Article
Biochemistry & Molecular Biology
Qi Lu, Jun Xiong, Yuan Yuan, Zhanwei Ruan, Yu Zhang, Bo Chai, Lei Li, Shufang Cai, Jian Xiao, Yanqing Wu, Peng Huang, Hongyu Zhang
Summary: This study demonstrates that minocycline can improve the functional recovery of traumatic brain injury (TBI) by reducing the levels of aquaporin-4 (AQP4). Minocycline treatment effectively reduces neuronal apoptosis, ameliorates brain edema and blood-brain barrier disruption in TBI. The expression of tight junction proteins and the morphology of astrocytes are also optimized by minocycline administration. AQP4 may be an important therapeutic target for minocycline treatment of TBI.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ehsan Dadgostar, Shiva Rahimi, Shahin Nikmanzar, Sina Nazemi, Mojtaba Naderi Taheri, Zahra Alibolandi, Michael Aschner, Hamed Mirzaei, Omid Reza Tamtaji
Summary: This review summarizes the current knowledge and evidence on the relationship between AQP4 and TBI, as well as the potential mechanisms involved.
NEUROCHEMICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Shotaro Michinaga, Yutaka Koyama
Summary: Traumatic brain injury (TBI) is immediate damage to the brain caused by a blow to the head, resulting in death or serious disabilities. Astrocytes play a key role in the pathogenesis of TBI, with both beneficial and detrimental effects. They are attractive targets for novel therapeutic drugs for TBI, although such drugs have not yet been developed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Emergency Medicine
Ao Xiong, Renping Xiong, Jing Yu, Yijia Liu, Ke Liu, Ge Jin, Jianzhong Xu, Jun Yan
Summary: The study found that the level of AQP4 is closely correlated with the severity of brain edema in the hippocampus after TBI, and abnormal levels can exacerbate the severity of brain edema. HIF-1α showed a similar trend in this process.
Article
Neurosciences
Jingshu Tang, Yuying Kang, Longjian Huang, Xinhong Feng, Lei Wu, Ying Peng
Summary: The study revealed that Hemocoagulase Agkistrodon (HCA) has neuroprotective effects in experimental traumatic brain injury (TBI), improving neurological deficits, reducing brain edema and hemorrhage, lowering proinflammatory cytokines while increasing anti-inflammatory cytokine levels, and diminishing BBB disruption by regulating tight junction proteins. These findings suggest the therapeutic potential of HCA in acute TBI to mitigate neuropathological damage.
BRAIN RESEARCH BULLETIN
(2021)
Review
Neurosciences
Yue Hu, Weiwei Tao
Summary: Traumatic brain injury (TBI) is associated with various pathological changes, with BBB breakdown leading to microenvironmental alterations like cerebral blood flow changes, brain edema, metabolic imbalances, and inflammatory molecule accumulation. Modulating the microenvironment presents promising targets for TBI recovery.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Kazufumi Ohmura, Hiroyuki Tomita, Akira Hara
Summary: Treating malignant glioma, which can invade healthy brain tissue and cause intense surrounding edema, is challenging. Steroid therapy has been the standard treatment for peritumoral edema, but the discovery of cerebral lymphatic vessels has prompted a re-evaluation of the mechanisms involved. This review summarizes the known mechanisms of glioma-related edema, discusses the limitations in current therapies, and presents prospects for future cerebral edema treatments. Further research is needed to enhance patient prognosis and treatment efficacy.
Article
Cell Biology
Wan-Chao Yang, Hong-Ling Cao, Yue-Zhen Wang, Ting-Ting Li, Hong-Yu Hu, Qiang Wan, Wen-Zhi Li
Summary: Hyperglycemia worsens brain damage by affecting vascular endothelial function. Nitric oxide synthase plays a crucial role in diabetic rats with traumatic brain injury, including anti-inflammatory, anti-oxidative stress, and anti-apoptotic activities.
NEURAL REGENERATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Ping Ma, Ning Huang, Jun Tang, Zunjie Zhou, Jing Xu, Yi Chen, Maoxin Zhang, Qin Huang, Yuan Cheng
Summary: The study shows that 9-PH effectively reduces cerebral edema by inhibiting the TRPM4 channel, reducing cytotoxic edema and preventing vasogenic edema. It also alleviates secondary brain injury by reducing inflammation and apoptosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Mohit Kumar, Rajat Sandhir
Summary: The present study demonstrates that sodium hydrogen sulfide (NaHS) supplementation can ameliorate BBB dysfunction and brain edema induced by hyperhomocysteinemia (HHcy), possibly through inhibiting the expression and activity of MMP-9.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Integrative & Complementary Medicine
Jeetprakash Barot, Bhagawati Saxena
Summary: The study demonstrates the neuroprotective effects of eugenol in a rat model of TBI, improving impaired locomotor function and short-term memory caused by trauma. Pretreatment with eugenol also alleviates histopathological, neurochemical, and behavioral consequences of the injury.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2021)
Article
Medicine, Research & Experimental
Muyao Wu, Yating Gong, Lei Jiang, Min Zhang, Haiping Gu, Hui Shen, Baoqi Dang
Summary: Blood-brain barrier (BBB) damage is closely related to prognosis in patients with traumatic brain injury (TBI). This study found that upregulation of VEGF and MMP-9 in TBI may contribute to BBB disruption and nerve damage.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Clinical Neurology
Mehdi Hekimoglu, Sevda Lule, Hidir Ozer, Canan Cakir-Aktas, Kader K. Oguz, Melike Mut
Summary: The study found that early treatment with AQP4-ASO significantly reduces brain edema in mice.
TURKISH NEUROSURGERY
(2022)
Article
Immunology
Michael C. Scott, Karthik S. Prabhakara, Andrew J. Walters, Scott D. Olson, Charles S. Cox
Summary: In a rodent model of traumatic brain injury, sex-based differences in pathology and neuroinflammation are limited, and only noted in one specific analysis of BBB permeability.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shotaro Michinaga, Kazuya Onishi, Kahori Shimizu, Hiroyuki Mizuguchi, Shigeru Hishinuma
Summary: This study discovered that the use of TRPV4 specific antagonists can alleviate vasogenic edema caused by TBI, and achieve this by inhibiting the gene expression of endogenous factors that trigger BBB disruption.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Clinical Neurology
Ching-Chang Chen, Shao-Wei Chen, Po-Hsun Tu, Yin-Cheng Huang, Zhuo-Hao Liu, Alvin Yi-Chou Wang, Shih-Tseng Lee, Tien-Hsing Chen, Chi-Tung Cheng, Shang-Yu Wang, An-Hsun Chou
JOURNAL OF NEUROSURGERY
(2019)
Article
Clinical Neurology
Mun-Chun Yeap, Ching-Chang Chen, Zhuo-Hao Liu, Po-Chuan Hsieh, Cheng-Chi Lee, Yu-Tse Liu, Alvin Yi-Chou Wang, Yin-Cheng Huang, Kuo-Chen Wei, Chieh-Tsai Wu, Po-Hsun Tu
JOURNAL OF NEUROSURGERY
(2019)
Article
Clinical Neurology
Ching-Chang Chen, Mun-Chun Yeap, Zhuo-Hao Liu, Po-Chuan Hsieh, Chun-Ting Chen, Yu-Tse Liu, Ching-Yi Lee, Hong-Yi Lai, Chieh-Tsai Wu, Po-Hsun Tu
WORLD NEUROSURGERY
(2019)
Article
Biochemistry & Molecular Biology
Ping K. Yip, Amy L. Bowes, Jodie C. E. Hall, Miguel A. Burguillos, T. H. Richard Ip, Tracey Baskerville, Zhuo-Hao Liu, Moumin A. E. K. Mohamed, Fanuelle Getachew, Anna D. Lindsay, Saif-Ur-Rehman Najeeb, Phillip G. Popovich, John Priestley, Adina T. Michael-Titus
HUMAN MOLECULAR GENETICS
(2019)
Article
Clinical Neurology
Mun-Chun Yeap, Po-Hsun Tu, Zhuo-Hao Liu, Po-Chuan Hsieh, Yu-Tse Liu, Ching-Yi Lee, Hung-Yi Lai, Chun-Ting Chen, Yin-Cheng Huang, Kuo-chen Wei, Chieh-Tsai Wu, Ching-Chang Chen
WORLD NEUROSURGERY
(2019)
Article
Clinical Neurology
Zhuo-Hao Liu, Chi-Hung Liu, Po-Hsun Tu, Ping K. Yip, Ching-Chang Chen, Yu-Chi Wang, Nan-Yu Chen, Yu-Sheng Lin
TRANSLATIONAL STROKE RESEARCH
(2020)
Article
Infectious Diseases
Nan-Yu Chen, Shu-Wei Kao, Zhuo-Hao Liu, Ting-Shu Wu, Chia-Lung Tsai, Hsi-Hsun Lin, Wing-Wai Wong, Yea-Yuan Chang, Shu-Sheng Chen, Stephane Wen-Wei Ku
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Multidisciplinary Sciences
Ching-Chang Chen, Victor Chien-Chia Wu, Chien-Hung Chang, Chun-Ting Chen, Po-Chuan Hsieh, Zhuo-Hao Liu, Ho-Fai Wong, Chia-Hung Yang, An-Hsun Chou, Pao-Hsien Chu, Shao-Wei Chen
SCIENTIFIC REPORTS
(2020)
Article
Psychiatry
Chun-Hao Liu, Eugene Yu-Chuan Kang, Yu-Hsiang Lin, Wei-Chi Wu, Zhuo-Hao Liu, Chang-Fu Kuo, Chi-Chun Lai, Yih-Shiou Hwang
Article
Biochemistry & Molecular Biology
Zhuo-Hao Liu, Yin-Cheng Huang, Chang-Yi Kuo, Chao-Ying Kuo, Chieh-Yu Chin, Ping K. Yip, Jyh-Ping Chen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Infectious Diseases
Shu-Wei Kao, Zhuo-Hao Liu, Ting-Shu Wu, Stephane Wen-Wei Ku, Chia-Lung Tsai, Shian-Sen Shie, Po-Yen Huang, Yen-Mu Wu, Yu-Hsiang Hsiao, Nan-Yu Chen
Summary: The study found that HIV DRM profiles in LLV cases were significantly different from those in ART-naive and ART-failure cases. For cases experiencing LLV episodes, approaches to consolidate ART compliance and early exploration of potential ART resistance may be necessary.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Clinical Neurology
Hsiao-Yun Chen, Chi-Cheng Chuang, Hsien-Chih Chen, Kuo-Chen Wei, Cheng-Nen Chang, Zhuo-Hao Liu, Cheng-Chi Lee, Chun-Chieh Wang, Ping-Ching Pai, Peng-Wei Hsu
JOURNAL OF CLINICAL NEUROSCIENCE
(2020)
Article
Health Policy & Services
Yu-Hsiang Hsiao, Ing-Kit Lee, Te-Yu Lin, Chia-Hung Liao, Chen-Hsiang Lee, Wen-Wei Ku, Shie-Shian Huang, Chia-Hui Yu, Zhuo-Hao Liu, Yi-Chi Chiu, Yi-Hui Lin, Nan-Yu Chen
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2020)
Article
Surgery
Tun-Chen Ong, Pin-Yeh Lin, Chieh-Tsai Wu, Tiing-Yee Siow, Chi-Cheng Chuang, Cheng-Nen Chang, Hsien-Chih Chen, Zhuo-Hao Liu, Yu-Jen Lu, Hong-Chieh Tsai, Peng-Wei Hsu
FORMOSAN JOURNAL OF SURGERY
(2019)