Antimicrobial resistance phenotypes and genotypes ofStreptococcus suisisolated from clinically healthy pigs from 2017 to 2019 in Jiangxi Province, China

Aims This study aimed to investigate the antimicrobial resistance (AMR) profiles and genotypes ofStreptococcus suisfrom Jiangxi Province, China. Methods and Results A total of 314 nasal swab samples were collected from clinically healthy pigs, with a positive isolation rate ofS. suisof 34 center dot 08%. Antimicrobial susceptibility testing showed that more than 80% of the isolates were susceptible to vancomycin, penicillin, minocycline and chloramphenicol. A high frequency of resistance to clindamycin, tetracycline, clarithromycin and erythromycin was observed. All of the isolates were resistant to three or more categories of antimicrobials. Theerm(B) andtet(O) served as the most frequent genotypes that contributed to lincosamide, macrolide and tetracycline resistances. A part of macrolide-resistant genotypes could not exhibit specific phenotypes. Finally, integrative and conjugative elements (ICEs) were identified in 28 center dot 97% of the isolates. Conclusions The multidrug resistance ofS. suishas widely emerged in Jiangxi Province. The most prevalent resistance genes and genotypes were similar to those in other regions or countries. The presence of ICEs is increasing the risk of horizontal transfer of AMR genes. Significance and Impact of the Study The findings could provide guidance for the rational use of antimicrobial drugs and be helpful for monitoring the AMR information ofS. suisin China.

Automated summary

This study investigated the antimicrobial resistance profiles and genotypes of Streptococcus suis in Jiangxi Province, China. The findings revealed the widespread emergence of multidrug-resistant strains, with prevalent resistance genes and genotypes similar to other regions or countries. The presence of integrative and conjugative elements (ICEs) is increasing the risk of horizontal transfer of antimicrobial resistance genes.