MD, has shown promise for precise diagnosis and therapy of cancer cells through targeted drug release and tumor cell imaging with a narrow pH response range and enhanced imaging contrast.
ANALYTICAL CHEMISTRY
(2021)
Article
Medicine, General & Internal
Irene Spinelli, Adriano De Santis, Laura Cesini, Mara Riminucci, Alessandro Corsi, Mariana Forlino, Elio Pietro Perrone, Clara Minotti, Claudio Cartoni
Summary: This case report describes a patient with acute myeloid leukemia who presented with clinical, biochemical, and radiological signs of acute hepatitis that totally regressed after chemotherapy.
JOURNAL OF MEDICAL CASE REPORTS
(2022)
Article
Pediatrics
Omar Sepulveda-Robles, Elva Jimenez-Hernandez, Victoria Dominguez-Catzin, Eber Gomez-Flores, Jorge Alfonso Martin-Trejo, Janet Flores-Lujano, Jose Refugio Torres-Nava, Juan Carlos Nunez-Enriquez, Marlon De Ita, Aurora Medina-Sanson, Minerva Mata-Rocha, Blanca Angelica Morales-Castillo, Juan Carlos Bravata-Alcantara, Alan Steve Najera-Cortes, Norberto Sanchez-Escobar, Jose Gabriel Penaloza-Gonzalez, Rosa Martha Espinosa-Elizondo, Luz Victoria Flores-Villegas, Raquel Amador-Sanchez, Dario Orozco-Ruiz, Maria Luisa Perez-Saldivar, Martha Margarita Velazquez-Avina, Laura Elizabeth Merino-Pasaye, Karina Anastacia Solis-Labastida, Ana Itamar Gonzalez-Avila, Jessica Denisse Santillan-Juarez, Vilma Carolina Bekker-Mendez, Silvia Jimenez-Morales, Angelica Rangel-Lopez, Haydee Rosas-Vargas, Juan Manuel Mejia-Arangure
Summary: This study aims to investigate the frequency of fusion genes, including RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1(p210), and KMT2A-MLLT3, in pediatric AML patients from Mexico City, as well as their impact on early mortality during treatment.
FRONTIERS IN PEDIATRICS
(2022)
Article
Oncology
Kevin Dang, Giulia Castello, Starlynn C. Clarke, Yuping Li, Aarti Balasubramani, Andrew Boudreau, Laura Davison, Katherine E. Harris, Duy Pham, Preethi Sankaran, Harshad S. Ugamraj, Rong Deng, Serena Kwek, Alec Starzinski, Suhasini Iyer, Wim van Schooten, Ute Schellenberger, Wenchao Sun, Nathan D. Trinklein, Roland Buelow, Ben Buelow, Lawrence Fong, Pranjali Dalvi
Summary: TNB-585, an anti-CD3xPSMA TCE, shows promising efficacy in vitro in inducing activation and proliferation of human T cells, killing PSMA(+) prostate tumor cells, and reducing cytokine release and regulatory T cell activation. In addition, TNB-585 demonstrates potent efficacy against patient-derived prostate tumors ex vivo and in vivo, suggesting it may be a promising therapy for mCRPC with lower incidence and severity of CRS compared to TCEs with high-affinity anti-CD3 domains.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Oncology
Meriem Ben Khoud, Tiziano Ingegnere, Bruno Quesnel, Suman Mitra, Carine Brinster
Summary: Acute myeloid leukemia (AML) is a cancer characterized by impaired differentiation and excessive expansion of blood progenitor cells leading to their accumulation in the bone marrow and circulation. The disease alters the bone marrow microenvironment, inhibits proper hematopoiesis, and causes sustained cytopenia and immunodeficiency. AML influences the immune system, particularly T lymphocytes, and therapeutic strategies aim to improve the anti-leukemic immune response and patient outcomes.