Article
Food Science & Technology
Naihui Dong, Siyu Xue, Hui Guo, Kexin Xiong, Xinping Lin, Huipeng Liang, Chaofan Ji, Zhiguo Huang, Sufang Zhang
Summary: A novel ethyl carbamate hydrolase (ECH) with high specificity to EC was discovered, and immobilization was used to enhance its stability and tolerance. The study also found that immobilized ECH can effectively reduce the concentration of EC in liquor, with minimal impact on flavor substances.
Article
Chemistry, Analytical
Janira Jaen, Celia Domeno, Pilar Alfaro, Cristina Nerin
Summary: The study aimed to select and identify the best markers of aromatic hydrocarbon mineral oil (MOAH) in food packaging. Various mineral oils were analyzed and markers were confirmed through mass spectrometry in different samples, showing contamination in recycled PET and cardboard but not in couscous and semolina packaging.
Article
Environmental Sciences
Yongjun Xiao, Wen Yee Wong, Li Yan Chan, Chee Keat Yong, Kosuke Abe, Peter Hancock, Simon Hird
Summary: Despite worldwide restrictions, phthalates remain a health concern, particularly in edible oil and fatty food. The commonly used GC-MS method for phthalate analysis suffers from sensitivity and selectivity issues. This study developed a simple and quick method using APGC-MS/MS for determining phthalates in vegetable oil, achieving suitable method quantitation limits for dietary exposure investigation.
Article
Environmental Sciences
Qingya Xu, Taoze Liu, Bangyu Liu, Hongguang Cheng, Cheng Yang, Bing Wang, Andrew R. Zimmerman, Bin Gao
Summary: This study investigated the effects of hydrothermal treatment on the nutrient composition of hydrothermal liquid products (HLPs) derived from different distillers grains. The results showed that increasing the temperature of hydrothermal treatment led to higher pH, dissolved organic carbon content, and aromaticity in the HLPs, while decreasing electrical conductivity. The maximum extraction efficiencies for NH4+-N, NO3--N, and PO43- were found to be 92.0%, 89.9%, and 94.3%, respectively. The optimal conditions for nutrient extraction efficiency were determined to be a hydrothermal treatment temperature of 200 degrees C for 1 hour with a solid-liquid ratio of 10%. Comparative studies demonstrated that the HLPs have suitable nutritional value for agricultural use, and substituting synthetic fertilizers with HLPs could enhance the sustainability and profitability of farming.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Pharmacology & Pharmacy
Hui Wang, Jian-Ying Dai, Yu-Zhen He, Zhe-Wei Xia, Xiao-Fei Chen, Zhan-Ying Hong, Yi-Feng Chai
Summary: This study examined the therapeutic effect and mechanism of Anemarrhenae Rhizoma (AR) on AD model rats using serum metabolomics. The results showed that AR significantly affected the levels of multiple metabolites involved in various metabolic pathways in the serum of AD model rats. These findings were consistent with the results of behavior study, histopathological observations, and biochemical analyses, providing a scientific basis for the application of AR in the prevention and treatment of AD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Sunghyeon Jung, Seungmin Kim, Inhwan Kim, Myung-Sub Chung, BoKyung Moon, Sangah Shin, Jihyun Lee
Summary: This study estimated the EC content in 145 alcoholic beverages in Korea, with stone fruit-containing beverages showing higher EC levels. Soju and beer were found to be the main contributors to EC exposure in the Korean population. The risk of EC exposure differed between average drinkers and heavy drinkers in the Korean population.
Article
Chemistry, Applied
Mariana Rodrigues da Silva, Felipe Sanchez Bragagnolo, Renato Lajarim Carneiro, Isabela de Oliveira Carvalho Pereira, Jose Antonio Aquino Ribeiro, Clenilson Martins Rodrigues, Rebecca E. Jelley, Bruno Fedrizzi, Cristiano Soleo Funari
Summary: This study conducted a comprehensive chemical investigation of coffee by-products, identifying a variety of bioactive compounds. Some compounds in the by-products even showed higher content than coffee beans, indicating potential economic and environmental benefits that can be explored.
Article
Food Science & Technology
Siyu Xue, Naihui Dong, Kexin Xiong, Hui Guo, Yiwei Dai, Huipeng Liang, Yingxi Chen, Xinping Lin, Beiwei Zhu, Sufang Zhang
Summary: In this study, two Candida ethanolica strains (J1 and J116) capable of directly degrading ethyl carbamate (EC) were isolated and immobilized. These immobilized strains reduced EC concentrations in Chinese Baijiu by 42.27% and 27.91%, respectively. Furthermore, the main flavor substances in Chinese Baijiu were not affected by the presence of these strains, suggesting their potential for the treatment and commercialization of Chinese Baijiu.
Article
Chemistry, Applied
Harischandra R. Naik, M. S. Pallavi, M. Bheemanna, K. PavanKumar, V. Chandra Sekhara Reddy, Udaykumar R. Nidoni, M. Paramasivam, Satish Yadav
Summary: A method for simultaneous determination of 79 pesticide residues in pigeonpea has been developed and validated, with low LOD and LOQ, good recoveries, and applicability for routine monitoring purposes.
Article
Food Science & Technology
Jinlin Fan, Zheng Xiao, Wanwei Qiu, Chao Zhao, Chao Yi, Dongmei Lin, Zhanxi Lin
Summary: This study used GC-QTOF-MS metabolomics and multivariate statistical analysis to investigate the dynamic changes of metabolites during the fermentation of JUNCAO wine. It identified key metabolic pathways and differential metabolites, providing a comprehensive overview of metabolite changes during fermentation.
Article
Environmental Sciences
Yiyang Li, Nyuk Ling Ma, Huiling Chen, Jiateng Zhong, Dangquan Zhang, Wanxi Peng, Su Shiung Lam, Yafeng Yang, Xiaochen Yue, Lijun Yan, Ting Wang, Bjarne Styrishave, Tomasz Maciej Ciesielski, Christian Sonne
Summary: According to the World Health Organization, breast cancer is a common and serious health issue for women. This study focuses on searching for bioactive compounds from plants for breast cancer treatment. By screening plant extracts from Chinese ancient forests, the researchers identified potent extracts from Amur honeysuckle and Nigaki plants. Further experiments showed that these extracts significantly reduced tumor growth and killed breast cancer cells. The study also found that the extracts target and interact with known breast cancer genes, providing new insights for future cancer treatments.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Food Science & Technology
Srikanth Ponneganti, Upadhyayula Suryanarayana Murty, Chandrakant Bagul, Roshan M. Borkar, P. Radhakrishnananda
Summary: In this study, the chemical profile of Phlogacanthus thyrsiformis leaf extracts was analyzed, and their antioxidant and enzyme inhibitory potential were evaluated. The results showed that the chloroform extract had the highest total phenolic content and antioxidant activity, while the ethyl acetate extract exhibited the highest enzyme inhibition potential.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Applied
Ting Zeng, Baohua Fang, Fenglin Huang, Li Dai, Zhi Tang, Jinglin Tian, Guodong Cao, Xuanlin Meng, Yuanchen Liu, Bo Lei, Minghua Lu, Zongwei Cai
Summary: Through metabolomics analysis, it was found that under cadmium stress, most carbohydrates and amino acids were down-regulated as the cadmium concentration increased in rice grains, except for myoinositol which can prevent cadmium toxicity. D-Mannitol and L-cysteine were up-regulated in low-cadmium-accumulating rice with the increase of cadmium concentration. Organic acids, especially 13-(S)-hydroperoxy-9(Z),11(E),15(Z)-octadecatrienoic acid related to alphalinolenic acid metabolism and jasmonic acid production, were activated.
Article
Plant Sciences
Noga Sikron-Persi, Gila Granot, Albert Batushansky, David Toubiana, Gideon Grafi, Aaron Fait
Summary: A study on the petioles of perennial desert shrub Zygophyllum dumosum Boiss revealed a consistent seasonal pattern in petiole metabolism, involving organic acids, polyols, phenylpropanoids, sulfate conjugates, and piperazines. The metabolic changes were primarily related to the plant's development stage and its interaction with the environment, rather than specific environmental conditions.
Article
Food Science & Technology
Junlin Deng, Zhuoya Xiang, Changbin Lin, Yongqing Zhu, Kaijun Yang, Tinghui Liu, Chen Xia, Jian Chen, Wenhui Zhang, Yuhong Zhang, Boyu Zhu
Summary: In this study, phenolic fractions were extracted from grains of fourteen hulless barley varieties, revealing higher phenolic content and antioxidant capacity in the insoluble-bound fraction. Ferulic acid was identified as the dominant phenolic component in all varieties, while new phenolic compounds were also discovered in hulless barley for the first time. Additionally, the antioxidant activities were significantly contributed by total phenolic contents, ferulic acid, and luteolin, providing valuable insights into the phenolics in grains of hulless barley varieties.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Agronomy
Anna Levina, Owen Hoekenga, Mikhail Gordin, Corey Broeckling, Walter S. De Jong
Summary: The study used metabolomic profiling to analyze potato tubers, identifying associations between compositional features and SNP markers, with significant SNPs for glycoalkaloids distributed on chromosomes 2, 7, and 8.
Article
Cardiac & Cardiovascular Systems
Lars Lind, Samira Salihovic, Johan Sundstrom, Corey D. Broeckling, Patrik K. Magnusson, Jessica Prenni, Tove Fall, Johan Arnlov
Summary: Using plasma metabolomics, a novel biomarker for atrial fibrillation, 9-decenoylcarnitine, was identified. However, it is likely not causally related to atrial fibrillation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemical Research Methods
Corey D. Broeckling, Linxing Yao, Giorgis Isaac, Marisa Gioioso, Valentin Ianchis, Johannes P. C. Vissers
Summary: Metabolomics is a powerful platform for high-throughput analyses, primarily utilizing mass spectrometry for metabolite profiling. Recent advancements in coupling mass spectrometry with ion mobility spectrometry have shown potential for faster analysis time and improved resolution. This analysis uses a probabilistic approach to evaluate the strengths and limitations of the technology, highlighting the importance of orthogonality in resolving dimensions and the impact of metabolome composition on resolution demands.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2021)
Article
Biochemical Research Methods
Linxing Yao, Emily A. Davidson, Maliha W. Shaikh, Christopher B. Forsyth, Jessica E. Prenni, Corey D. Broeckling
Summary: Short-chain fatty acids (SCFAs) are volatile fatty acids produced by gut microbial fermentation of dietary nondigestible carbohydrates. This study presents a sensitive method for quantifying SCFAs through extraction with methyl tert-butyl ether after plasma/serum acidification. The method simplifies sample preparation, reduces contamination risk, and offers potential for automated sample preparation.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Genetics & Heredity
Lauren J. Brzozowski, Haixiao Hu, Malachy T. Campbell, Corey D. Broeckling, Melanie Caffe, Lucia Gutierrez, Kevin P. Smith, Mark E. Sorrells, Michael A. Gore, Jean-Luc Jannink
Summary: This study investigates the variation and genetic influence on the metabolite profiles of oats, specifically the seed metabolites with antioxidant properties. The research finds reduced genetic variation in modern oat germplasm compared to diverse germplasm, mainly due to increased seed size from intensive breeding. The abundance of avenanthramides, one of the specialized metabolites, increases with seed size, while avenacoside abundance decreases. The study highlights the importance of understanding how plant breeding influences plant traits and the genetic basis behind these changes.
G3-GENES GENOMES GENETICS
(2022)
Editorial Material
Biochemical Research Methods
Corey D. Broeckling
Summary: De novo structure generation from tandem mass spectrometry data will improve the annotation of unknown metabolomic signals.
Article
Developmental Biology
Giovana D. Catandi, Lance LiPuma, Yusra M. Obeidat, Lisa J. Maclellan, Corey D. Broeckling, Tom Chen, Adam J. Chicco, Elaine M. Carnevale
Summary: Short-term dietary supplementation can directly affect oocyte function in older mares, resulting in oocytes with increased metabolic activity, reduced lipid content, and increased developmental potential.
Article
Mycology
Franz J. Lichtner, Wayne M. Jurick, Michael Bradshaw, Corey Broeckling, Gary Bauchan, Kirk Broders
Summary: A Penicillium species belonging to section Lanata-Divaricata was isolated from crop production soils in south central Colorado. The isolate was identified as Penicillium raperi using morphological methods, metabolite analysis, scanning electron microscopy, and multi-locus sequencing phylogeny. It exhibited various growth characteristics and showed potential as a biological control agent against certain plant pathogens.
MYCOLOGICAL PROGRESS
(2022)
Article
Agriculture, Dairy & Animal Science
Jessie M. Overton, Lyndsey Linke, Roberta Magnuson, Corey D. Broeckling, Sangeeta Rao
Summary: The global threat posed by the resistance of pathogens to antimicrobial drugs is increasing. This study used metabolomic approaches to compare the metabolite expressions of antimicrobial-resistant Salmonella Typhimurium from different hosts. The results showed that antibiotic exposure affected the regulation of metabolites, regardless of the host species. Certain metabolic pathways and associated metabolites, known to be associated with antimicrobial resistance, could be potential targets for new drug discoveries and diagnostic methods.
Article
Developmental Biology
Sophie C. Walsh, Jeremy R. Miles, Corey D. Broeckling, Lea A. Rempel, Elane C. Wright-Johnson, Angela K. Pannier
Summary: This study identified potential mechanisms of porcine conceptus elongation, specifically changes in phospholipid and amino acid metabolic processes, as well as RGD-mediated elongation.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2023)
Article
Food Science & Technology
Jacqueline M. Chaparro, Rachel R. Jones, Susan B. Mitchell, Corey D. Broeckling, Adam L. Heuberger, Tracy Shafizadeh, Steven Watkins, Jessica E. Prenni
Summary: Sensitive, accurate, and comprehensive assessment of mineral element and metal content in food is crucial for nutrition and food safety recommendations. However, current methods described in the literature have limitations in terms of the measured elements, application to different food matrices, and instrument accessibility. In this study, an ICP-MS method is presented for simultaneous quantification of 26 elements, and its utility is demonstrated through analysis of 100 foods from plant and animal sources. The method allows measurement of elements with concentrations varying over 6 orders of magnitude, making it an efficient option for identifying suitable foods to address mineral nutrient deficiency and possible toxic element content assessment.
ACS FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Cell Biology
G. D. Catandi, D. R. Bresnahan, S. O. Peters, K. J. Fresa, L. J. Maclellan, C. D. Broeckling, E. M. Carnevale
Summary: Many age-related changes in metabolite abundance suggest impaired mitochondrial metabolic function and oxidative stress in oocytes and follicular cells. The results also indicate impaired transfer of carbohydrate and free fatty acid substrates from cumulus cells to the oocytes of old mares, potentially related to disruption of transzonal projections between the cell types. The identification of age-associated alterations in the abundance of specific metabolites and their correlations among cells contribute to our understanding of follicular dysfunction with maternal aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Engineering, Environmental
Nohyeong Jeong, Marin E. E. Wiltse, Aaron Boyd, Tamzin Blewett, Shinyun Park, Corey Broeckling, Thomas Borch, Tiezheng Tong
Summary: Treatment and reuse of unconventional oil and gas (UOG) produced water are crucial to addressing water scarcity and pollution issues. This study examined the effectiveness of pretreatment followed by nanofiltration (NF) and reverse osmosis (RO) in treating UOG produced water. The results showed that the pretreatment had a minor impact, NF permeates did not meet water quality criteria, and while RO removed most contaminants, some exceeded irrigation guidelines. Thorough analysis is required to understand the feasibility and potential risks of treating UOG produced water for beneficial reuse.
ACS ES&T ENGINEERING
(2023)
Article
Food Science & Technology
Brooke Sayre-Chavez, Bridget Baxter, Corey D. Broeckling, Maria Munoz-Amatriain, Mark Manary, Elizabeth P. Ryan
Summary: This study analyzed the composition of cowpea, pigeon pea, and common bean using UPLC-MS technology. It identified several metabolites that can differentiate these legumes, with cowpea having higher abundance of novel metabolites compared to other legumes. Additionally, specific metabolite markers were found in different cowpea varieties.
FOOD CHEMISTRY: MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Katrice A. Lippa, Juan J. Aristizabal-Henao, Richard D. Beger, John A. Bowden, Corey Broeckling, Chris Beecher, W. Clay Davis, Warwick B. Dunn, Roberto Flores, Royston Goodacre, Goncalo J. Gouveia, Amy C. Harms, Thomas Hartung, Christina M. Jones, Matthew R. Lewis, Ioanna Ntai, Andrew J. Percy, Dan Raftery, Tracey B. Schock, Jinchun Sun, Georgios Theodoridis, Fariba Tayyari, Federico Torta, Candice Z. Ulmer, Ian Wilson, Baljit K. Ubhi
Summary: This review emphasizes the importance of reference materials (RMs) and methodologies in ensuring standardization and comparability of results in untargeted metabolomics and lipidomics research. RMs are critical tools for quality control, improving the reliability and standardization of data analysis and interpretation.
