Review
Endocrinology & Metabolism
John P. Bilezikian, Aliya A. Khan, Shonni J. Silverberg, Ghada El-Hajj Fuleihan, Claudio Marcocci, Salvatore Minisola, Nancy Perrier, Antonio Sitges-Serra, Rajesh Thakker, Gordon Guyatt, Michael Mannstadt, John T. Potts, Bart L. Clarke, Maria Luisa Brandi
Summary: The last international guidelines on the evaluation and management of primary hyperparathyroidism (PHPT) were published in 2014. New research since then has led to new insights in epidemiology, pathophysiology, diagnosis, measurements, genetics, outcomes, presentations, new imaging modalities, target and other organ systems, pregnancy, evaluation, and management. An international group of experts reviewed these advances in knowledge and provided evidence-based recommendations and guidelines for the evaluation and management of PHPT.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Aliya A. Khan, Mishaela R. Rubin, Peter Schwarz, Tamara Vokes, Dolores M. Shoback, Claudia Gagnon, Andrea Palermo, Claudio Marcocci, Bart L. Clarke, Lisa G. Abbott, Lorenz C. Hofbauer, Lynn Kohlmeier, Susanne Pihl, Xuebei An, Walter Frank Eng, Alden R. Smith, Jenny Ukena, Christopher T. Sibley, Aimee D. Shu, Lars Rejnmark
Summary: TransCon PTH demonstrated efficacy in maintaining normocalcemia and allowing independence from conventional therapy in individuals with hypoparathyroidism. The treatment also showed significant improvements in health-related quality of life and hypoparathyroidism-related symptoms.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Aliya A. Khan, John P. Bilezikian, Maria Luisa Brandi, Bart L. Clarke, Neil J. Gittoes, Janice L. Pasieka, Lars Rejnmark, Dolores M. Shoback, John T. Potts, Gordon H. Guyatt, Michael Mannstadt
Summary: This clinical practice guideline provides evidence-based recommendations for the prevention, diagnosis, and management of hypoparathyroidism. Evaluating serum PTH within 12 to 24 hours post total thyroidectomy can predict the development of permanent postsurgical hypoparathyroidism. Genetic testing may be helpful for individuals with nonsurgical hypoparathyroidism.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Charles Ginsberg, Andrew N. Hoofnagle, Ronit Katz, Jan Hughes-Austin, Lindsay M. Miller, Jessica O. Becker, Stephen B. Kritchevsky, Michael G. Shlipak, Mark J. Sarnak, Joachim H. Ix
Summary: Among a diverse cohort of community-dwelling older adults, a lower VMR was more strongly associated with both loss of bone mineral density (BMD) and fracture risk compared with 25(OH)D-3. Further trials are needed to evaluate the VMR as a therapeutic target in individuals at risk for worsening BMD and fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Kelly L. Roszko, Tiffany Y. Hu, Lori C. Guthrie, Beth A. Brillante, Michaele Smith, Michael T. Collins, Rachel Gafni
Summary: Patients with hypoparathyroidism experience poor quality of life, including fatigue and brain fog. Treatment with PTH 1-34 had limited and non-sustained effects on improving quality of life, inconclusive changes in fatigue experience, and no change in the 6-minute walk test.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Zhikang Ye, Shonni J. Silverberg, Ashwini Sreekanta, Kyle Tong, Ying Wang, Yaping Chang, Mengmeng Zhang, Gordon Guyatt, Wimonchat Tangamornsuksun, Yi Zhang, Veena Manja, Layla Bakaa, Rachel J. Couban, Maria Luisa Brandi, Bart Clarke, Aliya A. Khan, Michael Mannstadt, John P. Bilezikian
Summary: This systematic review examines the efficacy and safety of medical therapy and surgery in patients with asymptomatic primary hyperparathyroidism (PHPT). Medical therapies such as alendronate, denosumab, vitamin D, and estrogen therapy can increase bone density, while cinacalcet may reduce serum calcium and parathyroid hormone levels. Surgery can achieve biochemical cure in patients with asymptomatic PHPT.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
John P. Bilezikian, Shonni J. Silverberg, Francisco Bandeira, Filomena Cetani, Manju Chandran, Natalie E. Cusano, Peter R. Ebeling, Anna Maria Formenti, Morten Frost, Jessica Gosnell, E. Michael Lewiecki, Frederick R. Singer, Neil Gittoes, Aliya A. Khan, Claudio Marcocci, Lars Rejnmark, Zhikang Ye, Gordon Guyatt, John T. Potts
Summary: This article summarizes new information on the management of primary hyperparathyroidism, covering aspects such as evaluation, diagnosis, epidemiology, and genetics. Through systematic reviews and narrative reviews, it provides the most comprehensive information available to date.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Iris R. Hartley, Rachel Gafni, Kelly L. Roszko, Sydney M. Brown, Luis F. de Castro, Amanda Saikali, Carlos R. Ferreira, William A. Gahl, Karel Pacak, Jenny E. Blau, Alison M. Boyce, Isidro B. Salusky, Michael T. Collins, Pablo Florenzano
Summary: Measurement of fibroblast growth factor-23 (FGF23) is crucial for the evaluation of patients with phosphate homeostasis disorders. Existing laboratory reference ranges may lead to misdiagnosis in FGF23-mediated hypophosphatemia patients, so it is important to determine diagnostic FGF23 levels for these patients. By studying patients with different types of hypophosphatemia, we established cut-off levels for intact FGF23 (iFGF23) and C-terminal FGF23 (cFGF23) that accurately distinguish between FGF23-mediated and FGF23-independent hypophosphatemia.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Monica Reyes, Masayo Kagami, Sayaka Kawashima, Johanna Pallotta, Dirk Schnabel, Maki Fukami, Harald Juppner
Summary: Pseudohypoparathyroidism type Ib (PHP1B) is a rare disorder characterized by methylation loss at GNAS exon A/B, leading to resistance to parathyroid hormone. A PHP1B patient was found to have a de novo genomic GNAS duplication of approximately 88 kb, associated with methylation restricted to exon A/B.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
M. Jimenez, D. Ivanovic-Zuvic, C. Loureiro, C. A. Carvajal, G. Cavada, P. Schneider, E. Gallardo, C. Garcia, G. Gonzalez, O. Contreras, M. T. Collins, P. Florenzano
Summary: The most comprehensive clinical and molecular characterization of XLH patients performed in Chile showed high prevalence of musculoskeletal burden and pain, associated with significantly impaired physical capacity and quality of life. These findings suggest a significant unmet need and can inform care for XLH patients in similarly socioeconomically defined countries.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Yasuo Imanishi, Nobuaki Ito, Yumie Rhee, Yasuhiro Takeuchi, Chan Soo Shin, Yutaka Takahashi, Hiroki Onuma, Masahiro Kojima, Masanori Kanematsu, Hironori Kanda, Yoshiki Seino, Seiji Fukumoto
Summary: Burosumab (KRN23) shows promising efficacy and tolerability in patients with TIO, effectively increasing serum phosphate levels, improving bone metabolism and pain, especially beneficial for patients who are not eligible for tumor resection.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Janice L. Pasieka, Kelly Wentworth, Caitlin T. Yeo, Serge Cremers, David Dempster, Seiji Fukumoto, Ravinder Goswami, Pascal Houillier, Michael A. Levine, Jesse D. Pasternak, Nancy D. Perrier, Antonio Sitges-Serra, Dolores M. Shoback
Summary: This article utilized a systematic review to investigate the etiologies and pathogenesis of hypoparathyroidism, with a particular focus on new knowledge about parathyroid gland viability and intraoperative parathyroid hormone monitoring. Non-surgical factors, especially genetic factors, play a significant role in hypoparathyroidism. Due to the widespread impact of PTH deficiency on multiple organ systems, the article provides a detailed review of skeletal, renal, neuromuscular, and ocular complications. The burden of illness on patients and their caregivers leads to reduced quality of life and increased social costs for this chronic endocrinopathy.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Karl Michaelsson, Liisa Byberg, Bodil Svennblad, Susanna C. Larsson, John A. Baron, Hakan Melhus
Summary: The study found that the association between serum 25-hydroxyvitamin D (S-25OHD) and fracture risk varies depending on season and fat mass. The relationship between low S-25OHD and fracture risk was only observed in women with high BMI during periods of seasonally high levels.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Ignacio Portales-Castillo, Petra Simic
Summary: Bone-mineral ion regulators, such as PTH, FGF23, Klotho, and 1,25(OH)2 vitamin D, play important roles in calcium and phosphate metabolism and cell signaling. These factors are tightly regulated through genetic, epigenetic, and post-translational mechanisms. Epigenetic mechanisms, including DNA methylation and histone modification, have been found to affect the function of these regulators.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Maria Victoria Pendon-Ruiz De Mier, Noemi Vergara, Cristian Rodelo-Haad, Maria Dolores Lopez-Zamorano, Cristina Membrives-Gonzalez, Rodrigo Lopez-Baltanis, Juan Rafael Munoz-Castaneda, Francisco Caravaca, Alejandro Martin-Malo, Arnold J. Felsenfeld, Eugenio J. De la Torre, Sagrario Soriano, Rafael Santamaria, Mariano Rodriguez
Summary: The study aimed to investigate the role of the P/UUN ratio in identifying patients with high inorganic phosphate intake, and found that the ratio can serve as a marker for inorganic phosphate intake. Patients with the highest P/UUN ratio were found to have a higher intake of inorganic phosphate.
Review
Urology & Nephrology
Rajiv Agarwal, James Burton, Maurizio Gallieni, Kamyar Kalantar-Zadeh, Gert Mayer, Carol Pollock, Jacek C. Szepietowski
Summary: Despite the limited increase in life expectancy for patients with end-stage kidney disease after the breakthrough of kidney replacement therapy, the quality of life and relief of symptoms have become increasingly important to patients. Currently, most dialysis-associated symptoms and adverse effects do not have approved treatments, and the few available treatments may add further adverse effects. This article demonstrates how understanding the pathophysiology of a particular symptom (chronic kidney disease-associated pruritus) in dialysis led to the development and regulatory approval of a treatment for that symptom. This approach can be applied to other dialysis-associated symptoms, improving the remaining years of patients' lives.
CLINICAL KIDNEY JOURNAL
(2023)
Editorial Material
Urology & Nephrology
Ekamol Tantisattamo, Ramy M. Hanna, Kamyar Kalantar-Zadeh
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2023)
Review
Urology & Nephrology
Ramy M. M. Hanna, Rebecca S. S. Ahdoot, Connie M. M. Rhee, Ekamol Tantisattamo, Fawaz Al Ammar, Kamyar Kalantar-Zadeh
Summary: A low protein diet is often recommended for the nutritional management of chronic kidney disease, but there is a need for more exploration of dietary recommendations for different types of renal patients. Proteinuria is a serious issue for renal disease patients, and nutritional strategies need to be explored to control proteinuria and inflammation, which is of great significance for the treatment of autoimmune kidney diseases such as glomerulonephritis.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2023)
Review
Urology & Nephrology
Dawn P. Edwards, Kamyar Kalantar-Zadeh, Elani Streja, Rebecca S. Ahdoot, Keith C. Norris, Donald Molony
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2023)
Review
Urology & Nephrology
Fawaz Al Ammary, Abimereki D. Muzaale, Ekamol Tantisattamoa, Ramy M. Hanna, Uttam G. Reddy, Suphamai Bunnapradist, Kamyar Kalantar-Zadeh
Summary: There has been a decrease in living kidney donation over the past two decades, particularly among low-income families and racial/ethnic minorities who face barriers to completing complex evaluations. Telemedicine, specifically the use of live-video visits, is seen as a potential solution to overcome these barriers and improve access to transplant centers for donor evaluation. However, providers perceive payor policy and out-of-state licensing as major obstacles to the growth of telemedicine.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2023)
Review
Urology & Nephrology
Maria Clarissa Tio, Tariq Shafi, Xiaoqian Zhu, Kamyar Kalantar-Zadeh, Alexandre Chan, Lee Nguyen
Summary: This review focuses on the evolution of GFR estimating equations, nuances in eGFR interpretation, and the utility of eGFR in drug dosing.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2023)
Review
Urology & Nephrology
Ekamol Tantisattamo, Kamyar Kalantar-Zadeh
Summary: Living donor kidney transplantation may lead to long-term complications, but dietary interventions have the potential to prevent them and improve the health outcomes of donors. Low protein and low sodium intake, as well as certain healthy dietary patterns, may help slow down the decline in kidney function. However, further research is needed to determine the optimal protein and sodium intake as well as the appropriate dietary patterns for living kidney donors.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2023)
Review
Urology & Nephrology
Dana Bielopolski, Elani Streja, Tali Steinmetz, Benaya Rozen-Zvi, Kamyar Kalantar-Zadeh
Summary: Assessing and estimating glomerular filtration rate (GFR) has been a long-standing challenge in medicine and public health. Current estimation formulas do not account for variations in body surface area (BSA) or metabolic rate compared to nephron number, and fail to define renal hyperfiltration accurately.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2023)
Editorial Material
Nutrition & Dietetics
Kamyar Kalantar-Zadeh, Rachelle Bross, Christina Wang, Linda W. Moore
JOURNAL OF RENAL NUTRITION
(2023)
Article
Transplantation
Juan Carlos Ayus, Kamyar Kalantar-Zadeh, Ekamol Tantisattamo, Connie M. Rhee, Armando L. Negri
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Nutrition & Dietetics
Mengjing Wang, Jiaying Zhang, Kamyar Kalantar-Zadeh, Jing Chen
Summary: Phosphorus is a crucial micromineral that plays a key role in cellular metabolism and tissue structure. The endocrine system coordinates the maintenance of serum phosphorus levels through the actions of hormones like FGF23, PTH, Klotho, and 1,25D. Phosphorus overload, characterized by higher than necessary phosphorus load, can be caused by diet, renal dysfunction, bone disease, dialysis insufficiency, and medications. Serum phosphorus remains the most commonly used indicator for phosphorus overload.
Article
Oncology
Kenji Ishikura, Kenji Omae, Sho Sasaki, Yugo Shibagaki, Satoko Ichioka, Yusuke Okuda, Kenichiro Koitabashi, Koichi Suyama, Takuro Mizukami, Chihiro Kondoh, Sumio Hirata, Takeshi Matsubara, Junichi Hoshino, Motoko Yanagita
Summary: Chronic kidney disease (CKD) is a disabling disorder with high incidence and prevalence in cancer survivors due to kidney damage caused by cancer and its treatment. Special attention should be given to the treatment of CKD and its complications in cancer survivors, considering their comorbidities, risk of cancer recurrence, limited physical function, and life expectancy. Shared decision-making should be adopted when selecting renal replacement therapies with sufficient information and evidence.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Nutrition & Dietetics
Valentin Faerber, Katharina S. Kuhn, Liliana Garneata, Kamyar Kalantar-Zadeh, Sahir Kalim, Dominic S. Raj, Martin Westphal
Summary: In chronic kidney disease (CKD), a protein-restricted diet with essential amino acid (EAA) and their ketoanalogues (KA) supplementation can delay disease progression and improve clinical outcomes. This approach improves nitrogen balance and other metabolic disturbances, and also modulates gut dysbiosis and reduces the generation of gut-derived uremic toxins. Lowering urea levels can contribute to decreased morbidity and mortality, possibly through reducing protein carbamylation. Further studies are needed to investigate the effects on the gut microbiome, uremic toxin generation, and carbamylation markers.
Article
Medicine, General & Internal
Rebecca S. Ahdoot, Jui-Ting Hsiung, Abiy Agiro, Yasmin G. Brahmbhatt, Kerry Cooper, Souhiela Fawaz, Laura Westfall, Kamyar Kalantar-Zadeh, Elani Streja
Summary: Liver disease is commonly associated with potassium imbalance, but its role as a risk factor for hyperkalemia is not well-established. This study aimed to investigate the relationship between liver disease and recurrent hyperkalemia. The results showed that patients with liver disease had a significantly higher risk of recurrent hyperkalemia within one year after the initial event.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Praveen K. Potukuchi, Hamid Moradi, Frank Park, Cameron Kaplan, Fridtjof Thomas, Ankur A. Dashputre, Keiichi Sumida, Miklos Z. Molnar, Abduzhappar Gaipov, Justin D. Gatwood, Connie Rhee, Elani Streja, Kamyar Kalantar-Zadeh, Csaba P. Kovesdy
Summary: This observational study found no association between cannabis use and the risk of acute kidney injury in patients with advanced chronic kidney disease.
CANNABIS AND CANNABINOID RESEARCH
(2023)