Journal
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
Volume 25, Issue 8, Pages 1107-1116Publisher
SPRINGER
DOI: 10.1007/s00775-020-01827-7
Keywords
Re(I) complex; Cytotoxicity; Mitochondria; Apoptosis
Funding
- National Natural Science Foundation of China [21101034]
- Science and Technology Plan of Guangdong Province [2016A020217020]
- Scientific Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine [20182070]
- Group-type special support project for Education Talents in University [4SG19045G, 4SG19053G, 4SG19057G]
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As the powerhouse of a cell, mitochondria maintain energy homeostasis, synthesize ATP via oxidative phosphorylation, generate ROS signaling molecules, and modulate cell apoptosis. Herein, three Re(I) complexes bearing guanidinium derivatives have been synthesized and characterized. All of these complexes exhibit moderate anticancer activity in HepG2, HeLa, MCF-7, and A549 cancer cells. Mechanism studies indicate that complex 3, [Re(CO)3(L)(Im)](PF6)(2), can selectively localize in the mitochondria and induce cancer cell death through mitochondria-associated pathways. In addition, complex 3 can effectively depress the ability of cell migration, cell invasion, and colony formation. [GRAPHICS] .
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