Article
Gastroenterology & Hepatology
Carlos Moctezuma-Velazquez, Aldo J. Montano-Loza, Judith Meza-Junco, Kelly Burak, Mang Ma, Vincent G. Bain, Norman Kneteman, Phillipe Sarlieve, Richard J. Owen
Summary: Hepatocellular carcinoma (HCC) is the second most common lethal cancer for which effective therapies are needed. Selective internal radiation therapy (SIRT) has the potential to be used across the BCLC stages in cases with preserved liver function. When using SIRT as a rescue treatment, consideration should be given to variables reflecting liver function, HCC extension, and systemic inflammation, which are associated with mortality.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Oncology
Feiqian Wang, Kazushi Numata, Atsuya Takeda, Katsuaki Ogushi, Hiroyuki Fukuda, Hiromi Nihonmatsu, Koji Hara, Makoto Chuma, Yuichirou Tsurugai, Shin Maeda
Summary: RFA and SBRT treatment may be potential options for patients with multifocal HCC in BCLC stage A4-B1 due to favorable prognosis and safety. Prospective, controlled, large-scale studies are needed to further confirm these conclusions before clinical application.
Review
Oncology
Hannah J. Roberts, Jennifer Y. Wo
Summary: Radiation therapy for primary liver cancers has historically been limited due to the risk of radiation-induced liver disease. However, stereotactic body radiation therapy (SBRT) has advanced to safely treat liver tumors while sparing functional liver tissue. Although studies have examined SBRT for liver cancers, there is a lack of well-powered randomized studies to definitively guide management strategies.
Article
Medicine, General & Internal
Jun-Xiang Li, Peng Zhou, De-Hua Chang, Yao Tong, Yan Bao, Yu-Dong Xiao, Shi Zhou, Wen-Wu Cai
Summary: This study compared the prognosis of liver resections (IPLRs) between the Barcelona Clinic Liver Cancer (BCLC) staging and the Hong Kong Liver Cancer (HKLC) staging systems and found that IPLRs in the BCLC staging system had a better prognosis. However, IPLRs in the HKLC staging system but beyond the BCLC staging may have equivalent prognosis if the tumor size is <= 5 cm and liver cirrhosis is absent.
FRONTIERS IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Ming Chao Tsai, Chee-Chien Yong, Chih-Che Lin, Wei-Chen Lee, Chih-Chi Wang, Chao-Hung Hung, I-Hsuan Chen, Yu-Fan Cheng, Chang-Chun Hsiao, Tsung-Hui Hu, Chao-Long Chen
Summary: The study found that LDLT may be a valuable therapeutic option for selected patients with BCLC stage B HCC, as patients treated with LDLT achieved better overall survival compared to the non-LDLT group. Age, NLR, and LRT before LDLT were identified as independent risk factors for HCC recurrence and overall survival.
HEPATOBILIARY SURGERY AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Chih-Wen Lin, Yaw-Sen Chen, Gin-Ho Lo, Tsung-Chin Wu, Jen-Hao Yeh, Ming-Lun Yeh, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Lewis Roberts, Dae Won Jun, Hidenori Toyoda, Satoshi Yasuda, Mindie H. Nguyen, Ming-Lung Yu
Summary: This study established a new subclassification system for BCLC-C HCC, dividing patients into C0 to C4 sub-stages, to better predict overall survival and tailor therapy.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Won Ick Chang, Byoung Hyuck Kim, Yoon Jun Kim, Jung-Hwan Yoon, Yong Jin Jung, Eui Kyu Chie
Summary: This study aimed to investigate the clinical benefits of locoregional radiation therapy (RT) before, after, and concurrent with sorafenib therapy for Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC) patients. The results showed that locoregional RT was associated with significantly longer survival in BCLC stage C HCC patients who were treated with sorafenib, especially in patients treated with sorafenib for 12 weeks or more. Incorporating locoregional RT could improve the dismal prognosis for these patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Pelvis Nitin Ohri, Wolfgang A. Tome, Alejandra Mendez Romero, Moyed Miften, Randall K. Ten Haken, Laura A. Dawson, Jimm Grimm, Ellen Yorke, Andrew Jackson
Summary: The study evaluated local control rates after SBRT for primary and metastatic liver tumors. Results showed high rates of durable local control for primary liver tumors with no clear dose-response relationship, while better outcomes were observed for liver metastases treated with higher BEDs.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Medicine, General & Internal
Hwa Kyung Byun, Nalee Kim, Jinsil Seong
Summary: The study found that the optimal timing for administering radiotherapy after incomplete TACE is within 5 weeks, with early administration associated with better local control.
YONSEI MEDICAL JOURNAL
(2021)
Review
Oncology
Tomoki Kimura, Toshiki Fujiwara, Tsubasa Kameoka, Yoshinori Adachi, Shinji Kariya
Summary: SBRT plays a crucial role in the treatment of early-stage HCC, portal vein or inferior vena cava thrombi, and may have potential in pre-transplantation and the treatment of oligometastases. Further research is needed to establish the rationale for utilizing SBRT in different scenarios.
Article
Oncology
Deepti Sharma, Deepak Thaper, Rose Kamal, Hanuman Prasad Yadav
Summary: This study evaluated the role of palliative stereotactic body radiation therapy (SBRT) in BCLC-C hepatocellular carcinoma patients who are not suitable for other loco-regional therapies. The results showed that SBRT can improve pain and discomfort in patients and has acceptable toxicity.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Oncology
Feng Xia, Zhiyuan Huang, Qiao Zhang, Elijah Ndhlovu, Mingyu Zhang, Xiaoping Chen, Yifa Chen, Bixiang Zhang, Peng Zhu
Summary: Ruptured hepatocellular carcinoma (rHCC) typically has a poor prognosis. This study aimed to evaluate the impact of rHCC and the effectiveness of hepatectomy in patients with Barcelona Clinic Liver Cancer (BCLC) stage 0/A rHCC. The results showed that patients with BCLC stage 0/A rHCC treated with surgery had worse prognosis compared to patients with BCLC stage 0/A non-rHCC treated with surgery. However, the prognosis of patients with BCLC stage 0/A rHCC who underwent surgery was comparable to patients with BCLC stage B HCC who underwent surgery or TACE.
Article
Oncology
Sai Duriseti, James A. Kavanaugh, Jeff Szymanski, Yi Huang, Franco Basarabescu, Aadel Chaudhuri, Lauren Henke, Pamela Samson, Alexander Lin, Clifford Robinson, Matthew B. Spraker
Summary: This study evaluated the acute toxicity and quality of life of patients with large tumors treated with Lattice SBRT. The results showed no significant treatment-related severe toxicity in the 90-day period, but there was one case of severe toxicity possibly associated with Lattice SBRT.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tiffany Cho-Lam Wong, Victor Ho-Fun Lee, Ada Lai-Yau Law, Herbert H. Pang, Ka-On Lam, Vince Lau, Tracy Yushi Cui, Adrianna Sze-Yin Fong, Sarah Wai-Man Lee, Edwin Chun-Yin Wong, Jeff Wing-Chiu Dai, Albert Chi-Yan Chan, Tan-To Cheung, James Yan-Yue Fung, Rebecca Mei-Wan Yeung, Mai-Yee Luk, To-Wai Leung, Chung-Mau Lo
Summary: The study showed that stereotactic body radiation therapy (SBRT) as a bridge to liver transplantation for HCC has a significantly higher tumor control rate and lower risk of waitlist dropout compared to conventional bridging therapies, making it a safe alternative option.
Article
Medicine, General & Internal
Hyo-Sin Kim, Soo Jin Na Choi, Ho Kyun Lee, Korean Liver Canc Assoc Korean Liver Canc Assoc
Summary: The purpose of this study was to evaluate the proper position of single large hepatocellular carcinoma (HCC) in the Barcelona Clinic Liver Cancer (BCLC) staging system. The findings suggest that single large HCC should be relocated to BCLC stage B rather than BCLC stage A.
Review
Oncology
Armando De Virgilio, Andrea Costantino, Bianca Maria Festa, Giuseppe Mercante, Davide Franceschini, Ciro Franzese, Marta Scorsetti, Andrea Marrari, Raffaele Cavina, Salvatore Marano, Carlo Castoro, Giuseppe Spriano
Summary: Definitive chemoradiotherapy is a valuable first-line treatment for cervical esophageal squamous cell carcinoma (CESCC) with favorable oncological outcomes. Further research is needed to identify survival predictors for stage-based clinical guidelines.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Otorhinolaryngology
Armando De Virgilio, Andrea Costantino, Bianca Maria Festa, Giuseppe Mercante, Davide Franceschini, Ciro Franzese, Marta Scorsetti, Andrea Marrari, Raffaele Cavina, Salvatore Marano, Carlo Castoro, Giuseppe Spriano
Summary: The study aims to determine the oncological outcomes of surgery for cervical esophageal cancer. The results showed different survival rates between larynx preserving surgery and non-preserving surgery, and further research is needed to compare the effects of surgery and chemoradiotherapy.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Ciro Franzese, Beatrice Marini, Davide Baldaccini, Marco Badalamenti, Pierina Navarria, Luisa Bellu, Davide Franceschini, Tiziana Comito, Elena Clerici, Maria Ausilia Teriaca, Maria Massaro, Luciana Di Cristina, Lorenzo Lo Faro, Stefano Tomatis, Marta Scorsetti
Summary: This study confirms the efficacy and safety of SABR for oligoprogression from RCC, with the potential to prolong ongoing systemic therapy and eliminate resistant metastases.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Nicola Lambri, Damiano Dei, Victor Hernandez, Isabella Castiglioni, Elena Clerici, Leonardo Crespi, Chiara De Philippis, Daniele Loiacono, Pierina Navarria, Giacomo Reggiori, Roberto Rusconi, Stefano Tomatis, Stefania Bramanti, Marta Scorsetti, Pietro Mancosu
Summary: An automatic procedure was developed for treatment planning and field junction creation in total marrow (and lymphoid) irradiation (TMI-TMLI). The automatic plans achieved clinically acceptable dosimetric results, with significant differences found only in the junction region compared to manual plans. The introduction of the automatic procedure reduced treatment time and improved efficiency and standardization.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Review
Oncology
Sabrina Rossi, Arianna Marinello, Arianna Pagliaro, Davide Franceschini, Pierina Navarria, Giovanna Finocchiaro, Luca Toschi, Marta Scorsetti, Armando Santoro
Summary: Oncogene-addicted non-small cell lung cancer patients often experience CNS metastases, leading to worse prognosis and exclusion from clinical trials. Targeted agents for ALK/ROS1/NTRK-positive NSCLC have been tested, and their intracranial efficacy is evaluated and compared based on subgroup analysis from pivotal trials.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Article
Oncology
D. Franceschini, L. Cozzi, V. Vernier, A. M. Marzo, B. Marini, S. Stefanini, P. Navarria, M. Scorsetti
Summary: The purpose of this study was to identify factors associated with poly-progression in patients receiving SRT for OMD. The study found four independent factors associated with poly-progression in these patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicola Lambri, Damiano Dei, Victor Hernandez, Isabella Castiglioni, Elena Clerici, Chiara De Philippis, Daniele Loiacono, Pierina Navarria, Giacomo Reggiori, Roberto Rusconi, Stefano Tomatis, Stefania Bramanti, Marta Scorsetti, Pietro Mancosu
Summary: The impact of the planner's experience and optimization algorithm on the plan quality and complexity of TMLI delivered by VMAT was assessed. The study found that plan complexity significantly reduced over time, and there were significant differences in plan complexity and dosimetric quality among different algorithms. Knowledge-based models improved the dosimetric results to the organs at risk. In conclusion, the planner's experience and algorithm version are crucial for achieving an optimal plan quality in TMLI plans.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2023)
Article
Oncology
Pierina Navarria, Federico Pessina, Giuseppe Minniti, Ciro Franzese, Beatrice Marini, Giuseppe D'agostino, Marco Badalamenti, Luca Raspagliesi, Giacomo Reggiori, Francesca Lobefalo, Laura Fariselli, Davide Franceschini, Luisa Bellu, Elena Clerici, Valentina Pinzi, Marta Scorsetti
Summary: Around 2-15% of primary renal cell carcinoma patients will develop brain metastases. The prognosis of brain metastatic RCC patients is poor and determining the optimal local therapeutic approach is a challenge. A retrospective multi-institutional study was conducted to assess the efficacy of local treatments and identify prognostic factors. The study confirmed the efficacy and safety of SRS/HSRS and found that patients with specific characteristics had a better outcome.
Article
Oncology
Damiano Dei, Nicola Lambri, Sara Stefanini, Veronica Vernier, Ricardo Coimbra Brioso, Leonardo Crespi, Elena Clerici, Luisa Bellu, Chiara De Philippis, Daniele Loiacono, Pierina Navarria, Giacomo Reggiori, Stefania Bramanti, Marcello Rodari, Stefano Tomatis, Arturo Chiti, Carmelo Carlo-Stella, Marta Scorsetti, Pietro Mancosu
Summary: The contouring of lymph node clinical target volume (CTV_LN) in total marrow and lymph node irradiation (TMLI) is complex and time-consuming. The introduction of internal guidelines reduced inter- and intraobserver variability in CTV_LN delineation. The guidelines improved the consistency of contouring in TMLI treatments.
Review
Health Care Sciences & Services
Ciro Franzese, Damiano Dei, Nicola Lambri, Maria Ausilia Teriaca, Marco Badalamenti, Leonardo Crespi, Stefano Tomatis, Daniele Loiacono, Pietro Mancosu, Marta Scorsetti
Summary: This review provides a comprehensive description of the applications of artificial intelligence (AI) tools in the radiotherapy (RT) process for head and neck cancer (HNC). The majority of the selected studies focused on the segmentation of organs at risk (OARs), while limited research was found on the impact of AI on clinical outcomes. It is suggested that future studies should be conducted by interdisciplinary groups, including clinicians and computer scientists, to ensure the effective alignment of AI technologies with clinical needs in RT.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Giulia Marvaso, Federico Mastroleo, Giulia Corrao, Mattia Zaffaroni, Maria Giulia Vincini, Paolo Borghetti, Francesco Cuccia, Manuela Federico, Giampaolo Montesi, Antonio Pontoriero, Davide Franceschini, Ciro Franzese, Marta Scorsetti, Barbara Alicja Jereczek-Fossa
Summary: The concept of oligometastatic state has revolutionized our understanding of cancer metastasis and progression, with ongoing research efforts to develop new treatment options. This study presents a bibliometric analysis of the oligometastatic disease/state, providing a comprehensive overview of the topic. A total of 3304 documents from 1995 to 2022 were analyzed, revealing the top keywords used by authors and identifying emerging themes and trends. This analysis serves as a valuable resource for researchers worldwide and highlights the significant scientific progress in the field of oligometastatic state.
Article
Oncology
Ciro Franzese, Stefano Tomatis, Sofia Paola Bianchi, Marco Pelizzoli, Maria Ausilia Teriaca, Marco Badalamenti, Tiziana Comito, Elena Clerici, Davide Franceschini, Pierina Navarria, Luciana Di Cristina, Damiano Dei, Carmela Galdieri, Giacomo Reggiori, Pietro Mancosu, Marta Scorsetti
Summary: Adaptive radiotherapy can help manage anatomical changes in head-neck cancer patients during radiotherapy and ensure adequate dose coverage and organ protection. This study investigated the effects of adaptive radiotherapy on patients treated with volumetric-modulated arc radiation therapy compared to simulated non-adaptive plans.