Article
Clinical Neurology
Gin S. Malhi, Pritha Das, Tim Outhred, Erica Bell, Danielle Gessler, Zola Mannie
Summary: The study found that irritability is common in adolescent girls and is positively associated with depressive and manic symptoms. Irritability is more prominent during mid-adolescence, with influencing factors including trait anxiety and emotion regulation difficulties. The effects of irritability on depressive and manic symptoms vary across different age groups.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
A. Murkar, T. Kendzerska, J. Shlik, L. Quilty, M. Saad, R. Robillard
Summary: This study found a correlation between increased cannabis use and worsening of depressive symptoms in individuals with self-reported PTSD during the COVID-19 pandemic. Those who increased cannabis consumption were more prone to experience meaningful worsening of depression symptoms.
Article
Clinical Neurology
Olivia M. Losiewicz, Allison V. Metts, Richard E. Zinbarg, Constance Hammen, Michelle G. Craske
Summary: This study examined the indirect effects of chronic interpersonal stress and irritability on anxiety and depression symptoms. The results showed that irritability mediated the relationship between chronic interpersonal stress and fears and anhedonia, while chronic interpersonal stress mediated the relationship between irritability and anhedonia. The findings suggest that targeted interventions for chronic interpersonal stress and irritability may improve prevention and treatment efforts for anxiety and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Multidisciplinary
Kristina Klug, Theano Tolgou, Miriam Schilbach, Sonja Rohrmann
Summary: Test anxiety is common among students and is associated with reduced academic performance and stress. Intrusive experiences, particularly physiological and visual intrusions, along with negative cognitions, contribute to additional psychological strain. Engaged coping strategies are largely functional, involving social interactions and physical activation.
CURRENT PSYCHOLOGY
(2021)
Article
Clinical Neurology
Tseng Wan-Ling, Rany Abend, Andrea L. Gold, Melissa A. Brotman
Summary: Through the use of data-driven latent phenotyping, researchers found that aberrant brain activation and connectivity during extinction recall may be a potential mechanism underlying the co-occurrence of anxiety and irritability in children.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Clinical
Nalan Zhan, Lan Zhang, Mingliang Gong, Fulei Geng
Summary: The study investigated the clinical significance of irritability, anger, and aggression in posttraumatic stress disorder (PTSD) and their associations with psychopathology. It found that irritability and anger were modestly related to all PTSD dimensions, while aggression was related to specific dimensions such as avoidance and hyperarousal. The study also highlighted the importance of independently measuring irritability and the need to incorporate PTSD dimensions in assessment.
PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY
(2023)
Article
Psychology, Clinical
Sansanee Nisu, Krittisak Anuroj, Sivaporn Wannaiampikul, Apichai Pangsorn, Romteera Chiencharoenthanakij, Siwat Chongbanyatcharoen
Summary: Medical students are vulnerable to cyberbullying, which can increase stress and lead to affective disorders. The moderating factors of this stressor in the Thai context have been understudied. An analysis of an annual survey on the mental health and stressors of medical students in 2021 revealed the effects of cyberbullying victimization, psychosocial stressors, and self-reported resilience measures on affective symptoms.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2023)
Article
Psychology, Clinical
Jules R. Dugre, Stephane Potvin
Summary: This study aimed to investigate the developmental trajectories of child psychological factors and their associations with aggression. The results showed that different combinations of developmental trajectories were associated with varying levels of risk for exhibiting physical aggression. Maternal cigarette and alcohol use during pregnancy, as well as maternal depression, consistently predicted the formation of multi-trajectory groups.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Substance Abuse
Nicholas A. Livingston, Stacey L. Farmer, Colin T. Mahoney, Brian P. Marx, Terence M. Keane
Summary: Returning veterans diagnosed with cannabis use disorder (CUD) showed higher levels of depression, anxiety, PTSD, alcohol use, and worse psychosocial functioning compared to those without the diagnosis. CUD was also associated with more severe and persistent alcohol use and PTSD symptom severity over the long term.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2022)
Article
Psychology, Clinical
Jutta Joormann, Samuel A. McLean, Francesca L. Beaudoin, Xinming An, Jennifer S. Stevens, Donglin Zeng, Thomas C. Neylan, Gari Clifford, Sarah D. Linnstaedt, Laura T. Germine, Scott L. Rauch, Paul Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Gregory Fermann, Lauren A. Hudak, Kamran Mohiuddin, Vishnu Murty, Meghan E. McGrath, John P. Haran, Jose Pascual, Mark Seamon, David A. Peak, Claire Pearson, Robert M. Domeier, Paulina Sergot, Roland Merchant, Leon D. Sanchez, Niels K. Rathlev, William F. Peacock, Steven E. Bruce, Deanna Barch, Diego A. Pizzagalli, Beatriz Luna, Steven E. Harte, Irving Hwang, Sue Lee, Nancy Sampson, Karestan C. Koenen, Kerry J. Ressler, Ronald C. Kessler
Summary: This is the first report on the association between trauma exposure and depression. The study found that the characteristics of motor vehicle collision (MVC) and peritraumatic symptoms are associated with 8-week depression, while peritraumatic symptoms are associated with 2-week depression. The findings suggest the possibility of diverse and complex underlying biological and psychological processes.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Developmental
Carla B. Kalvin, Theresa R. Gladstone, Rebecca Jordan, Sonia Rowley, Carolyn L. Marsh, Karim Ibrahim, Denis G. Sukhodolsky
Summary: Irritability is a common problem in children with ASD, where anxiety and noncompliance both contribute to irritability. The ARI is likely to be a useful measure of irritability in children with ASD.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2021)
Review
Substance Abuse
Michele Bedard-Gilligan, Elizabeth Lehinger, Sarah Cornell-Maier, Ash Holloway, Lori Zoellner
Summary: This review examines the impact of cannabis use on PTSD recovery and highlights some limitations and issues in the research. While some studies suggest that cannabis can alleviate symptoms, results from randomized controlled trials show that the effect of cannabis on PTSD symptoms is not clear. More rigorous long-term studies are needed to understand the long-term impact of cannabis on PTSD recovery.
CURRENT ADDICTION REPORTS
(2022)
Article
Psychiatry
Nitsa Nacasch, Chen Avni, Paz Toren
Summary: Targeting the endocannabinoid system may be beneficial in treating PTSD, but more research is needed to determine the effectiveness of cannabis. A retrospective naturalistic study found that medicinal cannabis improved sleep quality and symptoms of PTSD in treatment-resistant patients.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Yahya Salimi, C. Hoeboer, Seyed Ali Motevalli Haghi, R. E. Williamson, Mohammad Dawood Rahimi, Nader Rajabi-Gilan, Ali Almasi, M. Olff
Summary: This study translated and cross-culturally adapted the GPS instrument and tested it in a city in Iran. The results suggest that the Persian GPS is a useful, reliable, and valid tool for screening trauma-related symptoms in non-Western societies, specifically in Iran.
Article
Clinical Neurology
Dakota Mauzay, Emily M. LaFrance, Carrie Cuttler
Summary: The study found that inhaling cannabis can significantly reduce symptoms of OCD in the short term, but tolerance to the effects on intrusive symptoms may develop over time. Higher concentrations of CBD and doses of cannabis can predict the extent of reduction in compulsive symptoms. Long-term self-medication with cannabis for OCD symptoms may result in smaller reductions in intrusive symptoms over time.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Multidisciplinary
Kyle A. Schofield, Steven Hobaica, Alexander Jensen, Carrie Cuttler
Summary: Research indicates that openly disclosing one's sexual identity, either explicitly or implicitly, in a liberal university setting, may enhance positive perceptions of LGB individuals by others, particularly in positive traits, with minimal impact on negative traits.
PSYCHOLOGY & SEXUALITY
(2022)
Article
Psychology, Biological
Cecilia L. Bergeria, Justin C. Strickland, Tory R. Spindle, Maja Kalaba, Prem Umang Satyavolu, Matthew Feldner, Ryan Vandrey, Marcel Bonn-Miller, Erica N. Peters, Elise Weerts
Summary: Delta-8-tetrahydrocannabinol (Delta 8-THC) is a new retail cannabinoid product in the U.S. This study investigated the characteristics and effects of Delta 8-THC use. Participants reported that Delta 8-THC had weaker effects than Delta 9-THC and stronger effects than CBD. Users cited reasons for Delta 8-THC use including its legal status, similarity to Delta 9-THC, and milder effects. Human laboratory studies are needed to further understand the pharmacokinetics, pharmacodynamics, and cognitive effects of Delta 8-THC.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Multidisciplinary
Alexander Jensen, Kyle A. Schofield, Amanda Stueber, Steven Hobaica, Carrie Cuttler
Summary: Selecting and sharing a sexual identity label is a significant and stressful process for LGB individuals. Previous research has shown that using sexual identity labels tends to have positive effects in liberal-leaning environments, but may lead to more negative perceptions in the general population.
PSYCHOLOGY & SEXUALITY
(2023)
Letter
Medical Laboratory Technology
Morgan L. Ferretti, Ryan Vandrey, Jessica G. Irons, Heather Jackson, Mallory J. Loflin, Travis Hyke, Marcel O. Bonn-Miller
THERAPEUTIC DRUG MONITORING
(2023)
Article
Pharmacology & Pharmacy
Laura MacNair, Justyna Kulpa, Melanie L. Hill, Graham M. L. Eglit, Irina Mosesova, Marcel O. Bonn-Miller, Erica N. Peters
Summary: There is a lack of data on sex differences in the pharmacokinetics of CBD and its primary metabolites. This study analyzed data from a multiple-dose trial of a CBD-dominant oral cannabis product and found that females exhibited greater exposure to CBD metabolites in plasma over time, indicating potential sex differences in CBD metabolism or elimination.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Substance Abuse
Joshua A. Lile, Brian W. Turner, David H. Cox, Marcel O. Bonn-Miller, Ned R. Katz, Thomas P. Shellenberg, William W. Stoops, Justin C. Strickland
Summary: This study explores the preferences of individuals interested in treating cannabis use disorder (CUD). The results suggest that CUD medications should be nonsynthetic compounds administered orally or by mouth spray once per day, and remote adherence monitoring and one-on-one outpatient behavioral treatments, particularly contingency management, are anticipated to enhance participation. Most participants prefer to reduce, rather than quit, their cannabis use.
JOURNAL OF ADDICTION MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Kyle Schofield, Carrie Cuttler, Bradley T. Conner, Mark A. Prince
Summary: Gay, lesbian, and bisexual individuals have a higher frequency of cannabis use compared to heterosexuals, but there is limited research on the patterns of cannabis use and motivations among sexual minorities. This study found that bisexual individuals were more likely to use cannabis, use it more frequently, use various forms of cannabis, and experience more severe symptoms of cannabis use disorder. They also reported higher levels of mental health symptoms compared to heterosexuals.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Bryan W. Jenkins, Catherine F. Moore, Dan Covey, Jacob D. McDonald, Timothy W. Lefever, Marcel O. Bonn-Miller, Elise M. Weerts
Summary: This study evaluated the effects of minor cannabinoids and terpenes in tests sensitive to anxiety. The results suggest that some minor cannabinoids and terpenes may have anxiolytic properties.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Justyna Kulpa, Rayetta G. Henderson, Daniela Schwotzer, Wendy Dye, Kristen R. Trexler, Jacob Mcdonald, Timothy W. Lefever, Marcel O. Bonn-Miller
Summary: Minor cannabinoids were well tolerated at the assessed doses during 14 days of daily oral administration. Modest, dose-dependent trends in relative organ weights and serum chemistry parameters warrant further study at higher oral doses.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Justyna Kulpa, Amy Harrison, Lance Rudolph, Graham M. L. Eglit, Cynthia Turcotte, Marcel O. Bonn-Miller, Erica N. Peters
Summary: This case series explores the effects of oral CBD administration on bone turnover in postmenopausal women. The study found that CBD was well tolerated and associated with a reduction in measured markers of bone turnover. Large-scale randomized clinical trials are needed to further investigate the bone protective effects of CBD in postmenopausal women.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Catherine F. Moore, Julie Marusich, Mehdi Haghdoost, Timothy W. Lefever, Marcel O. Bonn-Miller, Elise M. Weerts
Summary: This study found that the minor cannabinoids and terpenes in cannabis have little effect on the interoceptive effects of D9-THC, suggesting that they are unlikely to lower the psychoactive effects of D9-THC in human users.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Catherine F. Moore, Elise M. Weerts, Justyna Kulpa, Daniela Schwotzer, Wendy Dye, Jacob Jantzi, Jacob D. McDonald, Timothy W. Lefever, Marcel O. Bonn-Miller
Summary: This study examined the pharmacokinetics of four minor cannabinoids (THCV, CBC, CBN, and D8-THC) after repeated oral dosing. The results showed detectable levels of these cannabinoids in plasma and their translocation to brain tissue. D8-THC exhibited the highest dose-normalized Cmax and AUClast. The concentration of THCV was lower on day 14, indicating potential adaptation and increased drug elimination. These findings are important for determining target dose ranges and dosing schedules in future studies evaluating the potential effects of these compounds.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Marcel O. Bonn-Miller, Megan Brunstetter, Alex Simonian, Mallory J. Loflin, Ryan Vandrey, Kimberly A. Babson, Hal Wortzel
Summary: This study found that PTSD patients who used cannabis experienced a greater decrease in symptom severity and were more likely to no longer meet the diagnostic criteria for PTSD. It suggests that medical cannabis could serve as an alternative treatment for PTSD.
CANNABIS AND CANNABINOID RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Carrie Cuttler, Emily M. LaFrance, Rebecca M. Craft
Summary: Inhaled cannabis reduces self-reported pain severity by approximately 42-49%, but these reductions appear to diminish over time and patients may require larger doses for pain relief. Factors such as gender, method of administration, and dose have an impact on the reduction of pain. The study suggests the development of analgesic tolerance with continued use.
CANNABIS AND CANNABINOID RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Lyndsey L. Anderson, Maia G. Etchart, Laura MacNair, M. Hunter Land, Irina A. Mosesova, Marcel O. Bonn-Miller, Jonathon C. Arnold
Summary: The legalization of medicinal cannabis has led to increased use of commercial cannabis-based products, which can potentially interact with other drugs. This study evaluated the inhibitory potential of three commercially available cannabis-based products on human transporters and found that some of these products can inhibit transporter function.
CANNABIS AND CANNABINOID RESEARCH
(2022)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)