Article
Medicine, General & Internal
Hugo Babel, Patrick Omoumi, Killian Cosendey, Hugues Cadas, Brigitte M. Jolles, Julien Favre
Summary: This study introduced a new method to standardize three-dimensional bone mineral density quantification in the knee using computed tomography and computational anatomy algorithms. The method showed excellent reliability and adequate reproducibility, making it suitable for research and clinical applications. Additionally, the method could potentially be adapted to quantify other bone parameters in three dimensions based on CT images or images acquired using different modalities.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Yogesh Deepak Bansod, Maeruan Kebbach, Daniel Kluess, Rainer Bader, Ursula van Rienen
Summary: The study investigates bone remodeling under electromechanical stimulation, demonstrating an increase in bone density as a result of electrical stimulation that could potentially replace mechanical loads during daily physical activities to minimize bone loss.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Orthopedics
Keith A. Knurr, Stephanie A. Kliethermes, Colten R. Haack, Justin S. Olson, Neil C. Binkley, Tamara A. Scerpella, Bryan C. Heiderscheit
Summary: This study evaluated the bilateral changes in femur and tibia bone mineral density (BMD) in collegiate athletes before and after ACL reconstruction. The results showed that BMD deficits persisted at the distal femur of the surgical limb 24 months after ACLR. However, there were no significant differences in other regions of both limbs.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Medicine, General & Internal
Xin Zheng, Yanyan Qi, Hongjun Zhou, Haiqiong Kang, Yanming Tone, Lina Bi
Summary: This study found that bone mineral density (BMD) at the distal femur (DF), proximal tibia (PT), and hip in spinal cord injury (SCI) patients significantly decreased during the first year post-injury, with the most rapid loss occurring at the PT and DF compared to the hip. Age, gender, and 25OHD were identified as influencing factors on BMD levels.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Sola Kim, JaeJoon Hwang, Bong-Hae Cho, Yujin Kim, Jae-Yeol Lee
Summary: This study evaluated bone volume change at donor sites in patients who underwent mandibular body bone block grafts using intensity-based automatic image registration. The results showed that the mean regenerated bone volume on follow-up images (4 months after surgery) was 34.87% +/- 17.11% compared to the original bone volume. The pixel value rate of the follow-up images was also significantly different from the pre-operation images. The study concluded that a longer follow-up period may be necessary for a second bone harvesting.
APPLIED SCIENCES-BASEL
(2022)
Article
Orthopedics
Yuqi Zhang, Minxun Lu, Li Min, Jie Wang, Yitian Wang, Yi Luo, Yong Zhou, Hong Duan, Chongqi Tu
Summary: This study describes the design and surgical techniques of three-dimensional-printed porous implants for proximal giant cell tumors of bone and evaluates the short-term clinical outcomes. Results showed no surgical related complications in the short term, successful osseointegration between bone and implants, and significant improvement in functional scores postoperatively.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Elena Merkuryeva, Tatiana Markova, Anton Tyurin, Diana Valeeva, Vladimir Kenis, Maria Sumina, Igor Sorokin, Olga Shchagina, Mikhail Skoblov, Maria Nefedova, Rita Khusainova, Ekaterina Zakharova, Elena Dadali, Sergey Kutsev
Summary: Calvarial doughnut lesions (CDL) with bone fragility is a rare autosomal dominant skeletal disorder characterized by low bone mineral density, fractures, and specific sclerotic lesions of the cranial bones. The disease is caused by pathogenic variants in the SGMS2 gene, with a recurrent variant c.148C>T (p.Arg50Ter) identified in multiple families. The phenotypic variability in patients with this variant highlights the importance of considering it in the diagnosis of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Tiina Savikangas, Sarianna Sipila, Timo Rantalainen
Summary: The study found that light physical activity may help decelerate bone loss in older adults who do not meet physical activity recommendations, while the amount of high impact activity may be insufficient to stimulate bone remodelling in this population.
Article
Pediatrics
Ge Yang, Siyu Xu, Haibo Mei, Guanghui Zhu, Yaoxi Liu, Qian Tan, Hui Yu
Summary: This study found that children with congenital pseudarthrosis of the tibia (CPT) have lower bone strength compared to children with non-metabolic diseases. The severity of CPT, as indicated by the CPT Crawford classification, is negatively correlated with bone strength. This phenomenon is not related to neurofibromatosis type 1 (NF1).
FRONTIERS IN PEDIATRICS
(2022)
Review
Endocrinology & Metabolism
Y. Zhang, Z. Tian, S. Ye, Q. Mu, X. Wang, S. Ren, X. Hou, W. Yu, J. Guo
Summary: The study found that individuals with Down syndrome have significantly lower bone mineral density in total body and different regions (hip, lumbar spine, and femoral neck) compared to controls. It also showed a decreasing trend in lumbar spine volumetric bone mineral density and an elevated femoral neck volumetric bone mineral density in Down syndrome individuals versus controls.
OSTEOPOROSIS INTERNATIONAL
(2022)
Review
Pharmacology & Pharmacy
Jiangbi Li, Yang Sun, Zhuo Chen, Xiaoping Xie, Feng Gu, Songqi Bi, Tiecheng Yu
Summary: This review examined the effects of bisphosphonates on bone density, fractures, and bone markers in osteopenic older women. The study found that bisphosphonates had significant positive effects on bone density and bone markers, as well as reducing the risk of fractures. However, further research is needed to determine their safety.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Saad Mohammed AlQahtani
Summary: Nowadays, dental implant is widely used in oral rehabilitation, and its success relies on bone density. Cone-beam computed tomography (CBCT) is a well-known method for measuring bone mineral density (BMD) through grayscale values on 3-D images. This study aimed to analyze bone density using CBCT and test its reliability and reproducibility. The results showed that CBCT can be a valuable technique in estimating bone density.
Review
Clinical Neurology
Jeffrey W. Chen, Martin G. McCandless, Archis R. Bhandarkar, Patrick M. Flanigan, Nikita Lakomkin, Anthony L. Mikula, Giorgos D. Michalopoulos, Mohamad Bydon
Summary: This study found that low preoperative bone mineral density and a diagnosis of osteoporosis were associated with higher postoperative proximal junctional kyphosis (PJK) risk. Additionally, lower Hounsfield units (HU) on computed tomography (CT) at the upper instrumented vertebra (UIV) were identified as significant risk factors for postoperative PJK. These findings suggest the importance of considering preoperative bone mineral density in assessing PJK risk among patients with adult spinal deformity (ASD).
JOURNAL OF NEUROSURGERY-SPINE
(2023)
Review
Nutrition & Dietetics
Elham Kazemian, Ali Pourali, Fatemeh Sedaghat, Mehrdad Karimi, Vahid Basirat, Zohreh Sajadi Hezaveh, Sayed Hossein Davoodi, Michael F. Holick
Summary: A systematic review and meta-analysis evaluated the effects of vitamin D-3 supplementation on bone health in adults. The results showed a protective effect of vitamin D-3 supplementation on bone mineral density (BMD) at the lumbar spine, femoral neck, and total hip. Dose-response analysis revealed a linear relationship between vitamin D-3 supplementation doses and BMD. However, no significant effect of vitamin D-3 supplementation on whole-body or total hip BMD was found. The relationship between vitamin D-3 supplement doses and markers of bone turnover was nonlinear.
Article
Immunology
Ming-Han Chen, Shan-Fu Yu, Jia-Feng Chen, Wei-Sheng Chen, The-Ling Liou, Chung-Tei Chou, Chung-Yuan Hsu, Han-Ming Lai, Ying-Chou Chen, Chang-Youh Tsai, Tien-Tsai Cheng
Summary: The study compared the impact of different treatment regimens for rheumatoid arthritis on patients' bone mineral density, finding that abatacept may have a better effect in preserving bone density. Anti-osteoporosis therapy can prevent systemic bone loss in patients regardless of the type of rheumatoid arthritis treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Thomas Huegle, Sonia Nasi, Driss Ehirchiou, Patrick Omoumi, Alexander So, Nathalie Busso
Summary: This study describes the mechanisms by which fibrin directly mediates cartilage degeneration and finds that fibrin deposits are associated with the severity of cartilage damage. Fibrin impairs cartilage integrity through a triad of catabolism, adhesion, and calcification.
Review
Radiology, Nuclear Medicine & Medical Imaging
Shivani Ahlawat, Patrick Debs, Behrang Amini, Frederic E. Lecouvet, Patrick Omoumi, Daniel E. Wessell
Summary: Whole-body MRI (WB-MRI) is increasingly being used for screening and staging of malignancies in high-risk individuals. It is also being explored as a technique for detecting metastatic disease in patients with visceral malignancies. WB-MRI has shown potential utility in evaluating disease extent and treatment response in non-oncologic conditions as well.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Tom Hilbert, Patrick Omoumi, Marcus Raudner, Tobias Kober
Summary: This review provides an overview of the existing techniques and methods for generating synthetic contrasts from magnetic resonance imaging data, with a focus on musculoskeletal MRI. The approaches are categorized into three methodological groups: mathematical image transformation, physics-based, and data-driven approaches. Each group is characterized and examples are provided, along with a brief overview of their clinical validation, when available. The advantages, disadvantages, and caveats of synthetic contrasts are discussed, with a focus on image information preservation, validation, and aspects of the clinical workflow.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Acoustics
Sandra Marcadent, Johann Heches, Julien Favre, David Desseauve, Jean-Philippe Thiran
Summary: The article presents a method for calibrating 3-D freehand ultrasound systems using phantoms with parallel wires to form perpendicular planes. The algorithm co-optimizes the phantom pose and calibration, eliminating the need for precise phantom tracking. A geometrical analysis is provided to explain the proposed acquisition protocol. The system accuracy and precision are evaluated based on measurements acquired on an independent test phantom, with error norms of 1.6 mm at depths up to 6 cm and 3.5 mm between 6 and 14 cm. The study concludes that ultrasound tracked-probe systems can be calibrated with reasonable accuracy using a commercially available general-purpose phantom.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Neurosciences
Julian Madrid, Baptiste Ulrich, Alejandro N. Santos, Brigitte M. Jolles, Julien Favre, David H. Benninger
Summary: This study compared the spatiotemporal parameters of young and elderly healthy adults during 90°, 180°, and 360° turns. The results showed that elderly adults were slower, required more steps and time for larger amplitude turns compared to young adults. Cadence did not differ between age groups or turning amplitudes. The spatial parameters were smaller and temporal parameters enhancing stability were larger in elderly adults, especially for turns with larger amplitudes. The study highlights the importance of considering age-related differences and turning amplitude in rehabilitation protocols for the elderly.
Article
Biophysics
Baptiste Ulrich, Luis C. Pereira, Brigitte M. Jolles, Julien Favre
Summary: Shortening stride length has been proposed for gait retraining in medial knee osteoarthritis, but its effects have not been assessed in this patient population. This study found that reducing stride length can decrease knee adduction and flexion moments in some patients with medial knee osteoarthritis. Further research is needed to explore dose-response relationships and long-term effects, but these findings suggest that stride length modifications could be easily incorporated into rehabilitation protocols.
JOURNAL OF BIOMECHANICS
(2023)
Article
Medicine, General & Internal
Guillaume Jaques, Baptiste Ulrich, Laurent Hoffmann, Brigitte M. M. Jolles, Julien Favre
Summary: Using insoles to modify walking biomechanics for knee osteoarthritis treatment has been highly researched. However, current insole interventions mainly focus on reducing the peak of the knee adduction moment (pKAM) and have inconsistent clinical outcomes. This study evaluated the effects of different insoles on various gait variables related to knee osteoarthritis and emphasized the importance of considering multiple variables instead of solely focusing on pKAM. The results showed that different insoles had significant effects on gait variables with high variability among patients, and personalized interventions are recommended to address inter-patient variability.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Baptiste Ulrich, Jennifer C. Erhart-Hledik, Jessica L. Asay, Patrick Omoumi, Thomas P. Andriacchi, Brigitte M. Jolles, Julien Favre
Summary: This study analyzed knee moment parameters of 98 individuals with different medial knee osteoarthritis severity and found that 6 parameters showed significant differences among severity groups, and 5 parameters were significantly correlated with disease severity. A reliable severity index was also proposed, which could be used to assess knee moments comprehensively.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simon Kuhn, Aurelien Bustin, Aicha Lamri-Senouci, Simone Rumac, Jean-Baptiste Ledoux, Roberto Colotti, Jessica A. M. Bastiaansen, Jerome Yerly, Julien Favre, Patrick Omoumi, Ruud B. van Heeswijk
Summary: In this study, an isotropic three-dimensional (3D) T2 mapping technique was developed for the quantitative assessment of knee cartilage composition with high accuracy and precision. Improved accuracy and precision were demonstrated by using patch-based image denoising and dictionary-based reconstruction for T2 mapping of knee cartilage.
EUROPEAN RADIOLOGY EXPERIMENTAL
(2023)
Correction
Radiology, Nuclear Medicine & Medical Imaging
Patrick Omoumi, Bruno Vande Berg
SEMINARS IN MUSCULOSKELETAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bruno C. Vande Berg, Charbel Mourad, Patrick Omoumi, Jacques Malghem
Summary: This review examines the hypothetical association between accelerated bone remodeling and bone marrow edema (BME)-like signal intensity on magnetic resonance imaging, based on literature and clinical arguments. BME-like signal is defined as a confluent ill-delimited area of bone marrow with specific signal characteristics on certain imaging sequences. It is suggested that these BME-like patterns, with their distinct distribution and signal features, are linked to accelerated bone remodeling. The limitations in recognizing these patterns are also discussed.
SEMINARS IN MUSCULOSKELETAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Charbel Mourad, Aurelio Cosentino, Marie Nicod Lalonde, Patrick Omoumi
Summary: This article summarizes that conventional magnetic resonance imaging (MRI) is the preferred technique for imaging bone marrow, but new MRI techniques and nuclear medicine techniques have emerged in recent decades. The technical bases of these methods are presented in relation to common physiological and pathological processes involving the bone marrow. The strengths and limitations of these imaging methods are discussed, as well as their added value compared to conventional imaging in assessing non-neoplastic disorders. The potential usefulness of these methods in differentiating between benign and malignant bone marrow lesions is also discussed, along with the limitations hindering their widespread use in clinical practice.
SEMINARS IN MUSCULOSKELETAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Charbel Mourad, Patrick Omoumi, Bruno Vande Berg
Summary: Depending on the age and location within the skeleton, bone marrow can be mostly fatty or hematopoietic, and both types can be affected by marrow necrosis.Fatty marrow necrosis is detected by a specific finding on T1-weighted images, while collapse is a common complication of epiphyseal necrosis and can be detected through various imaging techniques. Nonfatty marrow necrosis is less frequently diagnosed and is poorly visible on T1-weighted images, but can be detected on fluid-sensitive images or by lack of enhancement after contrast injection. Pathologies historically misnamed as osteonecrosis but do not share the same features as marrow necrosis are also highlighted.
SEMINARS IN MUSCULOSKELETAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ophelye Chiabai, Sandy Van Nieuwenhove, Marie-Christiane Vekemans, Bertrand Tombal, Frank Peeters, Joris Wuts, Perrine Triqueneaux, Patrick Omoumi, Thomas Kirchgesner, Nicolas Michoux, Frederic E. Lecouvet
Summary: This study compared the diagnostic accuracy of a single T2 Dixon sequence to the combination of T1+STIR sequences for detecting tumoral bone marrow lesions in whole-body MRI. The results showed that the T2 Dixon sequence with fat+water reconstructions had similar reproducibility and diagnostic accuracy as the recommended combination of T1+STIR sequences, and it can save significant time.
EUROPEAN RADIOLOGY
(2023)
Review
Rheumatology
Daichi Hayashi, Frank W. W. Roemer, Thomas Link, Xiaojuan Li, Feliks Kogan, Neil A. A. Segal, Patrick Omoumi, Ali Guermazi
Summary: The OA research community advocates for a shift from radiography-based criteria to MRI-based definition in OA clinical trials. Various evaluation tools and advanced technologies, including PET-MRI and AI, have been introduced in osteoarthritis imaging, aiming to improve precision and reproducibility in image interpretation.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)