Article
Oncology
Hannan A. Qureshi, Xiaodong Zhu, Grace H. Yang, Melissa Steadele, Robert H. Pierce, Neal D. Futran, Sylvia M. Lee, Eduardo Mendez, A. McGarry Houghton
Summary: The impact of immune cell composition and tumor reactivity on HPV-positive and HPV-negative head and neck squamous cell carcinoma was studied. Results showed significant differences in immune features based on HPV status, and increased B cell and plasma cell content in tumors were associated with improved progression-free survival in HPV-negative patients treated with immune checkpoint inhibitors.
Article
Immunology
Zhifeng Liu, Diekuo Zhang, Chao Liu, Guo Li, Huihong Chen, Hang Ling, Fengyu Zhang, Donghai Huang, Xingwei Wang, Yong Liu, Xin Zhang
Summary: By establishing a myeloid gene score (MGS) risk model, it can help predict the prognosis and immune infiltration status of patients with head and neck squamous cell carcinoma (HNSCC). MGS shows high accuracy in identifying patients with poor prognosis, aggressive clinical parameters, and response to immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Ruoyan Cao, Lin Cui, Jiayu Zhang, Xianyue Ren, Bin Cheng, Juan Xia
Summary: This study identifies subtypes of head and neck squamous cell carcinoma based on immune-related lncRNAs and characterizes their biological behaviors. The researchers found that certain subtypes are associated with good prognosis and sensitivity to immunotherapy, and identified a critical lncRNA TRG-AS1 involved in the tumor microenvironment. This provides new potential targets for the treatment of this subtype.
CANCER CELL INTERNATIONAL
(2022)
Article
Immunology
Qimin Zhou, Ouyang Yuan, Hongtu Cui, Tao Hu, Gary Guishan Xiao, Jiao Wei, Honglei Zhang, Chengjun Wu
Summary: HPV infection is identified as a significant carcinogen for head and neck squamous cell carcinomas, altering the tumor microenvironment. Through RNA sequencing analysis, genes associated with HNSCC development and patient survival were identified, regulated negatively by DNA methylation and correlated with the tumor microenvironment and immune infiltration in HNSCC.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Baoyi Shao, Zheng Ye, Bo Sun, Zhongdang Xiao
Summary: In this study, the immune microenvironment of head and neck cancer was analyzed using gene expression profiles and clinical information from two cohorts. Three immune subtypes with different molecular profiles and clinical outcomes were identified and validated. B-lymphocyte infiltration was found to be associated with the best prognosis. Furthermore, a classifier based on 19 genes was constructed to accurately classify head and neck cancer.
Article
Immunology
Dandan Song, Haoyu Lyu, Qiushi Feng, Jiangti Luo, Lin Li, Xiaosheng Wang
Summary: Hierarchical clustering identified three HNSCC subtypes, Immunity-H, Immunity-M, and Immunity-L, with Immunity-H showing the best response to ICIs; somatic copy number alteration was significantly negatively associated with anti-tumor immunity in HNSCC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Habib Sadeghi Rad, Yavar Shiravand, Payar Radfar, Rahul Ladwa, Chris Perry, Xiaoyuan Han, Majid Ebrahimi Warkiani, Mark N. Adams, Brett G. M. Hughes, Ken O'Byrne, Arutha Kulasinghe
Summary: This review discusses the characteristics of Head and Neck Squamous Cell Carcinoma (HNSCC), predictive biomarkers, and factors influencing the response to immunotherapy, with a focus on the tumor microenvironment.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Danilo Galizia, Silvia Minei, Elena Maldi, Giovanna Chila, Alessio Polidori, Marco Carlo Merlano
Summary: Most head and neck squamous cell carcinomas (HNSCCs) are caused by lifestyle factors such as smoking or virus infections including HPV and EBV. Despite improvements in surgical, radiation, and chemotherapy treatments, recurrent/metastatic (R/M) disease remains a challenge in clinical practice. While immunotherapy has shown promise in a small percentage of patients, the majority still do not benefit. Recent preclinical and clinical studies have explored the HNSCC tumor immune microenvironment (TIME) and identified important differences between smoking-associated and virus-associated HNSCCs, which impact immune escape mechanisms and response to immunotherapy.
Article
Multidisciplinary Sciences
Siming Gong, Changwu Wu, Yingjuan Duan, Jinfei Fu, Yuling Wang, Hao Wu, Bixi Zhang, Juyu Tang, Panfeng Wu
Summary: Head and neck squamous cell carcinoma (HNSCC) is a common type of cancer originating from the oral cavity, pharynx, and larynx. The overexpression of PLOD family proteins may be associated with poorer prognosis and increased immune infiltration in HNSCC, indicating their potential as biomarkers for personalized treatment.
Article
Oncology
Yue Chen, Tian-Qi Luo, Si-Si Xu, Chun-Yan Chen, Ying Sun, Li Lin, Yan-Ping Mao
Summary: This study developed a prognostic signature based on lncRNAs for HNSCC patients, which stratified patients into high and low IRLPS subgroups. Low-IRLPS patients showed better prognosis and remained significant after stratification by sex, grade, and HPV status. The IRLPS had better discriminability in prognostic prediction and ability to distinguish different tumor microenvironments in HNSCC patients.
Article
Genetics & Heredity
Qiwei Wang, Yinan Zhao, Fang Wang, Guolin Tan
Summary: This study identified hub genes significantly associated with immune-checkpoint blockade (ICB) and activated CD8(+) T-cell gene signatures, and constructed a novel immune signature named IMS. The high IMS group showed significant immune activation, better prognosis, and increased immunotherapy responsiveness. IMS potentially represents a candidate biomarker for ICB. Moreover, a higher IMS was associated with metabolic reprogramming and cellular crosstalk in the tumor microenvironment.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Maud Plaschka, Valentin Benboubker, Maxime Grimont, Justine Berthet, Laurie Tonon, Jonathan Lopez, Myrtille Le-Bouar, Brigitte Balme, Garance Tondeur, Arnaud de la Fouchardiere, Lionel Larue, Alain Puisieux, Yenkel Grinberg-Bleyer, Nathalie Bendriss-Vermare, Bertrand Dubois, Christophe Caux, Stephane Dalle, Julie Caramel
Summary: This study reveals that ZEB1 expression in melanoma cells is associated with decreased CD8(+) T cell infiltration, leading to tumor immune evasion and resistance to immune checkpoint blockade. ZEB1 directly represses the secretion of T cell-attracting chemokines, such as CXCL10, and targeting ZEB1 may enhance the efficacy of immunotherapy in melanoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Marit J. van Elsas, Camilla Labrie, Anders Etzerodt, Pornpimol Charoentong, Jordi J. C. van Stigt Thans, Thorbald Van Hall, Sjoerd H. van der Burg
Summary: A small population of CD163(hi) tissue-resident macrophages is identified to be responsible for primary and secondary resistance against T-cell-based immunotherapies. While these CD163(hi) M2 macrophages are resistant to Csf1r-targeted therapies, in-depth characterization and identification of the underlying mechanisms driving immunotherapy resistance allows the specific targeting of this subset of macrophages, thereby creating new opportunities for therapeutic intervention with the aim to overcome immunotherapy resistance.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Chemistry, Multidisciplinary
Hongxia Li, Ming Liu, Shuaiyin Zhang, Xinran Xie, Yuefei Zhu, Tianrun Liu, Jian Li, Zhaoxu Tu, Weiping Wen
Summary: The researchers synthesized polyethyleneimine-covered MoS2 nanosheets with different sizes and charge densities, enveloped CpG to construct nanoplatforms for the treatment of head and neck squamous cell carcinoma (HNSCC). The study found that CpG-loaded nanosheets with medium size and low charge density promoted the maturation and antigen-presenting capacity of dendritic cells (DCs). Combination therapy with CpG-loaded nanosheets and anti-programmed death 1 agents greatly improved tumor therapeutic effect.
Review
Immunology
Jiantong Bao, Annika C. Betzler, Jochen Hess, Cornelia Brunner
Summary: Distinct B cell subpopulations in the tumor milieu of head and neck squamous cell carcinoma (HNSCC) exert either pro- or anti-tumor activities. Certain B cell subsets in the tumor microenvironment exhibit immunosuppressive function, while B cells within tertiary lymphoid structures predominantly play anti-tumor effects.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Thomas Weiland, Alexander Eckert, Peter Valentin Tomazic, Axel Wolf, Prisca Pondorfer, Sarah Vasicek, Matthias Graupp, Clemens Holzmeister, Ulrich Moser, Alexandros Andrianakis, Georg Kangler, Peter Kiss, Luka Brcic, Matthias Kappler, Claudia Wickenhauser, Anja Haak, Maximilian Krueger, Bilal Al-Nawas, Sebastian Blatt, Norbert Brockmeyer, Adriane Skaletz-Rorowski, Anja Potthoff, Lars E. French, Sara Charnowski, Markus Reinholz, Andreas M. Kaufmann, Sarah Thies, Hans-Georg Lambrecht, Barbara Seliger, Dominik C. Wild, Dietmar Thurnher
Article
Oncology
Thomas Greither, Franziska Koser, Hans-Juergen Holzhausen, Antje Guettler, Peter Wuerl, Matthias Kappler, Sven Wach, Helge Taubert
Article
Otorhinolaryngology
Lauren Hum, Daniel Bethmann, Zipei Feng, Shu-Ching Chang, Alexander Eckert, Carmen Ballesteros-Merino, Claudia Keschke, Matthias Kappler, Carlo B. Bifulco, Claudia Wickenhauser, Barbara Seliger, Bernard A. Fox, Richard Bryan Bell
Summary: Analyzing the immune elements in patients with oral squamous cell carcinoma, particularly using the cumulative suppressive index (CSI) reflecting immune cell spatial relationships, can enhance the risk assessment of recurrence and overall survival. For cases with negative margins, high CSI was significantly associated with worse recurrence-free survival and overall survival compared to low CSI.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Biochemistry & Molecular Biology
Alexander W. Eckert, Matthias Kappler, Ivo Grosse, Claudia Wickenhauser, Barbara Seliger
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Otorhinolaryngology
Theresa Marie Galdirs, Matthias Kappler, Waldemar Reich, Daniel Bethmann, Claudia Wickenhauser, Alexander Eckert
Summary: This research conducted a comprehensive analysis of epithelial salivary gland tumors in the region, revealing the predominance of benign tumors, especially pleomorphic adenoma in the parotid gland. Malignant tumors, particularly adenoid cystic carcinoma in minor salivary glands, were also identified.
LARYNGO-RHINO-OTOLOGIE
(2021)
Article
Oncology
Claudia Wickenhauser, Daniel Bethmann, Matthias Kappler, Alexander Walter Eckert, Andre Steven, Jurgen Bukur, Bernard Aloysius Fox, Jana Beer, Barbara Seliger
Summary: The study analyzed the expression of HLA class I antigens and antigen processing machinery components in oral squamous cell carcinoma lesions, finding correlations with patient outcomes and intra-tumoral immune cell responses. The diverse expression levels were associated with different patient survival outcomes and immune cell compositions within the tumor.
Article
Biology
Thomas Greither, Tina Steiner, Matthias Bache, Ginette Serrero, Sven Otto, Helge Taubert, Alexander W. Eckert, Matthias Kappler
Summary: The study suggests that increased levels of GP88 in the serum of oral squamous cell carcinoma (OSCC) patients are associated with a better prognosis, and may serve as an independent predictor of OSCC patients' outcomes. Low serum GP88 levels are significantly linked to a worsened prognosis for OSCC, especially in patients over the age of 60.5.
Article
Biochemistry & Molecular Biology
Jonas Weisse, Julia Rosemann, Lisa Muller, Matthias Kappler, Alexander W. Eckert, Markus Glass, Danny Misiak, Stefan Huttelmaier, Wolfgang G. Ballhausen, Mechthild Hatzfeld, Monika Haemmerle, Tony Gutschner
Summary: Cancer metastasis is the main cause of mortality, with the identification of new therapeutic targets being crucial for survival improvement. Through the study of intratumoral heterogeneity, Lymphocyte cell-specific protein-tyrosine kinase (LCK) was discovered as a significant regulator of motility in oral cancer cells, suggesting that inhibition of LCK could be a promising anti-metastasis therapy option for oral cancer patients.
Article
Oncology
Karthikeyan Subbarayan, Chiara Massa, Sandra Leisz, Andre Steven, Daniel Bethmann, Katharina Biehl, Claudia Wickenhauser, Barbara Seliger
Summary: The extracellular matrix component biglycan (BGN) is reduced in K-RAS-associated malignancies, leading to altered growth properties, reduced immunogenicity, and worse patients' outcome.
Article
Medicine, General & Internal
Kathleen Schueler, Daniel Bethmann, Sandy Kaufhold, Carolin Hartung, Kathrin Stueckrath, Tilmann Lantzsch, Christoph Uleer, Volker Hanf, Susanne Peschel, Jutta John, Marleen Poehler, Jorg Buchmann, Karl-Friedrich Buerrig, Edith Weigert, Christoph Thomssen, Eva Johanna Kantelhardt, Martina Vetter
Summary: Tumour-infiltrating lymphocytes (TILs) have prognostic and predictive value for patients with early breast cancer, especially in HER2-positive breast cancer. The distribution of TILs varies among different breast cancer types, and the percentage of TILs is associated with improved prognosis.
Article
Cell Biology
Antje Guettler, Claus Weinholdt, Elisabeth Ruff, Judith Reidt, Elisa Darnstaedt, Alicia Wildemann, Marina Petrenko, Jacqueline Kessler, Matthias Kappler, Ivo Grosse, Dirk Vordermark, Matthias Bache
Summary: Betulinic acid (BA) is a natural compound with various beneficial effects, including anti-inflammatory, anti-viral, anti-bacterial, anti-malarial, and anti-tumor properties. In human breast cancer cells, BA exhibits enhanced cytotoxicity and radiosensitization under hypoxic conditions, potentially through the regulation of the p53 pathway.
Review
Biochemistry & Molecular Biology
David Muallah, Jan Matschke, Matthias Kappler, Lysann Michaela Kroschwald, Gunter Lauer, Alexander W. Eckert
Summary: Xerostomia, or dry mouth, is mainly caused by hypofunction of the salivary glands due to various factors. Current treatment methods are not very effective and regenerative medicine using dental pulp stem cells shows promise. Dental pulp stem cells can differentiate into different cell types and have immunomodulatory effects. However, more clinical studies are needed to fully understand their potential for salivary gland regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Biochemistry & Molecular Biology
Jonas Weisse, Julia Rosemann, Lisa Mueller, Matthias Kappler, Alexander W. Eckert, Markus Glass, Danny Misiak, Stefan Huettelmaier, Wolfgang G. Ballhausen, Mechthild Hatzfeld, Monika Haemmerle, Tony Gutschner