Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 587, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2020.119663
Keywords
Anticancer drug delivery systems; Biodegradable polymers; Polyester; Sterilization; Radiation sterilization; Gamma-irradiation; E-beam irradiation
Categories
Funding
- (European Social Fund) [POWR.03.02.00-00-I009/17-00]
Ask authors/readers for more resources
Recently, growing interest in biodegradable polyesters as drug carriers in the development of innovative anticancer drug delivery systems (DDSs) has been observed. These compounds are thermally unstable, and are therefore, particularly demanding due to the limited number of available sterilization techniques. Furthermore, the DDSs sterilization process is often limited to aseptic filtration. Ensuring aseptic production is very demanding and costly, and it is therefore necessary to work on the application of new sterilization methods. In view of this, this review presents the current state of knowledge regarding the radiation sterilization process of some anticancer drugs as well biodegradable polyester carriers (such as polylactide, polyglycolide, poly(epsilon-caprolactone), poly(trimethylene carbonate) and coor terpolymers of lactide, glycolide, epsilon-caprolactone and trimethylene carbonate). The structural changes in anticancer DDSs under the influence of ionizing radiation and the potential degradation mechanisms of both, polyester carriers and cytostatics during the sterilization process of ionizing radiation as well as their effects on the microstructure and properties of DDSs have been discussed in this paper.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available