Review
Immunology
Mingxuan Chi, Kuai Ma, Yunlong Li, Min Quan, Zhongyu Han, Zhaolun Ding, Xin Liang, Qinxiu Zhang, Linjiang Song, Chi Liu
Summary: Systemic lupus erythematosus (SLE) is a typical autoimmune disease characterized by multiple immunoregulatory abnormalities that lead to damage to various tissues and organs. Researchers have identified aberrant expression of miRNAs in SLE patients, which may be associated with abnormal immune responses and disease progression in SLE.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yanming Cui, Jianbo Wei, Xiang Peng
Summary: Vaccination in patients with autoimmune diseases is controversial due to the possibility of thrombotic thrombocytopenic purpura. This case report describes a patient with systemic lupus erythematosus who developed thrombotic thrombocytopenic purpura after rabies vaccination. Prompt identification and treatment saved the patient from danger. This highlights the potential unexpected adverse effects of attenuated vaccines in patients on long-term immunosuppressive drugs and with autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Kun Xiang, Peng Wang, Zhiwei Xu, Yu-Qian Hu, Yi-Sheng He, Yue Chen, Ya-Ting Feng, Kang-Jia Yin, Ji-Xiang Huang, Jie Wang, Zheng-Dong Wu, Xiao-Ke Yang, De-Guang Wang, Dong-Qing Ye, Hai-Feng Pan
Summary: This study used Mendelian randomization to examine the causal links between gut microbiome components and SLE risk. The results suggest that certain gut microbiome components may have causal effects on the risk of SLE, with some components increasing the risk and others reducing it.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Xingyun Zhao, Shifen Wang, Shengjun Wang, Jue Xie, Dawei Cui
Summary: This review systematically summarizes the role of the mTOR signaling pathway in the pathogenesis of systemic lupus erythematosus (SLE), regulatory T cell dysfunction, and the treatment of SLE.
CLINICAL IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Tatiana Montoya, Maria Luisa Castejon, Rocio Munoz-Garcia, Catalina Alarcon-de-la-Lastra
Summary: Epigenetic modifications play a crucial role in the development and predisposition of autoimmune diseases, such as systemic lupus erythematosus (SLE). Environmental factors can affect gene expression through epigenetic mechanisms, and diet is one of the most important factors that can influence these alterations. Understanding the cross-link between epigenetic mechanisms, SLE, and dietary factors may lead to novel personalized therapies for SLE patients.
NUTRITION RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Julie Sarrand, Muhammad Soyfoo
Summary: IL-33 is a newly discovered cytokine that acts as an alarmin to alert the innate immune system following cell death or necrosis. It has been found to be significantly upregulated in patients with SLE and lupus nephritis, suggesting its involvement in the pathology of SLE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Wojciech Lubon, Malgorzata Lubon, Przemyslaw Kotyla, Ewa Mrukwa-Kominek
Summary: Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease, with up to one-third of patients experiencing various ocular manifestations. Ocular findings may be the initial signs of the disease and can lead to severe complications and vision loss. Early diagnosis and proper management are crucial, requiring collaboration among specialists. Adequate preparation of ophthalmologists can help differentiate SLE complications from other eye disorders. New therapies for SLE show promise, but their ocular side effects are still unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Holly Ryan, Laurence Morel, Erika Moore
Summary: Vascular inflammation caused by overly activated immune cells is a significant factor contributing to morbidity and mortality in systemic lupus erythematosus (SLE). There are several mouse models currently used to study the pathogenesis of SLE, each with different mechanisms. The diversity of these models allows for the investigation of different aspects of the disease. To better understand the mechanisms of vascular inflammation in SLE and assist future researchers in selecting appropriate mouse models to study cardiovascular complications, it is suggested to directly compare vascular inflammation among different mouse models of SLE. Additionally, the use of in vitro vascular assays is proposed to further investigate prevalent vascular inflammation processes in different mouse models of SLE.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Xuexiao Jin, Qin Xu, Chengfei Pu, Kaixiang Zhu, Cheng Lu, Yu Jiang, Lei Xiao, Yongmei Han, Linrong Lu
Summary: The study investigated the feasibility of using anti-CD19 CAR-T cell therapy for treating SLE in a mouse model. Results demonstrated that the therapy was effective in both preventing and treating the disease in the murine model, with better therapeutic efficiency observed in CAR-T cells with the 4-1BB costimulatory motif.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Immunology
Neelakshi R. Jog, Judith A. James
Summary: Infections or infectious reactivation can trigger systemic lupus erythematosus (SLE), and Epstein-Barr virus (EBV) is associated with various autoimmune diseases, including SLE. Recent advances suggest that EBV may play a role in immune dysregulation and its relationship to SLE disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Lucia Cayuela, Jose-Juan Pereyra-Rodriguez, Juan-Carlos Hernandez-Rodriguez, Alejandro Munoz-Jimenez, Aurelio Cayuela
Summary: This study analyzed the time trends in systemic lupus erythematosus (SLE) mortality in Spain and identified a cluster of provinces with higher mortality rates among women.
Article
Rheumatology
Antonis Fanouriakis, Myrto Kostopoulou, Jeanette Andersen, Martin Aringer, Laurent Arnaud, Sang-Cheol Bae, John Boletis, Ian N. Bruce, Ricard Cervera, Andrea Doria, Thomas Doerner, Richard A. Furie, Dafna D. Gladman, Frederic A. Houssiau, Luis Sousa Ines, David Jayne, Marios Kouloumas, Laszlo Kovacs, Chi Chiu Mok, Eric F. Morand, Gabriella Moroni, Marta Mosca, Johanna Mucke, Chetan B. Mukhtyar, Gyoergy Nagy, Sandra Navarra, Ioannis Parodis, Jose M. Pego-Reigosa, Michelle Petri, Bernardo A. Pons-Estel, Matthias Schneider, Josef S. Smolen, Elisabet Svenungsson, Yoshiya Tanaka, Maria G. Tektonidou, Y. K. Onno Teng, Angela Tincani, Edward M. Vital, Ronald F. van Vollenhoven, Chris Wincup, George Bertsias, Dimitrios T. Boumpas
Summary: The EULAR recommendations for the management of systemic lupus erythematosus (SLE) have been updated based on emerging new evidence. The updated recommendations provide consensus guidance on the use of various medications and treatment strategies to control the disease, as well as recommendations for assessing treatment response and tapering therapy.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Genetics & Heredity
Huiyan Li, Pingting Yang
Summary: This study analyzed SLE expression data and identified modules associated with neutrophils. Two molecular subtypes of SLE were reclassified based on identified biomarkers, revealing significant differences in immunological characteristics and potential gene targets. The study also revealed associations between biomarkers and metabolic pathways, providing insights for immunotherapy.
BMC MEDICAL GENOMICS
(2022)
Article
Rheumatology
Jingru Tian, Dingyao Zhang, Xu Yao, Yaqing Huang, Qianjin Lu
Summary: This study estimated the epidemiology of SLE globally, finding variations in incidence and prevalence rates across different countries and regions. It also highlighted the impact of gender, age, and prevalence estimation method on the findings. SLE was found to occur more frequently in high-income countries.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Jessica S. Kleer, Pascal A. Rabatscher, Jessica Weiss, Joel Leonardi, Severin B. Vogt, Andrea Kieninger-Grafitsch, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg
Summary: The study found that epitope-specific anti-C1q in SLE patients is associated with specific disease manifestations, providing more diagnostic value than conventional anti-C1q.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
K. Khosravi, E. Ataei, M. Mousavi, N. Khodaeian
OPERATIVE DENTISTRY
(2009)
Article
Rheumatology
Amirhossein Salehi, Mehrdad Nasrollahzadeh Sabet, Emran Esmaeilzadeh, Maryam Mousavi, Jalal Karimi, Bahram Pakzad
Summary: This study evaluated the associations between rs1053005 and rs1053023 SNPs in the STAT3 gene and the risk of SLE in the Iranian population for the first time. The results showed a significant association between the GG genotype and G allele of rs1053023 with an increased risk of SLE, but no important correlations were found between rs1053005 polymorphism and SLE susceptibility. Stratification analysis revealed correlations between these polymorphisms and disease activity and severity.
Article
Dermatology
Najmeh Shamspour, Mahin Aflatoonian, Maryam Khalili, Mohsen Seifi, Maryam Mousavi, Jalal Azmandian, Saman Mohammadi, Batoul Khoundabi, Elahenaz Parsimood, Azadeh Mohebbi
Summary: This study aimed to compare the effectiveness of Pregabalin and Ketotifen in treating uremic pruritus in hemodialysis patients. The results showed that Pregabalin had a significantly lower pruritus intensity and better quality of life in the second week of treatment, with fewer side effects compared to Ketotifen.
DERMATOLOGIC THERAPY
(2022)
Article
Allergy
Amirhossein Salehi, Ebrahim Hazrati, Hamta Ranjbar, Javad Behroozi, Bahram Pakzad, Maryam Mousavi, Mojtaba Mousavi, Marzieh Hossein Balam, Mansour Salesi
Summary: This study found an association between miRSNPs of STAT3 and the risk of developing RA, as well as its clinical features such as disease activity and kidney impairment.
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Masood Sayadi Shahraki, Mohsen Mahmoudieh, Behrouz Kalidari, Hamid Melali, Maryam Mousavi, Mohammad Raisi Ghourban Abadi, Seyed Hossein Mirhosseini, Seyed Ali Mirhosseini Dehabadi
Summary: Bariatric surgery is associated with adverse effects on bone health, including decreased bone mineral density and nutrient deficiencies. Regular evaluation and careful measurement methods such as DXA and QCT are crucial. Exercise, both endurance and resistance, can help mitigate the negative impact on bone health.
ADVANCED BIOMEDICAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Mansour Karimifar, Nafiseh Sereshti, Rasoul Salehi, Maryam Mousavi, Hadi Karimzadeh, Amirhossein Salehi, Bahram Pakzad
Summary: This study demonstrated a significant association between the rs6445975 polymorphism in the PXK gene and susceptibility to SLE as well as clinical characteristics in the Iranian population. The GG and TG genotypes were associated with an increased risk of SLE, and individuals carrying the G allele were more susceptible to SLE. Furthermore, the G allele was correlated with serum markers and clinical manifestations.
IRANIAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
Parisa Taheri, Najmeh Salek, Maryam Mousavi, Razieh Maghroori
Summary: This study evaluated the effect of shock wave therapy on the improvement of symptoms and function in patients with Dupuytren's contracture. The results showed that shock wave therapy significantly reduced pain severity and improved functional status and finger contraction angle in patients with Dupuytren's contracture.
ADVANCED BIOMEDICAL RESEARCH
(2022)
Article
Oncology
Maryam Mousavi, Sepideh Elyasi, Maryam Esmaeili, Mohammad Mahdi Kooshyar, Azar Fani Pakdel
MIDDLE EAST JOURNAL OF CANCER
(2020)
Article
Medicine, General & Internal
Mansour Karimifar, Bahram Pakzad, Hadi Karimzadeh, Maryam Mousavi, Mehdi Kazemi, Amirhossein Salehi, Nasimeh Vatandoust, Guilda Amini, Mojtaba Akbari, Rasoul Salehi
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2019)
Article
Pharmacology & Pharmacy
Batool Zarei, Maryam Mousavi, Saeideh Mehdizadeh, Hassan Mehrad-Majd, Maryam Zarif, Zahra Erfanian, Ali Moradi
JOURNAL OF RESEARCH IN PHARMACY PRACTICE
(2019)
Article
Medicine, General & Internal
Hadi Karimzadeh, Zahra Seyedbonakdar, Maryam Mousavi, Mehdi Karami
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2016)
Meeting Abstract
Oncology
A. Fani Pakdel, M. Mousavi, M. S. Roohani, S. Elyasi, M. M. Kooshyar
ANNALS OF ONCOLOGY
(2016)
Letter
Medicine, Research & Experimental
Bahram Pakzad, Hadi Karimzadeh, Mohammad Dadgostarnia, Maryam Mousavi, Amirhosein Salehi, Mojtaba Akbari
ADVANCED BIOMEDICAL RESEARCH
(2019)
Article
Medicine, Research & Experimental
Maryam Mousavi, Hadi Karimzadeh, Bahram Pakzad, Farzaneh Mirrokni
ADVANCED BIOMEDICAL RESEARCH
(2019)